corneal edema after cataract surgery - malek al kott
TRANSCRIPT
![Page 1: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/1.jpg)
Presented by
Malek Mohammad Al-Kott
M.B. B.Ch.
Al-azhar UniversityAssiut, Egypt
2013
![Page 2: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/2.jpg)
Cornea consists of 5 layers
![Page 3: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/3.jpg)
CORNEATransparent and avascular
Refractive power: 40-45 diopters
Thick ness: 0.52mm at its center,
0.66mm at the periphery
![Page 4: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/4.jpg)
The epithelium1-Superficial cells microvilli
2-Suprabasilar cells Winglike
3-Basal cells mitosis
![Page 5: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/5.jpg)
2- Bowman’s layerA condensation of superficial stroma
![Page 6: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/6.jpg)
3- The stroma:90% of corneal thickness (200 to 250 lamellae of collagen fibers) Collagen fibres type I mainly + proteoglycan matrix +keratocytes
![Page 7: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/7.jpg)
4- Descmet’s membraneCollagen fibres typeVI + laminin
![Page 8: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/8.jpg)
5-The endotheliumsingle layer
polygonal cells apical microvilli + thin layer of mucinous material
Density at birth 3500 to 4000 cell/mm2
Can not replicate but sliding and rearrangement of neighboring cells (polymegathism and pleomorphism)
Average cell loss 0.3% to 0.6% per year
Numerous mitochondria highly metabolically active.
Numerous endoplasmic reticulum, Golgi apparatus
protein synthesis
![Page 9: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/9.jpg)
The endothelium(NORMAL)
![Page 10: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/10.jpg)
Polymegathism and Pleomorphism
![Page 11: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/11.jpg)
1-Endothelium barrier functionTight junctions allow small molecules to pass
prevent bulk flow of fluid
![Page 12: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/12.jpg)
2- Endothelium pump functionControls ion movement osmotic gradient draws water from the stroma.
Pumps:-
-Na+/K+-ATPase
-bicarbonate-dependent Mg2+-ATPase
-aquaporins or water-selective channels
![Page 13: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/13.jpg)
Endothelium pump function
![Page 14: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/14.jpg)
Corneal edema
![Page 15: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/15.jpg)
Corneal edemaDefinition: Cornea that is more hydrated than its normal physiologic state of 78% water
Critical density of endothelial cells (400 to 700 cells/mm2)
Pump function can maintain stromal hydration in the normal range of 78 percent without significant effort BECASE OF:-
![Page 16: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/16.jpg)
1-Anionic repulsive forcesNegatively charged proteoglycans electrostatic repulsive forces = expansive force swelling pressure (SP). around +55 mmHg
Stroma has cohesive and tensile stiffness (elasticity) that resists expansion
IF stroma is compressed (high IOP or mechanical applanation) SP will increase
IF the stroma is expanded(corneal edema) SP will decrease
![Page 17: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/17.jpg)
2-Cationic attractive forcesNegatively charged GAG side-chains attracts and binds Na+ cations absorption of water imbibition pressure (-40 mmHg)
3-Barrier functionAllow Low flow so pumps can maintain stromal hydration in the normal range of 78 percent without significant effort.
![Page 18: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/18.jpg)
In vivo IP is less than SP becauseHydrostatic pressure induced by (IOP) must now be
accounted, so:-
IP = IOP – SP
SO, clinical appearance of corneal edema depends on:
Loss of corneal barrier function.
An IOP ≥ 55 mmHg.
A combination of the two.
![Page 19: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/19.jpg)
![Page 20: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/20.jpg)
If ≥83% stromal hydration1. Increase thickness
2. Loss of transparency
3. Decreased vision
4. Glare
5. Sub-epithelial bullae and degenerative pannus in severe chronic cases of epithelial edema
6. Stromal edema + Descemet's membrane foldsAnterior-posteriorly not circumferentially
Mostly in the posterior 2/3 maintains the anterior corneal curvature (depth-related differences in lamellar interweaving)
![Page 21: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/21.jpg)
Sub-epithelial bullae
![Page 22: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/22.jpg)
Descemet's membrane folds
![Page 23: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/23.jpg)
Preoperative predisposing factorsCorneal endothelium in vivo has minimal proliferative capacityAny cause that decreases cell density and morfology, predisposes for corneal edema after cataract surgery
![Page 24: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/24.jpg)
Preoperative predisposing factors1. Age. (old age)
Chronic ultraviolet light exposure DNA damage
Decreased antioxidant enzymatic activity
![Page 25: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/25.jpg)
2. Sex. (females)
3. Diabetes. (10 years)
4. Long-term contact lens use. (Partially reversible)
5. History of ocular infection, trauma, previous ocular surgery.
6. Glucoma
Endothelial cell loss of 30-77% in acute angle-closure attacks
![Page 26: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/26.jpg)
7-Fuchs’ corneal endothelial dystrophy(FED)
Bilateral, slowly progressive, primary disorder of the corneal endothelium that causes corneal edema and eventually painful blindness.
Cataract surgery accelerates corneal endothelial cell loss in patients with FED.
![Page 27: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/27.jpg)
Fuchs’ corneal endothelial dystrophy(FED)
![Page 28: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/28.jpg)
Intraoperative causes
1- Instrument contact or lens contact Greatest in the superior part of the cornea (maximal manipulation)Vertical disparity in endothelial cell density
A-Mechanical injury
![Page 29: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/29.jpg)
Instrument contact or lens contact
![Page 30: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/30.jpg)
2- Ultrasound energy1. Directly phacoing the corneal endothelium
2. Free radicals
Ultrasound oscillations acoustic cavitations thermal dissociation of water hydrogen atoms +(hydroxyl radicals) highly reactive lethal injuries to endothelial cells
3. Temperature
![Page 31: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/31.jpg)
3-TemperatureCentral corneal temperature 30.7°C to 35.0°C
Heat generation by the phaco tip increase aqueous temperature and cause wound burn
An endothelial cell loss of up to 10% occurs after an increase in aqueous temperature from 29.1°C to 33.4°C
Internal and external flow of irrigation-aspiration fluid prevent endothelial damage and wound burn.
![Page 32: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/32.jpg)
Wound burn
![Page 33: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/33.jpg)
4. Nuclear fragments hitting the endothelium.
Brunescence effect on endothelial cell loss has been noted as the most significant risk factor for endothelial injury
5. Air bubblesAir fluid level along the endothelium interact with the
thin layer of mucin on apical surface of EC
6. Vitrocorneal touch.
7. Detachment of the Descemet’s membrane.Stripping of the membrane by instruments
Fluid injection without the cannula tip fully inside AC
![Page 34: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/34.jpg)
Detachment of the Descemet’s membrane
![Page 35: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/35.jpg)
8-Corneal folding and anterior chamber collapse
![Page 36: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/36.jpg)
B. Chemical Injury
1- Antiseptic solutions (Povidone iodine) Residuals from sterilization enter thtough surgical
incision
2- AnestheticsTopical
Epithelial keratitis , corneal edema(1/1000 patient)
If injected intracameral irreversible corneal edema
IntracameralBupivacaine in some studies induced endothelial damage and
increased corneal thickness
![Page 37: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/37.jpg)
3-Preservatives (Benzalkonium chloride)Highest safe intraocular concentration is 0.001
0.05% BAC irreversible endothelial necrosis.
0.01% BAC reversible corneal edema
4-Irrigating solutions1-Normal saline and lactated Ringer’s solution edema
2-BSS Prolonged infusion studies have demonstrated increased endothelial injury.
3-BSS PLUS most safe (maintains endothelial cell function over periods ranging from 15 minutes to few hours)
![Page 38: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/38.jpg)
Ringer’sBSS PlusAqueousComponent
130.0122.2163.0Sodium chloride
5.55.82.2–3.9Potassium chloride
21.051.8Calcium chloride
__0.981.10Magnesium chloride
____2.6-4.3Sodium lactate
____0.12Sodium citrate
__3.00.62Disodium phosphate
__25.020.2Sodium bicarbonate
__5.112.7-3.7Dextrose
__0.30.0019Glutathione
6.257.407.38PH
280305304Osmolarity
Composition of human aqueous, Ringer’s solution and BSS Plus (concentrations in mMol/L fluid).
![Page 39: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/39.jpg)
5-StainsMethylene blue 1% not safe
Indocyanine green safe for 3 minutes
Trypan blue most safe
6-Detergent residues (subtilisin,alpha
amylase enzymes )Deactivated at temperature exceeding 140C
Most autoclaves reach only 120C to 130C
![Page 40: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/40.jpg)
Postoperative causes1-Raised intraocular pressure and glaucoma
Narrow angle
glaucoma
Open angle
glaucomaMalignant glaucoma
•Transient and related to
retained viscoelastic
•Topical steroids in
susceptible individuals
•Retained lens matter
•Postoperative hyphaema
•Alpha-chymotrysin in ICCE
•Pupillaryblock•more in:- AC IOL
- Aphakia
wound leak
shallow AC
![Page 41: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/41.jpg)
2-IOL syndromes
A-Direct endothelial touch
Strong adhesive force of methacrylate IOL.
(coat with a hydrophilic material)
B-Long-term toxicity
More in Closed loop AC IOLs ±cystoid macular edema
Less than 1% with PC IOL
Prostaglandins!!
![Page 42: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/42.jpg)
3-Any prolonged endothelial contact with other ocular tissues
-Flat chamber-Iris bombe-Suprachoroidal effusion/hemorrhage
4-Epithelial Downgrowth•Epithelial cells are introduced into the anterior chamber during surgery begin to proliferate as a cellular membrane
![Page 43: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/43.jpg)
Epithelial Downgrowth
![Page 44: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/44.jpg)
5-Retained lens nuclear fragment •Anterior to the iris Proinflammatory•Posterior to the iris noninflammatory
![Page 45: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/45.jpg)
6-Brown-McLean SyndromeDefenition :
Peripheral corneal edema which involves the epithelium and the stroma that commences inferiorly and progresses circumferentially
Cause :
A- Subclinical endothelial dystrophy decompensated by the microtrauma
B- Genetic predisposition
May be totally asymptomatic
![Page 46: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/46.jpg)
Brown-McLean Syndrome
![Page 47: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/47.jpg)
7-Toxic anterior segment syndrome (TASS)Toxic solutions intraocular inflammation + corneal edema
Sterile, noninfectious endophthalmitis.
Toxic Endothelial Cell Destruction Syndrome (TECDS)
Presentation mimic endophthalmitis:
Pain
Photophobia
Severe reduction in visual acuity
Marked AC reaction
Within 12-24 hours of cataract surgery (endophthalmitistypically develops 2-7 days )
Limbus-to-Iimbus corneal edema
![Page 48: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/48.jpg)
Limbus-to-Iimbus corneal edema
![Page 49: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/49.jpg)
Examination and evaluation techniques(1)Assesment of corneal endothelium.
1. Slit lamp.
2. Specular microscopy.
3. Confocal microscopy.
4. HRT-II with Rostock cornea module..
(2)Assessment of the Central Corneal Thickness1. Ultrasound.
2. Optical pachymetry.
3. Specular microscopy.
4. Scanning slit based (orbscan).
5. Optical coherence tomography and optical low-coherence reflectometry.
6. Confocal microscopy through-focusing.
7. Laser Doppler interferometry.
![Page 50: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/50.jpg)
1-Slit lamp1-Diffuse broad- beam illumination
For general inspection
2-Specular reflection
3-Retroillumination
4-Sclerotic scatter
![Page 51: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/51.jpg)
Specular reflection
![Page 52: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/52.jpg)
Retroillumination
![Page 53: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/53.jpg)
2-Specular microscopyDetects:1-Number of endothelial cells per square millimeter 2-Percentage of normal cellsBut:1- Cornea must be transparent.2-Does not permit three dimensional optical sectioning of the corneaEvaluation A-Qualitative analysisB-Quantitative analysis
![Page 54: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/54.jpg)
Konan NonCon RoboImaging of endothelium is fully automatic
![Page 55: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/55.jpg)
A-Qualitative analysis(morphology)
![Page 56: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/56.jpg)
B- Quantitative analysis
Using:1-Fixed-frame analysis
2-Variable-frame analysis
3-Comparison cell analysis (cells mosaic is compared to a cell pattern of known size)
Detect:1-Cell density 2-Mean cell area3-Pleomorphism
![Page 57: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/57.jpg)
1-Fixed-frame analysisCells lying completely within a given area
2-Variable-frame analysisBorders of an entire group of cells are outlined with the aid of a computer
![Page 58: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/58.jpg)
C- Confocal microscopyProvides quantitative data of endothelial cells even in edematous hazy cornea
1-Tandem scanning confocal microscopes (TSCM)
2-Slit scanning confocal microscopes (SSCM)
![Page 59: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/59.jpg)
Confocal microscopy
![Page 60: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/60.jpg)
D-HRT-II with Rostock cornea module
Rostock Cornea Module
High-quality microscope lens positioned between the eye and
the HRT-II providing a laser focus less than 1 ml in
diameter Moveing the confocal image plane inside the cornea permits rapid and reliable visualization and evaluation of all the microstructures in the cornea, including the endothelium.
![Page 61: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/61.jpg)
HRT-II with Rostock cornea module
![Page 62: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/62.jpg)
2)Assessment of the Central Corneal Thickness (Pachymetry)
1-UltrasoundDry contact technique
Underestimates corneal thickness in edematous corneas
![Page 63: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/63.jpg)
Normal cornea :1-Smooth, curved, specular reflection from tear film-epithelial interface2- 2nd Reflective line (Bowman's membrane).3- Stroma has a uniform, low reflectivity.4-Highly reflective interface between Descemet'smembrane/endothelium and the aqueous
3
4
![Page 64: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/64.jpg)
Edematous cornea 1-The epithelium is thickened, and the smooth, highly
reflective surface line replaced by a more irregular, less reflective line
2- Higher reflectivity of the corneal stroma.
3- Increased corneal thickness
W
![Page 65: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/65.jpg)
2-Optical pachymetrySlit- lamp mounted device
Observer-dependent technique
![Page 66: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/66.jpg)
3-Specular microscopyRecording the adjustment required in the focal plane of the specular microscope
Overestimates the thickness
4-Scanning slit based (orbscan),Pentacam
• Noncontact technique• Underestimates corneal thickness in edematous corneas
![Page 67: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/67.jpg)
The occulus Pentacam
![Page 68: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/68.jpg)
5-Optical coherence tomography (OCT) and Optical Low-Coherence reflectometry
Based on optical interferometry
OLCT Can perform measurements during corneal ablation
OLCT
![Page 69: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/69.jpg)
Visante optical coherence tomography (OCT)
Slit-lamp OCT
![Page 70: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/70.jpg)
6-Confocal microscopy through-focusing (CMTF)
Through-focusing confocal microscope
7- Laser Doppler interferometry
•Non contact •dual-beam infrared laser
![Page 71: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/71.jpg)
Prevention and TreatmentPrevention1-Avoid the causes
2-Use of ophthalmic viscoelastic devices(OVD)
3-Use tortional phacoemulsification
4-Triple procedure in FED
Treatment1-Eliminate the cause.
2-Enhance surface dehydration.
3-Treat pain.
4-Restore anatomy.
![Page 72: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/72.jpg)
2-Use of ophthalmic viscoelastic devices(OVD)1-Dispersive
lower molecular weight and shorter molecular chains
2-Cohesive
longer chains ,easier to remove from the anterior chamber.
*Ideal OVD:
1-Maintain space
2-Protect the corneal endothelium
3-Remain in the eye during surgery
4-Easy to remove at the conclusion
of surgery
![Page 73: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/73.jpg)
Comparing Healon 5, Healon GV, Ocu-Coat, Celoftaland Viscoat Healon 5 allowed the least mean endothelial cell loss
Soft-shell technique
Inject dispersive viscoelastic (e.g. Viscoat) adjacent to the endothelium then expand the AC below using cohesive viscoelastic, thus spreading dispersive agent against endothelium.)
![Page 74: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/74.jpg)
3-Tortional phacoemulsificationAdvantages in decreasing post operative corneal
edema :
1-Less repulsion tip is kept in an occluded state decreases turbulence
2-Intraoperative fluid use with this technology appeared to be less than with conventional ultrasound
3-Temperature control
4- Reduced time
5- Torsional phacoemulsification is cataract-density independent
![Page 75: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/75.jpg)
4-Triple procedure in FED(cataract surgery and IOL implantation combined with
keratoplasty)
If there is evidence of corneal epithelial edema at the time of cataract removal:
Triple procedureshould be considered for visual rehabilitation
If preoperative pachymetry > 640 :
Triple procedure can be considered but not necessarily performed
![Page 76: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/76.jpg)
Treatment1-Eliminate the cause
1-Re-attach Descemet’s membraneSmall detachment resolve spontaneously
Alternatively use :
Viscoelastic
Bubble of air
Long acting gas
Tissue fibrinogen glue
Sutures
Penetrating keratoplasty (if failed re-attachment)
![Page 77: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/77.jpg)
Sutureing
![Page 78: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/78.jpg)
2-Lower the intraocular pressure
Pressure on the posterior lip of a preexisting paracentesis
Topical and/or systemic pressure-lowering agents
3-Retained nuclear fragmentsSurgical removal
4- IOL exchange.Closed loop by open loop
5- Treat Toxic anterior segment syndromeBrief course of systemic corticosteroid
6- Treat inflammationStrong topical steroids
![Page 79: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/79.jpg)
2-Enhance surface dehydration
Trade Name (Manufacturer) Composition
Adsorbonac
Solution,
2% and 5%
(Alcon)
NaCl, povidone and other
water-soluble polymer,
thiomerosal 0.0004%, EDTA 0.1%
Muro-128
Solution,
2% and 5%
(Bausch & Lomb)
NaCl, hydroxypropylethylcellulose,
methylparaben, propylparaben,
boric acid
Muro-128
Ointment, 5%(Bausch & Lomb)
NaCl, anhydrous lanolin,
mineral oil, white petrolatum
AK-NaCl 5%
Ointment(Akorn)
NaCl, anhydrous lanolin,
mineral oil, white petrolatum
Sochlor, 5%
solution , ointment(OCuSoft) NaCl
Glycerin (Glycerol)
Ophthalgan
(compounded
product)Anhydrous glycerin
Topical Hyperosmotic Preparations
![Page 80: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/80.jpg)
Topical Hyperosmotic Preparations
![Page 81: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/81.jpg)
3-Treat pain(epithelial bullae)A-Hydrophilic contact lenses.
Extended-wear
Shields the abnormal epithelium
B-Anterior stromal cautery
To Bowman’s layer
Salleras procedure scars excellent pain relief
C-Anterior stromal puncture
Improve epithelial adhesion
D-Amniotic membrane transplantation
E-Conjunctival flap transplantation
Thin ,thick
![Page 82: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/82.jpg)
Anterior stromal puncture Conjunctival flap transplantation
![Page 83: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/83.jpg)
F-Excimer laser phototherapeutic keratectomy(PTK)
G- UV–riboflavin therapySymptomatically effective in the short term (up to 8 months)
![Page 84: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/84.jpg)
4-Restore the anatomy1. Penetrating keratoplasty(PK)
2. Deep lamellar endothelial keratoplasty (DLEK)
3. Descemet-stripping endothelial keratoplasty (DSEK).
4. Descement membrane endothelial keratoplasty (DMEK)
5. Descemet-stripping automated endothelial keratoplasty(DSAEK)
![Page 85: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/85.jpg)
1-Penetrating keratoplasty(PK)
Standard of care for the treatment of corneal edema resulting from pseudophakic bullous keratopathy
Entire corneal thickness is replaced, regardless of the layer that is diseased
![Page 86: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/86.jpg)
2-Deep lamellar endothelial keratoplasty (DLEK)
lamellar dissection
![Page 87: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/87.jpg)
3-Descemet's stripping with endothelial keratoplasty (DSEK)
scraping
![Page 88: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/88.jpg)
D-Descemet's membrane endothelial keratoplasty (DMEK)
ROLLDescematorhexis
![Page 89: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/89.jpg)
4-Descemet-stripping automated endothelial keratoplasty (DSAEK)
All patients must be pseudophakic with a posterior chamber IOL
![Page 90: Corneal edema after cataract surgery - MALEK AL KOTT](https://reader033.vdocuments.net/reader033/viewer/2022042518/55a19cf41a28ab1b4e8b45f9/html5/thumbnails/90.jpg)