Eliquis Revlimid Imbruvica Xarelto Biktarvy Ibrance Xtandi Tagrisso Jardiance Trikafta Tecfidera Invega Sustenna Genvoya Januvia Triumeq Pomalyst Gilenya Veklury Symbicort Vyvanse 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20(Apixaban) (Lenalidomide) (Ibrutinib) (Rivaroxaban) (Bictegravir, Emtricitabine, Tenofovir

Alafenamide) (Palbociclib) (Enzalutamide) (Osimertinib) (Empagliflozin) (Elexacaftor, Tezacaftor, Ivacaftor) (Dimethyl Fumarate) (Paliperidone Palmitate) (Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Alafenamide) (Sitagliptin) (Abacavir, Dolutegravir,

Lamivudine) (Pomalidomide) (Fingolimod) (Remdesivir) (Budesonide, Formoterol) (Lisdexamfetamine)

$14.117 Billion $12.106 Billion $9.442 Billion $7.806 Billion $7.259 Billion $5.392 Billion $5.1 Billion $4.328 Billion $4.108 Billion $3.864 Billion $3.841 Billion $3.653 Billion $3.338 Billion $3.306 Billion $3.197 Billion $3.07 Billion $3.003 Billion $2.811 Billion $2.721 Billion $2.559 BillionCardiovascular Diseases Oncology Oncology Cardiovascular Diseases Infectious Diseases Oncology Oncology Oncology Diabetes Genetic Disorders CNS & Anesthesia CNS & Anesthesia Infectious Diseases Diabetes Infectious Diseases Oncology CNS & Anesthesia Infectious Diseases Respiratory Disorders CNS & Anesthesia

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40Lynparza Entresto Aubagio Zytiga Ofev Sprycel Xeljanz Alimta Nexium Otezla Prezcobix Farxiga Spiriva Advair Tivicay Latuda Janumet Breo Ellipta Tasigna Vimpat(Olaparib) (Sacubitril, Valsartan) (Teriflunomide) (Abiraterone Acetate) (Nintedanib) (Dasatinib) (Tofacitinib) (Pemetrexed) (Esomeprazole) (Apremilast) (Darunavir, Cobicistat) (Dapagliflozin) (Tiotropium) (Salmeterol) (Dolutegravir) (Lurasidone) (Metformin, Sitagliptin) (Fluticasone Furoate, Vilanterol) (Nilotinib) (Lacosamide)

$2.501 Billion $2.497 Billion $2.474 Billion $2.47 Billion $2.448 Billion $2.438 Billion $2.437 Billion $2.33 Billion $2.209 Billion $2.195 Billion $2.184 Billion $2.157 Billion $2.136 Billion $2.128 Billion $2.117 Billion $2.019 Billion $1.971 Billion $1.97 Billion $1.958 Billion $1.883 BillionOncology Cardiovascular Diseases CNS & Anesthesia Oncology Respiratory Disorders Oncology Immunology Oncology Gastrointestinal Disorders Dermatology Infectious Diseases Diabetes Respiratory Disorders Respiratory Disorders Infectious Diseases CNS & Anesthesia Diabetes Respiratory Disorders Oncology CNS & Anesthesia

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Lenvima Descovy Mavyret Jentadueto Abilify Maintena Pradaxa Xyrem Promacta Prograf Odefsey Opsumit Epclusa Samsca Brilinta Tafinlar Abraxane Afinitor Myrbetriq Xifaxan Crestor(Lenvatinib) (Emtricitabine,

Tenofovir Alafenamide) (Glecaprevir, Pibrentasvir) (Linagliptin, Metformin) (Aripiprazole) (Dabigatran Etexilate) (Sodium Oxybate) (Eltrombopag Olamine) (Tacrolimus) (Emtricitabine, Rilpivirine, Tenofovir Alafenamide) (Macitentan) (Sofosbuvir, Velpatasvir) (Tolvaptan) (Ticagrelor) (Dabrafenib, Trametinib) (Paclitaxel) (Everolimus) (Mirabegron) (Rifaximin) (Rosuvastatin)

$1.863 Billion $1.861 Billion $1.83 Billion $1.801 Billion $1.798 Billion $1.777 Billion $1.742 Billion $1.738 Billion $1.695 Billion $1.672 Billion $1.639 Billion $1.599 Billion $1.597 Billion $1.593 Billion $1.542 Billion $1.539 Billion $1.535 Billion $1.492 Billion $1.482 Billion $1.458 BillionOncology Infectious Diseases Infectious Diseases Diabetes CNS & Anesthesia Hematology CNS & Anesthesia Oncology Immunology Infectious Diseases Cardiovascular Diseases Infectious Diseases Cardiovascular Diseases Cardiovascular Diseases Oncology Oncology Oncology Nephrology Infectious Diseases Cardiovascular Diseases

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Truvada Sandostatin Rexulti Lixiana Velcade Somatuline Keppra Jakavi Venclexta Lyrica Mirena Alecensa Lipitor Esbriet Vyndaqel Adempas Galvus Group Gleevec Trintellix Trelegy Ellipta(Emtricitabine, Tenofovir

Disoproxil) (Octreotide) (Brexpiprazole) (Edoxaban) (Bortezomib) (Lanreotide) (Levetiracetam) (Ruxolitinib) (Venetoclax) (Pregabalin) (Levonorgestrel) (Alectinib) (Atorvastatin) (Pirfenidone) (Tafamidis) (Riociguat) (Vildagliptin) (Imatinib) (Vortioxetine) (Fluticasone Furoate, Vilanterol Trifenatate, Umeclidinium Bromide)

$1.448 Billion $1.439 Billion $1.42 Billion $1.412 Billion $1.389 Billion $1.386 Billion $1.359 Billion $1.339 Billion $1.337 Billion $1.313 Billion $1.308 Billion $1.292 Billion $1.291 Billion $1.29 Billion $1.288 Billion $1.261 Billion $1.199 Billion $1.188 Billion $1.16 Billion $1.135 BillionInfectious Diseases Oncology CNS & Anesthesia Hematology Oncology Oncology CNS & Anesthesia Oncology Oncology CNS & Anesthesia Urology Oncology Cardiovascular Diseases Immunology Rare Disorders Cardiovascular Diseases Diabetes Oncology CNS & Anesthesia Respiratory Disorders

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Kyprolis Plavix Uptravi Ventolin Leuprorelin Cymbalta Pulmicort Diovan Group Ingrezza Exforge Group Edurant Nexgard Vraylar Chantix Verzenio Orkambi Zoladex Doliprane Isentress Ninlaro(Carfilzomib) (Clopidogrel) (Selexipag) (Albuterol) (Leuprorelin) (Duloxetine) (Budesonide) (Hydrochlorothiazide, Valsartan) (Valbenazine) (Amlodipine, Valsartan) (Rilpivirine) (Afoxolaner) (Cariprazine) (Varenicline) (Abemaciclib) (Lumacaftor, Ivacaftor) (Goserelin) (Acetaminophen) (Raltegravir) (Ixazomib)

$1.13 Billion $1.108 Billion $1.093 Billion $1.088 Billion $1.082 Billion $1.019 Billion $1.01 Billion $1.003 Billion $993 Million $980 Million $964 Million $958 Million $951 Million $919 Million $913 Million $908 Million $888 Million $883 Million $857 Million $828 MillionOncology Cardiovascular Diseases Cardiovascular Diseases Respiratory Disorders Oncology CNS & Anesthesia Respiratory Disorders Cardiovascular Diseases Neurology Cardiovascular Diseases Infectious Diseases Infectious Diseases CNS & Anesthesia CNS & Anesthesia Oncology Respiratory Disorders Oncology Infectious Diseases Infectious Diseases Oncology

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120Lopressor Sutent YAZ Kalydeco Invokana Parasbiv Inlyta Restasis Vasostrict Aspirin Nexavar Synthroid Takecab Azilva Erleada Anoro Ellipta Lupron Lamictal Adalat Rinvoq(Metoprolol) (Sunitinib) (Drospirenone, Ethinyl Estradiol) (Ivacaftor) (Canagliflozin, Metformin) (Etelcalcetide) (Axitinib) (Cyclosporine) (Vasopressin) (Acetylsalicylic Acid) (Sorafenib) (Levothyroxine) (Vonoprazan) (Azilsartan) (Apalutamide) (Umeclidinium, Vilanterol) (Leuprolide) (Lamotrigine) (Nifedipine) (Upadacitinib)

$821 Million $819 Million $810 Million $803 Million $795 Million $791 Million $787 Million $787 Million $786 Million $773 Million $773 Million $771 Million $771 Million $764 Million $760 Million $758 Million $752 Million $744 Million $741 Million $731 MillionCardiovascular Diseases Oncology Urology Respiratory Disorders Diabetes Hormonal Disorders Oncology Immunology Nephrology Cardiovascular Diseases Oncology Hormonal Disorders Gastrointestinal Disorders Cardiovascular Diseases Oncology Respiratory Disorders Oncology CNS & Anesthesia Cardiovascular Diseases Immunology

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140Kisqali Juluca Implanon Augmentin Celebrex CellCept Cialis Aprovel Norvasc Vemlidy Exjade Jevtana Avodart IIIRisperdal Consta Olumiant Austedo Votrient Symdeko Ultibro Group Concerta(Ribociclib) (Dolutegravir, Rilpivirine) (Etonogestrel) (Amoxicillin, Clavulanate) (Celecoxib) (Mycophenolate Mofetil) (Tadalafil) (Irbesartan, Hydrochlorothiazide) (Amlodipine) (Tenofovir Alafenamide) (Deferasirox) (Cabazitaxel) (Dutasteride) (Risperidone) (Baricitinib) (Deutetrabenazine) (Pazopanib) (Tezacaftor, Ivacaftor) (Indacaterol, Glycopyrronium) (Methylphenidate)

$687 Million $686 Million $680 Million $679 Million $677 Million $675 Million $675 Million $670 Million $666 Million $657 Million $653 Million $648 Million $646 Million $642 Million $639 Million $637 Million $635 Million $629 Million $623 Million $622 MillionOncology Infectious Diseases Women's Healthcare Infectious Diseases Musculoskeletal Immunology Urology Cardiovascular Diseases Cardiovascular Diseases Infectious Diseases Oncology Oncology Nephrology CNS & Anesthesia Immunology CNS & Anesthesia Oncology Genetic Disorders Respiratory Disorders CNS & Anesthesia

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160Sulperazon AmBisome Flovent Faslodex Stivarga Nesina Dexilant Wellbutrin Xalkori Calquence Dovato Remodulin Allegra Neupro Duodopa EpiPen Symtuza Frontline Zetia Decapeptyl(Cefoperazone, Sulbactam) (Amphotericin B) (Fluticasone Propionate) (Fulvestrant) (Regorafenib) (Alogliptin) (Dexlansoprazole) (Bupropion) (Crizotinib) (Acalabrutinib) (Dolutegravir, Lamivudine) (Treprostinil) (Fexofenadine) (Rotigotine) (Carbidopa, Levodopa) (Epinephrine) (Darunavir, Cobicistat, Emtricitabine,

Tenofovir Alafenamide) (Fipronil) (Ezetimibe) (Triptorelin)

$618 Million $583 Million $581 Million $580 Million $575 Million $555 Million $553 Million $552 Million $544 Million $522 Million $518 Million $517 Million $500 Million $500 Million $494 Million $491 Million $488 Million $484 Million $482 Million $472 MillionNephrology Infectious Diseases Respiratory Disorders Oncology Oncology Diabetes Gastrointestinal Disorders CNS & Anesthesia Oncology Oncology Infectious Diseases Respiratory Disorders Respiratory Disorders CNS & Anesthesia CNS & Anesthesia Immunology Infectious Diseases Infectious Diseases Cardiovascular Diseases Oncology

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Vidaza Onglyza Zejula Singulair Kuvan Atozet Bosulif Baraclude Lutathera Banzel Amitiza Northera Trenda Pantoprazole Injectafer Zyprexa Sensipar Madopar Medrol Focalin(Azacitidine) (Saxagliptin, Metoprolol) (Niraparib) (Montelukast) (Sapropterin) (Ezetimibe, Atorvastatin) (Bosutinib) (Entecavir) (Lutetium Lu 177 dotatate) (Rufinamide) (Lubiprostone) (Droxidopa) (Bendamustine) (Pantoprazole) (Ferric Carboxymaltose) (Olanzapine) (Cinacalcet) (Levodopa, Benserazide) (Methylprednisolone) (Dexmethylphenidate)

$472 Million $470 Million $470 Million $462 Million $458 Million $453 Million $450 Million $447 Million $445 Million $431 Million $425 Million $415 Million $415 Million $413 Million $410 Million $407 Million $403 Million $402 Million $402 Million $393 MillionOncology Diabetes Oncology Respiratory Disorders Nephrology Cardiovascular Diseases Oncology Infectious Diseases Oncology CNS & Anesthesia Gastrointestinal Disorders CNS & Anesthesia Oncology Gastrointestinal Disorders Hematology CNS & Anesthesia Hormonal Disorders CNS & Anesthesia Immunology CNS & Anesthesia

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Eucreas Lexapro Lonsurf Hyzaar Lumigan Multaq Xiidra Heartgard Ultravist Voltaren Tenelia Halaven Trajenta Lo Loestrin Tamdura Cabometyx Atripla Briviact Viagra Xeloda(Vildagliptin, Metformin) (Escitalopram) (Trifluridine, Tipiracil) (Losartan, Hydrochlorothiazide) (Bimatoprost) (Dronedarone) (Lifitegrast) (Ivermectin, Pyrantel) (Iopromide) (Diclofenac) (Teneligliptin) (Eribulin) (Linagliptin) (Norethindrone Acetate,

Ethinyl Estradiol) (Tamsulosin) (Cabozantinib) (Efavirenz, Emtricitabine, Tenofovir Disoproxil) (Brivaracetam) (Sildenafil) (Capecitabine)

$391 Million $387 Million $386 Million $386 Million $378 Million $377 Million $376 Million $372 Million $367 Million $360 Million $360 Million $359 Million $359 Million $356 Million $351 Million $349 Million $349 Million $348 Million $342 Million $335 MillionDiabetes CNS & Anesthesia Oncology Cardiovascular Diseases Ophthalmology Cardiovascular Diseases Ophthalmology Infectious Diseases Diagnostics Infectious Diseases Diabetes Oncology Diabetes Urology Nephrology Oncology Infectious Diseases CNS & Anesthesia Urology Oncology

Key Oncology CNS & Anesthesia Diabetes Cardiovascular Diseases Infectious Diseases Respiratory Disorders Immunology Gastrointestinal Disorders Urology Miscellanious

Top 200 Small Molecule Pharmaceuticals by Retail Sales in 2020Compiled and Produced by M. Haziq Qureshi from the Njarðarson Group (The University of Arizona)