choice pathology informatics 2010 boston, massachusetts dataready ® : a deployable data management...

CHOICE

Pathology Informatics 2010

Boston, Massachusetts

DataReady®: A Deployable Data Management and Integration

System for Large-scale CancerRepositories and Intelligent

Databases

© 2010 Integrated Solutions, Inc. All Rights Reserved

Jun-Min Liu’s Status report

• Tissue Micro Array (TMA) first introduced in 1998

• Revolutionized the manner in which investigators address the challenges of limited tissue resources.

• Ideal TMA study: TMA blocks coupled with a data parameters • images• tissue diagnosis• patient demographics • other biomaterial descriptions • quantified experimental results

• Technical Standards Committee of the Association for Pathology Informatics : XML based TMA data exchange specification

Jun-Min Liu’s Status reportEarly Advances in Tissue Micro

Array Data Exchange



• Large-scale TMA projects continue to shift towards multi-institutional efforts

• Sharing information across centers and campuses

• Propel new advances in drug discovery and therapy planning

• Challenge: analysis and interpretation in large, decentralized, distributed environments

Jun-Min Liu’s Status reportA Shift Towards Multi-

Institutional Efforts



• Natural extension of the early efforts and advances made in TMA data exchange and integration: developed a prototype for automated TMA

• Integrated Solutions, Inc. (ISI) joined with The Cancer Institute of New Jersey (CINJ) at UMDNJ-Robert Wood Johnson Medical School to leverage early advances

• Concept system will feature both stand-alone and network modes for image analysis and mining for tissue microarrays

• Data sharing and integration system to facilitate the collection and management of bio-informatics data

Jun-Min Liu’s Status reportAdvancements in

Technology


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportPrototype Concept

Field Engineer

Researcher

Scientist

DataReady in Boston

Composite Health Care System in LA

Personnel Center in Houston

Clinical Information System in NYC



• Integrated Solutions, Inc. (ISI) is in a unique position to develop an application for the integration of the TMA Data Sharing

• Primary goals: • User-friendly interface • Quick and reliable selection of data resources for extraction and assessment • Suite of tools that will enable investigators at strategically networked sites to

quickly search, interrogate and integrate pathology metadata • Data owner has full control of data sharing security

Jun-Min Liu’s Status reportInnovative Design

Success in feasibility studies at The Cancer Institute of NJ

Support from Emory University, University of Pennsylvania to Evaluate DataReady® TMA Data Center Sharing (TMADCS)


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportConcept Design



• InfoSentinel® Single Interface Technology (SIFT)

• Unique approach to the linkage of information

• Allows a single interface to communicate with multiple types of interfaces

• SIFT is compatible with industrial standards bridge the gaps between legacy and emergent technologies with minimum IT effort

Jun-Min Liu’s Status reportInnovative Core Technology



• Data owner has full control of data sharing security

• Security Matrix offers: • Full audit trail capabilities • Track, manage, and record user account activity• Maintain an itemized list of accessed data and resources

• Offers full capability to de-identify and re-identify data

Jun-Min Liu’s Status reportDataReady® Security Matrix


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportDataReady® Permission

Matrix Interface


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportDataReady® Study

Management Interface



• Expansion of archived reference images of pathology specimens and correlated clinical data

• Develop tools to support query-enabled databases distributed across multiple clinical and research sites

• Create a data analysis module that will serve as the integrated data analysis center

Jun-Min Liu’s Status reportAdaptability: Moving

towards the Future


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportDataReady® TMADCS

Cancer Query System


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportIntegrated Data Analysis

Module

SURVIVAL_TIME_MOD (Month) UNIT_OF_SURVIVALS0 - 50 1251 - 100 1101 - 150 5151 - 200 18201 - 250 16251 - 300 20301 + 6



• Pilot system for DataReady® TMADCS data integration management:• illustrated efficiency and effectiveness in gathering information from multiple data

sources provided by multiple sites

• Demonstrated results through successful complex queries related to tissue micro-array images, clinical subjects, and distributed environments

• Established success of our proposed data integration system in the use of pathology information and image management

• Extremely valuable tool to assist pathologists and clinicians in analyzing relevant TMA data effectively, efficiently and securely

Inherent flexibility of the DataReady® TMADCS technology will assure continued success in data integration as the TMA data sharing grows and evolves

Jun-Min Liu’s Status reportDataReady® TMADCS


Jun-Min Liu’s Status reportJun-Min Liu’s Status reportAcknowledgements

Center for Biomedical Imaging and Informatics at the Cancer Instituteof New Jersey, UMDNJ- Robert Wood Johnson Medical School,

Piscataway, NJDavid J. Foran, PhD ([email protected])

Wenjin Chen PhDVicky Chu MS

Integrated Solutions Inc., Holmdel, NJ. Rachel Wilhite MPH

Esther Yu BSJun-Min Liu PhD

ASIFT Software, Holmdel, NJ


mailto:[email protected]

choice pathology informatics 2010 boston, massachusetts dataready ® : a deployable data management...

Documents

informatics data

rights reserved slide

deployable data management

tma blocks

pathology metadata data

ideal tma study

integration system

early advances concept