…Is it Essential ?

On

Quality (of Life) by Design.

The Question Sounds like:

Is It Essential to Eat Good Fresh Balanced Indigenous Diet?

Or

Can I keep the Option of Eating Fresh Garbage?

‘Sales' depend on the

Product QUALITY * Intended PURPOSE * Product PERFORMANCE

These three should be built-in during PRODUCT DESIGN and Manufacturing.

Thus every one involved in the ‘product DESIGN and manufacturing’ must have an idea of the sales part of it.

“High grade-High QUALITY-Low price is given top priority”

But in the competitive world

Low grade-High QUALITY is preferred over High grade-Low QUALITY.

Thus at the end of the day it is about the

High QUALITY product suitable for intended PURPOSE” with promised “PERFORMANCE.

(CURRICULUM DESIGN, Teaching &Training, and Duty/Job/Employment)

Material Path Spiritual Path

Synchronized Path

Confused State

Synchronized Path will help Defeat: Excessive JoyJealousy, Fear, Anger, Sadness, Sorrow Greed,Corruption

Is It About MINDSET ?Excessive Joy...may be a sing of….Circulation & LV malfunctionJealousy………..may be a sign of….Too many Toxins in BloodFear………….....may be a sign of…..Kidney malfunction Anger……….....may be a sign of…..Liver malfunctionSadness……….may be a sign of..…Lungs, Intestine malfunction Sorrow………..may be a sign of….Spleen, Digestive malfunction

Greed…….......may be a sign of........Metabolic disturbanceCorruption…..may be a sign of………Total System Failure

Lear

ning

Per

iod

Earn

ing

Perio

d…that depends on many factors

"Evil is Powerless, if the Good are Unafraid“...Ronald Reagan.

I believe, from what I have understood so far, this is the essence of all the ancient world wisdom traditions.

'Goodness' is the healthy state of mind and that in turn will never intentionally commits any wrong doing and that is why unafraid

(i.e., defeats fear and anger because there is no self interest (desire), there is no 'I' or 'Mine' thing in the duty therefore

absence of Ego).

The only thing that is there is 'We‘, which is the collective 'I' (i.e., team work), and the only duty that is there is 'serving the

society'. God bless all with good health and longevity.

…Dr. K. V. SarmaAuthor of Book: Quality of Life by DesignDr. Karra, that was the nicest way I’ve ever heard to stop promoting self

interest and think of the team. I sincerely liked it……Harold Cope

Retired, Deputy Sheriff, State of Ohio, USA

It’s always a challenge to assess someone’s mind

“There do seem to be links between some of the health conditions and creativity, and the notion that your brain can operate differently”

... Claudia KalbScience journalist

Very Hard To Say

Balance / Moderation

23,000 Human genes

> 150 times DNA content comes from Bacteria

Quit the place that is not fit for living

Castor Oil ?

What are the Input Variables?1. Think Right2. Speak Right3. Do Right

WHY QbD IS ESSENTIAL?

Knowledge

Design

Cont

rol

To Improve Manufacturing ‘by my people’ ……………………....What for?….…………………

To Develop Quality Products ‘for my people’ …….....………......Why?………….……………....

Because WE CAREabout the Quality-of-Life ‘of my people’.......................Thank You……………………

Duty

Con

scio

us

The Fist Step – Team WorkIgnore

“I”

“MINE”

“Desire”(Selfishness)

(Greed)

Spiritual

PEAC

E

Material

QUALIT

Y

Think

“We”

“Us”

“Ours”(Self-lessness)

(Oneness)

Success

Bliss

Result

InteractionsDesignSpace

Second Step - Understand the Gap(s)

“QbD” should start and end with the CUSTOMER (in Mind) ONLY- Quality, its intended purpose and Performance- Eliminate the seemingly inevitable variation (with OFAT or modeling -

QbD)

Product Pain killer Kill the pain, not the patient

Over promising and under serving

Courtsy: linda

Bench Mark Data from Benson & MaCab

S.No Measure Pharma Industry

Winning Pharma Industry

World class factory

1 Stock turn 3-5 14 502 On-time delivery 60-80 % 97.4 % 99.6 %3 Right First Time 85-95 % 96% 99.4 %4 Overall Equipment

Effectiveness (OEE)30 % 74 % 92 %

5. Cycle time 720 hrs 48 hrs 8 hrs6 Safety / 10^5 hrs 0.100 0.050 0.001

Current Status of ‘Cost of Poor Quality’ (CPQ)as % of sales – Indian Scenario.

S.No Industry Sigma Value Ppm defects Yield % CPQ as % of Sales

1 Pharma 2 Sigma 3,08,537 69.2 25 – 30

2 Pharma 3 Sigma 66,807 93.3 20 – 25

3 Pharma 4 Sigma 6,210 99.4 12 – 18

4 Semiconductor 5 Sigma 233 99.98 4 – 8

5 Semiconductor 6 Sigma 3.4 99.99966 1 - 3

What is Fundamental ?

Scientific Data from

Analytical testing must be

reliable & trustworthy.

QbD Softwares built based on time-tested mathematical models will perhaps

help

• Process Development in any field

• Manufacturing Efficiency

• Product Variability

• Process Capability

• Interactions among the input variables

• Help understand the Quality Spectrum - Scope, Quality, Time, Cost, Risk

• Easy to understand contour diagrams to extract the desired Design Space

• ??? Clinical Performance

ImproveQualityof Life

by DesignDr. K. V. Sarma. Author

Quality of Life by Design

Conscious Design Multiplies the Quality of Life