circ d. case 52 clinical : male baby

Circ DCirc D

Case 52Case 52

Clinical : Male baby. Clinical : Male baby.

Most popular diagnosis….Most popular diagnosis….

Myofibromatosis (+/- infantile) 8.39Myofibromatosis (+/- infantile) 8.39

Case 53Case 53

Clinical: Female, 19 years. Vascular polyp Clinical: Female, 19 years. Vascular polyp on left side of nose. on left side of nose.

PGP 9.5 and CD63 = Positive. PGP 9.5 and CD63 = Positive.

S100, Melan A, SMA, Desmin, EMA, S100, Melan A, SMA, Desmin, EMA, MNF116 = Negative.MNF116 = Negative.

Most popular diagnosis…Most popular diagnosis…

Neurothekeoma (+/-cellular) Neurothekeoma (+/-cellular) 6.776.77

Case 54Case 54

Clinical: Female, 28 years old. Slowly Clinical: Female, 28 years old. Slowly growing lesion on chest wall.growing lesion on chest wall.

Immunohistochemistry: Tumour cells in Immunohistochemistry: Tumour cells in both components of the tumour are both components of the tumour are positive for CD34. Negative staining for positive for CD34. Negative staining for EMA, Desmin, SMA, S100, FXIIIa, CD31.EMA, Desmin, SMA, S100, FXIIIa, CD31.

DFSP with giant DFSP with giant

cell fibroblastoma areas cell fibroblastoma areas 5.595.59

Case 55Case 55

Clinical: Female, 30 years. Lesion on Clinical: Female, 30 years. Lesion on thigh. ?Haemangioma.thigh. ?Haemangioma.

Most popular diagnoses…Most popular diagnoses…

Epithelioid haemangioma Epithelioid haemangioma 4.464.46 Cutaneous epithelioid angiomatous noduleCutaneous epithelioid angiomatous nodule 1.231.23 Microvenular haemangioma Microvenular haemangioma 0.950.95

Case 56Case 56

Clinical: Male, 73 years. Multiple nodules Clinical: Male, 73 years. Multiple nodules on the buttocks. ?Squamous cell on the buttocks. ?Squamous cell carcinoma.carcinoma.

Scabies (+/- Norwegian) 9.80Scabies (+/- Norwegian) 9.80

Case 57Case 57

Clinical: Male, 63 years. ?BCC.Clinical: Male, 63 years. ?BCC.

Cutaneous lymphadenoma Cutaneous lymphadenoma 8.718.71

Case 58Case 58

Clinical: Male, 23 years. Lesion right ring Clinical: Male, 23 years. Lesion right ring finger. finger.

Special stains: Lesional cells - S100 and Special stains: Lesional cells - S100 and EMA positive.EMA positive.

Neurothekeoma (+/- myxoid)Neurothekeoma (+/- myxoid) 9.729.72

Case 59Case 59 Clinical: Male, 87 years. Six month history of itchy dermal nodules.Clinical: Male, 87 years. Six month history of itchy dermal nodules.

Special stains: Diffuse positivity for CD79a. Special stains: Diffuse positivity for CD79a.

Patchy CD20 and Bcl2 positivity. Patchy CD20 and Bcl2 positivity.

CD5 and CD10 negative in this population. CD5 and CD10 negative in this population.

Few aggregates of Bcl6 positive cells. CD23 highlights residual Few aggregates of Bcl6 positive cells. CD23 highlights residual FDC networks only. FDC networks only.

Prominent CD3 positive population. Prominent CD3 positive population.

Monotypic expression of Lambda light chains Monotypic expression of Lambda light chains

Marginal zone lymphoma Marginal zone lymphoma 6.166.16

Case 60Case 60

Clinical: Female, 75 years. Plaque left Clinical: Female, 75 years. Plaque left shin. ?Lichen simplex.shin. ?Lichen simplex.

Hypertrophic lichen planus Hypertrophic lichen planus 7.367.36

Case 61Case 61

Clinical: Male, 69 years. Forehead lesion. Clinical: Male, 69 years. Forehead lesion. ?Lentigo maligna just above left eyebrow ?Lentigo maligna just above left eyebrow

Lentigo maligna melanomaLentigo maligna melanoma

Case 62Case 62

Female, 61 years old. Lesion excision by Female, 61 years old. Lesion excision by plastic surgeon with a diagnosis of plastic surgeon with a diagnosis of verrucous epidermal naevus. verrucous epidermal naevus.

Submitted diagnosis…Submitted diagnosis…

Granular parakeratosis Granular parakeratosis

Case 63Case 63 Female, 38 years. Nodule on the sole of the left Female, 38 years. Nodule on the sole of the left

foot. foot.

Special stains: Cytokeratin, focally EMA and Special stains: Cytokeratin, focally EMA and S100 protein positive. S100 protein positive.

Negative for SMA, HMB45, p63, CD31 and Negative for SMA, HMB45, p63, CD31 and GFAP. GFAP.

Approximately 10% of the cells show MIB-1 Approximately 10% of the cells show MIB-1 positivitypositivity

Benign adnexal tumourBenign adnexal tumour

Case 64Case 64

Male, 79 years old.Male, 79 years old.

Generalised thickening of skin, papular Generalised thickening of skin, papular like. ?Scleroderma.like. ?Scleroderma.

History of monoclonal gammopathy (IgG, History of monoclonal gammopathy (IgG, Kappa)Kappa)

Scleromyxoedema Scleromyxoedema

Case 65Case 65

female 30 yrs. 2 yr history of cyst neck female 30 yrs. 2 yr history of cyst neck midline. midline.

EMA++ CD34++EMA++ CD34++

Low grade fibromyxoid sarcomaLow grade fibromyxoid sarcoma

Case 66Case 66

Clinical: Female large tumour mass at tip Clinical: Female large tumour mass at tip of nose infiltrating septum.of nose infiltrating septum.

Strongly positive TdT, bcl2, CD99, Strongly positive TdT, bcl2, CD99, MNF116, CK20. MNF116, CK20.

Negative for CD3, CD20, CD79a, CD10, Negative for CD3, CD20, CD79a, CD10, bcl6, CD34, S100 and MPObcl6, CD34, S100 and MPO

Merkel cell carcinoma Merkel cell carcinoma

The EndThe End

circ d. case 52 clinical : male baby

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positivity slide

left eyebrow slide

granular parakeratosis

circ d slide

benign adnexal tumour

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years old

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