composition of blood
DESCRIPTION
COMPOSITION OF BLOOD. DR. AYESHA JUNAID MBBS,MCPS,FCPS. Professor of Pathology Consultant Haematology Incharge Blood Transfusion Services SIH. OBJECTIVES: COMPOSITION OF BLOOD. Composition of blood. Little bit of functions of blood. Plasma and its composition. CELLULAR COMPONENTS: - PowerPoint PPT PresentationTRANSCRIPT
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COMPOSITION OF BLOOD
DR. AYESHA JUNAIDMBBS,MCPS,FCPS.Professor of PathologyConsultant HaematologyIncharge Blood Transfusion Services SIH
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Composition of blood. Little bit of functions of blood. Plasma and its composition.CELLULAR COMPONENTS: RBCs: their structure, function and count. WBCs: their types, structure, function & count. Platelets: their structure, function and count.
OBJECTIVES: COMPOSITION OF BLOOD
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COMPOSITION OF BLOOD
5 LITRE
55% PLASMA 45% CELLULAR COMPONENTS
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Blood is slightly denser and approximately 3-4 times more viscous than water, blood consists of cells which are suspended in a liquid. Cellular Components 99% red blood cells, with white blood cells and platelets making up the remainder. Water, of blood has amino acids, proteins, carbohydrates, lipids, hormones, vitamins, electrolytes, dissolved gases, and cellular wastes.
COMPOSITION OF BLOOD
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By volume. Plasma is about 92% water, with plasma proteins as the most abundant solutes. The main plasma protein groups are albumin globulin fibrinogen The primary blood gases are oxygen, carbon dioxide, and nitrogen.
COMPOSITION OF BLOOD
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COMPOSITION OF BLOOD
Centrifuged blood:
Plasma 55% Buffy coat
WBCs <1% Erythrocytes Hematocrit 45%.
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COMPOSITION OF BLOOD Plasma.
90% water 10% solutes
Ions, e.g., Na+, Cl-, Ca++ Nutrients, e.g., simple sugars, amino
acids, lipids Wastes, e.g., urea, ammonia, CO2 Miscellaneous: O2, hormones, vitamins,
plasma proteins.
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COMPOSITION OF BLOODPlasma Proteins. Albumin
Helps control osmotic pressure Helps control diffusion of water
Globulin Includes antibodies Transport proteins (lipids, iron, copper, etc.)
Fibrinogen Involved in clotting
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COMPOSITION OF BLOOD
Serum: Blood plasma from which the protein fibrinogen, which causes clotting of the blood, has been removed.
For all blood chemistry serum of blood is preferred over plasma
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WBC, Total.............(4000/μL -11000/μL)RBC, Total......M(4.5 - 6.5)m/μL, F(3.85.8)m/μL.Hemoglobin... M(13.0-18.0)g/dL F(11.6-16.5)g/dLHCT......................... M(40 - 54)% F(38 - 47)%MCV..................... (80 - 90)fLMCH....................... (27 - 32)pgMCHC..................... (33 - 38)g/dLPlatelet Count....................(150,000-400,000)/μL
COMPOSITION OF BLOOD
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COMPOSITION OF BLOODRed cell indices
MCV MCH MCHC RDW
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COMPOSITION OF BLOOD
MCV is a measure of the average red
cell volume HCT/RBC Normocytic 75-95 fl Macrocytic >95fl Microcytic <75fl
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PERIPHERAL FILM
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COMPOSITION OF BLOOD
MCH Is the average mass of Hemoglobin
per red blood cell. HB/RBC MCH:27 -31 pg Anemia : low MCH Cannot increase than normal
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COMPOSITION OF BLOOD
MCHC is a measure of the concentration of
Hemoglobin in a given volume of packed red blood cells.
MCHC:32 to 36 g/dl Decreases in anemia
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COMPOSITION OF BLOOD
RDW
is an index of the variation in cell volume within the red cell population
RDW = (Standard deviation ÷ mean cell volume) x 100
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