cheminform abstract: synthesis of 6α-hydroxypaclitaxel, the major human metabolite of paclitaxel
TRANSCRIPT
1998 terpenes
terpenesU 0200
41 - 188Synthesis of 6α-Hydroxypaclitaxel, the Major Human Metabolite ofPaclitaxel. — 6α-Hydroxypaclitaxel (I), the major human metabolite ofpaclitaxel, is synthesized via epimerization of 6α-hydroxy-7-epipaclitaxel, whichis prepared from paclitaxel in four steps in high yield. The optimum conditionsafforded 80–88% yield. The stereochemistry of paclitaxel 6,7-epoxide is revisedfrom β- to α-epoxide. — (YUAN, H.; KINGSTON, D. G. I.; TetrahedronLett. 39 (1998) 28, 4967-4970; Dep. Chem., Va. Polytech. Inst. State Univ.,Blacksburg, VA 24061, USA; EN)
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