BIOPHARMACEUTICS & DRUG DISPOSITION

Biopharm. Drug Dispos

Contents Volume 25, Numbers 1-9

ISSUE 1 JANUARY 2004

ORIGINAL PAPERS

Comparative Pharmacokinetics of Acetyl Salicylic Acid and its Metabolites in Children Suffering

from Autoimmune Diseases

H. Juarez Olguin, J. Flores Pérez, I. Lares Asseff, A. Loredo Abdala and L. Carbajal Rodriguez

Transdermal Delivery System for Zidovudine: in vitro, ex vivo and in vivo Evaluation

S. T. K. Narishetty and R. Panchagnula

Comparative Evaluation of Digoxin Concentrations Determined by Three Assay Systems: TDx,

IMx and OPUS

Y. Kagawa, T. Iwamoto, H. Matsuda, R. Mukohara, J.-I. Sawada and M. Kojima

Disposition of WR-1065 in the Liver of Tumor-bearing Rats Following Regional vs Systemic

Administration of Amifostine

M. Levi, S. J. DeRemer, C. Dou, W. D. Ensminger and D. E. Smith

In vitro Investigation on the Impact of the Surface-active Excipients Cremophor EL, Tween 80

and Solutol HS 15 on the Metabolism of Midazolam

R. C. Bravo Gonzalez, J. Huwyler, F. Boess, I. Walter and B. Bittner

ISSUE 2 MARCH 2004

ORIGINAL PAPERS

Steady-State Pharmacokinetics of Fluvastatin in Healthy Subjects Following a New Extended

Release Fluvastatin Tablet, Lescol XL D. Barilla, P. Prasad, M. Hubert and K. Gumbhir-Shah

Rapid Determination Method of Caffeine and Application to Monitoring of Caffeine-Assisted

Chemotherapy

M. Kawahara, H. Kagiyama, Y. Kanazawa, H. Tsuchiya, K. Tomita, K. Yokogawa and K.-I. Miyamoto

Evaluation of Pharmacokinetics, Brain Levels and Protein Binding of Centpropazine in Rats

V. A. Bhattaram, J. K. Paliwal and R. C. Gupta

Pharmacokinetics of Nifedipine in Taiwanese

S.-C. Chien, Y.-S. Uang, H.-Y. Lin and K.-Y. Hsu

Pharmacokinetics of HEPP, a New Anticonvulsant, in Healthy Subjects and Rabbits After Multiple

Doses

D. F. Gonzalez-Esquivel, R. M. Pérez and H. J. Cook

In vitro Dissolution and In vivo Oral Absorption of Methylphenidate from a Bimodal Release

Formulation in Healthy Volunteers

Y. Wang, L. Lee, R. Somma, G. Thompson, R. Bakhtiar, J. Lee, G. S. Rekhi, H. Lau, G. Sedek and M. Hossain

SHORT COMMUNICATION

Mathematical Comparison Between Volume of Distribution (V) and Volume of Distribution at

Steady-State (V,,) Utilizing Model-Independent Approach

E. Sobol and M. Bialer

VOLUME CONTENTS

ISSUE APRIL 2004

ORIGINAL PAPERS

Bioequivalence Evaluation of Two Brands of Aceclofenac 100 mg Tablets (Aceclofar and

Bristaflam) in Healthy Human Volunteers

ajib, N. Idkaidek, M. Beshtawi, M. Bade: Admour, S. Mahmood Alam, Q. Zaman and R. Dham

The Bioavailability and Pharmacokinetics of Glucosamine Hydrochloride and Chondroitin Sulfate

after Oral and Intravenous Single Dose Administration in the Horse

J. Du, N. White and N. D. Eddington

Identification of Rat Faecal, Urinary and Biliary Metabolites of Thionorphine, a Novel Mixed

Agonist-Antagonist Analgesic, Using Liquid Chromatography/Electrospray lonization Tandem

Mass Spectrometry

Wang and J.-F. Guo

Pharmacokinetics, Blood Partition and Protein Binding of DA-7867, a New Oxazolidinone

Kwon, W. B. Kim and M. G. Lee

SHORT COMMUNICATIONS

Pharmacokinetic Changes of DA-8159, a New Erectogenic, After Intravenous and Oral

Administration to Rats with Acute Renal Failure Induced by Uranyl Nitrate

H. J. Shim, Y. C. Kim, E. J. Kim, D. G. Kim, J. W. Kwon, W. B. Kim and M. G. | s. Lee

Dose-dependent Pharmacokinetics of KR-31378, a New Neuroprotective Agent for

Ischaemia-reperfusion Damage in Dogs

S.-O. Kim, S.-H. Kwak, B. H. Lee, D.-H. Lee, H. Lim, S.-E N Yoo, H. J. Chung and M G. Lee

ORIGINAL PAPERS

Pharmacokinetic Tracer Kinetics Analysis of Changes in Erythropoietin Receptor Population in

Phlebotomy-Induced Anemia and Bone Marrow Ablation D 1

Veng-Pedersen hapel, N. H. Al-Huniti, R. L. Schmidt, E. M. Sedars, R. J. Hohl and J. A. Widness

The Relationships Between Half-Life (t,,;,) and Mean Residence Time (MRT) in the

Two-Compartment Open Body Model

E. Sobol and M. Bialer

Interaction of Dexloxiglumide, a Cholecystokinin Type-1 Receptor Antagonist, with Human

Cytochromes P450

Cheung, A. Matthews, Z. R. Cybulski, J. D. Holding, R. Kapil, M. D'Amato, F. Makovec and L. C. Rovati

Interspecies Scaling of the Monoclonal Anti-EGF Receptor ior EGF/r3 Antibody Disposition

Using Allometric Paradigm: is it Really Suitable? iT ne } j ge, E. Fernandez-Sanchez and D. Alvarez

Pharmacokinetics of Mebudipine, a New Calcium Antagonist, Following Single Intravenous and

Oral Administrations in Rats

S. Bohlooli, F. Keyhanfar and M. Mahmoudian

Dose-dependent Pharmacokinetics of KR-31378, a New Neuroprotective Agent for

Ischaemia-reperfusion Damage in Dogs

S.-O. Kim, S.-H. Kwak, B. H. Lee, D.-H. Lee, H. Lim, S.-E. Yoo, H. J. Chung and M. G. Lee

VOLUME CONTENTS

ISSUE 5 JULY 2004

ORIGINAL PAPERS

Topical Disposition of Two Strengths of a ‘?°I-rhEGF Jelly in Rat Skin Wounds

Duconge, P. A. Prats, C. Valenzuela, A. Aguilera, I. Rojas, M. A. Becquer, D. Alvarez, L. Estrada, S. Alfonso-Ortiz

E. Hardy-Rando, O. Garcia-Pulpeiro and E. Fernandez-Sanchez

Bioequivalence Evaluation of Two Brands of Ketoconazole Tablets (Onofin-K “ and Nizoral") in a

Healthy Female Mexican Population

G. Marcelin-Jiménez, J. Hernandez, A. P. Angeles, L. Contreras, M. Hinojosa, L. Rivera, L. Martinez-Rossier, O. Amancio and

A. Fernandez

Effect of Intravenous Infusion Time on the Pharmacokinetics and Pharmacodynamics of the Same

Total Dose of Torasemide in Rabbits

Y. C. Kim, M. G. Lee, S.-H. Ko and S. H. Kim

Pharmacodynamics of Controlled Release Verapamil in Patients with Hypertension: An Analysis

using Spline Functions

L. Aarons, C. Baxter and S. Gupta

DM27, an Enaminone, Modifies the In Vitro Transport of Antiviral Therapeutic Agents

N. N. Salama, K. R. Scott and N. D. Eddington

ISSUE 6 SEPTEMBER 2004

ORIGINAL PAPERS

Acetylation Phenotype Status in a Bangladeshi Population and its Comparison with that of Other

Asian Population Data

R. B. Zaid, M. Nargis, S. Neelotpol, J. M. A. Hannan, S. Islam, R. Akhter, L. Ali and A. K. Azad Khan

Identification of Human UDP-Glucuronosyltransferase Enzyme(s) Responsible for the

Glucuronidation of 3-Hydroxydesloratadine

A. Ghosal, Y. Yuan, N. Hapangama, A. Duen (Iris) Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, J. E. Patrick and S. Zbaida

Absorption, Distribution, Metabolism and Excretion of YM466, a Novel Factor Xa Inhibitor, in Rats

Y. Mano, T. Sonoda, E. Nakamura, T. Usui and H. Kamimura

Pharmacokinetics and Dose Proportionality of Extended-Release Metformin following

Administration of 1000, 1500, 2000 and 2500 mg in Healthy Volunteers

E. Cullen, J. Liao, P. Lukacsko, R. Niecestro and L. Friedhoft

The Plasma Pharmacokinetics and Cerebral Spinal Fluid Penetration of Intravenous Topiramate in

Newborn Pigs

J. L. Galinkin, C. D. Kurth, H. Shi, M. A. Priestley, A. W. Loepke and P. C. Adamson

Pharmacokinetics of Clarithromycin in Rats with Acute Renal Failure Induced by Uranyl Nitrate

A. K. Lee, J. H. Lee, J. W. Kwon, W. B. Kim, S. G. Kim, S. H. Kim and M. G. Lee

ISSUE 7 OCTOBER 2004

ORIGINAL PAPERS

Interactions of Tamoxifen, N-Desmethyltamoxifen and 4-Hydroxytamoxifen with P-Glycoprotein

and CYP3A

D. J. Greenblatt, L. L. von Moltke, J. L. Weemhoff, M. D. Perloff and T. S. Bekaii-Saab

A Multiple-Dose, Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Study of Oral

Recombinant Human Interleukin-11 (Oprelvekin)

M. M. Cotreau, L. Stonis, A. Strahs and U. S. Schwertschlag

VOLUME CONTENTS

Characterisation of Early Plasma Concentrations of Midazolam in Pigs after Administration by an

Autoinjector

A. Levy, M. Kushnir, S. Chapman, R. Brandeis, Z. Teitelbaum and E. Gilat

Pharmacokinetics and Safety of Oral Almotriptan in Healthy Male Volunteers

|. McEwen, M. Salva, J. M. Jansat and X. Cabarrocas

Pharmacokinetics and Splenic Accumulation of N-Acetylamino-3-Chloro-N-(2-Diethylamino-Ethy])

Benzamide after a Single Administration to Rats

J. Hua, Y. Sheng, M. Olin, R. Pero and K. Edvardsen

Intravenous Pharmacokinetics, Oral Bioavailability and Dose Proportionality of Ragaglitazar, a

Novel PPAR-dual Activator in Rats

N. R. Srinivas, N. V. S. Rao Mamidi, R. Mullangi, M. Rao Chaluvadi and K. Jagannath

ISSUE 8 NOVEMBER 2004

ORIGINAL PAPERS

Pharmacokinetics, Metabolism and Excretion of Intravenous ['*C]-Palonosetron in Healthy Human

Volunteers

+ t? Par A yah nd A \N ) Stoitz, S. Parisi Shah and A. Macciocchi

Effects of B-estradiol and Propofol on the 4-Methylumbelliferone Glucuronidation in Recombinant

Human UGT Isozymes 1A1, 1A8 and 1A9

Mano and H. Kamimura

Bioavailability of Divalproex Extended-Release Formulation Relative to the Divalproex

Delayed-Release Formulation

S. Dutta and Y. Zhang

SHORT COMMUNICATION

Comparison of the Bioavailability of 250 and 500 mg Divalproex Sodium Extended-Release

Tablets in Healthy Volunteers

S. Dutta, Y. Zhang, L. L. Lee and R. O'Dea

ORIGINAL PAPER

Cetirizine from Topical Phosphatidylcholine Liposomes: Evaluation of Peripheral Antihistaminic

Activity and Systemic Absorption in a Rabbit Model

4. A.W. I X. Gu, F. E. R. Simons and K. J. Simon 1K ions

SSUE < DECEMBER 2004

ORIGINAL PAPERS

Bioequivalence Evaluation of Two Brands of Amoxicillin/Clavulanic Acid 250/125 mg

Combination Tablets in Healthy Human Volunteers: Use of Replicate Design Approach 4 A |} 4 cies J NIai; A \ l Idkaidek, Ahmad Al-Ghazawi and Naji M. Najib

The Utility of Mixed-Effects Covariate Analysis in Rapid Selection of Doses in Pediatric Subjects:

A Case Study with Fexofenadine Hydrochloride

h Krishna, Sriram Krishnaswami, Barbara Kittner, Abdul J. Sankoh and Bradford K. Jensen

Erythropoietin Production Rate in Phlebotomy-Induced Acute Anemia

t 1. Al-Hunit ‘ Vidness, R. L. Schmidt and P. Veng-Pedersen

Author Index

Keyword Index .

Volume Contents