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contents continued from outside back cover Toxicokinetics of α α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice Suramya Waidyanatha, Jerry D. Johnson, S. Peter Hong, Veronica Godfrey Robinson, Seth Gibbs, Steven W. Graves, Michelle J. Hooth, Cynthia S. Smith . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216 Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf- ERK-Nrf2 signaling and AMPK-independent pathways Minh Truong Do, Hyung Gyun Kim, Tilak Khanal, Jae Ho Choi, Dong Hee Kim, Tae Cheon Jeong, Hye Gwang Jeong . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229 Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling Young-Ok Son, Poyil Pratheeshkumar, Lei Wang, Xin Wang, Jia Fan, Dong-Hern Kim, Ju-Yeon Lee, Zhuo Zhang, Jeong-Chae Lee, Xianglin Shi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239 Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles Jackye Peretz, Jodi A. Flaws . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway Yi Wang, Wei Wei, Yuan Wang, Jing Dong, Binbin Song, Hui Min, Weiping Teng, Jie Chen . . . . . . 257 Comparative developmental toxicity of environmentally relevant oxygenated PAHs Andrea L. Knecht, Britton C. Goodale, Lisa Truong, Michael T. Simonich, Annika J. Swanson, Melissa M. Matzke, Kim A. Anderson, Katrina M. Waters, Robert L. Tanguay . . . . . . . . . . . . . . . . . . . 266 Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis Katrien Van Beneden, Caroline Geers, Marina Pauwels, Inge Mannaerts, Karl M. Wissing, Christiane Van den Branden, Leo A. van Grunsven . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276 JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats Xinjin Guo, Qiang Meng, Qi Liu, Changyuan Wang, Huijun Sun, Jinyong Peng, Xiaochi Ma, Taiichi Kaku, Kexin Liu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285

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Page 1: Contents Continued

contents continued from outside back cover

Toxicokinetics of αα-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice

Suramya Waidyanatha , Jerry D. Johnson , S. Peter Hong , Veronica Godfrey Robinson , Seth Gibbs , Steven W. Graves , Michelle J. Hooth , Cynthia S. Smith . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

Minh Truong Do , Hyung Gyun Kim , Tilak Khanal , Jae Ho Choi , Dong Hee Kim , Tae Cheon Jeong , Hye Gwang Jeong . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229

Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling

Young-Ok Son , Poyil Pratheeshkumar , Lei Wang , Xin Wang , Jia Fan , Dong-Hern Kim , Ju-Yeon Lee , Zhuo Zhang , Jeong-Chae Lee , Xianglin Shi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239

Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles

Jackye Peretz , Jodi A. Flaws . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway

Yi Wang , Wei Wei , Yuan Wang , Jing Dong , Binbin Song , Hui Min , Weiping Teng , Jie Chen . . . . . . 257 Comparative developmental toxicity of environmentally relevant oxygenated PAHs

Andrea L. Knecht , Britton C. Goodale , Lisa Truong , Michael T. Simonich , Annika J. Swanson , Melissa M. Matzke , Kim A. Anderson , Katrina M. Waters , Robert L. Tanguay . . . . . . . . . . . . . . . . . . . 266

Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fi brosis

Katrien Van Beneden , Caroline Geers , Marina Pauwels , Inge Mannaerts , Karl M. Wissing , Christiane Van den Branden , Leo A. van Grunsven . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276

JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats

Xinjin Guo , Qiang Meng , Qi Liu , Changyuan Wang , Huijun Sun , Jinyong Peng , Xiaochi Ma , Taiichi Kaku , Kexin Liu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285

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