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CONTENTS THE AMERICAN JOURNAL OF CARDIOLOGY â VOL. 111, NO. 3 FEBRUARY 1, 2013 Coronary Artery Disease Temporal Trends in Medical Therapies for ST- and Non-ST Elevation Myocardial Infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study) ........................................ 305 Emily C. O’Brien, Kathryn M. Rose, Chirayath M. Suchindran, Til Sturmer, Patricia P. Chang, Alvaro Alonso, Christopher D. Baggett, and Wayne D. Rosamond Influence of Gender on Ischemic Times and Outcomes After ST-Elevation Myocardial Infarction ........... 312 Matthijs A. Velders, Hele `n Boden, Adrianus J. van Boven, Bas L. van der Hoeven, Anton A.C.M. Heestermans, Suzanne C. Cannegieter, Victor A.W.M. Umans, J. Wouter Jukema, Sjoerd H. Hofma, and Martin J. Schalij Relation of the Systemic Blood Pressure to the Collateral Pressure Distal to an Infarct-Related Coronary Artery Occlusion During Acute Myocardial Infarction...................................................... 319 Simcha Ron Meisel, Aaron Frimerman, David Simeon Blondheim, Avraham Shotan, Aya Asif, Jacob Shani, Yoseph Rozenman, and Michael Shochat Relation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes ................................................... 324 Luis C.L. Correia, Fa ´bio Sodre ´, Guilherme Garcia, Michael Sabino, Mariana Brito, Felipe Kalil, Bruno Barreto, Jose ´ C. Lima, and Ma ´rcia M. Noya-Rabelo Utility of High-Sensitivity C-Reactive Protein Versus Coronary Artery Calcium for the Detection of Obstructive Stenoses in Stable Patients ............. 328 John S. Ho, John J. Cannaday, Carolyn E. Barlow, Dale B. Reinhardt, Wendy A. Wade, and Joe R. Ellis Real Incidence of Diabetes Mellitus in a Coronary Disease Population ........................................ 333 Jesu ´s M. de la Hera, Jose M. Garcı ´a-Ruiz, Pablo Martı ´nez-Camblor, Marı ´a Martı ´n, Ana L. Tellerı ´a, Cecilia Corros, Francisco Torres, Oliva C. Ferna ´ ndez-Cimadevilla, Irene Alvarez-Pichel, Esmeralda Capı ´n, Pablo Avanzas, and Elı ´as Delgado Use of Complementary Therapies in Cardiovascular Disease ........................................................ 339 Kavita Prasad, Varun Sharma, Kandace Lackore, Sarah M. Jenkins, Abhiram Prasad, and Amit Sood Preventive Cardiology Effect of Exercise-Based Cardiac Rehabilitation on Multiple Atherosclerotic Risk Factors in Patients Taking Antidepressant Medication.................... 346 Neil F. Gordon, Anwer Habib, Richard D. Salmon, Kathy Lee Bishop, Ami Drimmer, Kevin S. Reid, Brenda S. Wright, George C. Faircloth, Terri L. Gordon, Barry A. Franklin, Melvyn Rubenfire, Theresa Gracik, and Laurence S. Sperling Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-Lowering (CPC) Study ............ 352 Binh An P. Phan, Luis Mun ˜oz, Pey Shadzi, Daniel Isquith, Michael Triller, B. Greg Brown, and Xue-Qiao Zhao Impact of Coronary Artery Calcium Progression and Statin Therapy on Clinical Outcome in Subjects With and Without Diabetes Mellitus ......................... 356 Sarkis Kiramijyan, Naser Ahmadi, Hussain Isma’eel, Ferdinand Flores, Leslee J. Shaw, Paolo Raggi, and Matthew J. Budoff Arrhythmias and Conduction Disturbances Prevalence, Clinical Characteristics and Management of Atrial Fibrillation in Patients With Brugada Syndrome..................................................... 362 THE AMERICAN JOURNAL OF CARDIOLOGY® (ISSN 0002-9149) is published semi-monthly by Elsevier Inc, (360 Park Avenue South New York, NY 10010-1710). Further information on this journal is available from the Publisher or from the Elsevier Customer Service Department nearest you or from this journal’s website (http://www.ajconline.org). Information on other Elsevier products is available through Elsevier’s website (http://www.elsevier.com). Periodicals Postage Paid at New York, NY, and at additional mailing offices. POSTMASTER: Send change of address to THE AMERICAN JOURNAL OF CARDIOLOGY , Elsevier Customer Service Department, 3251 Riverport Lane, Maryland Heights, MO 63043, USA. A4 THE AMERICAN JOURNAL OF CARDIOLOGY â VOL. 111 FEBRUARY 1, 2013

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Page 1: Contents

CONTENTS THE AMERICAN JOURNAL OF CARDIOLOGY�

VOL. 111, NO. 3 FEBRUARY 1, 2013

THE AMERICAN JOURNAL OF CARDIOLOGY® (ISSN 0002-9149) is pubNew York, NY 10010-1710). Further information on this journal is availableDepartment nearest you or from this journal’s website (http://www.ajconlinthrough Elsevier’s website (http://www.elsevier.com). Periodicals Postage Pai

POSTMASTER: Send change of address to THE AMERICAN JOURNAL OF CRiverport Lane, Maryland Heights, MO 63043, USA.

A4 THE AMERICAN JOURNAL OF CARDIOLOGY� VOL. 111 FEBRUAR

Coronary Artery Disease

Temporal Trends in Medical Therapies for ST- andNon-ST Elevation Myocardial Infarction: (from theAtherosclerosis Risk in Communities [ARIC]Surveillance Study) ........................................305Emily C. O’Brien, Kathryn M. Rose,Chirayath M. Suchindran, Til Sturmer,Patricia P. Chang, Alvaro Alonso,Christopher D. Baggett, and Wayne D. Rosamond

Influence of Gender on Ischemic Times and OutcomesAfter ST-Elevation Myocardial Infarction ...........312Matthijs A. Velders, Helen Boden,Adrianus J. van Boven,Bas L. van der Hoeven, Anton A.C.M. Heestermans,Suzanne C. Cannegieter, Victor A.W.M. Umans,J. Wouter Jukema, Sjoerd H. Hofma, andMartin J. Schalij

Relation of the Systemic Blood Pressure to theCollateral Pressure Distal to an Infarct-RelatedCoronary Artery Occlusion During Acute MyocardialInfarction......................................................319Simcha Ron Meisel, Aaron Frimerman,David Simeon Blondheim, Avraham Shotan,Aya Asif, Jacob Shani, Yoseph Rozenman, andMichael Shochat

Relation of Severe Deficiency of Vitamin D toCardiovascular Mortality During Acute CoronarySyndromes ...................................................324Luis C.L. Correia, Fabio Sodre, Guilherme Garcia,Michael Sabino, Mariana Brito, Felipe Kalil,Bruno Barreto, Jose C. Lima, andMarcia M. Noya-Rabelo

Utility of High-Sensitivity C-Reactive Protein VersusCoronary Artery Calcium for the Detection ofObstructive Stenoses in Stable Patients .............328John S. Ho, John J. Cannaday, Carolyn E. Barlow,Dale B. Reinhardt, Wendy A. Wade, andJoe R. Ellis

Real Incidence of Diabetes Mellitus in a CoronaryDisease Population ........................................333

Jesus M. de la Hera, Jose M. Garcıa-Ruiz,Pablo Martınez-Camblor, Marıa Martın, Ana L. Tellerıa,Cecilia Corros, Francisco Torres,Oliva C. Fernandez-Cimadevilla, Irene Alvarez-Pichel,Esmeralda Capın, Pablo Avanzas, and Elıas Delgado

Use of Complementary Therapies in CardiovascularDisease ........................................................339Kavita Prasad, Varun Sharma, Kandace Lackore,Sarah M. Jenkins, Abhiram Prasad, and Amit Sood

Preventive Cardiology

Effect of Exercise-Based Cardiac Rehabilitation onMultiple Atherosclerotic Risk Factors in PatientsTaking Antidepressant Medication....................346Neil F. Gordon, Anwer Habib, Richard D. Salmon,Kathy Lee Bishop, Ami Drimmer, Kevin S. Reid,Brenda S. Wright, George C. Faircloth,Terri L. Gordon, Barry A. Franklin, Melvyn Rubenfire,Theresa Gracik, and Laurence S. Sperling

Effects of Niacin on Glucose Levels, CoronaryStenosis Progression, and Clinical Events in SubjectsWith Normal Baseline Glucose Levels (<100 mg/dl):A Combined Analysis of the Familial AtherosclerosisTreatment Study (FATS), HDL-AtherosclerosisTreatment Study (HATS), Armed Forces RegressionStudy (AFREGS), and Carotid Plaque Composition byMRI During Lipid-Lowering (CPC) Study ............352Binh An P. Phan, Luis Munoz, Pey Shadzi,Daniel Isquith, Michael Triller, B. Greg Brown, andXue-Qiao Zhao

Impact of Coronary Artery Calcium Progression andStatin Therapy on Clinical Outcome in Subjects Withand Without Diabetes Mellitus.........................356Sarkis Kiramijyan, Naser Ahmadi, Hussain Isma’eel,Ferdinand Flores, Leslee J. Shaw, Paolo Raggi, andMatthew J. Budoff

Arrhythmias and ConductionDisturbances

Prevalence, Clinical Characteristics and Managementof Atrial Fibrillation in Patients With BrugadaSyndrome.....................................................362

lished semi-monthly by Elsevier Inc, (360 Park Avenue Southfrom the Publisher or from the Elsevier Customer Service

e.org). Information on other Elsevier products is availabled at New York, NY, and at additional mailing offices.

ARDIOLOGY, Elsevier Customer Service Department, 3251

Y 1, 2013

Page 2: Contents

Moises Rodrıguez-Manero, Mehdi Namdar,Andrea Sarkozy, Ruben Casado-Arroyo,Danilo Ricciardi, Carlo de Asmundis,Gian-Battista Chierchia, Kristel Wauters,Jayakeerthi Y. Rao, Fatih Bayrak,Sophie Van Malderen, and Pedro Brugada

Relation of Morbid Obesity and Female Gender toRisk of Procedural Complications in PatientsUndergoing Atrial Fibrillation Ablation .............368M. Benjamin Shoemaker, Raafia Muhammad,Maureen Farrell, Babar Parvez, Brenda W. White,Megan Streur, Tanya Stubblefield, Jason Rytlewski,Sunthosh Parvathaneni, Rangadham Nagarakanti,Dan M. Roden, Pablo Saavedra, Christopher Ellis,S. Patrick Whalen, and Dawood Darbar

Valvular Heart Disease

Indexes of von Willebrand Factor as Biomarkers ofAortic Stenosis Severity (from the Biomarkers ofAortic Stenosis Severity [BASS] Study) ..............374Joseph L. Blackshear, Ewa M. Wysokinska,Robert E. Safford, Colleen S. Thomas, Mark E. Stark,Brian P. Shapiro, Steven Ung, Gretchen S. Johns, andDong Chen

Pregnancy Outcomes in Women With Aortic ValveSubstitutes ....................................................382Helena J. Heuvelman, Bardia Arabkhani,Jerome M.J. Cornette, Petronella G. Pieper,Ad J.J.C. Bogers, Johanna J.M. Takkenberg, andJolien W. Roos-Hesselink

Cardiomyopathy

Comparison of Surgical Septal Myectomy to MedicalTherapy Alone in Patients With HypertrophicCardiomyopathy and Syncope ........................388Nicholas M. Orme, Paul Sorajja, Joseph A. Dearani,Hartzell V. Schaff, Bernard J. Gersh, andSteve R. Ommen

Significance of Low Desmin Expression inCardiomyocytes in Patients With Idiopathic DilatedCardiomyopathy ...........................................393Agnieszka Pawlak, Robert Julian Gil,Wiesława Grajkowska,Anna Maria Nasierowska-Guttmejer,Jarosław Rzezak, and Tomasz Kulawik

Desmin Mutations and Arrhythmogenic RightVentricular Cardiomyopathy............................400Alessandra Lorenzon, Giorgia Beffagna,Barbara Bauce, Marzia De Bortoli, Ilena E.A. Li Mura,Martina Calore, Emanuela Dazzo, Cristina Basso,Andrea Nava, Gaetano Thiene, andAlessandra Rampazzo

Congenital Heart Disease

Correlation of Exercise Response in RepairedCoarctation of the Aorta to Left Ventricular Mass andGeometry.....................................................406Eric V. Krieger, Mathieu Clair, Alexander R. Opotowsky,Michael J. Landzberg, Jonathan Rhodes,Andrew J. Powell, Steven D. Colan, andAnne Marie Valente

Transcatheter Recanalization of Totally OccludedProximal Pulmonary Arteries and Major SystemicVeins in Patients With Congenital Heart Disease 412Athar M. Qureshi, James A. Hill, Lourdes R. Prieto,Janine Arruda, Shannon Morrison, Sarah Worley, andLarry A. Latson

Miscellaneous

Relation of Vitamin D and Parathyroid Hormone toCardiac Biomarkers and to Left Ventricular Mass(from the Cardiovascular Health Study) ............418Adriana J. van Ballegooijen, Marjolein Visser,Bryan Kestenbaum, David S. Siscovick, Ian H. de Boer,John S. Gottdiener, Christopher R. deFilippi, andIngeborg A. Brouwer

Cardiovascular Risk Assessment of PulmonaryEmbolism With the GRACE Risk Score ..............425Luis V. Paiva, Rui C. Providencia, Sergio N. Barra,Ana C. Faustino, Ana M. Botelho, andAntonio L. Marques

Association of N-Terminal Pro-B-Type NatriureticPeptide With Left Ventricular Structure and Functionin Chronic Kidney Disease (from the Chronic RenalInsufficiency Cohort [CRIC]) .............................432RakeshK. Mishra,Yongmei Li,AnaC. Ricardo,Wei Yang,Martin Keane, Magdalena Cuevas, Robert Christenson,Christopher DeFilippi, Jing Chen, Jiang He,Radhakrishna R. Kallem, Dominic S. Raj,Jeffrey R. Schelling, Jackson Wright, Alan S. Go, andMichael G. Shlipak, Chronic Renal Insufficiency CohortInvestigators

Review

Refining the Role of Antiplatelet Therapy in MedicallyManaged Patients With Acute CoronarySyndrome.....................................................439William E. Boden, Alexandra Lansky, andDominick J. Angiolillo

Case Reports

Usefulness of Intravenous Lipid Emulsion for CardiacToxicity from Cocaine Overdose ......................445

CONTENTS A5

Page 3: Contents

Natasha Purai Arora, William Allen Berk,Cynthia Kurke Aaron, and Kim Allan Williams

Necropsy Findings Early After TranscatheterAortic Valve Implantation for AorticStenosis .......................................................448William C. Roberts, Robert C. Stoler,Paul A. Grayburn, Robert F. Hebeler, Jr.,Jong M. Ko, David L. Brown,William T. Brinkman, Michael J. Mack, andJoseph M. Guileyardo

Readers’ Comments

Brugada Phenocopy: Redefinition and UpdatedClassification.................................................453

A6 THE AMERICAN JOURNAL OF CARDIOLOGY� VOL. 111

Cardiotoxicity With 5-Fluorouracil Based Agents:Rechallenge Cannot Currently Be SafelyAdvised .......................................................454

ANCHOR Trial Conclusions Regarding the Effectsof Pure Eicosapentaenoic Acid on Low-DensityLipoprotein Cholesterol...................................454

Authors’ Reply ..............................................455

Instructions to Authors can be found at the AJCwebsite: www.AJConline.org

Classifieds on page A1

Full Text: www.ajconline.org

FEBRUARY 1, 2013