cme test questions: september 2012
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1134 � Catheter-based Arterial Sympathectomy Prince et al � JVIR
31. Sanya EO, Tutaj M, Brown CM, et al. Abnormal heart rate and bloodpressure responses to baroreflex stimulation in multiple sclerosis pa-tients. Clin Auton Res 2005; 15:213–218.
2. Fisher JP, Fadel PJ. Therapeutic strategies for targeting excessivecentral sympathetic activation in human hypertension. Exp Physiol 1995;5:572–580.
3. Dibona GF. Physiology in perspective: the wisdom of the body. Neuralcontrol of the kidney. Am J Physiol Regul Integr Comp Physiol 2005;289:R633–R641.
4. Mahfoud F, Schlaich M, Kinderman I, et al. Effect of renal sympatheticdenervation on glucose metabolism in patients with resistant hyperten-sion. Circulation 2011; 123:1940–1946.
5. Witkowski A, Prejbisz A, Florczak E, et al. Effects of renal sympatheticdenervation on blood pressure, sleep apnea course, and glycemic controlin patients with resistant hypertension and sleep apnea. Hypertension2011; 58:559–565.
6. Matthew B, Patel SB, Reams GP, Freeman RH. Obesity-hypertension:emerging concepts in pathophysiology and treatment. Am J Med Sci2007; 334:23–30.
7. Boer-Martins L, Figueiredo VN, Demacq C, et al. Relationship of auto-nomic imbalance and circadian disruption with obesity and type 2 diabe-tes in resistant hypertensive patients. Cardiovasc Diabetol 2011; 10:24.
8. Lambert G, Straznicky NE, Lambert EA, et al. Sympathetic nervousactivation in obesity and the metabolic syndrome—causes, consequences,
9. Seals DR, Bell C. Chronic sympathetic activation: consequences andcauses of age associated obesity? Diabetes 2004; 53:276–284.
0. Davy KP, Orr JS. Sympathetic nervous system behavior in humanobesity. Neurosci Biobehav Rev 2009; 33:116–124.
1. Bell DSH. Treatment of diabetic hypertension. Diabetes Obes Metab2009; 1:433–444.
2. Frontoni S, Bracaglia D, Gigli F. Relationship between autonomic dys-function, insulin resistance and hypertension in diabetes. Nutr MetabCardiovasc Dis 2005; 15:441–449.
3. Nonogaki K, Iguchi A. Stress, acute hyperglycemia, and hyperlipid-emia: role of the autonomic nervous system and cytokines. TrendsEndocrinol Metab 1997; 8:192–197.
4. Damon DH. Vascular-dependent effects of elevated glucose on post-ganglionic sympathetic neurons. Am J Physiol Heart Circ Physiol 2011;300:H1386–H1392.
5. Suzuki H, Nishizawa M, Ichikawa M, et al. Basal sympathetic nerveactivity is enhanced with augmentation of baroreceptor reflex in Wistarfatty rats: a model of obesity-induced NIDDM. J Hypertens 1999; 17:959–964.
6. Inskip J, Plunet W, Ramer L, Ramsey JB, Yung A. Cardiometabolic riskfactors in experimental spinal cord injury. J Neurotrauma 2010; 27:275–285.
7. Hamed SA, Hamed EA, Ezz Eldin AM, Mahmoud NM. Vascular risk fac-tors, endothelial function, and carotid thickness in patients with migraine:relationship to atherosclerosis. J Stroke Cerebrovasc Dis 2010; 19:92–103.
8. Horie R, Yamori Y. Neural factors and genetic disposition in cerebro-
and therapeutic implications. Pharmacol Ther 2010; 126:159–172. vascular atherogenesis in rats. Clin Exp Hypertens 1980; 2:1097–1115.CME TEST QUESTIONS: SEPTEMBER 2012
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The CME questions in the September issue are derived from the article “Catheter-based Arterial Sympathectomy:Hypertension and Beyond” by Prince et al.
1. Regarding the medical treatment of patients with hy-pertension:a) More than half of patients are able to reach their
target blood pressure.b) One criterion for adding another medication is
reaching 50% of the maximum dose of the currentdrug.
c) Most patients require two medications for control.d) Resistant hypertension is seen in only 5% of
patients.
2. All of the following are true regarding the sympatheticnervous system EXCEPT:a) It causes increased vascular tone as a common
underlying condition in hypertensive patients.b) It can be evaluated by radioisotope dilution spill-
over analysis, which detects excess, unmetabolizedepinephrine from synaptic clefts.
c) It enervates the renal cortex, leading to reninsecretion.
d) It can be surgically denervated, resulting in lower-ing of blood pressure.
3. The described radiofrequency ablation device:a) Results in ablation of the nerve fibers in the renal
arterial intima.b) Is activated with four to six 2-minute treatments
delivered to the renal artery.c) Uses delivery of low energy, below 5 watts.d) Should only be used to treat one vessel per treat-
ment session.
4. Human studies regarding the use of renal sympatheticdenervation using radiofrequency ablation techniques:a) Demonstrated significant blood pressure improve-
ment in the experimental group at 6 months.b) Have shown mild vessel narrowing at 3 months of
follow-up.c) Note continued blood pressure reduction has not
been seen beyond 6 months after treatment.d) Describe no ablation-related complications.