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Purine derivativesR 0540 Microwave-Assisted One Step Synthesis of 8-Arylmethyl-9H-purin-6-amines. —

This simplified one-pot synthesis of title compounds (III) can generate the desired products with yields comparable or significantly higher than the previously published route. The applicability and the limitations of this method towards the development of a large diversity in the arylmethylpurinamine heat shock protein 90 (Hsp90) inhibitor series are discussed. — (TAO, H.; KANG, Y.; TALDONE, T.; CHIOSIS*, G.; Bioorg. Med. Chem. Lett. 19 (2009) 2, 415-417; Dep. Med., Meml. Sloan-Kettering Cancer Cent., New York, NY 10021, USA; Eng.) — H. Hoennerscheid

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