Chapter 17 (Part 1)

Amino Acid Metabolism:Nitrogen Assimilation

and Amino Acid Biosynthesis

Nitrogen Cycle

Nitrogenase

Nitrate and Nitrite to Ammonia

Ammonia Assimilation

Glutamate Dehydrogenase

Glutamine Synthetase (GS)

Glutamine back to Glutamate

Allosteric Modulation

of GS Acitivity in Bacteria

Regulation of Bacterial

GS by Covalent

Modification

Glutamate serves as primary N- donor for AA synthesis through transamination

reactions

Transamination rxns involve Pyridoxol-phosphate and formation of Schiff Base

Essential vs. Non-Essential AA’s

Amino Acid Biosynthesis is a Diverse Process