Con: An IBD patient on a biologic and/or an immunomodulator, who develops a malignancy (solid tumor, lymphoma or skin cancer), must stop and never restart these medications

Thomas A. Ullman, M.D.Chief Medical Officer Mount Sinai Doctors Faculty PracticeAssociate Professor of MedicineIcahn School of Medicine at Mount Sinai

Disclosures

Consulting/Advisory Board/Research Work and Support

Pfizer

Janssen

CDx

AbbVie

Genentech

What we are not asking

• Efficacy in IBD• Safety in general IBD patient population

IBD

ImmunomodulatorsAnti-TNF

Combination Therapy

Cancer

Stage at Diagnosis

Treatment

IBD/Flare

Survival

Cancer Cancer Recurrence/Incidence

Drugs

1. Does medical therapy for IBD predispose to developing cancer?

2. Once cancer develops in an IBD patient, is the cancer outcome different?3. In an IBD patient with a history of cancer, does IBD therapy impact cancer recurrence?4. In the IBD patient with active cancer does the cancer therapy affect IBD outcomes?5. If a malignancy develops on IBD therapy, is it ever safe to re-start that agent?

ChemotherapyRadiotherapy

Hormone Therapy

• 823 pts with history of cancer treated prior to renal transplant:

• 185 with cancer recurrence (22%)

Renal Transplant Pts with History of Cancer:High Risk of Recurrent Cancer due to

immunosuppression

Penn I. Transplantation 1993. 55; 742-7

Guidelines in IBD Patients with Hx of Cancer

ECCO (2010):Anti-TNF therapy is contraindicated in patients with a history of lymphoma, and “careful consideration should be given to initiating anti-TNF therapy” in those with a history of non-haematopoietic cancer.

Dignass et al J Crohns Colitis 4:28, 2010

ACG (2009) & WGO (2009):No recommendations regarding management of IBD in patients with a history of cancer.

Lichtenstein et al Am J Gastro 104:465, 2009Bernstein et al. Inflamm Bowel Dis 16:112, 2009

Imuran Black Box Warning

• WARNING - MALIGNANCY Chronic immunosuppression

with IMURAN, a purine antimetabolite increases risk of

malignancy in humans. Reports of malignancy include

post-transplant lymphoma and hepatosplenic T-cell

lymphoma (HSTCL) in patients with inflammatory bowel

disease. Physicians using this drug should be very familiar

with this risk as well as with the mutagenic potential to both

men and women and with possible hematologic toxicities.

Physicians should inform patients of the risk of malignancy

with IMURAN. See WARNINGS.

Imuran, Prescribing Information

Thiopurines: Contraindications

• Patients with rheumatoid arthritis previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan, or others) may have a prohibitive risk of malignancy if treated with IMURAN.

Imuran, Prescribing Information

Important Caveat:

• Malignancy within 5 years of study entry and exclusion criterion for EVERY study involved in the meta-analysis

Infliximab Prescribing Information

• “The potential role of TNF-blocking therapy in the

development of malignancies is not known [see Adverse

Reactions (6.1)]. Rates in clinical trials for INFLIXIMAB

cannot be compared to rates in clinical trials of other TNF-

blockers and may not predict rates observed in a broader

patient population. Caution should be exercised in

considering INFLIXIMAB treatment in patients with a

history of malignancy or in continuing treatment in patients

who develop malignancy while receiving INFLIXIMAB.”

Remicade, Prescribing Information

Adalimumab Prescribing Information

• “The risks and benefits of TNF-blocker treatment including Adalimumab should be considered prior to initiating therapy in patients with a known malignancy other than a successfully treated non-melanoma skin cancer or when considering continuing anti-TNF therapy in patients who develop a malignancy.”

Adalimumab Prescribing Information 2011

Certolizumab Prescribing Information“The potential role of TNF blocker therapy in the development of malignancies in adults is not known”

Certolizumab Prescribing Information

Limitations of Existing Studies

• Lack of randomized prospective data– Most data come from observational registries

• History of cancer = exclusion criterion in clinical trials– Based on theoretical risk of immunosuppression

• Most “Guidelines” advised practitioners to avoid using immunosuppressive IBD meds in patients who have a history of cancer– MDs are more likely to treat only patients with lower risk of

cancer recurrence with immunosuppressive regimens• Sample sizes too small to ask about specific malignancies

– Immunosuppression vs. inflammation– Common cancers: Breast, Prostate, Lung etc.

IBD pts with history of cancer:Thiopurine Exposure - No Increased Risk of Subsequent Cancer (CESAME)• 19,486 pts with IBD:

– Enrolled May 2004-June 2005, followed through December 2007– 405 with personal history of cancer with at least one follow up visit

• Compared risk of developing new/recurrent cancer:– 93 pts exposed to IT (thiopurine):

o 6 new cancerso 1 recurrence of meningioma

– 312 not exposed to ITo 12 new cancerso 4 recurrent cancers (lymphoma, breast, prostate, small bowel)

L Beaugerie et al. Abstract DDW 2012.

IT Naïve at Entry n=312

IT at Entryn=93

New Cancer (NS) 14.4/1000 PY 23.1/1000 PY

Recurrent Cancer (NS)

6.8/1000 PY 3.9/1000 PY

P=0.98

P=0.26

• Over 14,000 pts with RA– 293 with prior malignancy

o 177 anti-TNF treatedo 117 DMARD treated (no anti-TNF)

• Rates of incident malignancy compared– 25.3/1000 PY in anti-TNF– 38.3/1000 PY in DMARD– Prior Melanoma:

o 3/17 (18%) in anti-TNF developed incident malignancyo 0/10 (0%) in DMARD developed incident malignancy

DMARD Anti-TNF

Dixon et al., Arthritis Care & Research 2010. 62;755-63.

• BSR Guidelines at time of study read:• “Caution should be exercised….in pts with previous malignancy”• “If pts have been free of any recurrence of their malignancy for 10 yrs there is no

evidence for a contraindication to anti-TNF therapy”

RA Patients with History of Cancer:Anti-TNF Treatment Did Not Increase Risk of New

or Recurrent Cancer (British Registry)

• Biologic or conventional DMARD therapy between May 2001 and December 2006

• Prior malignancy in 122 out of 5,120 pts– 58 pts received anti-TNF– 55 conventional DMARDs– 14 pts exposed to anti-TNF with 15 recurrent cancers– Crude recurrence rates:

o 45.5/1000 PY in anti-TNF exposedo 31.4/1000 PY in DMARD exposedo Incidence rate ratio 1.4 (P=0.6)

Strangfeld et al. Arthritis Research &Therapy 2010. 12:R5.

RA Patients with History of Cancer:Anti-TNF Treatment Did Not Significantly Increase Risk

of New or Recurrent Cancer (German Registry)

IBD & Cancer

Cancer controlled

per oncologist?

Yes

Within 2 years

Treat severe flares with

steroids

IBD controlled?

Yes

Follow course

No

Consider

anti-TNF

Beyond 2 years

Favor step-up approach*

No

Hold IS

IBD controlled?

Yes

Follow course**

No

Consider cytotoxic chemotherapy

IBD controlled after

chemotherapy?

Yes

Follow course

No

First line: Steroids

Second line: Anti-TNF

*Avoid IS associated with the risk of prior cancer. The longer the IS is held, the lower the risk of cancer recurrence.

**Hormonal therapy is associated with IBD flare

Gut 2013. E-pub ahead of print

Recommendations:

• Multidisciplinary approach to the safety of using immunosuppression based on: – Cancer type– Overall risk of recurrence– Risk of IBD activity

Conclusions

• Managing IBD patients with past or current malignancy is an increasingly common problem.

• Few studies done in patients with IBD.• Caution using thiopurines if cancer therapy will

produce bone marrow suppression. • Fear of using anti-TNFs in patients with current

cancer may not be well-founded. • Decisions need to be made on case-by-case basis

with oncologist, taking patient’s awareness and preferences into consideration.

I’m No Perry Mason

• Rubin 6, Ullman 0• Mercy?

Thank You