cheminform abstract: total synthesis of (-)-epothilone a
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1997 other bioactive products
other bioactive productsU 1300
13 - 213Total Synthesis of (-)-Epothilone A. — Starting with the chiral buildingblocks (I) and (II) (preparations are described) coupling product (III) isobtained, the important precursor for the key cyclization. With (III) theaggressive strategy of employing the methyl group of the C-1 bound acetoxyfunction as the nucleophilic component in the macroaldolization is explored.This highly stereoselective macroaldolization results in the formation of the C-3(S)-alcohol (IV), from which the title compound (V) is prepared in several steps.— (BALOG, A.; MENG, D.; KAMENECKA, T.; BERTINATO, P.; SU, D.-S.;SORENSEN, E. J.; DANISHEFSKY, S. J.; Angew. Chem. 108 (1996) 23-24,2976-2978; Lab. Bioorg. Chem., Sloan-Kettering Inst. Cancer Res., New York,NY 10021, USA; DE)
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