immune globulin (IVIG) enriched for anti-LPS and/or antitoxin A antibody (2). Therefore, the currently described polyvalent conjugate vaccine might be better utilized to immunize healthy adult volunteers to obtain plasma that could be processed to yield an anti-P. aeruginosa IVIG.

References 1. Bodey, G. P., R. Bolivar, V. Fain-

stein, and L. Jadeja (1983). Infections caused by Pseudomonas aeruginosa. Rev. Infect. Dis. 5:279-313.

2. Collins, M. S., and R. E. Roby (1984). Protective activity of an intra- venous immune globulin (human) enriched in antibody against lipopoly- saccharide antigens of Pseudomonas aeruginosa. Am. J. Med. 76:168-174.

3. Cryz, S. J., Jr. (1984). Pseudomonas

aeruginosa infections. In: Germanier, R. (ed,). Bacterial Vaccines. Academic Press, Orlando, pp. 317-351.

4. Cryz, S. J., Jr., E. Filter, A. S. Cross, A. Wegmann, R. Germanier, and J. C. Sadoff (1987). Safety and immunogem'city of a Pseudomonas aeruginosa O-polysaccharide-toxin A conjugate vaccine in humans. J. Clin. Invest. 80:51-56.

5. Cryz, S. J., Jr., A. B. Lang, J. C. Sadoff, R. Germanier, and E. Riirer (1987). Vaccine potential of Pseudo- monas aeruginosa O-polysaccharide- toxin A conjugates. Infect. Immun. 55:1547-1551.

6. Cryz, S. J., Jr., J. C. Sadoff, E. FOrer, and R. Germanier (1986). Pseudomonas aeruginosa polysac- charide-tetanus toxoid conjugate vac- cine: safety and immunogenicity in humans. J. Infect. Dis. 154:682-688.

7. Cryz, S. J., Jr., E. Fiirer, J. C. Sa- doff, and R. Germanier (1986).

Pseudomonas aeruginosa immunotype 5 polysaccharide-toxin A conjugate vaccine. Infect. Immun. 52:161-165.

8. Pier, G. B., H. F. Sidberry, and J. C. Sadoff (1978). Protective immu- nity induced in mice by immunization with high-molecular-weight polysac- charide from Pseudomonas aeruginosa. Infect. Immun. 22:919-925.

9. Pollack, M., and L. S. Young (1979). Protective activity of antibodies to exo- toxin A and lipopolysaccharide at the onset of Pseudomonas aeruginosa sep- ticemia in man. J. Clin. Invest. 63:276-286.

10. Tsay, G. C., and M. S. Collins (1984). Preparation and characterization of a nontoxic polysaccharide-protein conjugate that induces active immunity and passively protective antibody against Pseudomonas aeruginosa im- munotype 1 in mice. Infect. Immun. 45:217-221.

Meeting Announcements

Molecular Biology of Receptors, Pumps, and Channels: Pharmaco- logic Targets Satemte Symposium to ASPET's 1988 Fall Meeting August 22-24, 1988 Topics: Plasma membrane ATPase (Na + , K + , Ca2 + ); Adrenergic and cholinergic receptors; C1 channel/ GABA receptor; Cloning, sequencing, modeling, and expression. Contact: Ms. Kathy Smidebush, Uni- versity of Cincinnati, 231 Bethesda Avenue, Cincinnati, OH 45267-0575

International Symposium on Bone Marrow Transplantation in Thalas-

semia and Related Problems September 22-25, 1988 Urbino, Italy Contact: Dr. Simanetta Campanelli, Organizing secretariat, Cso XI Set- tembre 129, 61100 Pesaro, Italy Telephone: (39) 721/32494

Conference on Sorting in Eukaryot- ic Cells September 11-15 Atholl Place Hotel, Pitlochary, Scotland Contact: Ms. Rosemary J. Simpson, ASCB National Office, 9650 Rockville Pike, Bethesda, MD 20814. Telephone: (301) 530-7153

Advances in Autoimmune Diseases November 6-8, 1988 Perugia, Italy Topics: Immunogenetics; Immune reg- ulation; Molecular aspects of autoim- mune reactions; Concepts of viral pathogenesis; Immune complex disease; Biology of inflammation Contact: Dr. Charles L. Christian, Hospital for Special Surgery, New York, NY Telephone: (212) 606-1328

Coming in August

Ataxia-Telangiectasia: A Recessive Human Genetic Disorder Causing Immune Deficiency and Predisposi- tion to Cancer by Yechiel Becker

Injury-induced immnnodeficiency by John L. Ninnemann

Soluble Immunosuppressor Factors in Human Cancer by Luisa Guidi, Carlo Bartoloni, and Gino Gambassi

Immunological Consequences of Transfusion by Sallie S. Cook

Clinical Immunology Newsletter 9:7,1988 © 1988 Elsevier Science Publishing Co., Inc. 0197-1859/88/$0.00 + 02.20 115