cheminform abstract: new synthesis of 5-amino-4-hydroxy-2,6-dimethylheptanoic acid, a...

2001 amino acids, peptides amino acids, peptides U 0400 11 - 191 New Synthesis of 5-Amino-4-hydroxy-2,6-dimethylheptanoic Acid, a Hydroxyethylene Isostere of the Val-Ala Dipeptide. — Starting from the L-valine derivative (I) compounds of type (X) and (XI) are prepared via nitrile (IX) and can be used as building blocks for pseudopeptide inhibitors in several steps. They are internally protected equivalents of enantiopure 5-amino-4-hydroxy-2,6-dimethylheptanoic acid. — (BENEDETTI, FABIO; MAMAN, PAOLO; NORBEDO, STEFANO; Tetrahedron Lett. 41 (2000) 51, 10075-10078; Dip. Sci. Chim., Univ. Trieste, I-34127 Trieste, Italy; EN) 1

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Page 1: ChemInform Abstract: New Synthesis of 5-Amino-4-hydroxy-2,6-dimethylheptanoic Acid, a Hydroxyethylene Isostere of the Val-Ala Dipeptide

2001 amino acids, peptides

amino acids, peptidesU 0400

11 - 191New Synthesis of 5-Amino-4-hydroxy-2,6-dimethylheptanoic Acid,a Hydroxyethylene Isostere of the Val-Ala Dipeptide. — Startingfrom the L-valine derivative (I) compounds of type (X) and (XI) are preparedvia nitrile (IX) and can be used as building blocks for pseudopeptide inhibitorsin several steps. They are internally protected equivalents of enantiopure5-amino-4-hydroxy-2,6-dimethylheptanoic acid. — (BENEDETTI, FABIO;MAMAN, PAOLO; NORBEDO, STEFANO; Tetrahedron Lett. 41 (2000) 51,10075-10078; Dip. Sci. Chim., Univ. Trieste, I-34127 Trieste, Italy; EN)

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