cheminform abstract: gallium(iii) halides catalyzed, microwave enhanced, synthesis of...

2008 Pyrimidine derivatives R 0510 Gallium(III) Halides Catalyzed, Microwave Enhanced, Synthesis of 3,4-Dihydro- pyrimidin-2-(1H)-ones under Solvent-Free Condition. — Title compounds (IV) (16 examples) are synthesized by an environmentally friendly Biginelli reaction using gallium(III) halide as catalyst. Of particular interest is the production of monastrol (IVi), a lead compound for anticancer activity, in a single step. — (SAINI, A.; KUMAR, S.; SANDHU*, J. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 46 (2007) 11, 1886-1889; Dep. Chem., Punjabi Univ., Patiala 147 002, India; Eng.) — C. Cyrus 10- 160

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Page 1: ChemInform Abstract: Gallium(III) Halides Catalyzed, Microwave Enhanced, Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones under Solvent-Free Condition

2008

Pyrimidine derivativesR 0510 Gallium(III) Halides Catalyzed, Microwave Enhanced, Synthesis of 3,4-Dihydro-

pyrimidin-2-(1H)-ones under Solvent-Free Condition. — Title compounds (IV) (16 examples) are synthesized by an environmentally friendly Biginelli reaction using gallium(III) halide as catalyst. Of particular interest is the production of monastrol (IVi), a lead compound for anticancer activity, in a single step. — (SAINI, A.; KUMAR, S.; SANDHU*, J. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 46 (2007) 11, 1886-1889; Dep. Chem., Punjabi Univ., Patiala 147 002, India; Eng.) — C. Cyrus

10- 160

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