1998 biochemical syntheses, microbiological syntheses

biochemical syntheses, microbiological synthesesO 0035

26 - 048Aldolase Antibodies of Remarkable Scope. — Aldolase antibodies38C2 and 33F12 are shown to catalyze intermolecular ketone–ketone, ketone–aldehyde, aldehyde–ketone, and aldehyde–aldehyde aldol addition reactionsand, in some cases, to catalyze their subsequent dehydration to yield aldolcondensation products. 23 Donors and 16 acceptors are identified as substratesfor these catalysts. Studies of retroaldol reactions demonstrate that theantibodies provide up to 108-fold enhanced efficiency relative to simple aminecatalyzed reactions. — (HOFFMANN, T.; ZHONG, G.; LIST, B.; SHABAT,D.; ANDERSON, J.; GRAMATIKOVA, S.; LERNER, R. A.; BARBAS, C. F.III; J. Am. Chem. Soc. 120 (1998) 12, 2768-2779; Dep. Mol. Biol. Chem.,Scripps Res. Inst., San Diego, La Jolla, CA 92037, USA; EN)

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