F. Caligaris -CappioR. Dalla -Favera (

ChronicLymphocyticLeukemia

B Cell Development and Its Deregulation to Transformed State sat the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage

' .F. Melchers

Gene Expression Patterns in Human and Mouse B Cell Development f9R.Hoffmann

New Insights into the Phenotype and Cell Derivationof B Cell Chronic Lymphocytic Leukemia 31.

U.Klein and R . Dalla-Favera

Chronic Lymphocytic Leukemia :Molecular Genetics and Animal Models

5 1Y. Pekarsky, G. A . Calin, R . Aqeilan, and C. M. Croce

What Do Somatic Hypermutation and Class Switch RecombinationTeach Us About Chronic Lymphocytic Leukaemia Pathogenesis?

7],P. Oppezzo and G . Dighiero

Chronic Lymphocytic Leukaemia : A Review of the Immuno-architecture 91,S.Rosati and Ph . M. Klui n

Clinical and Laboratory Parameter sThat Define Clinically Relevant B-CLL Subgroups

10 9N. Chiorazzi, S. L. Allen, and M. Ferrarin i

Differential MC-t$ 9n Ct .L Cell Survival Exerte dby Different Microenvironmental Elements

13 5P. Ghia, P. Circosta, C. Scielzo, A . Vallario, A . Camporeale, L. Granziero,and F. Caligaris-Cappio

Genotypic Prognostic Markers

14 7S. Stilgenbauer and H. Döhner

Chronic Lymphocytic Leukaemia : Clinical Translations of Biological Features . . 16 5T. J. Hambli n

Subject Index 187