creating the university of the highlands and islands department of diabetes & cardiovascular...
TRANSCRIPT
Creating the University of the Highlands and Islands
Free Radical Research Facility
Department of Diabetes &
Cardiovascular Science
HI STOPHI STOPHiHighland ghland SSchoolschools DiabeDiabetteses
PreventiPreventioonn PProgrammerogramme
Sandra MacRuryDept of Diabetes & Cardiovascular Science
UHI Millennium InstituteInverness
Free Radical Research Facility
“Diabetes is the greatest health challenge facing
the UK today”
Diabetes UK 2007
Free Radical Research Facility
Diabetes epidemic
Free Radical Research Facility
Pancreas
Brain
Liver
Stomach
Intestines
Pancreas
INSULIN
ISLET
Cell
Free Radical Research Facility
Types of Diabetes
• Type 1 15%
• Type 2 85%
World Health Organisation 2005
Free Radical Research Facility
Type 1 Diabetes
• Destruction of insulin producing cells
( cells in pancreas)
• Children, young people up to 35-40 years
• Late onset Type 1 > 40 years
• 10-15% occurs in families
• Treated with insulin
Free Radical Research Facility
What is diabetes
• The body cannot effectively use the insulin it produces • Middle aged or older 40+ years• Young onset type 2 < 35 years• 40% occurs in families• Treated with diet, tablets and sometimes insulin
World Health Organisation 2006
Free Radical Research Facility
Type 2 diabetes
• WeightWeight• Family Family history history • Age Age • EthnicityEthnicity
Free Radical Research Facility
Type 2 diabetes
• WeightWeight• WaistWaist circumferencecircumference• Family Family history history • Age Age • EthnicityEthnicity
+
Free Radical Research Facility
What Diabetes Epidemic?
Free Radical Research Facility
BMI
Free Radical Research Facility
T2DM and weight
0
2
4
6
8
10
12
14
18.5 or under 18.5 to 25 25 to 30 30 to 40 Over 40
BMI (kg/m2)
Pre
vale
nce
of
Typ
e 2
dia
be
tes
(%)
MaleFemale
Body Mass Index BMIWeight/height
Kg/m2
Free Radical Research Facility
Vascular problems in diabetes
75%
LIFE EXPECTANCY
SHORTENED
7-8 YEARS
IN T2DM
Free Radical Research Facility
Free Radical Research Facility
Progression of Type 2 diabetes
Adapted from Bailey. Br J Cardiol 2000; 7: 350–360DeFronzo & Ferrannini. Diabetes Care 1991; 14: 173–194
Insulin resistance
Blood glucose
Insulin production
Normal Pre diabetes Type 2 diabetes
Diagnosis
Free Radical Research Facility
What can we do?
Free Radical Research Facility
Watch what you eat
Free Radical Research Facility
Get active!