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Milano, XX mese 20XX

Come la Ricerca diventa Innovazione

Exposanità, Bologna 19/05/2016

- Innovazione come risorsa per migliorare i risultati e razionalizzare i costi -

Paola Bagnoli e Roberto Tiezzi

Politecnico di Milano

Technology Transfer Office (TTO)

Cos’è un’innovazione?

“Innovation is executing new ideas to create value”



• Creatività Idea

• Idea Pianificazione

• Pianificazione Execution

• Execution Investimenti

• Investimenti Rischio

• Rischio Execution

Tutela dell’idea “Appropriazione”

Dalla ricerca all’innovazione

Strategia IP

Progettazione Tutela Exploitation Valutazione

• Ricerca di anteriorità

• Libertà di attuazione

• Quale lo strumento

più adatto?

Progetto di Ricerca

• Analisi strategiche

• Pianificazione

• Analisi prior art

• Analisi dei concorrenti

Exe

cu

tion

Quale lo strumento più

adatto?

• Brevetti per invenzione

• Modelli di utilità

• Marchi

• Disegni e modelli

• Know-how


Strategia IP


Progetto di Ricerca

Exe

cu

tion

Quale lo strumento più

adatto?

• Brevetti per invenzione

• Modelli di utilità

• Marchi

• Disegni e modelli

• Know-how


Strategia IP


Progetto di Ricerca

Exe

cu

tion

BENI IMMATERIALI

Come tutelare l’innovazione? Differenti tipologie di

Proprietà Industriale (IP)

know-how

disegno (forma

esteriore)

marchio (azienda, prodotto)

brevetti per invenzione

diritto d’autore

(Software)

La PI nel settore delle Biotecnologie e

Scienze della Vita in Italia

www.uibm.gov.it/biotech/home/

Banca dati Biotecnologie e Scienze della Vita

http://www.uibm.gov.it/biotech/home/

Fonte: Banca dati Biotecnologie e Scienze della Vita

Classificazione domande di brevetti BioMed depositate in Italia tra il 1/07/2008 e il 2015**


N. domande di brevetto depositate in Italia

Life science

Biotecnologie

Numero di estensioni internazionali EP - PCT


Life science

Biotecnologie

Il trasferimento tecnologico

Trasferimento tecnologico

Valorizzazione della ricerca

dalla ricerca alla Società

Attori del trasferimento: • Ricercatori • Università

• Uffici di trasferimento tecnologico (TTO)

• Spin-off

• Imprese

Mercato IMPATTO

IP

IMPATTO

Non solo numeri:

-n. brevetti

-n. licenze

-n. spin-off

Impatto socio-economico della

ricerca sulla società

Impatto economico ma non solo!

Impatto sulla vita delle

persone…

non è semplice da quantificare…

…e le tecnologie di nicchia?!








• Rischio Execution GENERARE IMPATTO








• Rischio Execution

• Scarsa pianificazione della

ricerca

• Chi genera l’invenzione non è

chi poi la produrrà

• Definizione dell’applicazione

target

• Scarsa apertura del mercato

• Scarsa predisposizione delle

imprese al rischio

PRINCIPALI

CRITICITA’

In ambito universitario Uffici Trasferimento Tecnologico

- Supporto al ricercatore:

• analisi prior art brevettuale

• assistenza tutela IP

• bandi e contratti di ricerca per lo sviluppo

- Identificazione del corretto target di applicazione e mercato:

• Valutazioni del mercato

- Assistenza nel passaggio da prototipo a prodotto

- Supporto creazione spin-off

- procedura di accreditamento

- incubazione e accelerazione

- supporto alla creazione del business plan

- contatti con investitori

- Licensing:

• scouting di aziende

• link tra ricerca e azienda

• assistenza nella stipula di contratti

Supporto al trasferimento tecnologico

Ricerca

Execution

Technology Transfer Function al

Politecnico di Milano

PoliMI TTO mission

To promote protection and exploitation of the University research

To play a role in the relationships between University and Industry

To make possible the industrial applications of innovation also through the

entrepreneurship promotion and support

To improve the excellence of the University,

To attract students and outstanding Scientists

To attract research funds from Companies

Research valorisation

Technology Transfer Business Units

Technology

Transfer

Office

Training Intellect. property

&

Licensing

IP within

research contracts

National & international

projects

Spin-off

creation Networking

Polimi patents

64 85 128 165 209

255 298

339 384 419

454 498

146 191

306

395

502

614

727

815

913

1011

1109

1216

0

200

400

600

800

1000

1200

1400

Dato

cumulato1998-

2004

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

number of Patent Families

Numbers of Patents

Cumulative data

Spin-off companies

Politecnico di Milano has created 34 spin-off companies (27 still active as spin-

off) acting in different industrial sectors.

The other partners are professors of Politecnico, young graduates, in many cases industrial companies interested in cooperating and developing new

products.

Industrial

eng.

32%

Electronics

15% Services

7%

Automation

7%

Home

products

7%

ICT

32%

> 13.65 M€

Global Turnover 2014

T.I.Ve.T.

Politecnico spin-off companies: a channel for exploitation

Steriline Robotics

POLIHUB Startup District & Incubator

+ than 100 startups since 2000

+ than 80 millions euro turnover

generated during incubation

+ than 50 companies in 2014

83% operative companies

9th in the UBI-INDEX ranking of the

best European incubators

POLIHUB

is an initiative:

Polimi IP portfolio

Target Areas

These are areas of interests chosen with a human and industry need-based

approach. Each category is gathered by looking at the main advantage that our

technological solution brings in targeted sector.

Environment and Energy

Smart Products Life Science

Information & Communication

Technologies (ICT) Industrial Manufacturing

Micro & Nano Technologies

Number of IPRs vs. Target Area

10% Environment and Energy

Information &

Communication

Technologies (ICT)

Life Science

Micro & Nano

Technologies

Industrial

Manufacturing

Smart Products

7% 10%

23%

30%

16%

14%

2011-2015 IP Portfolio Analysis (235 IPRs)

Number of IPRs vs. Target Area

Environment

and Energy

7% 10% 23%

30%

16%

14%


ICT Industrial

Manufacturing

Smart

Products

Micro & Nano

Technologies

Life

Science

Autonomous

research

Industry funded

research

Number of IPRs vs. Technology keywords

These are significant keys to classify our IPRs by technological subject and application

field. The infographic shows the Technology Keywords related to the number of patents

represented by shade and size scale.

Heat Engines

Solar energy

Infrastructures

Management tools

Micro-fluid dynamics

Artificial neural

networks

Smart packaging

3D printing

Nanotechnologies

Wearable

Aerospace

Waste management

Chemical reactors Water, air and soil conservation

Fluid dynamics

Diagnostics

Industrial Plant Maintenance Design of machines

Cell culture

Chemical synthesis

Photonics

Micro & Nano Electronics

Smart building

Energy efficiency

Chemical process

Wellbeing and sport

Emission Reduction

Automotive

Industrial design

Smart Mobility

Medical

Devices

Human

Safety

Advanced Materials

Telecommunication

& Computer

Technologies


Number of IPRs vs. Technology keywords

Heat Engines

Solar energy

Infrastructures

Management tools

Micro-fluid dynamics

Artificial neural

networks

Smart packaging

3D printing

Nanotechnologies

Wearable

Aerospace

Waste management

Chemical reactors Water, air and soil conservation

Fluid dynamics

Diagnostics

Industrial Plant Maintenance Design of machines

Cell culture

Chemical synthesis

Photonics

Micro & Nano Electronics

Smart building

Energy efficiency

Chemical process

Wellbeing and sport

Emission Reduction

Automotive

Industrial design

Smart Mobility

Medical

Devices

Human

Safety

Advanced Materials

Telecommunication

& Computer

Technologies


These are significant keys to classify our IPRs by technological subject and application

field. The infographic shows the Technology Keywords related to the number of patents

represented by shade and size scale.

Life science: alcuni casi interessanti

Dispositivo per l’addestramento chirurgico

della litotrissia percutanea (PCNL)

PCNL Tecnica usata per la rimozione dei calcoli renali

Fantoccio per training dei chirurghi

Ricercatori Politecnico in collaborazione con chirurgo urologo progettano un

dispositivo ecogenico

Dispositivo per l’addestramento chirurgico della litotrissia

percutanea (PCNL)

• Brevetto Polimi esteso in US

• Necessità di validare

il prototipo

• Necessità di sviluppare

prototipo con patologie renali

• Scouting aziende Licensing


percutanea (PCNL)

Licenza esclusiva ad azienda americana


percutanea (PCNL)

PCNL-Boz

Heart on chip

Heart on Chip

•Microfluidic device able to

generate and culture 3D cell

constructs at the microscale

•Cardiac functional constructs (beating synchronously)

•Actuation mechanism that enables

the cyclic mechanical

stimulation of the cultured constructs

• In vitro drug screening and/or

discovery (i.e. generation of

functional cardiac micro-constructs exploitable as in vitro models

representative of native tissues).

Brevetto Polimi 2015 --> estensione internazionale (PCT) 2016

Heart on Chip

•Microfluidic device able to

generate and culture 3D cell

constructs at the microscale

•Cardiac functional constructs (beating synchronously)

•Actuation mechanism that enables

the cyclic mechanical

stimulation of the cultured constructs

• In vitro drug screening and/or

discovery (i.e. generation of

functional cardiac micro-constructs exploitable as in vitro models

representative of native tissues).

Tra i 10 finalisti di

Creazione di una spin-off Politecnico?

Programma di accelerazione

Eye Tracking device

Eye Tracking device

UVEAL MELANOMA

- Melanoma of the uveal tract (iris, ciliary body

and choroid)

- Incidence 6-7 cases per million people per

year (in Europe)

TREATMENT OPTIONS:

- Eye enucleation

- Brachytherapy

- External beam radiotherapy (stereotactic radiosurgery, proton therapy).

Highly invasive treatments

Eye Tracking device

1) SURGICAL OPERATION tantalum clips application on ocular tumor margins

LIMIT:

• invasiveness

• possible misalignment between clips and lesion

2) PATIENT SETUP

comparison between clip positions from eye radiographies

and planned reference coordinates

LIMIT:

• manual procedure based on a trial-and-error approach

• repeated patient exposure to ionizing radiation

3) DOSE DELIVERY

monitoring of the eye images acquired by a video camera

LIMIT:

• qualitative and inaccurate estimation of the eye position and

movements

• delays due to manual radiation interruption

CURRENT TREATMENT PROCEDURES

Eye Tracking device

Development of a non invasive eye tracking system for ocular proton therapy

ADVANTAGES: • real-time monitoring of 3D tumor position

• automatic verification of setup errors

• instantaneous dose delivery interruption in case of involuntary eye movements

• compatibility with CT/MRI image acquisition for treatment planning

Polimi Research and Patent

Eye Tracking device

MARKET of PARTICLE THERAPY

- 48 centers worldwide (+ 30 centers under constructions in 2015)

- 16 centers dedicated only to ocular proton therapy

- start of proton eye treatments in 1984

- over 20000 eye cancer patients treated with protons

CRITICITA’ Mercato di nicchia

Development of a non invasive eye tracking system for ocular proton therapy

ADVANTAGES: • real-time monitoring of 3D tumor position

• automatic verification of setup errors

• instantaneous dose delivery interruption in case of involuntary eye movements

• compatibility with CT/MRI image acquisition for treatment planning

Polimi Research and Patent

Eye Tracking device

Possibili mercati alternativi? Digital marketing, automotive etc.

Restech: Respiratory Technology

Restech Srl is a spin-off from Politecnico, established in 2010 by the

Biomedical Technologies Laboratory (TBM Lab) in the Department of

Bioengineering. For several years, the TBM Lab has been focusing its research

effort on developing new technologies for investigating the pathophysiology

of the respiratory system and respiratory medicine more generally.

Restech’s mission is to develop highly innovative medical devices and

solutions in the respiratory sector, from research to product engineering,

manufacturing and marketing.

Restech aims to become

a company of

international standing in

the development of

innovative biomedical systems.

http://www.restech.it/en/index.html



RESMON PRO Full

A professional device based on Forced Oscillation Technique (FOT), offering a complete, in-

depth functional assessment for patients with respiratory diseases.

Healthcare providers may personalize the measurement protocol to suit the patient and the

diagnostic objective, tailoring the type of stimulus to be applied and the duration of each

individual test. Once the measurements have been taken, the healthcare worker can

immediately see:

• the standard breathing-pattern indices

• any airflow limitation

• the degree and heterogeneity of the pulmonary obstruction

• the bronchial-reversibility and bronchial-challenge evaluation.

The device requires only a low level of compliance from the

patient, who must simply breathe normally into the device.

As this is a stand-alone device, no external computer is needed in

order to perform the test or to save and view the results.





Come la Ricerca diventa Innovazione

Tutela IP IMPATTO

Licensing

Trasferimento Tecnologico

Scouting di aziende Spin-off

Ricerca

Finanziamenti

Brevetti

Invenzioni

INNOVAZIONE

Contacts: Technology Transfer Office

Politecnico di Milano - Piazza Leonardo da Vinci 32, 20133 Milano

Website: http://www.polimi.it/ricerca-scientifica/brevetti/

Roberto Tiezzi Phone: +39 02 23999232

email: [email protected]

Paola Bagnoli Phone: +39 02 23999230

email: [email protected]

[email protected]

http://www.polimi.it/ricerca-scientifica/brevetti/




mailto:[email protected]



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