1999 pyridine derivatives

pyridine derivativesR 0380

17 - 142Potent and Selective Thrombin Inhibitors Featuring Hydrophobic,Basic P3-P4-Aminoalkyllactam Moieties. — In a continuous study onthrombin inhibitors different kinds of the title compounds such as (X) and (XIV)are synthesized. The most interesting substance is (X). The structure–activityrelationships are discussed. — (SEMPLE, J. EDWARD; ROWLEY, DAVIDC.; OWENS, TIMOTHY D.; MINAMI, NATHANIEL K.; UONG, THERESAH.; BRUNCK, TERENCE K.; Bioorg. Med. Chem. Lett. 8 (1998) 24,3525-3530; Dep. Med. Chem., Corvas Int., Inc., San Diego, CA 92121, USA;EN)

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