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OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY AND THE JAPANESE SOCIETY OF DRUG DELIVERY SYSTEM VOLUME 161, ISSUE 3, 10 AUGUST 2012 ISSN: 0168-3659 COVER STORY Extravascular transport of nanoparticles in solid tumors

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Vol. 161, Issue 3 JOURNAL OF CONTROLLED RELEASE 10 AUGUST 2012

CONTENTS

Cited in: BIOSIS/Biological Abstracts; CAB Abstracts; Chemical Abstracts Services; Current Contents (Life Sciences); EMBASE/Excerpta Medica; International Pharmaceutical Abstracts; PUBMED/MEDLINE/Index Medicus; Polymer Contents; Science Citation Index. Also covered in the abstract and citation database SciVerse Scopus®. Full text available in SciVerse ScienceDirect ®

Available online at www.sciencedirect.com

Cover StoryExtravascular transport of nanoparticles in solid tumors

K. Park (West Lafayette, Indiana, U.S.A.; Seoul, Korea) 967

ReviewsModeling the oral cavity: In vitro and in vivo evaluations of buccal drug delivery systems

V.F. Patel, F. Liu and M.B. Brown (Hatfield, Surrey, UK) 746Recent advances in nanocarrier-based mucosal delivery of biomolecules

O. Kammona and C. Kiparissides (Thessaloniki, Greece) 781

Research PapersMagnetic Active Agent Release System (MAARS): Evaluation of a new way for a reproducible, externally controlled drug release

into the small intestineC.T. Dietzel, H. Richert, S. Abert, U. Merkel, M. Hippius and A. Stallmach (Jena, Bamberg, Germany) 722

Site-specific targeting of antibody activity in vivo mediated by disease-associated proteasesO. Erster, J.M. Thomas, J. Hamzah, A.M. Jabaiah, J.A. Getz, T.D. Schoep, S.S. Hall, E. Ruoslahti and P.S. Daugherty (Santa Barbara,CA, USA) 804

Ultrafast and fast bioerodible electrospun fiber mats for topical delivery of a hydrophilic peptideL.K. Macri, L. Sheihet, A.J. Singer, J. Kohn and R.A.F. Clark (Stony Brook, NY, Piscataway, NJ, USA) 813

Defeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: A proof ofmechanism for trypanosomatid chemotherapyJ.R. Luque-Ortega, B.G. de la Torre, V. Hornillos, J.-M. Bart, C. Rueda, M. Navarro, F. Amat-Guerri, A.U. Acuña, D. Andreu and L. Rivas(Madrid, Barcelona, Armilla, Spain) 835

Injectable system for spatio-temporally controlled delivery of hypoxia-induced angiogenic signallingE. Hadjipanayi, U. Cheema, U. Hopfner, A. Bauer, H.G. Machens and A.F. Schilling (Munich, Germany; London, UK) 852

Formulations based on alpha cyclodextrin and soybean oil: an approach to modulate the oral release of lipophilicdrugsM.C. Hamoudi, F. Bourasset, V. Domergue-Dupont, C. Gueutin, V. Nicolas, E. Fattal and A. Bochot (Châtenay-Malabry, France) 861

Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymerhybrid nanoparticlesF. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R.J. Christie, K. Osada, N. Nishiyama and K. Kataoka(Tokyo, Japan) 868

Electrospun drug-eluting sutures for local anesthesiaC.B. Weldon, J.H. Tsui, S.A. Shankarappa, V.T. Nguyen, M. Ma, D.G. Anderson and D.S. Kohane (Boston, Cambridge,Massachusetts, USA) 903

Stent elution rate determines drug deposition and receptor-mediated effectsA.R. Tzafriri, A. Groothuis, G.S. Price and E.R. Edelman (Lexington, Cambridge, Boston, MA, Fremont, CA, USA) 918

Poly-ε-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development, characterization and invitro evaluation of their antitumoral efficacyD. Hernán Pérez de la Ossa, A. Ligresti, M.E. Gil-Alegre, M.R. Aberturas, J. Molpeceres, V. Di Marzo and A.I. Torres Suárez (Madrid, Spain;Pozzuoli, Italy) 927

The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in thetransdermal delivery of insulinS. Liu, M.-n. Jin, Y.-s. Quan, F. Kamiyama, H. Katsumi, T. Sakane and A. Yamamoto (Kyoto, Japan) 933

Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivorelease of the hydrophilic anti-epilepsy drug ethosuximideM.-H. Hsiao, M. Larsson, A. Larsson, H. Evenbratt, Y.-Y. Chen, Y.-Y. Chen and D.-M. Liu (Hsinchu City, Taipei, Taiwan, ROC; Gothenburg,Sweden; LA, CA, USA) 942

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OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETYAND THE JAPANESE SOCIETY OF DRUG DELIVERY SYSTEM

VOLUME 161, ISSUE 3, 10 AUGUST 2012 ISSN: 0168-3659

COVER STORYExtravascular transport of nanoparticles in solid tumors

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(Contents continued at inside back cover)