China Pharmaceutical University, Nanjing, Jiangsu, China

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CONFERENCE PROGRAMME

Conference Theme

Hamonization of Herbal Quality Standards for Natural Products, Phytopharmaceuticals and

Traditional Chinese Medicine and Application of New Technologies and Methods.

Scientific Topics

- Chemistry & Quality

- Pharmacology & Toxicology

- Clinical Study & Systems Biology

- Regulatory Affairs & Drug Discovery

Conference Programme

Conference format: Keynote Speech, Panel Discussion.

Conference language: English

Conference Schedule

Day 1 – Friday, 18 July 2014

Workshop I: GP-TCM Research Association Interest Group

Room 107, Conference Centre

09:00 –09:10 Opening Speech

Prof. Rudolf BAUER, President of GP-TCM RA

09:10 –10:20 Quality Interest Group

Chairmen: Prof. Kelvin CHAN & Prof. Yuan-shiun CHANG Chair Introduction: Overall Issues on Quality Control of CMM & Granules,

10 min

Speakers:

1. Prof. Rudolf BAUER, Recent Development of QC of CMM Decoction

Pieces and Granules in the EU, 20 min

2. Prof. Yuan-shiun CHANG, Quality Control of TCM Herbs and Herbal

China Pharmaceutical University, Nanjing, Jiangsu, China

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Preparations in Taiwan, 20 min

Discussion: The Future QCIG Plan, 20 min

10:20 –10:40 Coffee Break

10:40 –11:50 Pharmacology/Toxicology Interest Group

Chairmen: Prof. Pierre DUEZ & Dr. Fan QU Chair Introduction: The GP-TCM RA Pharmacology and Toxicology Interest

Group: an Integrated Action, 5 min

Speakers:

1. Prof. Peter HYLANDS, Omics in TCM Pharmacology Research, 15 min

2. Prof. Yi-zhun ZHU, Molecular New Mechanisms of Novel Compounds

from Chinese Herbs: Bench to Bedside, 15 min

3. Prof. Valérian BUNEL, Exploration of Herbal Compounds for

Preventing CisPt-induced Acute Kidney Injury, 15 min

Discussion: The Future PTIG Plan, 20 min

12:00–13:30 Board Member’s Lunch Meeting

13:30 – 14:40 Regulatory Affairs Interest Group

Chairmen: Prof. Tai-ping FAN & Prof. Wei-dong ZHANG Chair Introduction: 10 min

Speakers:

1. Prof. Werner KNöSS, Recent HMPC Guidance on Regulation of

(Traditional) Herbal Medicinal Products, 20 min

2. Prof. Charlie XUE, Building Community Trust and Protecting Public

Safety: the Australian National Registration of Chinese Medicine

Practitioners, 20 min

Discussion: The Future RAIG Plan, 20 min

14:40 –15:50 Clinical Studies Interest Group

Chairman: Prof. Ai-ping LU

Chair Introduction: 10 min

Speakers:

1. Dr. Chi ZHANG, Systematic Review on Clinical Trials in Chinese

Medicine, 20 min

2. Prof. Ai-ping LU, Pattern Classification and Clinical Trial in Chinese

Medicine, 20 min

Discussion: The Future CSIG Plan, 20 min

15:50 – 16:00 Coffee Break

16:00 – 17:10 Acupuncture and Moxibustion Interest Group

China Pharmaceutical University, Nanjing, Jiangsu, China

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Chairmen: Prof. Nicola ROBINSON & Prof. Jian-ping LIU Chair Introduction: the Acupuncture Special Interest Group, 5 min

Speakers:

1. Prof. Jian-ping LIU, Randomised Trials on Acupuncture Published in

Chinese Journals, 15 min

2. Prof. Xiao-feng ZHAO, Clinical Trials of Acupuncture and

Moxibustion, 15 min

3. Prof. Fan-rong LIANG, Acupoint Specificity-progress Based on

Functional Imaging Techniques, 15 min

Discussion: The Future AMIG Plan, 20 min

The preliminary election meeting of TCM

Pharmaceutical Analysis Specialty Committee of WFCMS

Room 205, Conference Centre 15:30 – 17:00 Participants: WFCMS leaders, President, Vice president, Secretary-General,

Board of Directors of TCM Pharmaceutical Analysis Specialty Committee of

WFCMS

1. Moderator: Prof. Jian-hua ZOU, Director of Academic Department of

WFCMS

2. Welcome Speech and Introduction by Secretary-General Wan-sheng

CHEN

3. A brief introduction of "World Federation of Chinese Medicine Societies

professional committee organization and management regulations" by

Prof. Jian-hua ZOU

4. Report of the President by Prof. De-an GUO

5. Election of the President for the second term

6. The council member election of the second term

7. Nomination of the new Secretary-General

China Pharmaceutical University, Nanjing, Jiangsu, China

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GP-TCM RA Annual General Meeting

Room 205, Conference Centre

17:10–18:10 Attendees: Members and other attendees are all welcome

Chairman: Professor Rudolf BAUER, President of the GP-TCM RA

Minutes: Dr. Qi-he XU, Vice President of GP-TCM RA

1. Welcome Speech by Chairman

2. Approval of minutes of 2013 AGM

3. Report of the President by Prof. Rudolf BAUER (University of Graz,

Austria)

4. Report of Secretary-General by Prof. Tai-ping FAN (University of

Cambridge, UK)

5. Report of Treasurer by Prof. Peter HYLANDS (King’s College London,

UK)

Any other business

Workshop II – Scientific Writing

Auditorium, Floor 3, Main Building

13:30 –17:30 Moderators: Prof. De-an GUO & Prof. Yue-qing GU

13:30 –14:30 Prof. Rudolf BAUER, Editor, Planta Medica, Austria

Title: Criteria for Publishing Scientific Papers in Planta Medica

14:30– 15:30 Prof. Robert VERPOORTE, Editor in Chief, Journal of Ethnophar-

macology, The Netherlands

Title: Instructions for Publishing Papers in Journal of Ethnopharmacology

15:30 –16:00 Coffee Break

16:00 –17:00 Prof. Salvatore FANALI, Editor, Journal of Chromatography A, Italy

Title: Remarks and Recommendations for Sending the Results of Your Research

to A Journal of Great Interest in Separations Science: Journal of

Chromatography A

17:00 –17:30 Q & A

China Pharmaceutical University, Nanjing, Jiangsu, China

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Day 2 –Saturday, 19 July 2014

Opening and Plenary Lectures

Auditorium, Floor 3, Main Building

9:00– 9:40 Opening Ceremony

Moderator: Prof. De-an GUO

Opening Remark Dr. Jian-hua ZOU, Director of Academic Department, WFCMS,

Announcement of Newly Approved List of Council Members of TCM

Pharmaceutical Analysis Specialty Committee

Prof. Zhen-ji LI, Vice President, World Federation of CM Societies,

Awarding Certificates to the New President, Vice presidents and

Secretary General followed by a opening remark

Prof. Hong-xin CAO, Director General, Department of Scientific

Research, State Administration of Traditional Chinese Medicine

Prof. Shi-ying XIAO, Vice Director General, China National Centre for

Biotechnology Development, MOST

Prof. Rudolf BAUER, President, GP-TCM Research Association,

Honorary Member Awarding Ceremony

Prof. Ping LI, Director, State Key Laboratory of Natural Medicines,

China Pharmaceutical University

Prof. De-an GUO, President of TCM Pharmaceutical Analysis Specialty

Committee, Announcement of Winner for Outstanding Contribution

Award

Dr. Ying ZHAO, Vice President, Agilent Technologies

Prof. Jian DING, Academician, Chinese Academy of Engineering,

Shanghai Institute of Materia Medica, CAS

Prof. Mao-de LAI, President, China Pharmaceutical University

9:40–12:00 Plenary Lectures

Moderators: Prof. Xin-sheng YAO & Prof. Salvatore FANALI

9:40–10:10 Prof. Werner KNöSS, Chairman of Herbal Medicinal Products Committee,

European Medicines Agency; University of Bonn, Germany

Title: European Regulatory Framework for Herbal Medicinal Products–

Challenges for Traditional Medicines

10:10–10:40 Prof. An-long XU, President, Beijing University of Chinese Medicine,

China

Title: System Biology of Pi-deficiency and Its Therapeutic Recipe

10:40 – 11:00 Coffee Break

11:00– 11:30 Prof. Geoffrey A. CORDELL, Natural Products Inc, USA

Title: Evidence-Based, Sustainable Traditional Medicines–Debunking The

Myths

China Pharmaceutical University, Nanjing, Jiangsu, China

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11:30 – 12:00. Prof. Jian-dong JIANG, the Institute of Medicinal Biotechnology of the

Chinese Academy of Medical Sciences, China

Title: Revisit Natural Medicines

12:00 – 13:30

Lunch Break (Editorial board members’ meeting, World Journal of Traditional Chinese Medicine, Room 205, Conference Centre / Visiting the State Key Laboratory of Natural Medicines, 7th Floor, Main Building)

Session 1: Chemistry & Quality

Room 107, Conference Centre

13:30 – 15:35 Moderators: Prof. Hai-xue KUANG & Prof. Robert VERPOORTE

13:30 – 13:55 Prof. Rudolf BAUER, University of Graz, Austria

Title: Best Practice in TCM Research: How to Identify the Active

Principles?

13:55 – 14:20 Prof. Teris van BEEK, WageningenUniversity, The Netherlands

Title: Can Ambient Mass Spectrometry Simplify Phytochemical Analyses?

14:20– 14:45 Prof. Shao-ping LI, University of Macau, China

Title: The Key of Quality Control in Chinese Medicines, A case of Cordyceps

14:45 – 15:10 Prof. Shuang-cheng MA, National Institute for Food and Drug Control

Title: A Novel Substitute Reference Method for Overall Quality Control of

TCMs: Linear Calibration Using Two Reference Substances

15:10 – 15:35 Prof. Kalman SZENDREI, University of Szeged, Hungary

Title: The Role of Traditional Use of Herbals in China and in Europe–

Convergence and Conflicts

15:35 – 15:55 Coffee Break

15:55 – 17:55 Moderators: Prof. Xin-miao LIANG & Prof. Haruki YAMADA

15:55 – 16:20 Prof. Salvatore FANALI, Consiglio Nazionale delle Ricerche, Istituto di

Metodologie Chimiche, Italy

Title: Herbal Medicine and Natural Products Analysis: A Challenging Issue

for Capillary Electromigration and Chromatographic Techniques

16:20 – 16:45 Prof. Leslie GUNATILAKA, University of Arizona, USA

Title: Traditional Medicine Inspired Discovery of Natural Product-Based

Drugs for the Treatment of Modern Day Diseases

16:45 – 17:10 Prof. Guido PAULI, University of Illinois at Chicago, USA

Title: Untangling Pharmacognosy Roots, Heavenly Stems, and Earthly

Branches

China Pharmaceutical University, Nanjing, Jiangsu, China

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17:10 – 17:35 Dr. Rong AN, Agilent Technologies, China

Title: An Analytical Tool for TCM-LC x LC

17:35 – 17:45 Prof. Min YE, Peking University Health Science Centre, China

Title: Discovery of Novel Chemical Constituents in Chinese Herbal

Medicine

17:45 – 17:55 Dr. Dezsõ CSUPOR, University of Szeged, Hungary

Title: Phytochemical and Pharmacological Research on Chinese and

European Aconitum Species

18:30 – 20:00 Banquet

20:30 – 21:30 Editorial board members’ meeting, Chinese Herbal Medicines, Room

205, Conference Centre

Session 2: Pharmacology & Toxicology

Room 306, Conference Centre

13:30 – 15:35 Moderators: Prof. Jie-fei CHENG & Prof. Gerhard FRANZ

13:30 – 13:55 Prof. Haruki YAMADA, Tokyo University of Pharmacy and Life Sciences,

Japan

Title: Comprehensive Approach for Elucidation of Action Mechanism of

Kampo Medicines

13:55 – 14:20 Prof. Ning-hua TAN, Kunming Institute of Botany, China

Title: Anti-tumor Cyclopeptides RAs

14:20 – 14:45 Prof. Tai-ping FAN, University of Cambridge, UK

Title: DBZ, a Novel Synthetic Compound Inspired by Compound Danshen

Dripping Pills, Promotes Angiogenesis in vitro through Activating Akt and

MAPK Signalling Pathways

14:45 – 15:10 Prof. Pulok MUKERJEE, Jadavpur University, India

Title: Safety Related Quality Issues - Approach for Evaluation of Herbal

Medicinal Plants through Marker Analysis

15:10 – 15:35 Prof. Clara LAU, Chinese University of Hong Kong, China

Title: The Newly Discovered Cytotoxic and Anti-angiogenic Compounds

from Two Easily Confused Species, Hedyotis Diffusa and Hedyotis

Corymbosa

15:30 – 15:55 Coffee Break

15:55– 17:30 Moderators: Prof. Yi-zhun ZHU & Prof. Pierre DUEZ

15:55– 16:20 Prof. Ge LIN, Chinese University of Hong Kong, China

Title: Beneficial Herb–drug Interaction in Combinational Therapy of Herbal

Medicine with Drug

China Pharmaceutical University, Nanjing, Jiangsu, China

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16:20 – 16:45 Dr. Edmund M. K. LUI, Editor, J Complem & Intergr Medicine,Western

University, Canada

Title: Immunomodulatory Effect of Polysaccharides of American Ginseng

and Pharmco-kinetics in Rats Following Oral Administration

16:45– 17:10 Prof. Kan DING, Shanghai Institute of Materia Medica, CAS, China

Title: The Mechanism Underlying Anti-cancer Bioactivity of Glycan from

Chinese Herbal Medicine

17:10– 17:20 Dr. Yang SUN, Nanjing University, China

Title: Andrographolide-driven Mitophagy-mediated NLRP3 Inflammasome

Inhibition is Responsible for the Prevention of Colitis-associated Cancer

17:20– 17:30 Dr. Lei ZHANG, Shanghai Changzheng Hospital, China

Title: Intergrated Omics-based Approach toward Understanding and

Regulation of Valuable Secondary Metabolism in Medicinal Plants

18:30 – 20:00 Banquet

Session 3: Clinical Study and Systems Biology

Room 307, Conference Centre

13:30–15:30 Moderators: Prof. Shi-lin YANG & Dr. Qi-he XU

13:30 – 13:55. Prof. Nicola ROBINSON, London South Bank University, UK

Title: Establishing Priorities for Acupuncture Research

13:55 – 14:20 Prof. Guo-an LUO, Tsinghua University, China

Title: Integrative Biomarker System for Clinical Systems Biology of TCM

14:20 – 14:45 Dr. Mei WANG, TNO, The Netherlands

Title: Systems Approach for Evaluating the Biological Effects of

Multi-herbal Chinese Medicine Formula

14:45 – 15:10 Prof. Ai-ping LU, Hong Kong Baptist University, China

Title: Developing Valid and Reliable Clinical Studies in TCM: AClear

Direction of GP-TCM RA Clinical Studies Interest Group (CSIG)

15:10 – 15:30 Q & A

15:30 – 15:55 Coffee Break

15:55 – 17:40 Moderators: Prof. Shi-lin CHEN & Prof. Nicola ROBINSON

15:55 – 16:20 Prof. Fan-rong LIANG, Chengdu University of Chinese Medicine, China

Title: Acupoint Specificity-progress Based on Functional Imaging

Techniques

China Pharmaceutical University, Nanjing, Jiangsu, China

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16:20 – 16:45 Prof. Jing-yan HAN, Peking University, China

Title: QiShenYiQi Pills® Prevents Cardiac Ischemia–reperfusion Injury via

Energy Modulation

16:45 – 17:10 Prof. Jian-ping LIU, Beijing University of Chinese Medicine, China

Title: Randomized Trials on Acupuncture Published in Chinese Journals: A

Systematic Literature Review

17:10 – 17:20 Prof. Yu-ping TANG, Nanjing University of Chinese Medicine, China

Title: Analysis of TCM Complicated Constituents’ Interaction by Using

Fuzzy Chemical Identification Strategy

17:20 – 17:40 Q & A

18:30 – 20:00 Banquet

China Pharmaceutical University, Nanjing, Jiangsu, China

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Day 3 – Sunday, 20 July 2014

Session 4: Chemistry & Quality

Room 107, Conference Centre

8:30 – 10:10 Moderators: Prof. Zheng-tao WANG & Prof. Guido PAULI

8:30 – 8:55 Prof. Yuan-shiun CHANG, China Medical University, Taiwan

Title: Quality Control of TCM Herbs and Herbal Preparations in Taiwan

8.55 – 9.20 Prof. Hermann STUPPNER, University of Innsbruck, Austria

Title: Supercritical Fluid Chromatography in Natural Product Analysis

9:20 – 9:45 Prof. Christian HUCK, University of Innsbruck, Austria

Title: Novel Analytical Tools for Quality Control in Traditional Chinese

Medicine

9:45 – 10:10 Dr. Yuan-chun MA, Canadian Phytopharmaceuticals Co., Canada

Title: Challenges and Solutions for the Quality Control of Natural Health

Products

10:10 – 10:30 Coffee Break

10:30 – 11:40 Moderators: Prof.Wan-sheng CHEN& Prof.Hermann STUPPNER

10:30 – 10:55 Prof. Alvaro VILJOEN, Tshwane University of Technology, South Africa

Title: Looks May be Deceiving–exposing Taxonomic Similarity through

Chemometric Modeling of Analytical Data

10:55 – 11:20 Prof. Zhi-hong JIANG, Macau University of Science and Technology,

China

Title: Multiple Mass Spectrometry-Based Glycomic Approach and its

Application

11:20 – 11:30 Prof. Lian-wen QI, China Pharmaceutical University, China

Title: Identification of Chemical Markers for Quality Control of Herbal

Medicine

11:30 – 11:40 Prof. Wan-ying WU, Shanghai Institute of Materia Medica, China

Title: Approach to the Quality Control of Chinese Herbal Formulas

12:00 –13:30 Lunch Break / Visiting the State Key Laboratory of Natural Medicines,

7th Floor, Main Building

China Pharmaceutical University, Nanjing, Jiangsu, China

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Session 5: Regulatory Affairs and Drug Discovery

Room 307, Conference Centre

8:30 – 10:10 Moderators: Prof. Zhen-liang YE & Dr. Burt KROES

8:30 – 8:55 Dr. Emiel van GALEN, Medicines Evaluation Board, The Netherlands

Title: Market Access in the Netherland for Traditional Chinese Medicine

8:55 – 9:20 Prof. Shi-shan YU, Institute of Materia Medica, Chinese Academy of

Medical Sciences, China

Title: Natural Medicine-based New Drug Discovery

9:20 – 9:45 Dr. Thomas BRENDLER, Plant Medicine Consulting Companies, USA

Title: Market Access for Herbal Products in Europe and the USA, a

Comparison

9:45 – 10:10 Prof. Bo-yang YU, China Pharmaceutical University, China

Title: Ophiopogon-based New Drug Discovery

10:10 – 10:30 Coffee Break

10:30 – 12:10 Moderators: Prof. Zhao-xiang BIAN & Prof. Tai-ping FAN

10:30 – 10:55 Prof. Alexander SHIKOV, St Petersburg Inst Pharm, Russia

Title: Regulation for Herbal Medicinal Products in Russian Federation

10:55 – 11:20 Dr. Shang-mei SHI, Chinese Pharmacopoeia Commission, China

Title: Recent Development of TCM Standards in Chinese Pharmacopoeia

11:20 – 11:45 Dr. Burt KROES, Section Botanicals and Novel Foods Medicines

Evaluation Board, The Netherlands

Title: The Legal Framework Governing the Quality of (Traditional) Herbal

Medicinal Products in the European Union

11:45 – 12:10 Dr. Jie-fei CHENG, Otsuka Shanghai Research Institute, China

Title: Innovation in New Drug Discovery and Development

12:30 – 13:30 Lunch Break / Visiting the State Key Laboratory of Natural Medicines,

7th Floor, Main Building

Workshop III: Agilent Two Dimentional Liquid Chromatography

Room 306, Conference Centre

8:30 – 12:00 Moderators: Prof. Shao-ping LI & Prof. Teris van BEEK

8:30 – 9:10 Prof. Dwight STOLL, Gustavus Adolphus College, USA

Topic: Theoretical Foundations of State-of-the-art 2D-LC, and Examples of

Recent Applications in the Analysis of Complex Samples

China Pharmaceutical University, Nanjing, Jiangsu, China

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9:10 – 9:50 Dr. Qing-ping TAO, Vice President for Research and Development, GC

Image, USA

Topic: Advanced Software Tools for Plant Substances Analyses with

Comprehensive Two-Dimensional Chromatography with High-Resolution

Mass Spectrometry.

9:50 – 10:10 Q& A

10:10 – 10:30 Coffee Break

10:30 – 11:10 Dr. Jens TRAFKOWSKI, Product Manager of the Agilent 2D-LC

solution, Agilent Germany

Topic: Comprehensive Analysis of Traditional Chinese Medicine using the

Agilent 1290 Infinity 2D-LC Solution

11:10 – 11:50 Dr. Yao XIAO, LC Application Engineer, Agilent China

Topic: Applications and Method Development of Agilent 2D-LC Solution in

Traditional Chinese Medicine Analysis

11:50– 12:00 Q& A

12:00 – 13:30 Lunch Break / Visiting the State Key Laboratory of Natural Medicines,

7th Floor, Main Building

Plenary Lectures and Closing Ceremony

Auditorium, Floor 3, Main Building

13:30 – 16:00 Plenary Lectures

Moderators: Prof. Brigitte KOPP & Prof. Werner KNöSS

13:30 – 14:00 Prof. Gerhard FRANZ, Chairman of TCM Working Group, European

Pharmacopoeia Commission

Title: Status Report about the Ongoing Process: TCM Herbal Drug

Quality Monographs for Europe

14:00 – 14:30 Prof. Kwok-fai SO, The University of Hong Kong, Hong Kong, China

Title: Molecular Mechanism of Protection in Neurodegenerative Diseases

using an Anti-aging Chinese Herb, Gouqizi (Wolfberry)

14:30 – 15:00 Prof. Robert VERPOORTE, University of Leiden, The Netherlands

Title: Synergy: Easier to Say than to Prove

15:00 – 15:30 Prof. Mao-de LAI, President, China Pharmaceutical University, China

Title: Translational Medicine and Drug Development-AView from A

Pathologist

15:30 – 16:00 Closing and Best Poster Awarding Ceremony