1997 antibiotics

antibioticsU 1200

40 - 289Stereoselective Syntheses and Evaluation of Compounds in the8- Desmethylepothilone A Series: Some Surprising ObservationsRegarding Their Chemical and Biological Properties. — The titlecompounds (I) and (II) are screened for their cytotoxicity in cell cultures.They show drastically reduced activity in comparison with their epothiloneA counterparts. — (BALOG, A.; BERTINATO, P.; SU, D.-S.; MENG, D.;SORENSEN, E.; DANISHEFSKY, S. J.; ZHENG, Y.-H.; CHOU, T.-C.; HE,L.; HORWITZ, S. B.; Tetrahedron Lett. 38 (1997) 26, 4529-4532; Lab. Bioorg.Chem., Sloan-Kettering Inst. Cancer Res., Cornell Univ., New York, NY 10021,USA; EN)

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