COVER STORIES

Hoffman, R.M. Three-dimensional histoculture: origins and applications in cancer research. Cancer Cells 3, 86-92, 1991.

Hoffman, R.M. Visualization of GFP-expressing tumors and metastasis in vivo. BioTechniques 30, 1016-1026, 2001.

Bouvet, M., et al. Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model. Cancer Res. 62, 1534-1540, 2002.

Hoffman, R.M. Green fluorescent protein imaging of tumor cells in mice. Lab Animal 31, 34-41, 2002 .

Hoffman, R.M. GFP-Expressing Metastatic-Cancer Mouse Models. In: Tumor Models in Cancer Research, pp. 99-112. Teicher, B., ed. Totowa, NJ: Humana Press Inc., 2002.

Hoffman, R.M. Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Lancet Oncology 3, 546-556, 2002.

Schmitt, C.A., et al. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1, 289-298, 2002.

John, C.M., et al. Truncated Galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin. Cancer Res. 9, 2374-2383, 2003.

Yamauchi, K., et al. Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res. 65, 4246-4252, 2005.

Jiang, P., et al. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle 5, 1198-1201, 2006.

Hayashi, K., et al. Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma. J. Surg. Res. 140, 165-170, 2007.

Amoh, Y., et al. Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle 7, 1865-1869, 2008.

Zajac, L. Glowing proteins with promising biological and medical applications. Chem Matters 12-14, 2008 (December).

Sakuma, S., et al. In vitro/in vivo biorecognition of lectin-immobil-ized fluorescent nano-spheres for human colorectal cancer cells. J Controlled Release 134, 2-10, 2009.

Hayashi, K., et al. Systemic targeting of primary bone tumor and lung met-astasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle 8, 870-875, 2009.

Gros, S.J., et al. Complementary use of fluorescence and magnetic resonance imaging of metastatic esophageal cancer in a novel orthotopic mouse model. Intl J Cancer 126, 2671-2681, 2010.

Tran Cao, H.S., et al. Metronomic gemcitabine in combination with Sunitinib inhibits multisite meta-stasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Therap 9, 2068-2078, 2010.

Kimura, H., et al. UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo. J. Cell. Biochem 110, 1439-1446, 2010.

Logan-Collins, J., et al. Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res. 70, 1130-1140, 2010.

Soda, Y., et al. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc. Natl. Acad. Sci. USA 108, 4274-4280, 2011.

Tran Cao, H.S., et al. Submillimeter-resolution fluorescence laparoscopy of pancreatic cancer in an orthotopic mouse model visualizes metastases not seen with standard laparoscopy. J. Laparoendosc. Adv. Surg. Tech. A 21, 485-489, 2011.

Hassanein, M.K., et al. Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. J. Cell. Biochem. 112, 3549-3554, 2011.

Amoh, Y., et al. In vivo imaging of nuclear-cytoplasmic deformation and partition during cancer cell death due to immune rejection. J. Cell. Biochem. 113, 465-472, 2012.

Hoffman, R.M., editor. In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols. Methods in Molecular Biology, Vol. 872. Walker, John M., series ed. Humana Press (Springer Science+ Business Media New York), 2012.

Hoffman, R.M. Fluorescent angiogenesis models using Gelfoam® implanted in transgenic mice expressing fluorescent proteins. Cerebral Angiogenesis: Methods and Protocols. Methods in Molecular Biology, Richard Milner, ed., Vol. 1135, pp. 213-222. Springer: 2014.

Hiroshima, Y., et al. Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX). J. Cell. Biochem. 115, 1254-1261, 2014

Maawy, A., et al. Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer. J. Biomed. Optics 19, 101504, 2014.

Hoffman, R.M. Transgenic nude mice ubiquitously-expressing fluorescent proteins for color-coded imaging of the tumor microenvironment. Mouse Genetics: Methods and Protocols. Methods in Molecular Biology, Shree Ram Singh, ed., Vol. 1194, Springer: 2014.

Matsumoto, Y., et al. Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian Cancer. J. Cell. Biochem. 115, 1996-2003, 2014.

Yashiro, M., et al. From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells. Cell Cycle 14, 2362-2366, 2015.