SPECIAL FEATURES

Highlights of This Issue 1771

Editorial

1773 Introducing a New Series: Immunotherapy Factsand HopesIgnacio Melero, Mario Sznol, Marlowe S. Tessmer,Theresa L. Whiteside, and Jedd D. Wolchok

CCR Translations

1775 Small-Cell Neuroendocrine Tumors: Cell StateTrumps the Oncogenic DriverMatthew G. Oser and Pasi A. J€anneSee related article, p. 1965

1777 Harnessing the Power of Patient-ReportedOutcomes in OncologyRyan D. Nipp and Jennifer S. TemelSee related article, p. 1780

CCR Perspectives in Regulatory Scienceand Policy

1780 Use of PRO Measures to Inform Tolerability inOncology Trials: Implications for Clinical Review,IND Safety Reporting, and Clinical SiteInspectionsJanice Kim, Harpreet Singh, Kassa Ayalew, Kristina Borror,Michelle Campbell, Laura Lee Johnson, Alyson Karesh,Ni A. Khin, Joanne R. Less, Jerry Menikoff, Lori Minasian,Sandra A. Mitchell, Elektra J. Papadopoulos,Richard L. Piekarz, Kevin A. Prohaska, Susan Thompson,Rajeshwari Sridhara, Richard Pazdur, and Paul G. KluetzSee related commentary, p. 1777

Review

1785 Analysis of Drug Development Paradigms forImmune Checkpoint InhibitorsDenis L. Jardim, D�ebora de Melo Gagliato, Francis J. Giles,and Razelle Kurzrock

Perspectives

1795 Drug Resistance in HER2-Positive Breast CancerBrain Metastases: Blame the Barrier or the Brain?Sheheryar Kabraji, Jing Ni, Nancy U. Lin, Shaozhen Xie,Eric P. Winer, and Jean J. Zhao

CANCER THERAPY: CLINICAL

1805 Pembrolizumab Plus Pegylated Interferon alfa-2bor Ipilimumab for Advanced Melanoma or RenalCell Carcinoma: Dose-Finding Results from thePhase Ib KEYNOTE-029 StudyMichael B. Atkins, F. Stephen Hodi, John A. Thompson,David F. McDermott, Wen-Jen Hwu, Donald P. Lawrence,Nancy A. Dawson, Deborah J. Wong, Shailender Bhatia,Marihella James, Lokesh Jain, Seth Robey, Xinxin Shu,Blanca Homet Moreno, Rodolfo F. Perini, Toni K. Choueiri,and Antoni Ribas

1816 Phase I Study of Single-Agent Utomilumab(PF-05082566), a 4-1BB/CD137 Agonist, inPatients with Advanced CancerNeil H. Segal, Aiwu R. He, Toshihiko Doi, Ronald Levy,Shailender Bhatia, Michael J. Pishvaian, Rossano Cesari,Ying Chen, Craig B. Davis, Bo Huang, Aron D. Thall, andAjay K. Gopal

1824 Induction Chemotherapy plus ConcurrentChemoradiotherapy in Endemic NasopharyngealCarcinoma: Individual Patient Data PooledAnalysis of Four Randomized TrialsYu-Pei Chen, Ling-Long Tang,Qi Yang, Sharon-Shuxian Poh,Edwin P. Hui, Anthony T.C. Chan, Whee-Sze Ong,Terence Tan, Joseph Wee, Wen-Fei Li, Lei Chen,Brigette B.Y. Ma, Macy Tong, Sze-Huey Tan, Shie-Lee Cheah,Kam-Weng Fong, Kiattisa Sommat, Yoke Lim Soong,Ying Guo, Ai-Hua Lin, Ying Sun, Ming-Huang Hong,Su-Mei Cao, Ming-Yuan Chen, and Jun Ma

1834 Complete Remission with Reduction of High-RiskClones following Haploidentical NK-Cell Therapyagainst MDS and AMLAndreas T. Bj€orklund, Mattias Carlsten, Ebba Sohlberg,Lisa L. Liu, Trevor Clancy, Mohsen Karimi, Sarah Cooley,Jeffrey S. Miller, Monika Klimkowska, Marie Schaffer,Emma Watz, Kristina Wikstr€om, Pontus Blomberg,Bj€orn Engelbrekt Wahlin, Marzia Palma, Lotta Hansson,Per Ljungman, Eva Hellstr€om-Lindberg,Hans-Gustaf Ljunggren, and Karl-Johan Malmberg

1845 Pathological Response in a Triple-Negative BreastCancer Cohort Treated with NeoadjuvantCarboplatin and Docetaxel According toLehmann's Refined ClassificationIsabel Echavarria, Sara L�opez-Tarruella, Antoni Picornell,

Jose �Angel García-Saenz, Yolanda Jerez, Katherine Hoadley,HenryL.G�omez, FernandoMoreno,MaríaDelMonte-Millan,Iv�anM�arquez-Rodas, Enrique Alvarez, Rocío Ramos-Medina,Javier Gayarre, Tatiana Massarrah, Inmaculada Oca~na,María Cebollero, Hugo Fuentes, Agusti Barnadas,Ana Isabel Ballesteros, Uriel Bohn, Charles M. Perou, andMiguel Martin

April 15, 2018 � Volume 24 � Number 8

Clinical Cancer Research

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PERSONALIZED MEDICINE AND IMAGING

1853 HER3-Mediated Resistance to Hsp90 InhibitionDetected in Breast Cancer Xenografts byAffibody-Based PET ImagingCarlos D. Martins, Chiara Da Pieve, Thomas A. Burley,Rhodri Smith, Daniela M. Ciobota, Louis Allott,Kevin J. Harrington, Wim J.G. Oyen, Graham Smith, andGabriela Kramer-Marek

1866 Further Investigation of the Role of ACYP2 andWFS1 Pharmacogenomic Variants in theDevelopment of Cisplatin-Induced Ototoxicity inTesticular Cancer PatientsBritt I. Dr€ogem€oller, Beth Brooks, Carol Critchley,Jos�e G. Monzon, Galen E.B. Wright, Geoffrey Liu,Daniel J. Renouf, Christian K. Kollmannsberger,Philippe L. Bedard, Michael R. Hayden, Karen A. Gelmon,Bruce C. Carleton, and Colin J.D. Ross

1872 Early Assessment of Lung Cancer ImmunotherapyResponse via Circulating Tumor DNASarah B. Goldberg, Azeet Narayan, Adam J. Kole,Roy H. Decker, Jimmitti Teysir, Nicholas J. Carriero,Angela Lee, Roxanne Nemati, Sameer K. Nath,Shrikant M. Mane, Yanhong Deng, Nitin Sukumar,Daniel Zelterman, Daniel J. Boffa, Katerina Politi,Scott N. Gettinger, Lynn D. Wilson, Roy S. Herbst, andAbhijit A. Patel

1881 Hybrid Capture–Based Genomic Profilingof Circulating Tumor DNA from Patients withAdvanced Cancers of the GastrointestinalTract or AnusAlexa B. Schrock, Dean Pavlick, Samuel J. Klempner,JonH. Chung, Brady Forcier, AllisonWelsh, Lauren Young,Bryan Leyland-Jones, Rodolfo Bordoni,Richard D. Carvajal, Joseph Chao, Razelle Kurzrock,Jason K. Sicklick, Jeffrey S. Ross, Philip J. Stephens,Craig Devoe, Fadi Braiteh, Siraj M. Ali, andVincent A. Miller

CANCER THERAPY: PRECLINICAL

1891 Nitric Oxide Production by Myeloid-DerivedSuppressor Cells Plays a Role in Impairing FcReceptor–Mediated Natural Killer Cell FunctionAndrew Stiff, Prashant Trikha, Bethany Mundy-Bosse,Elizabeth McMichael, Thomas A. Mace, Brooke Benner,Kari Kendra, Amanda Campbell, Shalini Gautam,David Abood, Ian Landi, Vincent Hsu, Megan Duggan,Robert Wesolowski, Matthew Old, John Harrison Howard,Lianbo Yu, Nancy Stasik, Thomas Olencki,Natarajan Muthusamy, Susheela Tridandapani,John C. Byrd, Michael Caligiuri, and William E. Carson

1905 A Combination of SAHA and Quinacrine IsEffective in Inducing Cancer Cell Death in UpperGastrointestinal CancersShoumin Zhu, Zheng Chen, Lihong Wang, Dunfa Peng,Abbes Belkhiri, A. Craig Lockhart, and Wael El-Rifai

1917 STAT5A/B Blockade Sensitizes Prostate Cancerto Radiation through Inhibition of RAD51 andDNA RepairCristina Maranto, Vindhya Udhane, David T. Hoang,Lei Gu, Vitali Alexeev, Kareem Malas, Karmel Cardenas,Jonathan R. Brody, Ulrich Rodeck, Carmen Bergom,Ken A. Iczkowski, Ken Jacobsohn, William See,Sara M. Schmitt, and Marja T. Nevalainen

1932 Ponatinib Shows Potent Antitumor Activity inSmall Cell Carcinoma of the OvaryHypercalcemic Type (SCCOHT) throughMultikinase InhibitionJessica D. Lang, William P.D. Hendricks,Krystal A. Orlando, Hongwei Yin, Jeffrey Kiefer,Pilar Ramos, Ritin Sharma, Patrick Pirrotte,Elizabeth A. Raupach, Chris Sereduk, Nanyun Tang,Winnie S. Liang, Megan Washington, Salvatore J. Facista,Victoria L. Zismann, Emily M. Cousins, Michael B. Major,Yemin Wang, Anthony N. Karnezis, Aleksandar Sekulic,Ralf Hass, Barbara C. Vanderhyden, Praveen Nair,Bernard E. Weissman, David G. Huntsman, andJeffrey M. Trent

1944 Overcoming Resistance to DNA-Targeted Agentsby Epigenetic Activation of Schlafen 11 (SLFN11)Expression with Class I Histone DeacetylaseInhibitorsSai-Wen Tang, Anish Thomas, JunkoMurai, Jane B. Trepel,Susan E. Bates, Vinodh N. Rajapakse, and Yves Pommier

BIOLOGY OF HUMAN TUMORS

1954 Wide Expression and Significance of AlternativeImmune Checkpoint Molecules, B7x and HHLA2,in PD-L1–Negative Human Lung CancersHaiying Cheng, Alain Borczuk, Murali Janakiram,Xiaoxin Ren, Juan Lin, Amer Assal, Balazs Halmos,Roman Perez-Soler, and Xingxing Zang

1965 Small-Cell Carcinomas of the Bladder and LungAre Characterized by a Convergent but DistinctPathogenesisMatthew T. Chang, Alexander Penson, Neil B. Desai,Nicholas D. Socci, Ronglai Shen, Venkatraman E. Seshan,Ritika Kundra, Adam Abeshouse, Agnes Viale,Eugene K. Cha, Xueli Hao, Victor E. Reuter,Charles M. Rudin, Bernard H. Bochner,Jonathan E. Rosenberg, Dean F. Bajorin, Nikolaus Schultz,Michael F. Berger, Gopa Iyer, David B. Solit,Hikmat A. Al-Ahmadie, and Barry S. TaylorSee related commentary, p. 1775

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1974 PBX3 Is Part of an EMT Regulatory Network andIndicates Poor Outcome in Colorectal CancerSebastian Lamprecht, Markus Kaller, Eva Marina Schmidt,Cristina Blaj, Tobias S. Schiergens, Jutta Engel,Andreas Jung, Heiko Hermeking,Thomas G.P. Gr€unewald, Thomas Kirchner, andDavid Horst

1987 Reactivation of cAMP Pathway by PDE4DInhibition Represents a Novel Druggable Axis forOvercoming Tamoxifen Resistance in ER-positiveBreast CancerRasmi R. Mishra, Nevin Belder, Suhail A. Ansari,Merve Kayhan, Hilal Bal, Umar Raza, Pelin G. Ersan,

Ünal M. Tokat, Erol Ey€upo�glu, €Ozge Saatci,Pouria Jandaghi, Stefan Wiemann, Ayşeg€ul Üner,

Caglar Cekic, Yasser Riazalhosseini, and €Ozg€ur Şahin

2002 Long Noncoding RNA LINC01234 Functions as aCompeting Endogenous RNA to Regulate CBFBExpression by Sponging miR-204-5p in GastricCancerXin Chen, Zhenyao Chen, Shanxun Yu, Fengqi Nie,Shuai Yan, Pei Ma, Qinnan Chen, Chenchen Wei,Hangjiang Fu, Tianwei Xu, Shengnan Ren, Ming Sun, andZhaoxia Wang

2015 REGg Controls Hippo Signaling and ReciprocalNF-kB–YAP Regulation to Promote Colon CancerQingwei Wang, Xiao Gao, Tong Yu, Lei Yuan, Jie Dai,Weicang Wang, Geng Chen, Chan Jiao, Wang Zhou,Quan Huang, Long Cui, Pei Zhang, Robb E. Moses,Jianhua Yang, Fengyuan Chen, Junjiang Fu, Jianru Xiao,Lei Li, Yongyan Dang, and Xiaotao Li

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ABOUT THE COVER

The cover shows a mixed urothelial and small cell carcinoma from a single patient. Deepsequencing of macrodissected urothelial and small-cell components revealed truncalmutations clonal in both components, indicating a common ancestral origin. Other drivermutations were clonal exclusively in one component. For details, see the article by Changand colleagues on page 1965 of this issue.

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2018;24:1771-2025. Clin Cancer Res 24 (8)

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