cheminform abstract: free radical (phenylsulfonyl)difluoromethylation of alkynes with phso2cf2i...

ChemInform 2009, 40, issue 22 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Halogen compounds Q 0090 Free Radical (Phenylsulfonyl)difluoromethylation of Alkynes with PhSO2CF2I Reagent: Stereoselective Preparation of PhSO 2 CF 2 - and CF 2 H-Substituted Alk- enes. — Radical addition of the sulfone (II) to terminal alkynes results in formation of substituted vinyl iodides with moderate to good E/Z selectivity. These compounds can further subjected to Suzuki and Sonogashira coupling. Reductive desulfonation affords CF2H-substituted alkenes like (VII) which are of biological interest. — (LI, Y.; LI, H.; HU*, J.; Tetrahedron 65 (2009) 2, 478-483; State Key Lab. Organofluorine Chem., Shanghai Inst. Org. Chem., Chin. Acad. Sci., Shanghai 200032, Peop. Rep. China; Eng.) — Bartels 22- 070

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Page 1: ChemInform Abstract: Free Radical (Phenylsulfonyl)difluoromethylation of Alkynes with PhSO2CF2I Reagent: Stereoselective Preparation of PhSO2CF2- and CF2H-Substituted Alkenes

www.cheminform.wiley-vch.de

Halogen compoundsQ 0090 Free Radical (Phenylsulfonyl)difluoromethylation of Alkynes with PhSO2CF2I

Reagent: Stereoselective Preparation of PhSO2CF2- and CF2H-Substituted Alk-enes. — Radical addition of the sulfone (II) to terminal alkynes results in formation of substituted vinyl iodides with moderate to good E/Z selectivity. These compounds can further subjected to Suzuki and Sonogashira coupling. Reductive desulfonation affords CF2H-substituted alkenes like (VII) which are of biological interest. — (LI, Y.; LI, H.; HU*, J.; Tetrahedron 65 (2009) 2, 478-483; State Key Lab. Organofluorine Chem., Shanghai Inst. Org. Chem., Chin. Acad. Sci., Shanghai 200032, Peop. Rep. China; Eng.) — Bartels

22- 070

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