conducting research in switzerland and the usa...amstad et al., journal of physical chemistry c,...
TRANSCRIPT
Esther Amstad [email protected]
Career fair, 1/31/2014
Conducting research in Switzerland and the USA
PhD thesis: ETH Zurich
Postdoc: Harvard University
Education
-O
-O NO2
HN
COOH O
-O
-ONO2
HN
HOOCO
-O
-O
NO2
HN
HOOCO
-O
-O
NO2
NH
HOOC
O
-O
-O
NO2
NHHOOC
O
-O
-O
NO2 NHHOOC
O
O-
-O
NO2NHHOOC
O
O-
-O
O2N
NHHOOC
O
O--O
O2N
NHHOOC
O
O--O
O2N
NH
HOOC
O
O--O
O2N
NH
HOOC
O
O-
-O
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOCO
O-
O-
O2N
NH
HOOCO
O-
O-O2N
NH
COOHOO-
O-
O2N
NH
COOHO
O-
O-
O2N
HN
COOH
O
O-
O-
O2N
HN
COOH
O
O-
O-
O2NHNCOOH
O
O-
O-
O2NHN COOH
O
-O
O-
NO2
HN COOH
O
-OO-
NO2
HNCOOH
O
-O O-
NO2
HN
COOH
O
-OO-
NO2
HN
COOH
O
-OO-
NO2
HN
COOH
O
-O
O-
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOHO
-O
-ONO2
HN
COOHO
Fe3O4
PhD thesis: Surface modification of oxide nanoparticles
Steric stabilization and functionalization of nanoparticles
Nanoparticles: actuators to trigger release from capsules
Characterization of Fe3O4 cores
HO
HO
HN
COOHO
OO
*n
NO2
HO
HO
HN
O
OO
*n
NO2
HO
HO
HN
COOHO
OO
*n
HO
HO
HN
O
OO
*n
HO
HO
HN
O
OO
*n
OH
NHO
O
HN
COOHO
OO
*n NHO
O
HN
O
OO
*n
CH3
O
O
HO
NH
O
OO
*n
HO O
O O
O*n
mimosine
Too strong anchor
Good anchors
nitroDOPA
nitrodopamine
Intermediate anchor
DOPA
Poor anchors
dopamine
hydroxydopamine
hydroxypyridine
hydroxypyrone
carboxy
Poor anchors
Amstad et al., Nano Letters 2009
Influence of surface coating on nanoparticle stability
delocalized electrons
Too strong anchors: NP dissolution
Good anchors: close to covalent bond to Fe3O4 NPs
Poor anchors: reversible adsorption→poor NP stability
Electron paramagnetic resonance spectroscopy (EPR)
Amstad et al., Journal of Physical Chemistry C, 2011 Amstad et al., Chemistry – A European Journal, 2011
•Nitrocatechols magnetically decouple Fe3+ → rhombohdreally distorted paramagnetic Fe3+ EPR signals. •Delocalized electrons indicate very strong nitrocatechol- Fe3+ interactions.
Magnetic nanoparticles as actuators to trigger release
Triggered Release
Amstad et al., Nano letters, 2011
-O
-O NO2
HN
COOH O
-O
-ONO2
HN
HOOC O-O
-O
NO2
HN
HOOCO
-O
-O
NO2
NH
HOOC
O
-O
-O
NO2
NHHOOC
O
-O
-O
NO2 NHHOOC
O
O-
-O
NO2NHHOOC
O
O-
-O
O2N
NHHOOC
O
O--O
O2N
NHHOOC
O
O--O
O2N
NH
HOOC
O
O--O
O2N
NH
HOOC
O
O-
-O
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOCO
O-
O-
O2N
NH
HOOCO
O-
O-O2N
NH
COOHOO-
O-
O2N
NH
COOHO
O-
O-
O2N
HN
COOH
O
O-
O-
O2N
HN
COOH
O
O-
O-
O2NHNCOOH
O
O-
O-
O2NHN COOH
O
-O
O-
NO2
HN COOH
O
-OO-
NO2
HNCOOH
O
-O O-
NO2
HN
COOH
O
-O O-
NO2
HN
COOH
O
-OO-
NO2
HN
COOH
O
-O
O-
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOHO
-O
-ONO2
HN
COOH O
-O
-O NO2
HN
COOH O
-O
-ONO2
HN
HOOC O-O
-O
NO2
HN
HOOCO
-O
-O
NO2
NH
HOOC
O
-O
-O
NO2
NHHOOC
O
-O
-O
NO2 NHHOOC
O
O-
-O
NO2NHHOOC
O
O-
-O
O2N
NHHOOC
O
O--O
O2N
NHHOOC
O
O--O
O2N
NH
HOOC
O
O--O
O2N
NH
HOOC
O
O-
-O
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOCO
O-
O-
O2N
NH
HOOCO
O-
O-O2N
NH
COOHOO-
O-
O2N
NH
COOHO
O-
O-
O2N
HN
COOH
O
O-
O-
O2N
HN
COOH
O
O-
O-
O2NHNCOOH
O
O-
O-
O2NHN COOH
O
-O
O-
NO2
HN COOH
O
-OO-
NO2
HNCOOH
O
-O O-
NO2
HN
COOH
O
-O O-
NO2
HN
COOH
O
-OO-
NO2
HN
COOH
O
-O
O-
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOHO
-O
-ONO2
HN
COOH O
-O
-O NO2
HN
COOH O
-O
-ONO2
HN
HOOC O-O
-O
NO2
HN
HOOCO
-O
-O
NO2
NH
HOOC
O
-O
-O
NO2
NHHOOC
O
-O
-O
NO2 NHHOOC
O
O-
-O
NO2NHHOOC
O
O-
-O
O2N
NHHOOC
O
O--O
O2N
NHHOOC
O
O--O
O2N
NH
HOOC
O
O--O
O2N
NH
HOOC
O
O-
-O
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOCO
O-
O-
O2N
NH
HOOCO
O-
O-O2N
NH
COOHOO-
O-
O2N
NH
COOHO
O-
O-
O2N
HN
COOH
O
O-
O-
O2N
HN
COOH
O
O-
O-
O2NHNCOOH
O
O-
O-
O2NHN COOH
O
-O
O-
NO2
HN COOH
O
-OO-
NO2
HNCOOH
O
-O O-
NO2
HN
COOH
O
-O O-
NO2
HN
COOH
O
-OO-
NO2
HN
COOH
O
-O
O-
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOHO
-O
-ONO2
HN
COOH O
-O
-O NO2
HN
COOH O
-O
-ONO2
HN
HOOC O-O
-O
NO2
HN
HOOCO
-O
-O
NO2
NH
HOOC
O
-O
-O
NO2
NHHOOC
O
-O
-O
NO2 NHHOOC
O
O-
-O
NO2NHHOOC
O
O-
-O
O2N
NHHOOC
O
O--O
O2N
NHHOOC
O
O--O
O2N
NH
HOOC
O
O--O
O2N
NH
HOOC
O
O-
-O
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOC
O
O-
O-
O2N
NH
HOOCO
O-
O-
O2N
NH
HOOCO
O-
O-O2N
NH
COOHOO-
O-
O2N
NH
COOHO
O-
O-
O2N
HN
COOH
O
O-
O-
O2N
HN
COOH
O
O-
O-
O2NHNCOOH
O
O-
O-
O2NHN COOH
O
-O
O-
NO2
HN COOH
O
-OO-
NO2
HNCOOH
O
-O O-
NO2
HN
COOH
O
-O O-
NO2
HN
COOH
O
-OO-
NO2
HN
COOH
O
-O
O-
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOH
O
-O
-O
NO2
HN
COOHO
-O
-ONO2
HN
COOH O
What structure do these capsules have? TEM cryo-TEM
Paul Scherrer Institute, Switzerland
Postdoc: Microfluidics, a tool to produce new materials
qinner : qmiddle = 1 : 1
50 μm
100 μm
The millipede device Production of highly monodisperse drops at a 100 higher throughput
100 μm
100 μm 500 nm
A new tool to formulate poorly water soluble drugs as nanoparticles of unprecedented small sizes
The microfluidic nebulator
What comes next? EPFL: Soft MAterials Lab (SMAL)