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Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

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Page 1: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

Classification of uterine corpus carcinomas,

carcinosarcomas and sarcomas

Focus on molecular approaches

Prof. Ben Davidson, MD PhD

Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

Page 2: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 3: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

Issues

• Evolution

• Diagnosis

• Prognosis

• Therapy

Page 4: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

Endometrial carcinoma

Page 5: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

Matias-Guiu and Davidson, Virchows Arch 2014;464:315-331

Molecular pathways

Page 6: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 7: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 8: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 9: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 10: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
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Matias-Guiu and Davidson, Virchows Arch 2014;464:315-331

Prognosis

Page 19: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 20: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
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Uterine carcinosarcoma

Page 26: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 27: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 28: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 29: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 30: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
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Uterine sarcoma

Page 33: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

• ESS cytogenetics: JAZF1-SUZ12 (JJAZ1)

JAZF1-PHF1

EPC1-PHF1

MEAF6-PHF1

ZC3H7B-BCOR

MBTD1-CXorf67

HG ESS: YWHAE-NUTM2A/B (FAM22A/B)

Page 34: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 35: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 36: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 37: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 38: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 39: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
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Page 43: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 44: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 45: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD
Page 46: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

Summary

• The evolution of several uterine cancers is unclear

• Diagnosis is based on combination of morphology, IHC and

(in some situations) molecular findings

• There are distinct sub-groups with prognostic relevance

within established histological entities, most evidently in EEC

• The potential of targeted therapy is yet to be realized in

uterine cancer

Page 47: Classification of uterine corpus carcinomas, …...Classification of uterine corpus carcinomas, carcinosarcomas and sarcomas Focus on molecular approaches Prof. Ben Davidson, MD PhD

Thank you for your attention


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Treating Symptomatic Uterine Fibroids with Uterine Fibroid

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Female Genital Tract 1-Vulva 2-Vagina 3-Cervix 4-Uterine corpus 5-Ovary 6-Placenta

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