COMBATING MOISTURE INGRESS & STREAMLINING PACKAGING PROCESSES

WITH NEXT-GENERATION ACTIVE PACKAGING SOLUTIONS

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• Introduction to CSP Technologies

• Oral Solid Dose/ Bottle Needs & Challenges

• Existing Options

• Engineered Polymeric Solutions

Overview

3

CSP TECHNOLOGIES

• HQ: Auburn, AL– Sales office in US, EU, Asia– Over 1 billion+ molded products

shipped annually

• Development sites in North America & Europe– Innovation Technical Center in Paris

• Production sites in Auburn & Niederbronn– Six Sigma, ISO 9001 certified, cGMP

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CORE CAPABILITIES

• Material Science• Complex/Precision

Molding• Design, Development &

Production

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CORE CAPABILITIESMATERIAL SCIENCE: ADDING CHEMISTRY TO POLYMERS

Three-Phase Polymers1. Channels created within a polymer

allow movement of gases

2. “Active” particles are added to the polymer in order to:

• Adsorb or Absorb (moisture, gases, reactive impurities, odors)

• Release (aromas, biocides, nutrients, carbon dioxide)

3. Gas diffusion controlled through the channel composition

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CORE CAPABILITIESMATERIAL SCIENCE: ADDING CHEMISTRY TO POLYMERS

Three-Phase Polymers1. Majority Polymer: Base structure

component2. Particle: Adsorbing/absorbing –

agent/active component3. Minority Polymer/channeling

agent: Immiscible in majority polymer

4. Can be extruded, injection molded and blow molded

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CORE CAPABILITIESCOMPLEX/PRECISION MOLDING

• Two & three-shot molding with polymers and elastomers

• In-mold labeling with superior graphics or the addition of functional barriers ( e.g. Al-foil)

• Molding medical devices/device components

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Elastomer Seal with 2-shot Molding

• In-house program management & cross-functional capabilities

• “Moisture Budget” analytical tools and process

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CommercializationDesign Development

ProgramManagement

ToolingPrototyping

Automation

“Moisture Budget” RH testing

CORE CAPABILITIESDESIGN, DEVELOPMENT & PRODUCTION: CONCEPT TO LAUNCH

INDUSTRIES SERVED

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Pharmaceutical/OTC

Industrial

INDUSTRIES SERVED

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Diagnostics

Food/Nutrition

ORAL SOLID DOSE/BOTTLE NEEDS & CHALLENGES

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ORAL SOLID DOSE STABILITY

Needs & Challenges• Moisture• Oxygen• CO2

• Reactive Impurities• Odors• Combination of moisture &

gas scavenging

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ORAL SOLID DOSE BOTTLE PACKAGINGNeeds & Challenges• Standard, CR/SF closures• Standard, tamper-evident features • Efficient filling and reduced downtime• Limited particulates• No product breakage• Consumer safety & satisfaction• No hazards

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EXISTING SCAVENGING OPTIONS FOR STANDARD BOTTLES

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STANDARD BOTTLE SCAVENGING OPTIONSCap-Based Features/Benefits• Assembled to inside of the cap• Doesn’t rest amongst contents of

packaging• Ok for anti-breakage packaging

additions• Doesn’t interfere with CR/SF caps• “Hidden” from consumers

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STANDARD BOTTLE SCAVENGING OPTIONSLimitations• Can’t be used with induction

sealing• Limited uptake/shelf life• Quick desiccant saturation

without immediate recapping• Risk of desiccant spillage if

damaged during shipping or assembly

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STANDARD BOTTLE SCAVENGING OPTIONSDrop-In Features/Benefits• Dropped into bottle during

packaging• Rests amongst contents of

packaging• Doesn’t interfere with CR/SF caps• Can be used with induction sealing

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STANDARD BOTTLE SCAVENGING OPTIONSLimitations• Equipment costs/extra assembly steps• Breakage/dusting with negative quality

cost/consumer perception• Fully visible to consumer – represents

source of confusion/annoyance or hazard

• Risk of being discarded by consumer• Multiple pieces to achieve shelf life

requirements

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ENGINEERED POLYMERIC SOLUTIONS

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PHARMAPUCK™ SCAVENGING DEVICES• Provides all your moisture, CO2, & odor

management needs into Drop-In or Cap-Integrated formats

– Can scavenge, moisture, odors and VOC’s/Reactive Impurities

– Can release aroma for enhanced consumer experience

• Available in variety of custom shapes including containers– Doesn’t require extra equipment

• Optimized capacity and uptake rates

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PHARMAPUCK™ SCAVENGING DEVICES• Custom printing & coloring

for drop-in means:– Enhanced branding

– Reduced consumer confusion

– Helps reduce risk

– Integrated cap can make product virtually invisible to consumer

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ACTIV-SEAL™ ORIFICE REDUCERS• Provides moisture, VOC’s, and/or odor

management in an orifice reducer for bottle applications– Scavenge moisture, reactive impurities, or odors– Integrated tamper-evident features– Can release aroma for enhanced consumer experience– Invisible to consumer - it can help to increase patient

compliance and maintain shelf life requirements

• Optimized capacity and uptake rates

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ACTIV-SEAL™ Orifice Reducer

• Can be applied with standard capping & induction sealing systems

• Provides foil seal, orifice reducer & desiccant within cap

• Orifice reducer is permanently secured to the bottle via induction sealing

– Lift and peel foil technology for tamper evidence & product stability

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ACTIV-SEAL™ Orifice Reducer

• Desiccant and reducer permanently positioned under orifice – No printing required - “Do Not Eat”– Desiccant never leaves bottle– Improved safety– No secondary inserting required

• Orifice reducer opening can be tailored to accommodate your product size to ensure optimum metered dosing

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Packaging Process

Activ-SealORProcess

CurrentPackProcess

ACTIV-SEAL™ ORIFICE REDUCERS• Product protection never leaves the bottle,

even after opening

• Reduction in assembly steps, complexity, & cost with one molded piece for all scavenging needs

• Fits all standard bottle sizes and maintains standard capping processes

• Customized kinetics/uptake rates with test and development service and support

• Can increase patient compliance

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PORTFOLIO SNAPSHOT

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DO NOT COMPROMISE• Manage your packaging environment

just the way you want, for as long as you need

• Scavenge moisture and gasses with one, virtually unbreakable piece

• Utilize existing equipment and processes

• Reduce your costs and complexity

• Have a one-stop partner who can design, test, and produce just for you

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James McGetrick, Associate Director, Business DevelopmentJames.McGetrick@CSPtechnologies.com