cheminform abstract: sna-8073-b, a new isotetracenone antibiotic inhibits prolyl endopeptidase. part...

1997 antibiotics antibiotics U 1200 42 - 280 SNA-8073-B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase. Part 1. Fermentation, Isolation and Biological Properties. — The title compound (I) inhibits prolyl endopeptidase of Flavobacterium non-competitively (IC50=8.9 μM) when Z-Gly-Pro-pNA is used as a substrate. — (KIMURA, K.; KANOU, F.; KOSHINO, H.; URAMOTO, M.; YOSHIHAMA, M.; J. Antibiot. 50 (1997) 4, 291-296; Res. Inst. Life Sci., Snow Brand Milk Prod. Co., Ltd., Shimotsuga, Tochigi 329-05, Japan; EN) 1

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Page 1: ChemInform Abstract: SNA-8073-B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase. Part 1. Fermentation, Isolation and Biological Properties

1997 antibiotics

antibioticsU 1200

42 - 280SNA-8073-B, a New Isotetracenone Antibiotic Inhibits ProlylEndopeptidase. Part 1. Fermentation, Isolation and BiologicalProperties. — The title compound (I) inhibits prolyl endopeptidase ofFlavobacterium non-competitively (IC50=8.9 µM) when Z-Gly-Pro-pNA is usedas a substrate. — (KIMURA, K.; KANOU, F.; KOSHINO, H.; URAMOTO,M.; YOSHIHAMA, M.; J. Antibiot. 50 (1997) 4, 291-296; Res. Inst. LifeSci., Snow Brand Milk Prod. Co., Ltd., Shimotsuga, Tochigi 329-05, Japan; EN)

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