2008

Pyridine derivativesR 0380 Synthesis, QSAR and Calcium Channel Antagonist Activity of New 1,4-Dihydro-

pyridine Derivatives Containing 1-Methyl-4,5-dichloroimidazolyl Substituents. — A series of diester analogues (I) of nifedipine is synthesized and evaluated as calci-um-channel antagonists. Compounds (Ia) and (Ie) appear to be the most active deriva-tives among the symmetrical and unsymmetrical diester derivatives, respectively. — (HOSSEINI, M.; MIRI*, R.; AMINI, M.; MIRKHANI, H.; HEMMATEENEJAD, B.; GHODSI, S.; ALIPOUR, E.; SHAFIEE, A.; Arch. Pharm. (Weinheim, Ger.) 340 (2007) 10, 549-556; Fac. Pharm., Tehran Univ. Med. Sci., Tehran 14174, Iran; Eng.) — A. Forchert

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