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Chemical Information Retrieval Final Exam2009

Drexel University - Instructor: Jean-Claude Bradley

1. Give 5 examples of primary sources (5 points)

2. Give 5 examples of secondary or tertiary sources (5 points)

3. Give 5 examples of sections in a typical journal article (5 points)

4. Give 5 examples of article-level metrics (5 points)

5. Give 3 examples of Creative Commons licenses (3 points)

6. List 2 of the 4 criteria used to determine if the use of a copyrighted work is consideredfair (2 points)

7. List 5 free chemistry databases (5 points)

8. List 3 commercial chemistry databases that Drexel provides (3 points)

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16. The American Chemical Societya. does not permit self-archiving under any conditionsb. does permit self-archiving under any conditionsc. permits self-archiving for papers resulting from work funded by the National ScienceFoundationd. allows authors to pay to make their articles Open Access

e. pays authors to self-archive their papers

17. Drexel's repository is an example ofa. Green Accessb. Gold Accessc. Green and Gold Accessd. neither Green or Golde. Drexel does not have a repository

18. Which of the following takes into account the importance of incoming citations?a. Thomson Impact Factorb. Eigenfactorc. Web of Science

d. Citation Summary Factore. none of the above

19. During peer review:a. reviewers must repeat at least one experiment in the submitted paperb. reviewers are expected to redo every calculation in the submitted paperc. reviewers are paid at least minimum wage for their effortd. reviewers ensure that nonsense cannot be included in the peer-reviewed literaturee. none of the above

20. What percentage of Open Access chemistry journals charge a publication fee?a. 0%b. 42%

c. 49%d. 9%e. 100%

21. Harold Varmus founded:a. PubChemb. Public Library of Sciencec. arXivd. PNASe. Thomson Impact Factor

22. Many identifiers can be associated with a chemical structure. Which of these is MOST

appropriate to enable structure based searching across the internet via Google?a. Molfileb. InChI Stringc. InChIKeyd. ChemSpider ID

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23. Which of the following identifiers can be used to resolve to a scientific article on theweb.a. CAS Numberb. Digital Object Identifierc. InChI Keyd. Publication ID

24. Which of the following structure databases offers the ability for crowdsourced curation ofthe data?a. PubChemb. ChemSpiderc. Sigma Aldrich websited. NIST Webbook

25. If two molecules are identical what is their Tanimoto similarity?a. 0.5b. 0.0c. 1.0d. 1.5

26. Suppose we define a fingerprint of 4 bits: Bit 1 (from the left) corresponds to thepresence of aromaticity, bit 2 corresponds to the presence of carboxyl groups, bit 3corresponds to the presence of amide bonds and bit 4 corresponds to the presence of anallylic group. With this definition what is the fingerprint for benzoic acid?a. 1100b. 0000c.1111d 1011

27. If you do not have the 3D structure of a protein target, which virtual screening methodcan you *not* usea. QSAR

b. Substructure searchingc. Dockingd. Similarity searching