class i class ii class iiidadun.unav.edu/bitstream/10171/29162/2/glut-12 figures.pdf · •...
TRANSCRIPT
![Page 1: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative](https://reader034.vdocuments.net/reader034/viewer/2022042221/5ec7394f203f5158ff7ac14b/html5/thumbnails/1.jpg)
Class I
Class II
Class III
![Page 2: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative](https://reader034.vdocuments.net/reader034/viewer/2022042221/5ec7394f203f5158ff7ac14b/html5/thumbnails/2.jpg)
NH2 COOH
N
1 2 3 4 5 7 8 6 12 11 10 9
Extracellular
Intracellular
LL LL
QLS
![Page 3: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative](https://reader034.vdocuments.net/reader034/viewer/2022042221/5ec7394f203f5158ff7ac14b/html5/thumbnails/3.jpg)
pm
ol/
oo
cyte
/min
0
10
20
30
40
50
60
70
NI
GLUT12
Na+ buffer Na
+- free
ree
buffer
![Page 4: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative](https://reader034.vdocuments.net/reader034/viewer/2022042221/5ec7394f203f5158ff7ac14b/html5/thumbnails/4.jpg)
A. Glucose 100 mM B. Glucose 100 mM
![Page 5: Class I Class II Class IIIdadun.unav.edu/bitstream/10171/29162/2/GLUT-12 Figures.pdf · • Galactose • Fructose SLC2A12/ GLUT12 orFunctional Glucose characteristics Equilibrative](https://reader034.vdocuments.net/reader034/viewer/2022042221/5ec7394f203f5158ff7ac14b/html5/thumbnails/5.jpg)
Related diseases
• Obesity ? • Type II diabetes? • Cancer Physiological
role
Breast and Prostate Cancer
Location
Physiological role
Adipose Tissue
Skeletal Muscle
Small intestine
Unknown
• Glucose • Galactose • Fructose
Glucose SLC2A12/ GLUT12 Functional characteristics
Equilibrative Concentrative
Glucose H+
or Na+ ?
or
Extracellular
Intracellular Substrates
Cytoplasmic Vesicles Translocation
IRS-1
PI3K PDKI
GLUT4
GLUT12
Insulin response Glucose Insulin
IR GLUT12 GLUT4
Glucose Glycolytic metabolism
Mitochondrion
Pyruvate
Lactate
GLUT1 GLUT12 MCT1
LDH-A Glycolysis
H+
Oxidative metabolism
Glucose