cheminform abstract: antitumor benzothiazoles. part 14. synthesis and in vitro biological properties...

2001 benzothiazole derivatives benzothiazole derivatives R 0270 30 - 136 Antitumor Benzothiazoles. Part 14. Synthesis and in vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles. — A series of mono- and diﬂuorinated title compounds is prepared following the pathways shown for (V) and (XI). The most potent derivative (V) is the favored candidate for clinical studies. — (HUTCHINSON, IAN; CHUA, MEI-SZE; BROWNE, HELEN L.; TRAPANI, VALENTINA; BRADSHAW, TRACEY D.; WESTWELL, ANDREW D.; STEVENS, MALCOLM F. G.; J. Med. Chem. 44 (2001) 9, 1446-1455; Cancer Res. Lab., Sch. Pharm. Sci., Univ. Nottingham, Nottingham NG7 2RD, UK; EN) 1

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Page 1: ChemInform Abstract: Antitumor Benzothiazoles. Part 14. Synthesis and in vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles

2001 benzothiazole derivatives

benzothiazole derivativesR 0270

30 - 136Antitumor Benzothiazoles. Part 14. Synthesis and in vitro BiologicalProperties of Fluorinated 2-(4-Aminophenyl)benzothiazoles. — Aseries of mono- and difluorinated title compounds is prepared following thepathways shown for (V) and (XI). The most potent derivative (V) is the favoredcandidate for clinical studies. — (HUTCHINSON, IAN; CHUA, MEI-SZE;BROWNE, HELEN L.; TRAPANI, VALENTINA; BRADSHAW, TRACEY D.;WESTWELL, ANDREW D.; STEVENS, MALCOLM F. G.; J. Med. Chem. 44(2001) 9, 1446-1455; Cancer Res. Lab., Sch. Pharm. Sci., Univ. Nottingham,Nottingham NG7 2RD, UK; EN)

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