corrosives- strong basescorrosives – strong bases chemical class standard operating procedure rev....

Corrosives–StrongBasesChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

Corrosives-StrongBasesH290H314H315H316H318H319H320

ThisSOPisnotasubstituteforhands-ontraining.PrintacopyandinsertintoyourlaboratorySOPbinder.

Department: Chemistry

DateSOPwaswritten: Thursday,March23,2017

DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017

PrincipalInvestigator:Name:F.Fischer

Signature:_____________________________

InternalLabSafetyCoordinatororLabManager:

Name:StephenvonKugelgen

LabPhone:510.301.1058

OfficePhone:510.642.8252

EmergencyContact:

Name:StephenvonKugelgen

PhoneNumber:510.301.1058

Location(s)coveredbythisSOP: TanHall674,675,676,679,680,683,684

1.PurposeThisSOPcoverstheprecautionsandsafehandlingproceduresfortheuseofCorrosives–StrongBases.ForalistofCorrosives-StrongBasescoveredbythisSOPandtheiruse(s),seethe“ListofChemicals”.ProceduresdescribedinSection12applytoallmaterialscoveredinthisSOP.Achangetothe“ListofChemicals”doesnotconstituteachangeintheSOPrequiringrevieworretraining.Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.

2.Physical&ChemicalProperties/DefinitionofChemicalGroupAstrongbaseisonethatcompletelyionizes(dissociates)inaqueoussolution.(SeeAppendixforacompletelistofStrongBases.)


Rev.Date:2017-03-28

3.PotentialHazards/Toxicity

Strongbasesareveryhazardousincaseofskincontact,eyecontact,ingestion,and/orinhalation.Strongbasesarecorrosivetoeyesandskin.Eyecontactcanresultincornealdamageorblindness.Skincontactcanproduceinflammationandblistering.Inhalationofdustwillproduceirritationtogastro-intestinalorrespiratorytract,characterizedbyburning,sneezingandcoughing.Inflammationoftheeyeischaracterizedbyredness,watering,anditching.Skininflammationischaracterizedbyitching,scaling,reddeningor,occasionally,blistering.

TheGloballyHarmonizedSystemofClassificationandLabelingofChemicals(GHS)designatescorrosivesbyoneormoreofthefollowingHcodes:

H290MaybecorrosivetometalsH314CausessevereskinburnsandeyedamageH315CausesskinirritationH316CausesmildskinirritationH318CausesseriouseyedamageH319CausesseriouseyeirritationH320Causeseyeirritation

StrongBasesmayalsohaveotherhazardouspropertiesinadditiontocorrosivity.Safeuserequiresassessingallpotentialhazards.ItisthePrincipal Investigator’s responsibility toensureactivity-specific laboratoryproceduresand/orprocessesaretakenintoaccountwhenusingthisChemicalClassSOP.Please,reviewtheSDSofanychemicalbeforeuse(seeSection11–SDSLocation)

4.EngineeringControlsUsetheengineeringcontrolslistedbelowunlessotherlab-specificinformationisincludedinSection12-Protocol/Procedure.

• WorkwithCorrosives–StrongBasesmustbeconductedinafumehoodunlessothercontrolsaredesignatedinthelab-specificProtocol/Proceduresection.Sashheightmustbekeptaslowaspossibletoavoidescapingfumesandprovideaphysicalbarrier.

• Laboratoriesandroomswherestrongbasesareusedmusthavegeneralroomventilationthatisnegativepressurewithrespecttothecorridorsandexternalenvironment.Thelaboratory/roomdoormustbekeptclosedatalltimes.

5.PersonalProtectiveEquipment

Ataminimum,thefollowingPPEmustbewornatalltimes.EyeandFaceProtection

A. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.

• Ordinary prescription glasses will NOT provide adequate protection unless they alsomeetANSIstandardandhavecompliantsideshields.

B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.


Rev.Date:2017-03-28

SkinandBodyProtection

A. Glovesarerequiredwhenhandlinghazardouschemicals.• RefertospecificchemicalSDSforinformationongloveselection.• Foradditionalinformationongloveselection,goto:

http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.htmlB. Labcoatsarerequiredwhenhandlinghazardouschemicalsinthelab.Selectthetypeoflabcoat

accordingtothehazardsatthespecificworkplace.C. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.

RespiratoryProtection

RespiratoryprotectionisnormallynotrequiredforUCBerkeleylaboratoryactivities.Anylabpersonnelconsideringtheuseofarespirator(e.g.N-95respirator,dustmask)mustcontactEH&Sforaworkplaceassessment.

6.FirstAidProceduresandMedicalEmergenciesIntheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.

GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or

Call911(fromacellphone:510-642-3333)if:

• itisalifethreateningemergency;or

• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or

• thecontaminated/injuredpersonisnotbreathingorisunconscious.

Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.

IncaseofskincontactImmediatelydrenchinthesafetyshowerwithcopiousamountsofwaterfornolessthan15minutestoremoveanyremainingcontaminants;removeanyjewelryorclothingasnecessarytofacilitateclearingofanyresidualmaterials.Washoffwithsoapandplentyofwaterfor15minutes.IncaseofeyecontactRinsethoroughlywithplentyofwaterusinganeyewashstationforatleast15minutes,occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.IfswallowedDoNOTinducevomitingunlessdirectedotherwisebytheSDS.Nevergiveanythingbymouthtoanunconsciousperson.Rinsemouthwithwater.IfinhaledMoveintofreshair.Needlestick/punctureexposureWashtheaffectedareawithantisepticsoapandwarmwaterfor15minutes.


Rev.Date:2017-03-28

7.SpecialHandling,Storage,andDisposalRequirementsLab-specificinformationonhandlingandstoragemaybeincludedintheProtocol/Proceduresection.

PrecautionsforSafeHandling

• Donotallowwatertogetintothecontainersbecauseofpotentiallyviolentreactions.Donotgetineyes,onskin,oronclothing.

• Whenmixingwithwater,alwaysaddbasesslowlytothewaterandstircontinuously.Neveraddwatertobase.

• Eliminateorsubstituteforalesshazardousmaterialwhenpossible.• Designyourexperimenttousetheleastamountofmaterialpossibletoachievethedesired

result.• DonotexceedthescaleofproceduresspecifiedinProtocol/Proceduresectionwithoutapproval

ofthePI.• Verifyyourexperimentalset-upandprocedurepriortouse.• Knowthelocationofthenearesteyewash,safetyshowerandfireextinguisherbeforebeginning

work.• Uponleavingtheworkarea,removeanypersonalprotectiveequipmentwornandwashhands.• Attheendofeachproject,thoroughlydecontaminatetheworkareaaccordingtothematerial

beinghandled.

ConditionsforSafeStorage

• Storeinacool,dry,well-ventilatedareaawayfromincompatiblesubstances.• Liquidstrongbasesmustbestoredinisolationfromallotherchemicalsinanapprovedbaseor

corrosivessafetycabinet.Ifnocorrosivecabinetavailable,usesecondarycontainertostorebases.

Disposal

● Wastematerialsgeneratedmustbetreatedasahazardouswaste.● TheemptycontainermustberinsedthreetimeswithaCOMPATIBLEsolvent;leaveitopen

inthebackofthehoodovernight.Solventrinsesandwaterrinsemustbedisposedofashazardouswaste.

● Asanalternative,unrinsedemptycontainerscanbedisposedofthroughEH&Sashazardouswaste.Theunrinsedemptycontainersmustbecapped.

● Donotmixwithincompatiblewastestreams.● Decontaminationoftheemptycontainerinordertouseitforotherpurposesisnot

permitted.

8.ChemicalSpillSpill–Assesstheextentofdanger;ifnecessaryrequesthelpbycalling911(fromacellphone:510-642-3333)foremergencyassistanceor510-642-3073fornon-lifethreateningsituations.Ifyoucannotassesstheconditionsoftheenvironmentwellenoughtobesureofyourownsafety,donotenterthearea.Ifpossiblehelpcontaminatedorinjuredpersons.Evacuatethespillarea.Avoidbreathingvaporsfromspill.Ifpossible,confinethespilltoasmallareausingaspillkitorabsorbentmaterial.Keepothersfromenteringcontaminatedarea(e.g.,usecautiontape,barriers,etc.).


Rev.Date:2017-03-28

• MinorSpill–Intheeventofaminorspill,ifthereisnopotentialforhazardouschemicalexposure,reportthespillto510-642-3073andifyouaretrained,proceedtocleanit.Useappropriatepersonalprotectiveequipmentandclean-upmaterialforchemicalspilled.Doublebagspillwasteinclearplasticbags,labelandrequestpick-up.

• MajorSpill–Anyhazardouschemicalspillthatinvolveschemicalexposure,anychemicalspillthatduetosizeand/orhazardrequirescapabilitiesbeyondyourtraining,oranychemicalspillthatgivestheperception(becauseofodor,forexample)thattherehasbeenahazardousrelease.Call911or510-642-3073forassistance.

9.CleaningandDecontaminationLab-specificinformationondecontaminationmaybeincludedinSection12-Protocol/Procedure.

• WearingproperPPE,laboratoryworksurfacesmustbecleanedattheconclusionofeachprocedureandattheendofeachworkday.

• Decontaminateallequipmentbeforeremovingfromadesignatedarea.

10.HazardousWasteDisposalLabelWaste

• Labelallwastecontainers.SeetheEH&SFactSheet,“HazardousWasteManagement”forgeneralinstructionsonproceduresfordisposingofhazardouswaste.

DisposeofWaste

• Disposeofregularlygeneratedchemicalwastewithin6months.

• ContactEH&Sat642-3073ifyouneedassistance.

11.SafetyDataSheet(SDS)LocationSDScanbeaccessedonlineathttp://ucsds.com


Rev.Date:2017-03-28


Rev.Date:2017-03-28

12.Protocol/Procedure–Corrosives–StrongBasesProcedure/Use Scale Engineering

Controls/EquipmentPPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions

1.Preparationofdilutesolutions(typically1-10M)startingwitha50%NaOHliquid.

Upto200mlconcentratedsodiumhydroxideassuppliedinthereagentbottleperdilution.Upto2Lofdilutesolution.RemembertoobtainPIapprovalifhigherscaleisnecessary.

Allreactionsusingthesematerialsmustbeperformedinaproperlyoperatingfumehoodwiththesashaslowaspossible.

Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat,fulllengthpantsorequivalent;andclose-toedclosedheeledshoes.Wearabaseresistantapronwhenhandlingthechemicalassuppliedinthereagentbottleorwhenthereisthepotentialforsplashing.

Eliminateincompatiblematerialsfromthepotentialspillarea.Concentratedsodiumhydroxidesolutionscancausesevereburnstotheeyes,skin,andmucousmembranes.Handlewithgreatcare.Determinetheamountofbaseandwaterrequiredforthedilution.Inspecttheglasswarepriortousetomakesureitisfreefromanycracks,scratchesorchipsthatwouldindicateaweaknessintheglass.Besuretouseborosilicateglass.Transferthebasetoabeakerforeasierhandling.Alwaysaddbaseslowlytothebulkwatercomponent.Donotaddthewatertothebase.Stirthesodiumhydroxide,alittleatatime,intoalargevolumeofwaterandthendilutethesolutiontomakeoneliter.Thedilutionofsodiumhydroxideisexothermic.Immersethecontainerinabucketoficetokeeptheheatdown.Setthemixingvesselinanicebath.Addalmostallthewaterrequiredforthedilutiontothevessel.Cooltheresultingsolutionanddilutetothefinalvolume.Transfertoaplasticstoragecontainer.Donotuseglass.Strongbasesetchglass.Rinseglasswareofresidueimmediately.Disposeofrinseasdescribedbelow.ChemicalDisposal


Rev.Date:2017-03-28

NeutralizesolutionswithdiluteHClanddraindisposewithexcesswater.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.Procedure/Use Scale Engineering


2.Preparationof1–5Msolutionsofstrongbaseusingpellets.

Upto100gramsofstrongbasepelletsassuppliedinthereagentbottle(e.g.,KOH,Ca(OH)2orLiOH.RemembertoobtainPIapprovalifhigherscaleisnecessary.


Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat,fulllengthpantsorequivalent;andclose-toedclosedheeledshoes.

Eliminateincompatiblematerialsfromthepotentialspillarea.Handlesolidpelletscarefullytopreventexposuretoskin.Slowlyaddthestrongbasepelletstowater;neverthereverse.Provideadequatecoolingcapacity(e.gicebath)whenpreparingconcentratedsolutionsofstrongbaseasthepelletsreactexothermicallywithwater.Disposeofanywasteintheproperchemicalwastecontainer.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.


Rev.Date:2017-03-28

Procedure/Use Scale Engineering


3.Usingalkalihydroxidesasreagentsinachemicalreaction.

Upto100gofalkalihydroxideassuppliedinthereagentbottle.RemembertoobtainPIapprovalifhigherscaleisnecessary.


Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat,fulllengthpantsorequivalent;andclose-toedclosedheeledshoes.

Measureoutthedesiredquantityofhydroxidebytransferringthewhitesolidtoatarredplasticweighboatpositionedonabalanceusingametalspatula.Addthehydroxideslowlytothedesiredreactionvesselinafumehood.Slowadditionavoidsthegenerationofexcessheat.Diluteanyhydroxidethatwasspilledduringtheaboveprocesseswithcopiousamountsofwaterandusepapertowelstosoakuptheresultingsolution.Disposeofanypapertowelsinachemicallycontaminatedwastecontainer.AllowthesolutiontocoolofffromheatofmixingAddwater/solventtocompletethefinalvolumerequiredPlaceastopperorlidsecurelyontheflaskandinvertseveraltimestothoroughlymix.



Rev.Date:2017-03-28

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Controls/EquipmentPPE(eye,face,gloves,clothing) ProcedureStepsandSpecialPrecautionsfor

thisProcedure4.Useofdilutehydroxidesolutionstoquenchacidicmediaand/ortowashorganicsolutionstoremoveexcessacid.

Upto2litersofdilutehydroxidesolutionperquenchorwash.RemembertoobtainPIapprovalifhigherscaleisnecessary.


Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat,fulllengthpantsorequivalent;andclose-toedclosedheeledshoes.Wearabaseresistantapronwhenthereisthepotentialforsplashing.

Eliminateincompatiblematerialsfromthepotentialspillarea.Whenquenchingorwashingproceduresemployaseparatoryfunnel,cautionmustbeexercisedsuchthatpressurebuild-upinthefunnelissafelyvented.Ventseparatoryfunneloften.Aimfunnelspoutbeforeandduringventtowardbackofhood.



Rev.Date:2017-03-28

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5.Useofconcentratedpotassiumhydroxidesolutionsforcleaningglassware(basebath).

Upto1kgofpotassiumhydroxideassuppliedinthereagentbottle.RemembertoobtainPIapprovalifhigherscaleisnecessary.

Secondarycontainmentforthebasebathmustbeusedatalltimes,andthebasebathshallbeusedinawell-ventilatedarea.

Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Wearlong-cuffheavyweightrubbergloveswhenworkingwithbasebathsolution.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat,fulllengthpantsorequivalent;andclose-toedclosedheeledshoes.Wearabaseresistantapronwhenthereisthepotentialforsplashing.

Eliminateincompatiblematerialsfromthepotentialspillarea.Makesureanyreactiveresiduesareremovedfromglasswarebeforeadditiontothebasebath.Whenpreparingthebasebath,addthepotassiumhydroxideslowlyandcarefully.



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13.DocumentationofTraining(signatureofallusersisrequired)

• PriortoconductinganyworkwithCorrosives–StrongBases,designatedpersonnelmustprovidetrainingtohis/herlaboratorypersonnelspecifictothehazardsinvolvedinworkingwiththissubstance,workareadecontamination,andemergencyprocedures.

• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPandacopyoftherelevantSDSsprovidedbythemanufacturer(s).

IhavereadandunderstandthecontentofthisSOP:Name Signature Identifier Date


Rev.Date:2017-03-28

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ListofChemicals

Chemical(s) Chemical(s) Chemical(s)Calciumhydroxide Cesiumhydroxide LithiumhydroxidePotassiumhydroxide Rubidiumhydroxide SodiumhydroxideStrontiumhydroxide

corrosives- strong basescorrosives – strong bases chemical class standard operating procedure rev....

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