cortico-cerebellar pathways for ......cortico-cerebellar pathways for understanding language...
TRANSCRIPT
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CORTICO-CEREBELLAR PATHWAYS FOR UNDERSTANDING LANGUAGE COORDINATION
MagdaL.Dumitru,LaurensVanCalster,MarionBouffier,SteveMajerusUniversityofLiège
Cognitiveprocessingactivatestheposteriorlobesofthecerebellum,correspondingtocontralateralareasofthecerebrum.
BACKGROUND
CONCLUSIONSRATIONALE&MATERIALS
Buckner,R.L.,Krienen,F.M.,Castellanos,A.,Diaz,J.C.,&Yeo,B.T.T.(2011).Theorganizationofthehumancerebellumestimatedbyintrinsicfunctionalconnectivity.J.Neurophysiol106,2322-2345;Diedrichsen,J.(2015).Cerebellartoolbox(SUIT).Availablefrom:http://www.icn.ucl.ac.uk/motorcontrol/imaging/suit.htm;Dumitru,M.L.,&Joergensen,G.H.(2016).Gestaltreasoningwithconjunctionsanddisjunctions.PLoSONE11(3):e0151774; Eickhoffetal.(2005).AnewSPMToolboxforcombiningprobabilisticcytoarchitectonicmapsandfunctionalimagingdata.Neuroimage25,(4):1325-1335;Penny,W.,Friston,K.,Ashburner,J.,Kiebel,S.,&Nichols,T.(2006).StatisticalParametricMapping:TheAnalysisofFunctionalBrain.1st Edition,AcademicPress;Stoodley,C.J.,&Schmahmann,J.D.(2010).Functionaltopographyinthehumancerebellum:ameta—analysisofneuroimagingstudies.Neuroimage,44,489-501;Schrouff,J.,Rosa,M.J.,Rondina,J.M.,Marquand,M.F.,Chu,C.,Ashburner,J.,etal.(2013).PRoNTo:PatternRecognitionforNeuroimagingToolbox.Neuroinformatics,11,319–337- https://github.com/CyclotronResearchCentre/PRoNTo_SearchLight;Turner,B.O.,Marinsek,N.,Ryhal,E.,&Miller,M.B.(2012).Hemisphericlateralisationinreasoning.Ann.N.Y.Acad.Sci,1359,47-64 25th MeetingoftheCognitiveNeuroscienceSociety,24-27March2018,BostonMA
Volunteers:22right-handedadultsScanner:3TSiemensMagnetomPrisma
Whole-BrainSearchlight
Wepredictedcomplementarycerebrallateralisationandcontralateralcerebellaractivation.
UnivariateAnalysis
AND>ORL.I.- 0.493
OR>ANDL.I.+0.362
Therightcerebellumismorerelevanttolinguisticprocessing;theleftcerebellumismoreconcernedwithspatialinformation.
Therightcerebralhemispheremanagesconflictsbyassessing,rejecting,orrefiningexplanationswhenfacedwithnewevidence.Theleftcerebralhemispherebuildscoherencebydrawinginferencesorcreatingexplanationsatthecostofignoringevidenceorclashingexplanations.
RestingStateNetw
orksWeinvestigatedtheroleofcortico-cerebellarpathwaysinunderstandingthediscourseconnectivesAND &OR.
ANDactivatestherightcerebralandtheleftcerebellarhemispheres.
MVP
Amod
elANDvs.O
R
Seed
-based
ana
lysis
ORactivatestheleftcerebralandtherightcerebellarhemispheres.
Neuralpatternsrevealedbywhole-brainsearchlightanalysissuggestrapidrecruitmentofspatialreasoningcorticalareasuponhearingthetwoconnectives.
TheconnectiveANDevokesasingleGestaltbyaccumulatingandmerginginformation.TheconnectiveORevokestwoGestalts.