Asterisks * preceding page numbers refer to studies using human-derived material.

Perspectives in Cancer Research

2651 Natural Killer Cells and Their Relationship to T-Cells: HypothesisontheRoleofT-Cell ReceptorGeneRearrangementontheCourseof Adaptive Differentiation. Zvi Grossman and Ronald B.Herberman.

BASIC SCIENCES

2659 Anthracycline-inducedInhibitionof a CalciumAction Potential inDifferentiatedMurine NeuroblastomaCells.KennethS.Santone,S.GeorgeOakes,StuartR. Taylor andGarth Powis.

* 2665QuantitativeDifferencesinHostCellReactivationofUltravioletdamagedVirus in Human Skin Fibroblasts and Epidermal Kerntinocytes Cultured from the Same Foreskin Biopsy. Rex M. Tyrrelland Mireille Pidoux.

2670 Inhibitionof CyclophosphamideandMitomycinC-inducedSisterChromatid Exchanges in Mice by Vitamin C. G. Krishna, J. Nathand T. Ong.

2675 Separation of Early Diffuse Alveolar Cell Proliferation from Enhanced Tumor Development in Mouse Lung. H. P. Witschi.

2680 Characterization of Lymphocytic Infiltrates in Normal, Preneoplastic, and Neoplastic Mouse Mammary Tissues. Wei-Zen Wei,Kevin Malone, Keith Mahoney, and Gloria Heppner.

* 2686 Leukoregulin-increasedPlasmaMembranePermeabilityandAssociatedIonic Fluxes.SusanC. BarnettandCharlesH. Evans.

2693 Xenobiotic Metabolizing Enzymes in Genetically and ChemicallyInitiated Mouse Liver Tumors. Daniel L. Stout and Frederick F.Becker.

* 2697 Benzo(a)pyrene:DNAAdductFormationinNormalHumanMammary Epithelial Cell Culturesand the Human Mammary CarcinomaT47D Cell Line. Donna Pruess-Schwartz,William M.Baird, Ann Nikbakht, B. Alex Merrick and JamesK. Selkirk.

* 2703 New ScreeningSystemforSelectionofAnticancerDrugsforTreatment of Human ColorectalCancer. Werner Scheithauer,Gary M. Clark, Mary P. Moyer and Daniel D. Von Hoff.

2709 Modification of the Cytotoxic Activity of Mitomycin C by Oxygenand Ascorbic Acid in ChineseHamster Ovary Cells and a RepairdeficientMutant. RaymondS. MarshallandA. MichaelRauth.

2714 Comparative Anthracycline Metabolism in Rats: Loss of MarcellomycinFluorescence.P. Dodion, J. M. Tamburini, B. M. Fox,C. E. Riggs,Jr., and N. R. Bachur.

* 2720 EpidermalGrowthFactorBindingandProteinKinaseC Activitiesin Human BreastCancerCell Lines:PossibleQuantitativeRelationship.Doriano Fabbro,Willy Kung, Werner Roos,RomanoRegazziand Urs Eppenberger.

* 2726 DifferentTypeofDNA DamageCausedbyThreeA.ziridinylSubstituted Cyclophosphazenesin a Human Small Cell LungCarcinomaCell Line. Jan 0. Zijlstra, Stevende Jong,JohanC.van de Grampel, Elisabeth G. E. de Vries and Nanno H. Mulder.

2730 Differential Interaction of Normal and Preneoplastic HamsterBronchi with Adriamycin. Brian I. Carr, Donna Langley,CeciliaB. Dias,William 0. HammondandJohnR. Benfield.

2735 Immunomodulation by Polyaromatic Hydrocarbons in Mice andMurine Cells. Robert H. Blanton, Mark Lyte, Michael J. Myersand PeterH. Bick.

* 2740InhibitionofHumanMelanomaGrowthbyProstaglandinA,D,andJ Analogues.Marvin D. Bregman,CaroleFunkandMasanoriFukushima.

2745 Effect of Diethyldithiocarbamateon cis-Diamminedichioroplatinum(II)-inducedCytotoxicity, DNA Cross-Linking, and 7-Glutamyl Transpeptidase Inhibition. Donald L. Bodenner, Peter C.Dedon, Peter C. Keng and Richard F. Borch.

2751 Selective Protection against cis-Diamminedichloroplatinum(II)induced Toxicity in Kidney, Gut, and Bone Marrow by Diethyldithiocarbainate.Donald L. Bodenner,PeterC. Dedon, PeterC.Keng, Janet C. Katz and Richard F. Borch.

2756 Heme Enzyme Patterns in Genetically and Chemically InducedMouseLiver Tumors.Daniel L. StoutandFrederickF. Becker.

2760 Bacterial and Mammalian Cell Mutagenicity of Four OpticallyActive Bay-Region 3,4-Diol-1,2-epoxides and Other Derivativesof the Nitrogen HeterocycleDiben4c,hlacridine.AlexanderW.Wood, Richard L. Chang, Wayne Levin, Subodh Kumar, NaohiroShirai, Donald M. Jerina, Roland E. Lehr and Allan H. Conney.

2767 Influence of the Duration of Topical 13-cis-Retinoic Acid Treatmenton Inhibitionof Mouse Skin Tumor Promotion.Helen L.Gensler,Dalice A. Sim and G. Tim Bowden.

* 2771EffectsofSteroidHormonesandAntisteroidsonAlkalinePhosphataseActivity in Human Endometrial Cancer Cells (IshikawaLine). Christian F. Holinka, Hiroki Hata, Hiroyuki Kuramotoand Erlio Gurpide.

2775 Use of a Cell Sorter for Assays of Cell Clonogenicity. Ralph E.Durand.

2779 Effect of Sidestream and Mainstream Smoke Exposure on inVitro a//s-Interferon Production by L-929 Cells. GeraldSonnenfeld and Russell W. Hudgens.

* 2784ImmunotherapyofMurineSarcomasUsingLymphokineActivated Killer Cells: Optimization of the Schedule and Route ofAdministration of Recombinant Interleukin-2. Stephen E.Ettinghausenand StevenA. Rosenberg.

* 2793Shape-dependentRegulationofProliferationinNormalandMalignant Human Cells and Its Alteration by Interferon. David A.Kulesh and JamesJ. Greene.

2798 Selective Modulation by a-Difluoromethylornithine of T-Lymphocyte and Antibody-mediated Cytotoxic Responses to Mouse Tumor Allografts.M. JaneEhrke,Carl W. Porter,Cheryl Eppolitoand Enrico Mihich.

t The CONTENTS arranged by Subject Category can be found immediatelyfollowingthese CONTENTS.

,@

ç@ @oncerResearchVOLUME 46 •NUMBER 6 •CNREA8 •PP 265 1-3209

CONTENTS t

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2804 Plasma Levels of a Viral Protein during Adjuvant Treatment:Reflection of Murine Mammary Tumor Status and TherapeuticEffect. Earl M. Ritzi, Daniel S. Martin and Robert L. Stolfi.

2810 IncreasedThymidylate Synthase in L1210 Cells PossessingAcquired Resistance to M°-Propargyl-5,8-dideazafolic Acid(CB3717): Development,Characterization, and Cross-ResistanceStudies.Ann L. Jackman, Dawn L. Alison, A. Hilary Calvert andKennethR. Harrap.

* 2816 InductionandModulationofAnchorage-independentGrowthbyPlatelet-derived Growth Factor, Fibroblast Growth Factor, andTransforming Growth Factor-fl. Angie Rizzino, Eric Ruff andHeather Rizzino.

* 2821 InfluenceofHypoxiaandanAcidicEnvironmentontheMetabolism and Visbifity of CulturedCells: Potential ImplicationsforCell Death in Tumors. Daniela Rotin, Brian Robinson and Ian F.Tannock.

* @27ExperimentalChemotherapyofHuman MedulloblastomawithClassicalAlkylators. Henry S. Friedman, 0. Michael Colvin,Susan M. Ludeman, S. Clifford Schold, Jr., Victoria L. Boyd,LawrenceH. Mulhbaier and Darell D. Bigner.

* 2834 CharacterizationandModulationofHuman Lymphokine(Interleukin 2) ActIvated Killer Cell Induction. Maureen Hoyer, TedMeineke,William Lewis,BruceZwillingandJohnRinehart.

2839 Covalent Binding of 1,2-Dihaloalkanes to DNA and Stability ofthe Major DNA Adduct, S-@2-(N@-Guanyl$hyIJglutathione.Philip B. Inskeep,Nobuyuki Koga,JoanL. Cmarik and F. PeterGuengerich.

* @45SelectiveModulationofGlutathioneLevelsinHuman Normal‘eras'sTumor Cells and Subsequent Differential Response toChemotherapy Drugs. Angelo Russo,William DeGrafl NormanFriedman and JamesB. Mitchell.

2849 31P-NuclearMagnetic ResonanceAnalysis of Interferon-inducedAlterations of Phospholipid Metabolites in Interferon-sensitiveand Interferon-resistant Friend Leukemia Cell Tumors in Mice.Enrico Proietti, Giulia Carpinelli, Massimo Di Vito, FiippoBelardelli, Ion Gresserand Franca Podo.

2858 Treatment of Dunning R3327-AT Rat Prostate Tumors with Pbstodynamic Therapy in Combination with Misonidazole. SalomonGonzalez, Mark R. Arnfield, Bert E. Meeker, John Tulip, WilliamH. Lakey,J. Donald Chapmanand Malcolm S. McPhee.

2863 EnhancedMalignant Progressionof Mouse Skin Tumors by theFree-Radical Generator Benzoyl Peroxide. John F. O'Connell,Andres J. P. Klein-Szanto, Donna M. DiGiovanni, JoAnn W.Fries and Thomas J. Slaga.

2866 Resistance to Multiple Adenine Nucleoside and MethionineAnalogues in Mutant Murine Lymphoma Cells with EnlargedS-Adenosylmethionine Pools. E. Olavi Kajander, MasaruKubota, Carlos J. Carrera, John A. Montgomery and Dennis A.Carson.

* @71EffectorMechanismsofHuman Monocyte-mediatedTumorCytotoxicity in Vitro: Biochemical,Functional,andSerologicalCharacterization of Cytotoxins Producedby Peripheral Blood Monocytes Isolated by Counterfiow Elutriation. Jim Klostergaard,William A. Foster,David A. Hamilton, Jim Turpin and GabrielLopez-Berestein.

2876 Effects of the Bidentate Malonate Ligand on the UtilizatiOn andCytotoxicity of Platinum Compounds in the L1210 Cell Line.Stanley K. Mauldin, Intisar Husain, Aziz Sancar and Stephen G.Chancy.

2883 In Vitro and in Vi,'o Radiation Sensitization by the Halogenated Pyrimidine 5-Chlors-2'-deoxycytidine. Kenneth J. Russell,Glenn C. RiceandJ. Martin Brown.

* 2888 SpeciesDifferencesintheFormationofBenzo(a)pyrene-DNAAdducts in Rodent and Human Endometrium. Mahmooda S.Kulkami, Karen Calloway, Marcos F. Irigaray and David G.Kaufman.

* 2892 Misonidazole-inducedChemopotentiationof1-(2-Chloroethyl)-3-cyclohexyl-I-nitrosourea Toxicity in O'-Methylguanine-DNAMethyltransferase Proficient (Mer@) and Deficient (Mer) CellLines. R. Timothy Mulcahy.

2898 Growth Inhibition of a Rat Colon Tumor by L-CanavanineDeborah A. Thomas, Gerald A. Rosenthal, David V. Gold andKenneth Dickey.

* 2904 DevelopmentandCharacterizationofaMouseMonoclonalAntibody,MoAb HMSA-l, againsta MelanosomalFractionof HumanMalignant Melanoma. Yutaka Akutsu and Kowichi Jimbow.

2912 Effects of Mutagens on the Immunogenicity of Tumor Cells:Comparison of Cell Surface Changes Induced by 5-AZacytidineandN-Methyl-N'-nitro-N-nitrosoguanidine.PeterAltevogt.

* 2917 DNA MethylationPatternsoftheCalcitoninGeneinHumanLung Cancers and Lymphomas. Stephen B. Baylin, Jo W. M.Hoppener, Andréede Bustros,Paul H. Steenbergh,C. J. M. Lipsand Barry D. Nelkin.

2923 Phenotypic Instability of Mouse Melanomas after Propagationin Viro and in Vitro. Jane Berkelhammer, Tod N. Luethans,ReuelR. Hook, Jr., and RonaldW. Oxenhandler.

* 2929 ComparativeEffectsofGrowthInhibitorsonDNA Replication,DNA Repair,and ProteinSynthesisin Human EpidermalKerntinocytes. Vilhelm Bohr, Jonathan Mansbridge and PhilipHanawalt.

* 2936 ImmunocytochemicalEvaluationofHuman EsophagealNonplasmaand PreneoplasticLesions for j@-ChorionicGonadotropin,Placental Lactogen, a-Fetoprotein, Carcinoembryonic Antigen,andNonspecificCross-ReactingAntigen.CarynL. Burg-Kurland,Dallas M. Purnell, John W. Combs, Elizabeth A. Hillman,Curtis C. Harris and Benjamin F. Trump.

* 2944 PatternsofDNA MethylationandGeneExpressioninHumanTumor Cell Lines. Lois A. Chandler, Yves A. DeClerck, EmilBogenmannand PeterA. Jones.

2950 Histological Study of the Effect of Hematoporphyrin DerivativePhotodynamic Therapy on the Rat Jejunum. Kallol Chaudhuri,Peter J. Goldblau, Martha Kreimer-Birnbaum, Rick W. KeckandStevenH. Selman.

2954 PancreaticCancer in the Syrian Hamster Induced by N-Nitrosobis(2-oxopropyl)amine: Cocarcinogenic Effect of EpidermalGrowth Factor. John F. Chester, Henning A. Gaissert, Jeffrey S.Rossand Ronald A. Malt.

2958 Renal Cell Carcinoma in the Wistar-Lewis Rat: A Model forStudying the Mechanisms of Cholesterol Acquisition by a Tumorin Vipo. Ralph V. Clayman, Lyman E. Bilhartz, L. MaximilianBuja, David K. Spadyand John M. Dietschy.

* 2964 SouthernBlotAnalysisofDNA ExtractedfromFormalin-fixedPathology Specimens. Louis Dubeau, Lois A. Chandler, Julie R.Gralow, PeterW. Nichols and PeterA. Jones.

* 2970 AntigensAssociatedwithHumanSquamousCellLungCarcinomaDefined by Murine Monoclonal Antibodies, Philip D. Fernsten,Katherine W. Pekny, Ralph A. Reisfeldand Leslie E. Walker.

2978 Resistance to Adriamycin: Relationship of Cytotoxicity to DrugUptake and DNA Single- and Double-Strand Breakage in ClonedCell Lines of Adriamycin-sensitive and-resistant P388 Leukemia.GeraldJ. Goldenberg,HungshuWangandGordon W. Blair.

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* 3099 Augmentationof1-fl-D-ArabinofuranosylcytosineResistanceinHuman KB Epidermoid Carcinoma Cells upon Induction of aSecondResistanceto Vincristine. SaburoSone,Kiyoshi Ishii andTakashi Tsuruo.

* 3105 InfluenceofGlucoseConcentrationonGrowthandFormationofNecrosis in Spheroids Derived from a Human Bladder CancerCell Line. Ian F. Tannockand Irma Kopelyan.

31 11 Sequential Protooncogene Expression during Rat Liver Regeneration.NancyL. Thompson,JanetE. Mend,LundyBraun,MicheleGoyette, PeterR. Shank and Nelson Fausto.

* 3118 DistributionofOncofetalAntigenTumor-associatedGlycoprotein-72 Defined by Monoclonal Antibody B72.3. Ann Thor,Noriaki Ohuchi, Cheryl A. Szpak, William W. Johnston andJeffrey Schlom.

3125 Prolongation of Fibroblast Life Span Associated with EpithelialRat Tumor Development. D. Wynford-Thomas, P. Smith andE. D. Williams.

3128 Ultrastructural Characterization of the Retrovirus Particles (SmMTV) Liberated from the Mammary Tumor Cell Line (Sm-MT)ofa HouseMusk Shrew,Suncusmurinus(Insectivora).JollyannaMalavasi Yamashiro, Yoshihiro Tsutsui, Shoichi Nagayoshi,Shinsuke Saga, Masahide Takahashi, Atsuko Aoyama, SeijunHayakawa,ToyoharuYokoi, Sen-ichiOda,Akira YokoyamaandMunemitsu Hoshino.

3138 PreventionofGrowth of Metastases in Rat Liver by PerioperativeImmunoactivation. Ryoichi Yamashita, Takehisa Hiraoka, IkuoKamimoto and Yoshimasa Miyauchi.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

3142 Phase I and Pharmacokinetic Study of LM9SS (Flavone AceticAcid Ester). D. J. Kerr, S. B. Kaye, J. Graham, J. Cassidy,M. Harding, A. Setanoians,J. C. McGrath, W. R. Vezin,D. Cunningham,G. Forrestand M. Soukop.

3147 Phase I Evaluation and Clinical Pharmacology of Tricyclic Nucleoside 5'-Phosphate Using a Weekly Intravenous Regimen.Rudolf B. Schilcher, Charles D. Ham, Michael K. Samson,John D. Young and Laurence H. Baker.

3152 Role and Mechanismof Actionof Tamoxifenin PremenopausalWomen with Metastatic Breast Carcinoma. Carol A. Sawka,Kathleen I. Pritchard, Alexander H. G. Paterson,Donald J. A.Sutherland, Damien B. Thomson, Wendy E. Shelley, Robert E.Myers, Betty G. Mobbs, Aaron Malkin and J. William Meakin.

3157 Pharmacokineticsof RadiolabeledMonoclonal Antibody B6.2in Patients with Metastatic Breast Cancer. Daniel F. Hayes,Michael R. Zalutsky, William Kaplan, Michael Noska,Ann Thor,David Coicher and Donald W. Kufe.

3164 Use of a Monoclonal Antibody to Detect Elevated Levels of aModified Nucleoside, N49-fl-I-Ribofuranosyl)purin-6-ylcarbamoyll-L-threonine, in the Urine ofBreast Cancer Patients. BarbaraS. Vold, LewisE. Kraus,VirginiaG. Rimer and R. C. Coombes.

3168 Plasma Uridine Changes in Cancer Patients Treated with theCombinationof Dipyridamole andN-Phosphonacetyl-L-aspartate.Thomas C. K. Chan, Maurie Markman, Stephen Cleary andStephenB. Howell.

3173 Prognostic Implications of Ploidy and Proliferative Activity inDiffuse Large Cell Lymphomas. Kenneth D. Bauer, Douglas E.Merkel, Jane N. Winter, Robert J. Marder, Walter W. Hauck,Carl B. Wallemark,ThomasJ. Williamsand Daina Variakojis.

3179 Role ofTumor-associated Macrophages in Lung Cancer. SadanonTakeo, KoseiYasumoto,Akira Nagashima,HisashiNakahashi,Keizo Sugimachi and Kikuo Nomoto.

* 2984 EffectofAdeno-associatedVirusonTransformationofNIH 3T3Cells by rasGeneandon Tumorigenicityof an NIH 3T3 Transformed Cell Line. Ehud Katz and Bame J. Carter.

* 2988 HighlySelectiveRecognitionofHuman NeuroblastomaCellsbyMouse MonoclonalAntibodyto a CytoplasmicAntigen.NicoleGross,Daniel Beck, StefanCarrel and Miguel Munoz.

2995 Carcinogenesisin Heterotopic Respiratory Epithelium in CanineSubcutaneousBronchial Autografts. William G. Hammond,John R. Benfield, Rao R. Paladugu,Norio Azumi, Hyun Y. Pakand Raymond L. Teplitz.

* 3000 Formationofa PhorbolEster-bindingFragmentfromProteinKinaseC by ProteolyticDigestion.MasahikoHoshijima,AkiraKikuchi, Tetsuji Tanimoto, Kozo Kaibuchi and Yoshimi Takai.

* 3005 DetectionofAntigensRecognizedbya NovelMonoclonalAntibody in Tissue and Serum from Patients with Breast Cancer.Stefanolacobelli, ElenaArnô,Alfonso d'Orazio and Gino Coletti.

* 3011 Interleukin2ActivationofCytotoxicT-LymphocytesInfiltratinginto Human Metastatic Melanomas. Kyogo Itoh, Arabella B.Tilden and Charles M. Balch.

3018 Effects of the Immunomodulator IS 2616on Growth and Metastasisof the Munne B16-FIO Melanoma.Teije Kalland.

3023 C-Type Virus Particles in Spontaneousand Virus-induced Leukemia and Malignant Lymphomasin Mice and Rats. LudwikGross, Dorothy Feldman and Yolande Dreyfuss.

* 3027 AlterationinGlycosphingolipidPatternduringPhorbol-12-myristate-13-acetate-induced Cell Differentiation in Human TLymphoidLeukemiaCells. K. Kiguchi,C. Henning-ChubbandE. Huberman.

3034 Dynamics of Lymphocytic Subpopulations in Friend LeukemiaVirus-inducedLeukemia. MasanobuKitagawa,OsamuMatsubaraand Tsutomu Kasuga.

3040 Substrates for Protein Kinase C in Cytosol of EtA Mouse ThymomaCells.CarolineM. Kramer andJulianneJ. Sando.

3046 32P-Postlabeling Assay in Mice of Transplacental DNA DamageInduced by the Enrivonmental Carcinogens Safrole, 4-Aminobiphenyl,and Benzo(a)pyrene.Lee-JaneW. Lu, RoseM. Disher,M. Vijayaraj Reddyand Kurt Randerath.

3055 Liver as a Tumor Cell Killing Organ: Kupffer Cells and NaturalKillers. MargareteMalter, EckhardFriedrichand RudolfSüss.

3061 EvidenceThat a Slowly Cycling Subpopulation of Adult MurineEpidermal Cells Retains Carcinogen. Rebecca J. Morris,SusanM. Fischerand Thomas J. Slaga.

* 3tJ@7EstablishmentandCharacteriZationofFourHuman MonocytoidLeukemiaCell Lines(JOSK-I, -5, -M, and-K) with Capabilitiesof Monocyte-MacrophageLineageDifferentiationand Constitutive Production of Interleukin 1. Masatsugu Ohta, YusukeFurukawa, Chizuka Ide, Nobuo Akiyama, Tadashi Utakoji,YasusadaMiura and Masaki Saito.

3075 Altered DNA TopoisomeraseII Activity in ChineseHamster CellsResistant to TopoisomeraseII Inhibitors. Yves Pommier, DonnaKerrigan, Ronald E. Schwartz, Judith A. Swack and AlisonMcCurdy.

* 3082 ClearingandReleaseofBasementMembraneProteinsfromSubstratesby MetastaticTumor Cell Variants.Daryl F. Sas,JamesB. McCarthyand LeoT. Furcht.

3090 Morphology and in Vivo Growth Characteristics of an AtypicalMurine Proliferative OsseousLesion Induced in Vitro. JOrgSchmidt, Erella Livne, Volker Erfie, Wolfgang GOssner andMichael Silbermann.

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2839 Covalent Binding of 1,2-Dihaloalkanes to DNA and Stability ofthe Major DNA Adduct, S-I2-(N@-Guanyl)ethyl@lutathione.Philip B. lnskeep, Nobuyuki Koga, Joan L. Cmarik and F. PeterGuengerich.

2863 EnhancedMalignant Progressionof Mouse Skin Tumors by theFree-Radical Generator Benzoyl Peroxide. John F. O'Connell,Andres J. P. Klein-Szanto, Donna M. DiGiovanni, JoAnn W.Friesand Thomas J. Slaga.

* 2888 SpeciesDifferencesintheFormationofBenzo(a)pyrene-DNAAdducts in Rodent and Human Endometrium. Mabmooda S.Kulkarni, Karen Calloway, Marcos F. Irigaray and David G.Kaufman.

* 2929 ComparativeEffectsofGrowthInhibitorsonDNA Replication,DNA Repair,and ProteinSynthesisin Human EpidermalKeratinocytes. Vilhelm Bohr, Jonathan Mansbndge and PhilipHanawalt.

* 2936 ImmunocytochemicalEvaluationofHuman EsophagealNonplasmaand PreneoplasticLesions for ft-Chorionk Gonadotropin,Placental Lactogen, a-Fetoprotein, Carcinoembryonic Antigen,and Nonspecific Cross-ReactingAntigen. Catyn L. Burg-Kurland,Dallas M. Pumell, John W. Combs, Elizabeth A. Hillman,Curtis C. Harris and Benjamin F. Trump.

2954 PancreaticCancer in the Syrian Hamster Induced by N-Nitrosobis(2-oxopropyl)amine: Cocarcinogenic Effect of EpidermalGrowth Factor. John F. Chester,Henning A. Gaissert,Jeffrey S.Rossand Ronald A. Malt.

2995 Carcinogenesisin Heterotopic Respiratory Epithelium in CanineSubcutaneous Bronchial Autografts. William G. Hammond,John R. Benfield, Rao R. Paladugu, Norio Azumi, Hyun Y.Pak and Raymond L. Teplitz.

3046 32P-Postlabeling Assay in Mice of Transplacental DNA DamageInduced by the Environmental CarcinogensSafrole, 4-Aminobiphenyl, and Henzo(a)pyrene Lee-JaneW. Lu, Rose M. Disher,M. Vijayaraj Reddyand Kurt Randerath.

3061 Evidence That a Slowly Cycling Subpopulation of Adult MurineEpidermal Cells Retains Carcinogen. Rebecca J. Morris,SusanM. Fischerand Thomas J. Slaga.

Endocrinology

* 2720 EpidermalGrowthFactorBindingandProteinKinaseC Activitiesin Human Breast Cancer Cell Lines: Possible Quantitative Relationship. Donano Fabbro, Willy KUng, Werner Roos, RomanoRegazziand Urs Eppenberger.

* 2771 EffectsofSteroidHormonesandAntisteroidsonAlkalinePhosphataseActivity in Human Endometrial Cancer Cells (IshikawaLine). Christian F. Holinka, Hiroki Hata, Hiroyuki Kuramotoand Erlio Gurpide.

Immunology

2680 Characterization of Lymphocytic Infiltrates in Normal, Preneoplastic, and Neoplastic Mouse Mammary Tissues.Wei-Zen Wei,Kevin Malone, Keith MahoneyandGloria Heppner.

* 2686 Leukoregulin-increasedPlasmaMembranePermeabilityandAssociatedIonic Huxes. SusanC. Barneti and CharlesH. Evans.

2735 Immunomodulation by Polyaromatic Hydrocarbons in Mice andMurine Cells. Robert H. Blanton, Mark Lyle, Michael J. Myersand Peter H. Bick.

2779 Effect of Sidestreamand Mainstream Smoke Exposureon inVitro a/@9-Interferon Production by L-929 Cells. GeraldSonnenfeldand RussellW. Hudgens.

* 2784 ImmunotherapyofMurineSarcomasUsingLymphokineActivatedKiller Cells: Optimizationof the Scheduleand Ronte ofAdministration of Recombinant Interleukin-2. Stephen E.Euinghausenand StevenA. Rosenberg.

2798 SelectiveModulationbya-DifluoromethylornithineofT-Lymphocyte and Antibody-mediated Cytotoxic Responsesto Mouse Tumor Allografts.M. JaneEhrke,Carl W. Porter,Cheryl Eppolitoand Enrico Mihich.

* 2834 CharacterizationandModulationofHuman Lymphokine(Interleukin 2) Activated Killer Cell Induction. Maureen Hoyer, TedMeineke, William Lewis, Bruce Zwilling and John Rinehart.

*@71 EffectorMechanismsof Human Monocyte-mediatedTumor Cytotoxicity in Vitro: Biochemical,FunCtiOnal,andSerologicalCharacteri.tation of Cytotoxins PrOducedby Peripheral Blood Monocytes Isolated by Counterfiow Elutriation. Jim Klostergaard,William A. Foster, David A. Hamilton, Jim Turpin and GabrielLopez-Berestein.

* 2904 DevelopmentandCharacterizationofaMouseMonoclonalAntibody, MoAb HMSA-1, against a Melanosomal Fraction of HumanMalignant Melanoma. Yutaka Akutsu and Kowichi Jimbow.

2912 Effects of Mutagens on the Immunogenicityof Tumor Cells:Comparison of Cell Surface ChangesInduced by 5-Azacytidineand N-Methyl-N'-nitro-N-nitrosoguanidine. PeterAltevogt.

* 2970 AntigensAssociatedwithHumanSquamousCellLungCarcinomaDefinedby Murine MonoclonalAntibodies.Philip D. Fernsten,Katherine W. Pekny, Ralph A. Reisfeld and Leslie E. Walker.

* 2988 HighlySelectiveRecognitionofHuman NeuroblastomaCellsbyMouse Monoclonal Antibody to a Cytoplasmic Antigen. NicoleGross,Daniel Beck,StefanCarrel and Miguel Munoz.

* 3005 DetectionofAntigensRecognizedbya NovelMonoclonalAntibody in Tissue and Serum from Patients with Breast Cancer.Stefanolacobelli, ElenaArnô,Alfonso D'Orazio and Gino Coletti.

301 1 Interleukin 2 Activation of Cytotoxic T-Lymphocytes Infiltratinginto Human Metastatic Melanomas. Kyogo Itoh, Arabella B.Tilden and CharlesM. Balch.

3034 Dynamics of Lymphocytic Subpopulations in Friend LeukemiaVirus-inducedLeukemia.MasanobuKitagawa,OsamuMatsubaraand Tsutomu Kasuga.

3055 Liver as a Tumor Cell Killing Organ: Kupifer Cells and NaturalKillers. Margarete Malter, Eckhard Friedrich and Rudolf Süss.

* 3118 DistributionofOncofetalAntigenTumor-associatedGlycoprotein-72 Defined by Monoclonal Antibody B72.3. Ann Thor,Noriaki Ohuchi, Cheryl A. Szpak, William W. Johnston andJeffrey Schlom.

Molecular Biology

* 2917 DNA MethylationPatternsoftheCalcitoninGeneinHumanLung Cancers and Lymphomas. Stephen B. Baylin, Jo W. M.Hoppener, Andréede Bustros, Paul H. Steenbergh, C. J. M. Lipsand Barry D. Nelkin.

* 2944 PatternsofDNA MethylationandGeneExpressioninHumanTumor Cell Lines. Lois A. Chandler, Yves A. DeClerck, EmilBogenmannand PeterA. Jones.

* 2964 SouthernBlotAnalysisofDNA ExtractedfromFormalin-fixedPathology Specimens.Louis Dubeau, Lois A. Chandler, Julie R.Gralow, Peter W. Nichols and PeterA. Jones.

3075 Altered DNA TopoisomeraseII Activity in ChineseHamster CellsResistant to TopoisomeraseII Inhibitors. Yves Pommier, DonnaKerrigan, Ronald E. Schwartz, Judith A. Swack and AlisonMcCurdy.

Continued

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* 2984 EffectofAdeno-associatedVirusonTransformationofNIH 3T3Cells by rasGeneandon Tumorigenicityof an NIH 3T3 Transformed Cell Line. Ehud Katz and Barrie J. Carter.

* 2988 HighlySelectiveRecognitionofHuman NeuroblastomaCellsbyMouse MonoclonalAntibodyto a CytoplasmicAntigen.NicoleGross, Daniel Beck,StefanCarrel and Miguel Munoz.

2995 Carcinogenesisin Heterotopic Respiratory Epithelium in CanineSubcutaneous Bronchial Autografts. William G. Hammond,John R. Benfield, Rao R. Paladugu, Norio Azumi, Hyun Y. Pakand Raymond L. Teplitz.

* 3@$Jd)Formationofa PhorbolEster-bindingFragmentfromProteinKinaseC by ProteolyticDigestion.MasahikoHoshijima,AkiraKikuchi, Tetsuji Tanimoto, Kozo Kaibuchi and Yoshimi TaICai.

* 3@5 DetectionofAntigensRecognizedbya NovelMonoclonalAntibody in Tissue and Serum from Patients with Breast Cancer.Stefano lacobelli, Elena Amô, Alfonso d'Orazio and Gino Coletti.

* 3011 Interleukin2ActivationofCytotoxicT-LymphocytesInfiltratinginto Human Metastatic Melanomas. Kyogo Itoh, Arabella B.Tilden and Charles M. Balch.

3018 Effects of the Immunomodulator LS 2616 on Growth and Metastasis of the Murine B16-FIO Melanoma. Terje Kalland.

3023 C-Type Virus Particlesin Spontaneousand Virus-inducedLeukemia and Malignant Lymphomasin Mice and Rats. LudwikGross, Dorothy Feldman and Yolande Dreyfuss.

* 3027 AlterationinGlycosphingolipidPatternduringPhorbol-12-myristate-13-acetate-induced Cell Differentiation in Human TLymphoidLeukemiaCells. K. Kiguchi,C. Henning-ChubbandE. Huberman.

3034 Dynamics of Lymphocytic Subpopulations in Friend LeukemiaVirus-inducedLeukemia.MasanobuKitagawa,OsamuMatsubaraand Tsutomu Kasuga.

3040 Substrates for Protein Kinase C in Cytosol of EL4 Mouse ThymomaCells.CarolineM. Kramer andJulianneJ. Sando.

3046 32P-Postlabeling Assay in Mice of Transplacental DNA DamageInduced by the Enrivonmental Carcinogens Safrole, 4-Aminobiphenyl, and Benzo(a)pyrene. Lee-Jane W. Lu, Rose M. Disher,M. Vijayaraj Reddy and Kurt Randerath.

3055 Liver as a Tumor Cell Killing Organ: Kupffer Cells and NaturalKillers. MargareteMalter, EckhardFriedrichand RudolfSüss.

3061 EvidenceThat a Slowly Cycling Subpopulation of Adult MurineEpidermal Cells Retains Carcinogen. Rebecca J. Morris,Susan M. Fischer and Thomas J. Slaga.

* 3(J@7EstablishmentandCharacterizationofFourHuman MonocytoidLeukemia Cell Lines (JOSK-I, -5, -M, and -K) with Capabilitiesof Monocyte-MacrophageLineageDifferentiationandConstitutive Productionof Interleukin 1. MasatsuguOhta, YusukeFurukawa, Chizuka Ide, Nobuo Akiyama, Tadashi Utakoji,YasusadaMiura and Masaki Saito.

3075 Altered DNA TopoisomeraseII Activity in ChineseHamster CellsResistantto TopoisomeraseII Inhibitors.YvesPommier,DonnaKerrigan, Ronald E. Schwartz, Judith A. Swack and AlisonMcCurdy.

* 3082 ClearingandReleaseofBasementMembraneProteinsfromSubstrates by Metastatic Tumor Cell Variants. Daryl F. Sas,JamesB. McCarthy and Leo T. Furcht.

3090 Morphologyand in Vivo Growth Characteristicsof an AtypicalMurine Proliferative OsseousLesion Induced in Vitro. JorgSchmidt, Erella Livne, Volker Erfie, Wolfgang GOssnerandMichael Silbermann.

*3099 Augmentation of 1-$-D-Arabinofuranosylcytosine Resistance inHuman KB Epidermoid Carcinoma Cells upon Induction of aSecondResistanceto Vincristine. SaburoSone,Kiyoshi Ishii andTakashi Tsuruo.

* 3105 InfluenceofGlucoseConcentrationonGrowthandFormationofNecrosis in Spheroids Derived from a Human Bladder CancerCell Line. Ian F. Tannockand Irma Kopelyan.

3111 SequentialProtooncogeneExpressionduringRat Liver Regeneration.NancyL. Thompson,JanetE. Mead,LundyBraun,MicheleGoyette, Peter R. Shank and Nelson Fausto.

* 3118 DistributionofOncofetalAntigenTumor-associatedGlycoprotein-72 Defined by Monoclonal Antibody B72.3. Ann Thor,Noriaki Ohuchi, Cheryl A. Szpak, William W. Johnston andJeffrey Schiom.

3125 Prolongation of Fibroblast Life Span Associatedwith EpithelialRat Tumor Development. D. Wynford-Thomas, P. Smith andE. D. Williams.

3128 Ultrastructural Characterization of the Retrovirus Particles (SmMTV) Liberated from the Mammary Tumor Cell Line (Sm-Mi')ofa HouseMusk Shrew,Suncusmurinus(Insectivora).JollyannaMalavasi Yamashiro, Yoshihiro Tsutsui, Shoichi Nagayoshi,Shinsuke Saga, Masahide Takahashi, Atsuko Aoyama, SeijunHayakawa,Toyoharu Yokoi, Sen-ichiOda, Akira Yokoyama andMunemitsu Hoshino.

3138 PreventionofGrowth ofMetastases in Rat Liver by PerioperativeImmunoactivation. Ryoichi Yamashita, Takehisa Hiraoka, IkuoKamimoto and Yoshimasa Miyauchi.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

3142 Phase I and Pharmacokinetic Study of LM985 (Flavone AceticAcid Ester). D. J. Kerr, S. B. Kaye, J. Graham, J. Cassidy,M. Harding, A. Setanoians, J. C. McGrath, W. R. Vezin,D. Cunningham, G. Forrest and M. Soukop.

3147 Phase I Evaluation and Clinical Pharmacology of Tricyclic Nucleoside 5'-Phosphate Using a Weekly Intravenous Regimen.Rudolf B. Schilcher, Charles D. Ham, Michael K. Samson,John D. Young and Laurence H. Baker.

3152 Role and Mechanismof Actionof Tamoxifenin PremenopausalWomen with Metastatic Breast Carcinoma. Carol A. Sawka,Kathleen I. Pritchard, Alexander H. G. Paterson,Donald J. A.Sutherland, Damien B. Thomson, Wendy E. Shelley, Robert E.Myers, Betty G. Mobbs, Aaron Malkin and J. William Meakin.

3157 Pharmacokineticsof RadiolabeledMonoclonal Antibody B6.2in Patients with Metastatic Breast Cancer. Daniel F. Hayes,Michael R. Zalutsky, William Kaplan, Michael Noska, Ann Thor,David Colcher and Donald W. Kufe.

3164 Use of a Monoclonal Antibody to Detect Elevated Levels of aModified Nucleoside, N-J9-@9-I-Ribofuranosyl)purin-6-ylcarbamoyl}.L-threonine,in the Urine ofBreast CancerPatients.BarbaraS. Vold, Lewis E. Kraus, Virginia G. Rimer and R. C. Coombes.

3168 Plasma Uridine Changes in Cancer Patients Treated with theCombinationof DipyridamoleandN-Phosphonacetyl-L-aspartate.Thomas C. K. Chan, Maurie Markman, Stephen Cleary andStephenB. Howell.

3173 Prognostic Implications of Ploidy and Proliferative Activity inDiffuse Large Cell Lymphomas. Kenneth D. Bauer, Douglas E.Merkel, Jane N. Winter, Robert J. Marder, Walter W. Hauck,Carl B. Wallemark, Thomas J. Williams and Daina Variakojis.

3179 RoleofTumor-associated Macrophagesin Lung Cancer.SadanoriTakeo, KoseiYasumoto,Akira Nagashima,HisashiNakahashi,Keizo Sugimachi and Kikuo Nomoto.

Continued

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3183 Limitations of RadiolabeledMonoclonal Antibodies for Localization of Human Neoplasms.AgamemnonA. Epenetos,DeborahSnook, Helga Durbin, Peter M. Johnson and Joyce TaylorPapadimitriou.

3192 Significance of DNA Abnormalities in Primary Malignant MelanomaandNevi, a RetrospectiveFlowCytometricStudy.JamieH.Von Roenn,SoniaM. Kheir, JanetM. WolterandJohnS.Coon.

3196 Detection of N-myc OncogeneExpression in Human Neuroblastomaby in Situ HybridizationandBlot Analysis:RelationshiptoClinical Outcome. Eileen F. Grady-Leopardi, Manfred Schwab,

Letter to the Editor

3200 Correspondencere: LawrenceA. Loebet aL Smokingand LungCancer: An Overview. Cancer Res., 44: 5940—5958,1984.PhilipR.J.Burch.RepliesbyJ.AbbottsandL.A.LoebandbyV.L.Ernster.

3204 Special Announcement

3204 Announcements

3207 ErratumR. B. Dickson et a!., 46: 1707—1713, 1986.

3207 RecentDeaths

3208 AuthorIndex

Arthur R. Ablin and Werner Rosenau.

* * *

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Perspectivesin CancerResearch

2651 NaturalKillerCellsandTheir RelationshiptoT-Cells:HypothesisontheRoleofT-CellReceptorGeneRearrangementontheCourseof Adaptive Differentiation. Zvi Grossman and Ronald B.Herberman.

BASIC SCIENCES

Biochemistry and Biophysics

2659 Anthracycline-inducedInhibitionof a CalciumActionPotentialinDifferentiatedMurine NeuroblastomaCells.KennethS.Santone,S.GeorgeOakes,Stuart R. Taylor and Garth Powis.

2775 Use of a Cell Sorter for Assays of Cell Clonogenicity. Ralph E.Durand.

2849 31P-NuclearMagnetic ResonanceAnalysis of Interferon-inducedAlterationsof PhospholipidMetabolites in Interferon-sensitiveand Interferon-resistantFriend LeukemiaCell Tumorsin Mice.Enrico Proietti, Giulia Carpinelli, Massimo Di Vito, FilippoBelardelli. Ion Gresser and Franca Podo.

2866 Resistanceto Multiple Adenine Nucleosideand Methionine Annlogues in Mutant Murine Lymphoma Cells with Enlarged 5-AdenosylmethioninePools.E. Olavi Kajander,MasaruKubota,Carlos J. Carrera, John A. Montgomery and Dennis A. Carson.

2876 Effects of the Bidentate Malonate Ligand on the Utilization andCytotoxicity of Platinum Compounds in the L1210 Cell Line.Stanley K. Mauldin, Intisar Husain, Aziz Sancarand StephenG.Chancy.

2958 Renal Cell Carcinomain the Wistar-Lewis Rat: A Model forStudyingthe Mechanismsof CholesterolAcquisitionbya Tumorin Vivo. Ralph V. Clayman, Lyman E. Bilhartz, L. MaximilianBuja, David K. Spadyand John M. Dietschy.

* 3000 Formation of a Phorbol Ester-binding Fragment from ProteinKinaseC by ProteolyticDigestion.MasahikoHoshijima,AkiraKikuchi, Tetsuji Tanimoto, Kozo Kaibuchi and Yoshimi Takai.

* 3027 Alteration in Glycosphingolipid Pattern during Phorbol-12-myristate-13-acetate-inducedCell Differentiation in Human TLymphoidLeukemiaCells. K. Kiguchi,C. Henning-ChubbandE. Huberman.

3040 Substrates for Protein Kinase C in Cytosol of EL4 Mouse ThymomsCells.CarolineM. KramerandJulianneJ. Sando.

Biology and Genetics

2670 Inhibitionof CyclophosphamideandMitomycinC-inducedSisterChromatidExchangesin Mice byVitaminC. G. Krishna,J. Nathand T. Ong.

2709 Modification of the Cytotoxic Activity ofMitomycin C by OxygenandAscorbicAcidin ChineseHamsterOvaryCellsanda RepairdeficientMutant. RaymondS. Marshalland A. MichaelRauth.

2730 Differential Interaction of Normal and Preneoplastic HamsterBronchiwith Adriamycin.Brian I. Carr, Donna Langley,CeciliaB. Dias,William G. HammondandJohnR. Benfield.

* 2793 Shape-dependentRegulationofProliferationinNormalandMalignant Human Cells and Its Alteration by Interferon. David A.Kulesh and James J. Greene.

* 2816 InductionandModulationofAnchorage-independentGrowthbyPlatelet-derivedGrowth Factor, FibroblastGrowth Factor, andTransforming Growth Factor-j@. Angie Rizzino, Eric Ruff andHeather Rizzino.

* 2821 InfluenceofHypoxiaandanAcidicEnvironmentontheMetabolism and Viability of CulturedCells: PotentialImplicationsforCell Deathin Tumors.DanielaRotin, BrianRobinsonand Ian F.Tannock.

* 2845 SelectiveModulationofGlutathioneLevelsinHuman Normalversus Tumor Cells and Subsequent Differential Response toChemotherapyDrugs.AngeloRusso,William DeGraff, NormanFriedman and JamesB. Mitchell.

2923 PhenotypicInstabilityof MouseMelanomasafter PropagationinVivo and in Vitro. Jane Berkelhammer, Ted N. Luethans,Reuel R. Hook, Jr., and Ronald W. Oxenhandler.

* 3tJ@7EstablishmentandCharacterizationofFourHuman MonocytoidLeukemiaCell Lines(JOSK-I, -5, -M, and-K) with Capabilitiesof Monocyte-MacrophageLineageDifferentiationand Constitutive Productionof Interleukin 1. MasatsuguOhta, YusukeFurukawa, Chizuka Ide, Nobuo Akiyama, Tadashi Utakoji,YasusadaMiura and Masaki Saito.

*31J@2 Clearing and Releaseof BasementMembrane Proteins from Substrates by Metastatic Tumor Cell Variants. Daryl F. Sas,JamesB. McCarthy and Leo T. Furcht.

* 3105 Influence of Glucose Concentration on Growth and Formation ofNecrosis in Spheroids Derived from a Human Bladder CancerCell Line. Ian F. Tannockand Irma Kopelyan.

3125 Prolongationof FibroblastLife SpanAssociatedwith EpithelialRat Tumor Development. D. Wynford-Thomas, P. Smith andE. D. Williams.

Carcinogenesis

* 2665 QuantitativeDifferencesinHostCellReactivationofUltravioletdamagedVirus in Human Skin Fibroblasts and Epidermal KerntinocytesCulturedfromtheSameForeskinBiopsy.RexM. Tyrrelland Mireille Pidoux.

2675 Separationof Early Diffuse Alveolar Cell Proliferation from EnhancedTumor Developmentin Mouse Lung. H. P. Witschi.

2693 XenobioticMetabolizingEnzymesin GeneticallyandChemicallyInitiatedMouse Liver Tumors.Daniel L. Stoutand FrederickF.Becker.

* 2697 Benzo(a)pyrene:DNA Adduct Formation in Normal Human Mansmary Epithelial Cell Cultures and the Human Mammary CarcinomaT47D Cell Line. Donna Pruess-Schwartz,William M. Baird,Ann Nikbakht, B. Alex Merrick and JamesK. Selkirk.

2756 Heme Enzyme Patterns in Genetically and Chemically InducedMouseLiver Tumors.Daniel L. StoutandFrederickF. Becker.

2760 Bacterial and Mammalian Cell Mutagenicity of Four OpticallyActive Bay-Region 3,4-Diol-1,2-epoxides and Other Derivativesof the Nitrogen HeterocycleDibenzfr,hlacridine.AlexanderW.Wood, Richard L. Chang,Wayne Levin, SubodhKumar, NaohiroShirai, Donald M. Jerina, Roland E. Lehr and Allan H. Conney.

* Indicates studies using human-derived material.

Cancer Research

VOLUME 46•NUMBER 6

CONTENTS Arranged by Subject Categories

Research. on September 9, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from

2839 Covalent Binding of 1,2-Dihaloalitanes to DNA and Stability ofthe Major DNA Adduct, S-(24N@-Guanyl)ethylIglutathione.Philip B. Inskeep, Nobuyuki Koga, Joan L. Cmarik and F. PeterGuengerich.

2863 EnhancedMalignant Progressionof Mouse Skin Tumors by theFree-Radical Generator Benzoyl Peroxide. John F. O'Connell,Andres J. P. Klein-Szanto, Donna M. DiGiovanni, JoAnn W.Friesand ThomasJ. Slaga.

* 2888 SpeciesDifferencesintheFormationofBenzo(a)pyrene-DNAAdducts in Rodent and Human Endometrium. Mahmooda S.Kulkarni, Karen Calloway, Marcos F. Irigaray and David 0.Kaufman.

* 2929 ComparativeEffectsofGrowthInhibitorsonDNA Replication,DNA Repair,and ProteinSynthesisin Human EpiderinalKerntinocytes. Vilhelm Bohr, Jonathan Mansbridge and PhilipHanawalt.

* 2936 ImmunocytochemicalEvaluationofHuman EsophagealNonplasmaand PreneoplasticLesions for $-ChOnOniCGonadotropin,Placental Lactogen, a-Fetoprotein, Carcinoembryonic Antigen,and NonspecificCross-ReactingAntigen. Caryn L. Burg-Kurland,Dallas M. Purnell, John W. Combs, Elizabeth A. Hillman,Curtis C. Harris and Benjamin F. Trump.

2954 PancreaticCancer in the Syrian Hamster Induced by N-Nitrosobis(2-oxopropyl)amine: Cocarcinogenic Effect of EpidermalGrowth Factor John F. Chester, Henning A. Gaissert, Jeffrey S.Rossand Ronald A. Malt.

2995 Carcinogenesisin Heterotopic Respiratory Epithelium in CanineSubcutaneous Bronchial Autografts. William G. Hammond,John R. Benfield, Rao R. Paladugu, Norio Azumi, Hyun Y.Pak and Raymond L. Teplitz.

3046 32P-PostlabelingAssay in Mice of Transplacental DNA DamageInducedby the EnvironmentalCarcinogensSafrole,4-Aminobiphenyl,and Benzo(a)pyrene.Lee-JaneW. Lu, RoseM. Disher,M. Vijayaraj Reddyand Kurt Randerath.

3061 EvidenceThat a Slowly Cycling Subpopulation of Adult MurineEpidermal Cells Retains Carcinogen. Rebecca J. Morris,SusanM. Fischerand Thomas J. Slaga.

Endocrinology

* 2720 Epidermal Growth Factor Binding and Protein Kinase C Activitiesin Human Breast Cancer Cell Lines: PossibleQuantitative Relationship.Doriano Fabbro,Willy Kung, Werner Roos,RomanoRegazziand Urs Eppenberger.

* 2771 EffectsofSteroidHormonesandAntisteroidsonAlkalinePhosphatase Activity in Human Endometrial Cancer Cells (IshikawaLine). Christian F. Holinka, Hiroki Hata, Hiroyuki Kuramotoand Erlio Gurpide.

Immunology

2680 Characterization of Lymphocytic Infiltrates in Normal, Preneoplastic, and Neoplastic Mouse Mammary Tissues.Wei-Zen Wei,Kevin Malone, Keith Mahoney and Gloria Heppner.

* 2686 Leukoregulin-increasedPlasmaMembranePermeabilityandAssociatedIonic Fluxes. SusanC. Barnett and CharlesH. Evans.

2735 Immunomodulationby PolyaromaticHydrocarbonsin Mice andMurine Cells. Robert H. Blanton,Mark Lyte, MichaelJ. Myersand Peter H. Bick.

2779 Effect of Sidestream and Mainstream Smoke Exposure on inVitro a/ft-Interferon Production by L-929 Cells. GeraldSonnenfeldand RussellW. Hudgens.

* 2784 ImmunotherapyofMurineSarcomasUsingLymphokineActivated Killer Cells: Optimizationof the Scheduleand Route ofAdministration of Recombinant Interleukin-2. Stephen E.Ettinghausenand StevenA. Rosenberg.

2798 SelectiveModulationbya-DifluoromethylornithineofT-Lymphocyte and Antibody-mediated Cytotoxic Responsesto Mouse Tnmor Allogrnfts.M. JaneEhrke,Carl W. Porter,Cheryl Eppolitoand Enrico Mihich.

* 2834 CharacterizationandModulationofHuman Lymphokine(Interleukin 2) Activated Killer Cell Induction. Maureen Hoyer, TedMeineke, William Lewis, Bruce Zwilling and John Rinehart.

* 2871 EffectorMechanismsofHuman Monocyte-mediatedTumorCytotoxicity in Vitro: Biochemical, Functional, and Serological Characterization of Cytotoxins Produced by Peripheral Blood Monocytes Isolated by Counterfiow Elutriation. Jim Klostergaard,William A. Foster, David A. Hamilton, Jim Turpin and GabrielLopez-Berestein.

* 2904 DevelopmentandCharacterizationofaMouseMonoclonalAntibody, MoAb HMSA-1, against a Melanosomal Fraction of HumanMalignant Melanoma. Yutaka Akutsu and Kowichi Jimbow.

2912 Effects of Mutagens on the Immunogenicityof Tumor Cells:Comparisonof Cell SurfaceChangesInducedby 5-Azacytidineand N-Methyl-N'-nitro-N-nitrosoguanidine. PeterAltevogt.

* 2970 AntigensAssociatedwithHumanSquamousCellLungCarcinomaDefmedby Murine MonoclonalAntibodies.Philip D. Fernsten,Katherine W. Pekny, Ralph A. Reisfeldand Leslie E. Walker.

* 2988 HighlySelectiveRecognitionofHuman NeuroblastomaCellsbyMouse MonoclonalAntibodyto a CytoplasmicAntigen.NicoleGross,Daniel Beck,StefanCarrel and Miguel Munoz.

* 3005 DetectionofAntigensRecognizedbya NovelMonoclonalAntibody in Tissue and Serum from Patients with Breast CancerStefano Iacobelli, Elena Arnô, Alfonso D'Orazio and Gino Coletti.

3011 Interleukin 2 Activation of Cytotoxic T-Lymphocytes Infiltratinginto Human Metastatic Melanomas. Kyogo Itoh, Arabella B.Tilden and Charles M. Balch.

3034 Dynamics of Lymphocytic Subpopulations in Friend LeukemiaVirus-inducedLeukemia.MasanobuKitagawa,OsamuMatsubaraand Tsutomu Kasuga.

3055 Liver as a Tumor Cell Killing Organ: Kupffer Cells and NaturalKillers. Margarete Malter, Eckhard Friedrich and Rudolf Süss.

*31 18 Distribution of Oncofetal Antigen Tumor-associated Glycoprotein-72 Defined by Monoclonal Antibody B72.3. Ann Thor,Noriaki Ohuchi, Cheryl A. Szpak, William W. Johnston andJeffrey Schlom.

Molecular Biology

* 2917 DNA MethylationPatternsoftheCalcitoninGeneinHumanLung Cancersand Lymphomas.StephenB. Baylin, Jo W. M.HOppener,Andréede Bustros, Paul H. Steenbergh,C. J. M. Lipsand Barry D. Nelkin.

* 2944 PatternsofDNA MethylationandGeneExpressioninHumanTumor Cell Lines. Lois A. Chandler, Yves A. DeClerck, EmilBogenmannand PeterA. Jones.

* 2964 SouthernBlotAnalysisofDNA ExtractedfromFormalin-fixedPathology Specimens.Louis Dubeau, Lois A. Chandler, Julie R.Gralow, Peter W. Nichols and PeterA. Jones.

3075 Altered DNA TopoisomeraseII Activity in ChineseHamster CellsResistant to Topoisomerase II Inhibitors. Yves Pommier, DonnaKerrigan, Ronald E. Schwartz, Judith A. Swack and AlisonMcCurdy.

Continued

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3111 SequentialProtooncogeneExpressionduringRat Liver Regeneration.NancyL. Thompson,JanetE. Mead,LundyBraun,MicheleGoyette, PeterR. Shank and Nelson Fausto.

Preclinical Pharmacology and Experimental Therapeutics

* 2703 New ScreeningSystemforSelectionofAnticancerDrugsforTreatment of Human Colorectal Cancer. Werner Scheithauer,Gary M. Clark, Mary P. Moyer and Daniel D. Von Hoff.

2714 Comparative Anthracycline Metabolism in Rats: Loss of MarcellomycinFluorescence.P. Dodion, J. M. Tamburini, B. M. Fox,C. E. Riggs,Jr., and N. R. Bachur.

* 2726 DifferentTypeofDNA DamageCausedby ThreeAziridinylSubstituted Cyclophosphazenesin a Human Small Cell LungCarcinoma Cell Line. Jan G. Zijlstra. Stevende Jong, Johan C.van de Grampel, ElisabethG. E. de Vries and Nanno H. Mulder.

* 2740 InhibitionofHuman MelanomaGrowthbyProstaglandinA,D,andJ Analogues.Marvin D. Bregman,CaroleFunkandMasanoriFukushima.

2745 Effect of Diethyldithiocarbamate on cis-Diamminedichloroplatinum(II)-inducedCytotoxicity,DNA Cross-Linking,and ‘y-Glutamyl TranspeptidaseInhibition.Donald L. Bodenner,PeterC.Dedon, PeterC. Keng and Richard F. Borch.

2751 Selective Protectionagainstcis-Diamminedichloroplatinum(II)inducedToxicity in Kidney,Gut, andBoneMarrow by Diethyldithiocarbamate. Donald L. Bodenner, Peter C. Dedon, Peter C.Keng, Janet C. Katz and Richard F. Borch.

2767 Influence of the Duration of Topical 13-cis-RetinoicAcid Treatmenton Inhibitionof Mouse Skin Tumor Promotion.Helen L.Gensler, Dalice A. Sim and G. Tim Bowden.

2810 IncreasedThymidylate Synthase in L1210 Cells PossessingAcquired Resistance to N'°-Propargyl-5,8-dideazafolic Acid(CB3717): Development,Characterization,andCross-ResistanceStudies.Ann L. Jackman, Dawn L. Alison, A. Hilary Calvert andKenneth R. Harrap.

* 2827 ExperimentalChemotherapyofHuman MedulloblastomawithClassical Alkylators. Henry S. Friedman, 0. Michael Colvin,Susan M. Ludeman, S. Clifford Schold, Jr., Victoria L. Boyd,Lawrence H. Mulhbaier and Darell D. Bigner.

2858 Treatment of Dunning R3327-AT Rat ProstateTumors with Photodynamic Therapy in Combination with Misonidazole. SalomonGonzalez,Mark R. Arnfield, Bert E. Meeker,John Tulip, WilliamH. Lakey, J. Donald Chapman and Malcolm S. McPhee.

2883 In Vitro and in Vipo Radiation Sensitization by the Halogenated Pyrimidine 5-Chloro-2'-deoxycytidine. Kenneth J. Russell,Glenn C. Rice and J. Martin Brown.

* 2892 Misonidazole-induced Chemopotentiation of 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea Toxicity in O'-Methylguanine-DNAMethyltransfernse Proficient (Mer@)and Deficient (Mer) CellLines. R. Timothy Mulcahy.

2898 Growth Inhibition of a Rat Colon Tumor by L-Caflavanine.Deborah A. Thomas, Gerald A. Rosenthal, David V. Gold andKenneth Dickey.

2950 HistologicalStudyof the Effect of HematoporphyrinDerivativePhotodynamic Therapy on the Rat Jejunum. Kallol Chaudhuri,Peter J. Goldblatt, Martha Kreimer-Birnbaum, Rick W. Keckand Steven H. Selman.

2978 Resistanceto Adriamycin: Relationship of Cytotoxicity to DrugUptakeandDNA Single-andDouble-StrandBreakagein ClonedCell Linesof Adriamycin-sensitiveand-resistantP388 Leukemia.Gerald J. Goldenberg, Hungshu Wang and Gordon W. Blair.

3018 Effects of the Immunomodulator iS 2616 on Growth and Metastasis of the Murine B16-F1OMelanoma. Teije K.alland.

* 3099 Augmentationof1-ft-D-ArabinofuranosylcytosineResistanceinHuman KB Epidermoid Carcinoma Cells upon Induction of aSecondResistanceto Vinesistine. SaburoSane,Kiyoshi Ishii andTakashi Tsuruo.

3138 PreventionofGrowth ofMetastases in Rat Liver by PerioperativeImmunoactivation. Ryoichi Yamashita, Takehisa Hiraoka, IkuoKamimoto and YoshimasaMiyauchi.

Virology

2804 Plasma Levels of a Viral Protein during Adjuvant Treatment:Reflection of Murine Mammary Tumor Status and TherapeuticEffect. Earl M. Ritzi, Daniel S. Martin and Robert L Stolfi.

* 2984 Effect of Adeno-assoclatedVirus on Transformation of NIH 3T3Cells by eQsGeneandonTumorigenicityof an NIH 3T3 TransformedCell Line. Ehud Katz and BarrieJ. Carter.

3023 C-Type Virus Particlesin Spontaneousand Virus-inducedLenkemia and Malignant Lymphomas in Mice and Rats. LudwikGross,DorothyFeldmanand YolandeDreyfuss.

3090 Morphology and in Viro Growth Characteristics of an AtypicalMurine Proliferative Osseous Lesion Induced in Vitro. JorgSchmidt, Erella Livne, Volker Erfie, Wolfgang Gossner andMichael Silbermann.

3128 Ultrastructural Characterization of the Retrovirus Particles (SmMT@')Liberated from the Mammary Tumor Cell Line (Sm-Mi')ofa HouseMusk Shrew,Suncusmurinus(Insectivora).JollyannaMalavasi Yamashiro, Yoshihiro Tsutsui, Shoichi Nagayoshi,Shinsuke Saga, Masahide Takahashi, Atsuko Aoyama, SeijunHayakawa,Toyoharu Yokoi, Sen-ichiOda, Akira Yokoyama andMunemitsu Hoshino.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

3142 PhaseI and PharmacokineticStudyof LM985 (FlavoneAceticAcid Ester). D. J. Kerr, S. B. Kaye, J. Graham, J. Cassidy,M. Harding, A. Setanoians,J. C. McGrath, W. R. Vezin,D. Cunningham,G. Forrestand M. Soukop.

3147 PhaseI Evalnationand Clinical PharmacOlOgyof Tricyclk Nucleoside5'-Phosphate Using a Weekly IntravenousRegimen.Rudolf B. Schilcher, Charles D. Ham, Michael K. Samson,John D. Young and Laurence H. Baker.

3152 Role and Mechanismof Actionof Tamoxifenin PremenopausalWomen with Metastatic Breast Carcinoma. Carol A. Sawka,Kathleen I. Pritchard, Alexander H. G. Paterson,Donald J. A.Sutherland, Damien B. Thomson, Wendy E. Shelley, Robert E.Myers, Betty G. Mobbs, Aaron Malkin and J. William Meakin.

3157 Pharmacokineticsof RadiolabeledMonoclonal Antibody B6.2in Patients with Metastatic Breast Cancer. Daniel F. Hayes,Michael R. Zalutsky, William Kaplan, Michael Noska, AnnThor, David Colcher and Donald W. Kufe.

3164 Use of a Monoclonal Antibody to Detect Elevated Levels of aMOdified Nucleoside, N-@9-ft-D-Ribofuranonyl)purln-6-ylcarbamoyl@-L-threonine,in the Urine ofBreast CancerPatients.BarbaraS. Vold, LewisE. Kraus,VirginiaG. Rimer and R. C. Coombes.

3168 Plasma Uridine Changes in Cancer Patients Treated with theCombinationof Dipyridamole andN-Phosphonacetyl-L-aspartate.Thomas C. K. Chan, Maune Markman, Stephen Cleary andStephenB. Howell.

3173 PrognosticImplicationsof Ploidy and ProliferativeActivity inDiffuse Large Cell Lymphomas. Kenneth D. Bauer, Douglas E.Merkel, Jane N. Winter, Robert J. Marder, Walter W. Hauck,Carl B. Wallemark, Thomas J. Williams and Daina Variakojis.

Continued

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3179 RoleofTumor-associatedMacrophagesin LungCancer.SadanoriTakeo, Kosei Yasumoto, Akira Nagashima, Hisashi Nakahashi,Keizo Sugimachi and Kikuo Nomoto.

3183 Limitationsof RadiolabeledMonoclonalAntibodiesfor Localization of Human Neoplasms.AgamemnonA. Epenetos,DeborahSnook, Helga Durbin, Peter M. Johnson and Joyce TaylorPapadimitriou.

3192 Significanceof DNA Abnormalitiesin Primary MalignantMelanomaand Nevi, a RetrospectiveFlow Cytometric Study. Jamie H.Von Roenn,SoniaM. Kheir,JanetM. WolterandJohnS.Coon.

31% DetectionofN-myc OncogeneExpressioninHuman Neuroblastomaby in Situ HybridizationandBlot Analysis:RelationshiptoClinical Outcome.Eileen F. Grady-Leopardi,Manfred Schwab,Arthur R. Ablin and Werner Rosenau.

* * *

Letter to the Editor

3200 Correspondencere: Lawrence A. Loeb et al. Smoking and LungCancer: An Overview. Cancer Res., 44: 5940—5958,1984.Philip R. J. Burch. Replies by J. Abbotts and L. A. Loeb andby V. L. Ernster.

3204 Special Announcement

3204 Announcements

3207 ErratumR. B. Dickson et a!., 46: 1707—1713,1986.

3207 RecentDeaths

3208 AuthorIndex

Research. on September 9, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from

1986;46:2651-3207. Cancer Res     46 (6)

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