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Confidential 2017 Dec 21 Slide 12018 Oct 20
IntroductionOct 2018
Contact: Sjaak Deckers, CEO +316 2249 0104 [email protected]
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The Spinal Cord Injury Iceberg
Heart rate Pressure ulcers
Blood pressure (hypo) Sleep
Transpiration Infections
Thermoregulation Antibiotics use
Bladder physiology Bone density
Bowel physiology Muscle mass
Sexual function Spasticity
Cardiovascular cap. Pain
Dependence on others Hours daily routine
Limitations in jobs, activities with kids,
weekend activities, travel, etc
Wheelchair
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Photo: Herb Ritts
400’000 spinal cord injuries every year
Single patient lifetime healthcare cost is above 2 m$
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GTXmedical
Eindhoven, The NetherlandsLausanne, Switzerland
▪ Lausanne and Eindhoven
▪ Spin-off of research group at EPFL
▪ Team started in 2016, now 40 employees
▪ Strong IP & licensing position
▪ Strong Investor support & solid financing (April 2016)
▪ Initial focus: paraplegic incomplete SCI patients
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Current: Lifelong severe disability
Care and rehab▪ Training
▪ Learning to perform tasks
▪ Achieving best quality of life
Lesion▪ Traffic accident
▪ Falls
▪ Bleeding
Live with the disability
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GTXmedical neuroprosthetic therapy (under development)
Spinal Cord Surgery▪ Place epidural lead +
pulse generator
▪ Test muscle responses
Intensive rehab training▪ Initial mapping phase
▪ 5mo, 5x/wk, 2h/d BWS
training to promote
neuroplasticity
Restored function▪ Unsupervised use at
home
Lesion▪ Traffic accident
▪ Falls
▪ Bleeding
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Breakthroughs Prof Courtine, EPFLNature 2018, 2016Science 2015, 2012Neuron 2016, 2015Science Trans Med 2017, 2015, 2014Nature Medicine 2016, 2012, 2008, 2007Nature Neuroscience 2018, 2010, 2009Cell 2014The Lancet 2011
Based upon solid scientific understanding
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THE SPINAL CORD
IS
NOT ITS SERVANT
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Implantation Mapping RehabilitationBeyond
Rehabilitation
Rehab with BWS
Rehab without BWS
Home Training + Home Use in daily life activities
Rehabilitation clinicians, Physiotherapists, Technician
Neurosurgeon
Neurologist
Functional mapping: - define stimulation
functional outcome. - define stimulation
configurations and training programs.
GTX medical
Developing a new therapy
Electrophysiologist, Technician
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Intensive body weight supported training activates neuroplasticity
Rysen 3D
overground Body
Weight Support
system
for flexible rehab
training.
Partnering with
MOTEK
(Amsterdam)
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Implantation surgery of lead and INSSTIMO
Cervical
Thoracic
Lumbar
Sacral
The electrode array is
inserted via incision L1-L2
The stimulator is implanted in
the belly
STIMO
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Stimulating at the right time & place (Courtine, Nature 2018)Muscle activity during gait cycle in healthy persons Corresponding electrical recordings Neuromotor hotspots
Muscle activity in SCI patient Muscle activity using stimulation Stimulation:
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Simulations predict muscle mappings (Courtine, Nature 2018)Muscle mappings and stimulation patterns in healthy persons Individualised simulations predict similar stimulation patterns
Targeted stimulation can separate between left hip flexion and left ankle extension
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Thank you