clinical ‘recovery’ by day 4 vs baseline nimodipine ischemic stroke neuroprotection study 1985...
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Clinical ‘Recovery’ by Day 4 vs BaselineNimodipine Ischemic Stroke Neuroprotection Study 1985
Mathew Score (100 = intact)
Baseline Day 4
Time from Onset
Total
Cases
Mathew
> 95
Mathew
> 95
< 6 hrs 25 0 2
< 12 hrs 150 0 2
< 18 hrs 250 0 5
< 24 hrs 373 0 8
< 48 hrs 943 0 15
Treatment Effect by Time of Rx Start
Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) Covarient Adjusted Means
Hours to Rx Mean Score Std Err P vs < 18 hr
< 18 69.2 3.6
18-24 49.2 5.4 0.002
24-30 50.9 4.8 0.002
30-36 53.1 4.2 0.004
36-42 55.7 5.8 0.05
42-48 57.0 4.5 0.04
Hrs Onset to Arrival &Neuro Exam NINDS MR/CT Study 1988
Interval # % Cum %
< 1 hrs 14 3.4
< 2 hrs 6 1.5 5.6
< 3 hrs 10 2.4 8.0
< 4 hrs 8 1.9 9.9
< 6 hrs 71 2.7 12.6
< 12 hr 26 5.2 18.9
< 24 hr 74 17.0 36.8
tPA CPMC Cumulative by Month to 10-02
0
5
10
15
20
25
30
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Acute Stroke Admissions per Month CPMC Aug-2000 to Oct-2002
0
25
50
75
1 3 5 7 9 11 13 15 17 19 21 23 25
Acute Stroke Admissions per Month CPMC Aug-2000 to Oct-2002
0
25
50
75
1 3 5 7 9 11 13 15 17 19 21 23 25