PERINATAL RISK FACTORS FOR CHRONIC LUNG DISEASE IN INFANTS BORN BEFORE 32 WEEKS OF GESTATIONAL AGE

Gmbuan Ana-Maria1, Cucerea Manuela

1UMF Trgu Mure

Background: Chronic lung disease (CLD) is one of the most severe late complication of prematurity, associated with oxygen therapy and mechanical ventilation. Objective: To identify risk factors for CLD.Material and methods: prospective study conducted at the Clinic of Neonatology I Targu-Mures. Data were collected over from 01.07.2014 to 31.12.2014. All the surviving infants born before 32 weeks of gestational age were included. Regarding the statistical analysis p-value < 0.05 ( 95% CI ) was considered significant.Results: 47 preterm neonates with mean gestational age (GA) 29.11 2,70 weeks and mean birthweight (BW) of 1109.36 257.40g were enrolled in the study. 8 of them were diagnosed with CLD (20.78%). The incidence of CLD was 54.54% in infants with BW 1000g and 0% in the group with BW between 1001-1500g. Infants with CLD had significantly lower GA (p=0.002), BW (p=0.000), Apgar score at 1 (p=0.010) and 5 minutes (p=0.044). The duration of CPAP support (p=0.009), mechanical ventilation (p=0.000) and oxygen therapy (p=0.000) were significantly higher. Significant correlations (r