Special Issue:

Computational approaches to understanding lipid-protein interactions

Editorial

A. GrossfieldSpecial Issue on Lipid-Protein Interactions 1

Continuum Models for Membrane Distortion

R. Tjörnhammar and O. Edholm (Sweden)The shape and free energy of a lipid bilayer surrounding a membrane inclusion 2

S. Loew, E.E. Kooijman and S. May (USA)Increased pH-sensitivity of protein binding to lipid membranes through the electrostatic-hydrogen bond switch 9

Kyu II Lee, R.W. Pastor, O.S. Andersen and W. Im (USA)Assessing smectic liquid-crystal continuum models for elastic bilayer deformations 19

S. Mondal, G. Khelashvili, L. Shi and H. Weinstein (USA)The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT 27

Lipid interactions with membrane proteins

J.Y. Lee, R. Patel and E. Lyman (USA)Ligand-dependent cholesterol interactions with the human A2A adenosine receptor 39

D.P. Hurst, M. Schmeisser and P.H. Reggio (USA)Endogenous lipid activated G protein-coupled receptors: Emerging structural features from crystallography and molecular dynamics simulations 46

E.J. Denning and O. Beckstein (USA)Influence of lipids on protein-mediated transmembrane transport 57

C. Neale, H. Ghanei, J. Holyoake, R.E. Bishop, G.G. Privé and R. Pomès (Canada)Detergent-mediated protein aggregation 72

Membrane interactions with peptides and sterols

M. Pourmousa and M. Karttunen (Canada)Early stages of interactions of cell-penetrating peptide penetratin with a DPPC bilayer 85

N. Castillo, L. Monticelli, J. Barnoud and D.P. Tieleman (Canada, France)Free energy of WALP23 dimer association in DMPC, DPPC, and DOPC bilayers 95

P.M. Kasson, B. Hess and E. Lindahl (USA, Sweden)Probing microscopic material properties inside simulated membranes through spatially resolved three- dimensional local pressure fields and surface tensions 106

G. Khelashvili and D. Harries (USA, Israel)How sterol tilt regulates properties and organization of lipid membranes and membrane insertions 113

Contents

Contents lists available at ScienceDirect

Chemistry and Physics of Lipids

journal homepage: www.elsevier .com/locate/chemphysl ip

Chemistry and Physics of Lipids 169 (2013) iv