7/24/2019 Classification of GN

1/1

Classifcation o GNPrimary: the pathological glomerular injury is limited to the kidney and

not part o a systemic disease maniestation.

Presenting primarily as heavy proteinuria/ nephrotic syndrome

Minimal change disease (usion o podocyte ood processes on electron

microscope)

ocal ! segmental glomerulosclerosis (areas o sclerosis" mesangial matri#

e#pansion" collapse o capillary loops a$ecting parts (segments) o some

glomeruli (ocal)

Mem%ranous nephropathy (thickening o glomerular &M on light

microscope)

Presenting primarily as nephritic syndrome

'g nephropathy (increase in mesangial matri# ! cells" in association ithmesangial deposition o 'g)

Mem%ranoprolierati*e glomerulonephritis

Presenting primarily as rapidly progressive glomerulonephritis (nephritic

syndrome over weeks to months)

nti+G&M anti%ody glomerulonephritis

,econdary: renal pathology in this group is a result o systemic disease

hich also has other organ in*ol*ement.

'mmunologic diseases: ,ystemic lupus erythematosus" polyarteritis"

-egeners granulomatosis" mi#ed connecti*e tissue disease" /enoch+

,chonlein purpura.

Genetic+meta%olic diseases: 0ia%etes mellitus" amyloidosis"sickle cell

disease.

/aemtologic+oncologic diseases: Multiple myeloma" macroglo%ulinaemia"

light chain disease" cryoglo%ulinaemia" throm%otic throm%ocytopaenia

purpura" haemolytic+uraemic syndrome" lymphoma" leukaemias and

carcinomas.

'nectious diseases: Post+streptococcal" endocarditis" occult a%scesses"

hepatitis & and C" malaria" schistosomiasis. 1thers: 0rug+induced.