2000 amino acids, peptides

amino acids, peptidesU 0400

29 - 161Guanylpiperidine Peptidomimetics: Potent and Selective Bis-CationInhibitors of Factor Xa. — Fifteen compounds of type (I) are preparedand shown to be highly potent and selective factor Xa inhibitors. Compounds(Ib)–(Id) are regarded as leading candidates that combine both high in vitropotency versus factor Xa with desirable selectivity profiles towards othertrypsin-like serine proteases. — (SEMPLE, J. EDWARD; ET AL.; Bioorg.Med. Chem. Lett. 10 (2000) 8, 745-749; Dep. Med. Chem., Corvas Int., Inc.,San Diego, CA 92121, USA; EN)

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