8/6/2019 Clinical Manifestations in Diabetes Mellitus

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n ca an es a ons n a e es e us

Lethargy

Insulin Deficiency/ Insulin Resistance

of Uptake of Glucose into Tissue

Energy Production

Lethargy

Paraesthesia (Numbness)

Hyperglycaemia

Sorbitol, Fructose

Damage to Schwann Cell (Segmental Demyeliniation)Delayed Nerve Conduction

Numbness

Polyuria, Nocturia

Less Entry of Glucose into Peripheral Tissue, Gluconeogenesis

Hyperglycaemia

Glucose Excretion Exceed Renal Threshold

for glucose reabsorption

Glycosuria

Osmotic Diuresis

H2O absorbed out of Tubules

Urine Production

Polyuria, Nocturia

Polyuria, Polydipsia

Hyperglycaemia

Glycosuria

Osmotic Diuresis

Polyuria

Loss of H2O, Electrolyte

Dehydration

Stimulate Thirst Centre

Polydipsia

Loss of Weight

Insulin Deficiency/ Insulin Resistance

Lipolysis, Protein Catabolism

Appetite Polyphagia

Intake is Insufficient to Compensate Breakdown

Loss of Weight

Boils, Abscess, Delayed Wound Healing

Relative Deficiency of Insulin/ Insulin Resistance

Glucose Utilization by Tissue Gluconeogenesis in Liver

Hyperglycaemia

Glucose as Medium for Growth

of Bacteria

Impaired Chemotaxis, Phagocytosis

by Polymorphonuclear Cells

Risk of Skin Infection

(most common S. aureus)

Delayed Wound Healing

Boils, Abscess

Glycosuria

Non-Insulin Dependent DM

Insulin Activity

Failure to Transfer Glucose from Plasma into Cells

Body response as in the Fasting state

Stimulation of Glycogenolysis, Gluconeogenesis, Lipolysis

Glucose accumulate in Blood

Glucose excreted in Urine

Glucosuria