ctsi-funded pilot programs: function, operation and outcomes susan autry, university of southern...
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CTSI-Funded Pilot Programs:Function, Operation and Outcomes
Susan Autry, University of Southern CaliforniaMike Conlon, University of Florida
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Pilot Program Goals
Investments to help meet overall CTSI goals:
• $s to help start new research ideas or advance to next step
• Young investigator investment• RFPs to foster specific outcomes/behaviors
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USC RFP categories, eligibility, size
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UCSF Pilot Funding RFPs• Pilot Research Award for Junior Investigators• Pilot Research Awards for Junior Investigators Utilizing CTSI Clinical Research
Services (CTSI-CRS)• General Pilot Award Program in HIV/AIDS• Pilot Research Awards in Research Policy• Mobile Health Research• Novel Clinical/Translational Methods Catalyst Awards• New Direction Awards• Post Childbearing Professional Development Leave• Shared Instrument Awards• Multi-center Start-Up Planning Awards• Multidisciplinary Research Project Planning Award• Under-represented Faculty in Clinical and Translational Research Awards
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Openly Developed Proposals
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UF RFP categories, eligibility, sizeCategory Eligibility Maximum Award
Trainee Degree seeking MS, MPH, MD, PhD w/ mentor
$7,500
Jr. Investigator Tenure track w/ mentor $20,000
Novel Methods and Technologies
All faculty and mentored trainees $25,000
Major Initiative(discontinued)
$100,000
Applications must demonstrate alignment with CTSI strategic goals
For 2012, the UF RFP emphasized use of the CTSI core laboratories and/or collaboration with the CTSI Communications Research Program
Previous RFPs have emphasized the data warehouse and community engagement
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Application Preparation
• Publicity of the opportunities• Timeline• Letters of Intent [do you use them and how]• Proposal length and format• Review criteria• Limit number of proposals by one investigator
in a cycle or RFP?• Mentor notification required?
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Review Committees
• Review process – transparency critical– Triage to committee– In person discussion vs asynchronous review
• Composition of committees• Managing COI• Scoring – process and how used• Funding decisions – not by score alone• Feedback to investigator
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Award Requirements
• Notification – pre-award letter– Award letter – lays out requirements
• Required documents– IRB / IACUC approvals etc
• Budget restrictions– Faculty salary– subawards
• Budget period• Carry over
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Post Award Management
• Who is responsible• How is project progress tracked– Financial vs progress/outcome
• Frequency• Metrics• ROI
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Pilot Program Management
• Funds available per year• Number of cycles per year• Staffing to manage– FTE and types
• Review committees– Number and composition– Staffing support
• Involvement/coordination with other intramural funding programs
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IT systems used
• Integrated/comprehensive or by function:• Proposal Submission• Triage to committee chairs• Submitting scores and comments• Feedback to investigators
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Impact of the Pilot Program
• Short term and long term– Varies with type of RFP
• Investigators viewpoint• Research programs created• Collaborations created• Presentations and papers• External funding
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Challenges• Developing well articulated RFPs that enable
you to meet goals• Trainees and junior investigators• Avoiding conflict of interests in reviews• Budget periods/ carry over• Changing the culture
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UCSF Pilot Funding Program (2007-10)
• Invested $1 million annually• 608 applications submitted, 118 awarded funding • Awards have resulted in 89 presentations, 50 publications• 77 submissions for extramural funding resulting in $7.02
million in new funding. • Web-based application and review process was so
efficient, other major campus pilot-funding agencies engaged with CTSI to create the UCSF Research Allocation Program (RAP) and now provides about $3.4M in annual pilot funds.
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USC Pilot Funding ROI
• 90 Presentations• 30 publications
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Florida Pilot Program Examples
• Program has funded 31 of 89 proposals over 3 years for a total of $906K.
• A 2009 pilot award of $50K for ethanol monitoring to Dr. Sara Jo Nixon led to a $1.8M grant to a team including Dr. Nixon.
• A 2010 pilot award of $20K to Dr. Michael Weiss established a 7 hospital consortium for brain cooling of neonates with Hypoxic Ischemic encephalopathy (HIE) that has treated 40 infants, prevented life-long disability for 5 and reduced care costs by $12M