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Curriculum Vita STEVEN ALLAN SOPER

MAILING ADDRESS:

Department of Biomedical Engineering 11855 Villa Creek Ave. University of North Carolina, Chapel Hill Baton Rouge, LA 70810 Chapel Hill, NC (225) 757-8384 225-578-1527 225-578-3458 (FAX) Internet: [email protected]

GROUP WEB SITE: http://chemistry.lsu.edu/chem/facultypages/soper/soper.html

EDUCATION: Los Alamos National Laboratory, Los Alamos, NM, 10/89 - 9/91, postdoctoral

fellow under the direction of Dr. Richard A. Keller The University of Kansas, Lawrence, KS, 9/85-9/89, Ph.D., Bioanalytical

Chemistry, Dr. Theodore Kuwana, research advisor University of Nebraska at Omaha, Omaha, NE, 9/80 - 5/82, B.A., Chemistry University of Nebraska at Omaha, Omaha NE, 9/75 - 5/80, B.S., Psychology

PROFESSIONAL EXPERIENCE:

University of North Carolina, Chapel Hill, Professor, Dept. of Biomedical Engineering, Chapel Hill, NC, 2011 – Present

University of North Carolina, Chapel Hill, Professor, Dept. of Chemistry, Chapel Hill, NC, 2011 – Present

World Class University Professor, Ulsan National Institute of Science & Technology, Ulsan, South Korea, 2009-2012

Visiting Scientist, University of North Carolina, Chapel Hill (Sabbatical Leave), Fall, 2008

Director, Center for BioModular Multi-Scale Systems, Spring, 2004 – Present Louisiana State University, Baton Rouge, LA, Dept. of Mechanical Engineering,

9/2004 – 9/2011, Professor of Mechanical Engineering Louisiana State University, Baton Rouge, LA, Dept. of Chemistry, 9/2002 –

9/2011, William L. & Patricia Senn, Jr. Professor of Chemistry Louisiana State University, Baton Rouge, LA, Dept. of Biological Sciences,

9/2001 – 9/2011, Adjunct Faculty Louisiana State University, Baton Rouge, LA, Dept. of Chemistry, 9/2001 -

Present, Professor of Chemistry Visiting Scholar, Baylor College of Medicine (Sabbatical Leave), Fall, 1998 Louisiana State University, Baton Rouge, LA, Dept. of Chemistry, 9/97 – 8/2001, Associate Professor of Chemistry Louisiana State University, Baton Rouge, La, Dept. of Chemistry, 9/91 - 8/97,

Assistant Professor of Chemistry Science Advisor, Food and Drug Administration, Southeast Region, 10/92-9/97 Los Alamos National Laboratory, Los Alamos, NM, 10/89 - 9/91, Postdoctoral

fellow in Chemical and Laser Sciences division The University of Kansas, Lawrence, KS, 9/86 - 12/87, Teaching assistant,

advanced Analytical Chemistry The University of Kansas, Lawrence, KS, 9/85 - 5/86, Teaching assistant,

general Chemistry Colgate Palmolive Co. Kansas City, KS, 9/83 - 9/85, Analytical Chemist

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AWARDS & HONORS:

American Chemical Society; Advances in Chemical Instrumentation, 2011 Fellow, Society for Applied Spectroscopy, 2010 Fellow, Royal Society of Chemistry, 2010 Fellow, American Association for the Advancement of Science, 2010 Rainmakers – LSU Top 100 Researchers, Louisiana State University, 2009 Rainmakers – LSU Top 100 Researchers, Louisiana State University, 2008 Distinguished Research Master, Louisiana State University (Top Research

Award Offered by the University), May 2008 Society for Applied Spectroscopy Tour Speaker, 2007 A.A. Benedetti-Pichler International Microchemical Award, November, 2006 Distinguished Faculty Award, Louisiana State University, April, 2004 William L. & Patricia Senn, Jr. Professor of Chemistry, August 2002-present Society for Applied Spectroscopy Tour Speaker, 2002 Charles E. Coates Award for Outstanding Contributions to Chemical/Engineering

Research in Louisiana, 2001 Outstanding Untenured Researcher (Physical Sciences), Phi Kappa Phi,

Louisiana State University, 1996 Outstanding Researcher, College of Basic Sciences, Louisiana State University,

1995 Whitaker Foundation Award, Whitaker Bioengineering Research Foundation,

1995 Shannon Award, National Institutes of Health (National Human Genome

Research Institute), 1994 R & D 100 Award, Single Molecule Detection Device, 1992 National ACS Fellowship (sponsored by the Pittsburgh Conference), 1989 Higuchi Distinguished Doctoral Candidate Award, The University of Kansas,

1989 KU Graduate School Summer Fellowship, The University of Kansas, 1989 Phillips/McCollum Research Award, The University of Kansas, 1988 H.P. Cady Award, The University of Kansas, 1986 Bailey Fellowship, The University of Kansas, 1985

JOURNAL ADVISORY/EDITORIAL BOARD:

Journal of Fluorescence, 1996 – present Single Molecules, Advisory Board, 2000 – 2004 The Analyst, Advisory Board, 2000 - 2008 Analytical Chemistry, A-Page Advisory Board, 2003 – 2006 The Analyst, International Editorial Board, 2008 – 2009 The Analyst, Editor for the Americas, 2010 - present Journal of Micro- and Nanosystems, Advisory Board, 2008 - present

STUDY PANELS: National Institutes of Heatlh, Integrated Molecular Analysis Study Panel (NCI), November, 2011 National Institutes of Health, Bioanalytical Systems Study Panel, June, 2011, Chair National Institutes of Health, Integrated Systems Development Study Panel, January, 2011 National Institutes of Heatly, Integrated Systems Development Study Panel,

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June, 2011 National Institutes of Health, Integrated Systems Development Study Panel, October, 2009, Chair National Institutes of Health, Integrated Systems Development Study Panel, September, 2009 National Cancer Institute, NIH Review panel for IMAT Program, July, 2009 Life Sciences Discovery Fund Review Panel, AAAS, June, 2009 Chair, Center for Scientific Review, P41 Site visit panel, August, 2008 National Center for Research and Resources, Biomedical Instrumentation, June, 2008 Chair, Center for Scientific Review, NIH Panel for K99 Fellowships, October 2007 National Center for Research and Resources, Biomedical Instrumentation, June, 2007 National Institute of General Medicine, K99 Special Emphasis Panel, March 2007 Chair, NIBIB (National Institutes of Health) Special Emphasis Panel, November, 2006 Chair, NIBIB (National Institutes of Health) Quantum Projects, July, 2006 Chair, NCI (National Institutes of Health) Point-of-Care Technologies, March, 2006 Bioengineering and Science Technology (Instrumentation and Systems Development, ISD) Study Panel, National Institutes of Health, 2004 – 2006 (permanent member) Human Genome Panel, National Institutes of Health, 2003 - 2004 (permanent member) National Cancer Institute Special Study Section, National Institutes of Health, 7/00; 4/01; 7/01; 2/02 (ad hoc member) National Human Genome Study Section, National Institutes of Health, 6/95; 2/97 (ad hoc member) Metallobiochemistry Study Section, National Institutes of Health, 6/98; 6/99; 2/00 (ad hoc member) Human Genetics SBIR Special Panel, National Institutes of Health, 5/96; 7/97; 2/98; 7/99; 11/00; 12/00 (ad hoc member) Environmental Management Study Panel, Department of Energy, 8/96; 9/97 (Committee Chair) (special study section) Shared Instrumentation Study Section, National Science Foundation, 8/98 (ad hoc member) Shared Instrumentation Study Section (Human Genetics), National Institutes of Health, 10/98 (ad hoc member) Breast Cancer Special Program, Department of Defense (U.S. Army), 4/98 (ad hoc member)

PROFESSIONAL ACTIVITIES:

American Chemical Society, Analytical Division Society for Applied Spectroscopy American Association for the Advancement of Science Royal Society of Chemistry, RSC

RESEARCH INTERESTS:

Development of micro-/nanofabricated biochemical analysis systems for high

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throughput applications; novel fabrication methods for personalized medicine; single-molecule fluorescence spectroscopy; dye photophysics and photochemistry; bioanalytical applications of near-infrared fluorescence; development of novel detection schemes for DNA and protein analysis; ultra-high throughput screening for drug discovery.

NOTEWORTHY ACTIVITIES: Director, Center for BioModular Multi-Scale Systems (CBM2), 2003 – present, funded by the NSF ($14,800,000 for 2003 – 2010). The Center is a highly interdisciplinary unit composed of 17 research activity faculty situated in 4 different institutions within the State of Louisiana and collaborators at several renowned institutions (Cornell Medical College, Baylor College of Medicine and Sloan Kettering Memorial Cancer Institute). The Center has 3 major missions: (1) Build a nationally competitive Center of Excellence; (2) develop strong ties with the private sector through collaborative research and foster new start-up companies; and (3) maintain a highly engaging K-20 program to educate a new work force and to inform the general public on new scientific/engineering discoveries being made at LSU and how they are used in medicine.

The Center was recently invited to submit a full-proposal to the National Science Foundation as part of their Engineering Research Center (ERC) competition (PI for the grant is Prof. Soper). Of 165 pre-proposal submissions, CBM2 was one of 34 invited to submit a full proposal. The proposal would have provided $25.5M (direct costs) in funding including matches from the Board of Regents and LSU. The partners in this proposal were University of Texas, Arlington; University of Massachusetts, Lowell; University of Southern Mississippi; Northeastern University; Xavier University; and Cornell Medical College. Units on the LSU campus that are participating include Chemistry, Mechanical Engineering, Chemical Engineering, Physics, Stephenson Entrepreneurship Institute, Center for Advanced Microstructures and Devices and the Center for Computational Technology. The Center proposal was not selected for funding, but received highly encouraging reviews. It has been re-packaged for resubmission to the ERC program at NSF. Another pre-proposal was submitted in July, 2009.

Research Mission of CBM2. The program consists of 17 research activity faculty with approximately 107 graduate students and 34 post-doctoral associates. As a group, the Center’s faculty produces nearly 200 peer-reviewed publications per year and generates $45M in

Research and technology building operated by CBM2 for carrying out its various missions. The building is a 35,000 sq. ft. facility with laboratories, conference rooms and offices. The building is also used for various outreach activities.

CBM2 and CAMD service for the BioMEMS community by providing fabrication capabilities for both academia and the private sector using the tools and expertise available at LSU. Shown is the booth set up at the 2005 µTAS show at Boston, MA.

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extramural research per year. The research mission of the Center is, “Engage a diverse group of scientists, engineers and clinicians in the delivery of new technologies that will provide unprecedented capabilities for medicine, basic biology, drug discovery and homeland security.” To facilitate collaborative efforts between Center participants, a BioMEMS working group meeting was created by Prof. Soper, which meets once a month during the academic year.

Industrial Outreach Mission of CBM2. The Center has a full-time industrial liaison that has facilitated the generation of joint research opportunities with a variety of private sector companies, such as Agilent, Microsystems Biotechnology, Inc., Reliagene and Li-COR Biotechnology. In addition, a small company has emerged from the Center, BioFluidica Microtechnologies, which was founded by Prof. Soper and is populated with various associates serving as the company’s administrative branch and technical workforce.

Educational Mission of CBM2. The Center, through efforts of Prof. Soper, have developed a variety of outreach programs that service the K-12 community of students, such as C3 (Chemistry, Concepts and Connections – high school students and their teachers), and Girl Scout Summer Camps (now sponsored by Exxon). These programs service nearly 400 students per year of which 30% are from underrepresented groups. In addition, research experience for undergraduate programs have been spawned by the Center and professional development workshops for graduate students (writing and communication skills, functioning in an interdisciplinary research environment, interviewing skills and entrepreneurial skills). Recently, a Research Experience for Teachers (NSF-RET) has been successfully funded by the Center.

Chair – Gordon Research Conference on Bioanaltyical Sensors (2012). Bioanalytical sensors play an integral role in managing a number of diseases in terms of diagnosis, prognosis and selecting and tracking the efficacy of therapeutic regimens. Highly novel and unpublished research was presented and freely discussed at the 2012 Bioanalytical Sensors Gordon Research Conference and Gordon-Kenan Graduate Research Seminar cutting across a number of enabling technologies including materials, molecular recognition, micro-/nanosystems, optical/electrochemical transducers and the utility of biosensors for monitoring a host of diseases. Soper arranged the program and wrote several grants (NIH, NSF) to support this meeting.

Biosensors Workshop (Sponsored by the NIH). Prof. Soper chaired a NIH (National Cancer Institute) workshop focused on the use of biosensors for the management of cancer-related diseases. This workshop resulted in the formulation of a white paper that was used to spawn a program solicitation focused on the development of biosensors for the diagnosis/prognosis of cancer. The workshop had over 250 participants and was attended by program officers at the NCI and NIH.

Cluster Hire and Governor’s Biotechnology Initiatives. Authored two grant proposals focused on recruiting new faculty (9 total) into highly interdisciplinary research initiatives on the LSU campus. The Governor’s Biotechnology program resulted in two faculty lines, one in Chemistry and another in Mechanical Engineering (see list below). The Cluster Hire Initiative will produce 7 new faculty lines with a research focus in the area of the design, synthesis, characterization and applications of soft materials, in particular high performance, nano-scale polymeric materials.

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1. Governor’s Biotechnology Initiative a. Prof. Samuel D. Gilman, Department of Chemistry, Louisiana State University,

Electrokinetic flow manipulation using electric fields b. Prof. Sunggook Park, Department of Mechanical Engineering, Louisiana State

University, Nanoimprint Lithography for the fabrication of enabling tools in biology and medicine

2. Multidisciplinary Hiring Initiative (as of 9/15/08) a. Prof. Mark Jarrell, Department of Physics, Louisiana State University, Computational

simulations of highly correlated materials b. Four faculty are currently being recruited to LSU as part of this hiring initiative.

Bioengineering Research Partnership (BRP) Grant: PI on a grant project funded by the National Institutes of Health as part of their new BRP program. The effort was an interdisciplinary project between LSU, Cornell Medical College and Sloan Kettering Memorial Cancer Institute. The BRP grant was focused on developing enabling tools for mutation analysis and resulted in 55 peer-reviewed publications over a 6 year funding period. Participants included materials scientists, molecular biologists, clinicians, organic chemists, mechanical engineers and bioanalytical chemists.

Analytical Chemistry Cover: Composed an article in the premier journal of analytical chemistry, Analytical Chemistry (Anal. Chem. 72 (2000) 642A-651A). The article appeared in the A-page section of this journal and focused on polymer-based microfluidics.

University-wide professional development seminar series for graduate students. Prof. Soper developed a monthly seminar series directed for university-wide graduate students engaged in science and technology

research. The seminar series includes talks focused toward developing skills in technical writing, entrepreneurial endeavors, collaborative and interdisciplinary research, and professional networking.

The Analyst Cover: In January 2009, our research was highlighted on the cover of this journal (Analyst 134 (2009) 97-106). This work dealt with single molecule detection configured in a high throughput format with applications in such areas as drug discovery. This article was noted as the most downloaded article in the Analyst as of April, 2009.

Electrophoresis Cover: In December 2008, our work appearing in that issue was featured as the cover page. The work was entitled, “Generating High Peak Capacity 2-Dimensional Maps of Complex Proteomes Using Poly(methyl methacrylate) Microchip Electrophoresis. Electrophoresis 29 (2008) 4984 – 4992.

Journal of Mass Spectrometry Cover: For the April 2009 issue of this journal, Prof. Soper collaborated with Prof. Kermit Murray on interfacing MALDI-MS to microchip solid-phase bioreactors and this work was featured on the cover of this issue. The article was entitled, “Development of an Automated Digestion and Droplet Deposition Microfluidic Chip for MALDI-TOF MS.” J. Am. Soc. Mass Spectrosc. 19 (2008) 964-972.

Funding history in the Departments of Chemistry and Mechanical Engineering. Prof. Soper has been very productive in generating major funding for projects with collaborators across the university, but in particular the Department of Chemistry and the Department of Mechanical Engineering. Shown below is the total funding (granted) for Chemistry showing the impact that Prof. Soper and his colleagues have had on improving the visibility of this department. Soper has received funding from the private sector, state agencies and the federal government (NIH and NSF). His total funding revenues have exceeded $39M during his tenure at LSU.

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Graduate Student Education: Has produced 31 Ph.D. candidates (as of 08/31/11), with 3 students receiving national awards (Li Zhu, Pfizer Fellowship, UpJohn 1-year Fellowship; Annie Obuabafo, Pfizer Fellowship). Andre Adams was the organizer of the student symposium for the Gordon Conference on Biosensors). Also initiated a new program for providing entrepreneurial training to graduate students in conjunction with the Stephenson’s Entrepreneurial Institute.

Young Investigators Special Issue in The Analyst: Initiated a special issue in this journal that focuses on research presentations in the form of manuscripts by new faculty (<2 years of service

as a faculty member) in the area of analytical sciences. The inaugural issue appeared in 2001 and consisted of

contributions from 13 researchers across North America. This program has continued in this journal.

Analytical Biosensors Gordon Conference. Prof. Soper in 2008 was elected as the Vice-Chair for the 2010 Gordon Research Conference on Biosensors. In the 2012 meeting, he will serve as the Chair of this Gordon Research Conference.

Publications. Soper’s total publication number (as of 08/31/11) is 250, which includes journal articles, books, patents and conference proceedings. Soper’s h-index (as calculated by the Web of Science, which does not include engineering publications) is 40 with a total number of citations being 4,535 (h-slope = 1.91). Of the publications emanating since his academic appointment at LSU (1991), nearly 72% have multiple faculty authors indicating his extraordinary interdisciplinary efforts.

Founder – BioFluidica Microtechnologies (2009). Soper founded this company to commercialize devices for the selection of Circulating Tumor Cells (CTCs) from whole blood. This company has now formed a merger with Emerscent LLC to further commercialization opportunities and secure VC funding. The company has already received Phase I SBIR funding and is currently writing a Phase II application with the NCI.

Soper in a laser research laboratory with graduate students Suzanne Lassiter (Ph.D., 2001) and Musundi Wabuyele (Ph.D., 2003).

Soper presents Intellectual property information to students at a 2006 Student Symposium Series Workshop. Pictured with Soper is Mayor-President Kip Holden of Baton Rouge, who discussed with students at the Student Symposium Series Workshop the role of technology in community developmental efforts (July, 2006).

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REFEREED PUBLICATIONS: 1. Long Optical Path Length Thin Layer Cuvette Cells, Y. Gui, S.A. Soper and T. Kuwana,

Anal. Chem. 60 (1988) 1645-1648.

2. High Sensitivity Fluorescence Detection of NDA-Derivatized Primary Amines with a Low Power He-Cd Laser for HPLC, S.A. Soper, S.M. Lunte and T. Kuwana, Anal. Sci. 5 (1989) 23-29.

3. Matrix-Isolated Luminescence of Primary Amines Derivatized with Naphthalenedialdehyde, S.A. Soper and T. Kuwana, Appl. Spectrosc. 43 (1989) 883-886.

4. Matrix-Isolated Surface-Enhanced Raman Spectroscopy: The Role of the Supporting Matrix, S.A. Soper and T. Kuwana, Appl. Spectrosc. 43 (1989) 1180-1187.

5. Nonlinear Surface-Enhanced Spectroscopy of Silver Colloids and Pyridine: Hyper-Raman and Second-Harmonic Scattering, C.K. Johnson and S.A. Soper, J. Phys. Chem. 93 (1989) 7281-7285.

6. Thin Layer Chromatography Diskette Storage of High-Performance Liquid Chromatographic Effluents with Off-Line Laser-Induced Fluorescence Detection, G. Strojek, S.A. Soper, K. Ratzlaff and T. Kuwana, Anal. Sci. 6 (1990) 121-129.

7. The Intramolecular Loss of Fluorescence by Lysine Derivatized with Naphthalenedialdehyde, S.A. Soper, S. Chamberlin, C.K. Johnson and T. Kuwana, Appl. Spectrosc. 44 (1990) 858-863.

8. Surface-Enhanced Resonance Raman Spectroscopy of Liquid Chromatographic Analytes on Thin-Layer Chromatographic Plates, S.A. Soper, K.L. Ratzlaff and T. Kuwana, Anal. Chem. 62 (1990), 1438-1444.

9. Detection of Single Fluorescent Molecules, E.B. Shera, N.K. Seitzinger, L.M. Davis, R.A. Keller and S.A. Soper, Chem. Phys. Lett. 174 (1990) 553-557. **This article has been referenced 298 times as of 8/11.

10. Single Molecule Detection of R-6G in Ethanolic Solutions Utilizing CW Excitation, S.A. Soper, J.H. Hahn, H.L. Nutter, E.B. Shera, J.C. Martin, J.H. Jett and R.A. Keller, Anal. Chem. 63 (1991) 432-437

11. Laser-Induced Fluorescence Detection of Rhodamine 6G at 5 x 10-15 M, J.H. Hahn, S.A. Soper, H.L. Nutter, J.C. Martin, J.H. Jett and R.A. Keller, Appl. Spectrosc. 45 (1991) 743-746.

12. Rapid DNA Sequencing Based Upon Single Molecule Detection, E.R. Fairfield, J.H. Jett, R.A. Keller, J.H. Hahn, L.A. Krakowski, B.L. Marrone, J.C. Martin, R.L. Ratliff, E.B. Shera and S.A. Soper, Gen. Anal. 8 (1991) 1-7.

13. The Photophysical Constants of Several Visible Fluorescent Dyes and Their Effects on Ultrasensitive Fluorescence Detection, S.A. Soper, E.B. Shera, L.M. Davis, H.L. Nutter and R.A. Keller, Photochem. & Photobiol. 57 (1992) 972-977.

14. Detection and Identification of Single Molecules in Solution, S.A. Soper, L.M. Davis, E. B. Shera, J. Opt. Soc. Am. B 9 (1992) 1761-1769.

15. Photon Burst Detection of Single Near-Infrared Fluorescent Dye Molecules, S.A. Soper, Q.L. Mattingly and P. Vegunta, Anal. Chem. 65 (1993) 740-747. This article was featured in Chemical and Engineering News Research Highlights (1993). Number of citations on this article is 170 (since 8/11).

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16. Error Analysis of Simple Algorithms for Determining Fluorescence Lifetimes in Ultradilute Dye Solutions, S.A. Soper and B.L. Legendre, Jr., Appl. Spectrosc. 48 (1994) 400-405.

17. Steady-state and Picosecond Laser Studies of Nonradiative Pathways in Tricarbocyanine Dyes: Implications to the Design of Near-IR Fluorochromes with High Fluorescence Efficiencies, S.A. Soper and Q.L. Mattingly, J. Am. Chem. Soc. 116 (1994) 3744-3752.

18. Molecular Fluorescence, Phosphorescence and Chemiluminescence Spectrometry, S.A. Soper, L.B. McGowen and I.M. Warner, Anal. Chem. 66 (1994) 428R-444R.

19. Binary Solvent Effects in Capillary Electrophoresis with Ultrasensitive Near-IR Fluorescence Detection of Related Tricarbocyanine Dyes and Dye-Labeled Amino Acids, J.H. Flanagan, B.L. Legendre, Jr., R.P. Hammer and S.A. Soper, Anal. Chem. 67 (1994) 341-347.

20. Determination of Partition Coefficients and Photophysical Properties of Near-Infrared Fluorescent Dyes in Organized Media Using Single Molecule Monitoring, S.A. Soper, B.L. Legendre, Jr. and J. Huang, Chem. Phys. Lett. 237 (1995) 339-345.

21. Ultrasensitive Near-IR Fluorescence Detection for Capillary Gel Electrophoresis and DNA Sequencing Applications, D.C. Williams and S.A. Soper, Anal. Chem. 67 (1995) 3427-3432.

22. On-Line Fluorescence Lifetime Determinations During Capillary Electrophoresis, S.A. Soper, B.L. Legendre, Jr. and D.C. Williams, Anal. Chem. 67 (1995) 4358-4365.

23. Single Molecule Detection in the Near-IR: Applications in Chemistry and Biochemistry, S.A. Soper, B.L. Legendre and D.C. Williams, Exp. Techn. Phys. 41 (1995) 167-182.

24. Spectroscopic and Binding Properties of Tricarbocyanine Dyes Bound to Double-Stranded DNA, Y. Davidson, B. Gunn and S.A. Soper, Appl. Spectrosc. 50 (1996) 211-221.

25. Molecular Fluorescence, Phosphorescence and Chemiluminescence Spectroscopy, I.M. Warner, S.A. Soper and L.B. McGowen, Anal. Chem. 68 (1996) 73R-91R.

26. High Resolution Separation of Proteins Stained with Tricarbocyanine Dyes using Capillary Zone Electrophoresis with Ultrasensitive Near-IR Fluorescence Detection, B.L. Legendre, Jr. and S.A. Soper, Appl. Spectrosc. 50 (1996) 1196-1202.

27. An All-Solid State Near-IR Time-Correlated Single Photon Counting Instrument for Dynamic Lifetime Measurements in DNA Sequencing Applications, B.L. Legendre, Jr., D.C. Williams, R. Erdmann, U.Ortmann, J. Enderlein, S.A. Soper, Rev. Sci. Instr. 67 (1996) 3984-3989.

28. Near-Infrared, Laser-Induced Fluorescence Detection for DNA Sequencing Applications, S.A. Soper, B.L. Legendre, D.C. Williams and J. H. Flanagan, IEEE J. Sel. Top. Quant. Electr. 2 (1996) 1129-1139.

29. Analysis of DNA Restriction Fragments using Capillary Electrophoresis with Near-IR Laser-Induced Fluorescence Detection, C.V. Owens, Y.Y. Davidson, S. Kar, S.A. Soper Anal. Chem. 69 (1997) 1256-1261.

30. Ultrasensitive Detection in CE using Near-IR Fluorescence and Diode Laser Excitation, B.L. Legendre, D. Sately and S.A. Soper, J. Chromatogr. 779 (1997) 185-194.

31. Single-Molecule Detection in the Near-IR Using CW Diode Laser Excitation with an Avalanche Photon Detector, S.A. Soper and B.L. Legendre, Appl. Spectrosc. 52 (1998) 1-6.

32. Synthesis of Tricarbocyanine Near-IR Fluorescent Dyes for Labeling of Primary Amines, J.H. Flanagan, S.A. Soper and R.P. Hammer, Bioconj. Chem. 8 (1997) 751-756.

33. Piezoelectric Mechanical Pump with Nanoliter per Minute Pulse-Free Flow Delivery for Pressure Pumping in Micro-Channels, S. Kar, S. McWhorter, S. Ford and S. A. Soper,

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Analyst 123 (1998) 1435-1441.

34. Molecular Fluorescence, Phosphorescence and Chemiluminescence Spectrometry, S.A. Soper, I.M. Warner and L.B. McGowen, Anal. Chem. 70 (1998) 477R-494R.

35. Near-Infrared Heavy-Atom-Modified Fluorescent Dyes for Base-Calling in DNA-Sequencing Applications using Temporal Discrimination, J. Flanagan, C. Owens, S. Romero, E. Waddell, S. Khan, R. Hammer and S. A. Soper, Anal. Chem. 70 (1998) 2676-2684.

36. Microcapillary Electrophoresis Devices Fabricated using Polymeric Substrates and X-Ray Lithography, S. Ford, B. Kar, S. McWhorter, J. Davies, S. A. Soper, M. Klopf, G. Calderon and V. Saile, J. Microcol. Sep. 10 (1998) 413-422.

37. Sanger DNA Sequencing Reactions Performed in a Solid-Phase Nano-Reactor Directly Coupled to Capillary Gel Electrophoresis, D.C. Williams, B. Cheng and S.A. Soper, Anal. Chem. 70 (1998) 4036-4043.

38. A Fiber Optic-based Multichannel Time-Correlated Single Photon Counting Device with Sub-Nanosecond Time Resolution, E. Waddell, W. Stryjewski, S. A. Soper, Rev. Sci. Instr. 70 (1998) 32-37.

39. High-Aspect Ratio Micromachining in Polymethylmethacrylate (PMMA) using X-Ray Lithography for the Fabrication of Micro-Electrophoresis Devices, S.M. Ford, J. Davies, B. Kar, C.V. Owens, S.A. Soper, M. Klopf, G. Calderon and V. Saile, J. Biomech. Eng. 121 (1999) 13-21.

40. A Scanning Near-Infrared Time-Correlated Single Photon Counting Instrument with a Pulsed Diode Laser and Avalanche Photodiode, Y. Zhang, S. A. Soper, L. Middendorf, J. Wurm, R. Erdmann, M. Wahl, Appl. Spectrosc. 53 (1999) 497-504.

41. Nanoliter-Scale Sample Preparation Methods Directly Coupled to PMMA-Based Micro-Chips and Gel-Filled Capillaries for the Analysis of Oligonucleotides. S. A. Soper, S. M. Ford, Y. Xu, S. Qi, S. McWhorter, S. Lassiter and D. Patterson, J. Chromatogr. A 853 (1999) 107-120.

42. Pseudosymmetry with Z'=4 in 1,3-propanesultone at 100K. D.R. Billodeaux, C.V. Owens, C.M. Sayes, S.A. Soper and F.R. Fronczek, Acta Crystallographica 55 (1999) 2126-2129.

43. Conductivity Detection of PCR Products Separated by Open Tubular Liquid Chromatography. S. McWhorter, S. A. Soper, J. Chromatogr. 883 (2000) 1-9. This article was featured in Analytical Chemistry, vol. 72, 2000.

44. Time-Resolved Near-IR Fluorescence Detection in Capillary Electrophoresis. E. Waddell, S. Lassiter and S.A. Soper, J. Liq. Chrom. & Rel. Technol. 23 (2000) 1139-1158.

45. Micro-Capillary Reactors for Direct Sample Introduction into Slab Gels for Solid-Phase DNA Sequencing. Y. Xu and S.A. Soper, BioTechniques 28 (2000) 904-912.

46. Near-Infrared Fluorescence Detection in Capillary Electrophoresis. S. McWhorter and S.A. Soper, Electrophoresis 21 (2000) 1267-1280.

47. Microelectromechnical Systems (MEMS) Fabricated in Polymeric Materials: Applications in Chemistry and Life Sciences. S.A. Soper, S.M. Ford, S. Qi, R.L. McCarley, K. Kelly and M.C. Murphy, Anal. Chem. 72 (2000) 642A-651A. This article was featured on the cover of Analytical Chemistry, vol. 72, 2000.

48. Surface Modification of Plastics Used in the Fabrication of Microanalytical Devices, A.C. Henry, T.T. Tutt, C.S. McWhorter, Y.Y. Davidson, M. Galloway, S.A. Soper, R.L. McCarley, Anal. Chem. 72 (2000) 5331-5337. This article has been cited over 155 times (02/10).

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49. Time-Resolved Fluorescence Imaging of Slab Gels for Lifetime Base-Calling in DNA Sequencing Applications, S.J. Lassiter, W. Stryjewski, B.L. Legendre, R. Erdmann, M. Wahl, J. Wurm, R. Peterson, L. Middendorf, S.A. Soper, Anal. Chem. 72 (2000) 5373-5382.

50. High Resolution Near-IR Imaging of DNA Micro-arrays with Time-Resolved Acquisition of Fluorescence Lifetimes, E. Waddell, Y. Wang, W. Stryjewski, S. McWhorter, A. Henry, D. Evans, R. L. McCarley and S. A. Soper, Anal. Chem. 72 (2000) 5907-5917.

51. Foreword: Young Investigators, S.A. Soper, Analyst 126 (2001), U1. Guest Editor for this special issue focused on highlighting the research of new investigators in the analytical chemistry community. Yearly feature in this journal from 2001 to the present.

52. Immobilization of Restriction Enzymes on Porous Silica Particles via a Glutaraldehyde Linkage for the Micro-Digestion of dsDNAs with Analysis by Capillary Electrophoresis. Y.Y. Davidson, S.A. Soper, S. Margolis and L.C. Sander, J. Sep. Sci. 24 (2001) 10-16.

53. Interfacing a Polymer-based Micromachined Device to a Nanoelectrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometer, Z. Meng, S. Qi, S.A. Soper, P.A. Limbach, Anal. Chem. 73 (2001) 1286-1291.

54. PCR Amplification and Sequencing of Single Copy DNA Molecules, M. Wabuyele and S.A. Soper, Single Molecules 2 (2001) 13-21.

55. Heteroduplex Analysis of Mycobacterium Tuberculosis using High-Resolution Capillary Electrophoresis, G. Thomas, L. Spring, V. Williams, and S.A. Soper, Clin. Chem. 47 (2001) 1195-1203.

56. Single Molecule Analysis of dsDNA Molecules in Polymer Microfluidic Chips, M. Wabuyele and S.A. Soper, Electrophoresis 22 (2001) 3939-3948.

57. Immobilization of the restriction enzyme HaeIII and HindIII on Porous Silica Particles via a Glutaraldehyde Linkage for the Micro-Digestion of dsDNA with Analysis by Capillary Electrophoresis. Y.Y. Davidson, S.A. Soper, S. Margolis, and L.C. Sander, J. Sep. Sci. 24 (2001) 10-16.

58. Fabrication of Modular Microsystems for Analyzing K-ras Mutations Using LDR, S.A. Soper, M.C. Murphy, R.L. McCarley, D. Nikitopoulos, X. Liu, B. Vaidya, J. Barrow, Y. Bejat, S.M. Ford, J. Goettert, Micro Total Analysis Systems 2001, Kluwer Acad. Press (2001), pg. 459-461.

59. Chemical Foundations for Plastic-based Microdevices: Chemically Modified Poly(methylmethacrylate) and Poly(carbonate) Substrates used in the Fabrication of Microanalytical Devices, R.L. McCarley, A.C. Henry, A. Smith, B. Vaidya, M. Galloway, Y. Wang, S.A. Soper, Micro Total Analysis Systems 2001, Kluwer Acad. Press (2001), pg. 607-609.

60. Shedding Light on DNA Analysis: Multiplexed Detection and Identification using Fluorescence Lifetime Methods, S. J. Lassiter, W. J. Stryjewski, Y. Wang and S.A. Soper, PharmaGenomics, Jan/Feb (2002) 16-32.

61. Hot Embossing High-Aspect-Ratio Microstructures in Poly(methyl methacrylate) for Constructing Microfluidic Devices with Integrated Components, S. Qi, S. Ford, X. Liu, J. Barrows, G. Thomas, K. Kelly, A. McCandless, K. Lian, J. Goettert, S.A. Soper, Lab Chip 2 (2002) 88-95.

62. Contact Conductivity Detection in PMMA-Based Microfluidic Devices for the Transduction of Mono- and Polyionic Molecules, M. Galloway, W. Stryjewski, D. Patterson, A. Henry, R.L. McCarley and S.A. Soper, Anal. Chem. 74 (2002) 2407-2415.

63. Optimization of Sequencing Conditions for Time-Resolved Multiplexed Detection in DNA Sequencing Applications using Near-IR Fluorescence Detection. S. Lassiter and S.A. Soper, Electrophoresis 23 (2002) 1480-1489.

64. Multiplexed Detection and Identification of DNAs using Lifetime Methods. S. Lassiter and S.A. Soper, Spectroscopy 17 (2002) 14-23.

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65. Surface Modification of Polymer-based Microfluidic Devices. S.A. Soper, M. Galloway, A.C. Henry, B. Vaidya, Y. Wang and R.L. McCarley, Anal. Chim. Acta, 470 (2002), 87-99.

66. BioMEMS using Electrophoresis for the Analysis of Genetic Mutations, G.A. Thomas, H.D. Farquar, S. Sutton, R.P. Hammer, S.A. Soper, Expert Rev. Molc. Diagn. 2 (2002) 429-447.

67. Asymmetrical, Water Soluble Phthalocyanine (Pc) Dyes for Covalent Labeling of Oligonucleotides. R.P. Hammer, C.V. Owens, S. Hwang, C. Sayes and S.A. Soper, Bioconj. Chem. 13 (2002) 1244-1252.

68. Surface Modification and Characterization of Microfabricated Poly(carbonante) Devices: Manipulation of Electroosmotic Flow. B. Vaidya, S.A. Soper and R.L. McCarley, Analyst 127 (2002) 1289-1292.

69. Contact Conductivity Detection of PCR Products Analyzed by Reverse-Phase Ion Pair Capillary Electrochromatography, M. Galloway and S.A. Soper, Electrophoresis 23 (2002) 3760-3768.

70. Microarrays Assembled in Microfluidic Chips Fabricated form Poly(methylmethacrylate) for the Detection of Low Abundant Mutations, Y. Wang, B. Vaidya, Y.-Wei Cheng, F. Barany, H.D. Farquar, R.P. Hammer and S.A. Soper, Anal. Chem. 75 (2003) 1130-1140.

71. Fluorescence Multiplexing with Both Time-Resolved and Spectral Discrimination Capabilities using a Near-IR Microscope, L. Zhu, W. Stryjewski, S. Lassiter, S.A. Soper, Anal. Chem. 75 (2003) 2280-2291.

72. Solid Phase Reversible Immobilization in Microfluidic Chips for the Purification of Dye-Labeled DNA Sequencing Fragment, Y. Xu, B. Vaidya, R.L. McCarley and S.A. Soper, Anal. Chem. 75 (2003) 2975-2984.

73. Single Pair FRET Generated from Molecular Beacon Probes for the Real-Time Analysis of Low Abundant Mutations, M. Wabuyele, W. Stryjewski, Y.-Wei Cheng, F. Barany, H. Farquar, R.P. Hammer and S.A. Soper, J. Am. Chem. Soc. 125 (2003) 6937-6945.

74. Detecting Low Abundant Point Mutations in K-ras Genes using Micro-electrophoresis in Plastic Chips, G.A. Thomas, R. Sinville, S. Sutton, H.D. Farquar, Y. Wei, F. Barany, R.P. Hammer and S.A. Soper, Electrophoresis 25 (2004) 1668-1677.

75. Fluorescence Lifetime Identification Methods for High Throughput DNA Sequencing in Plastic Chips, L. Zhu and S.A. Soper, Anal. Biochem. 330 (2004) 206-218.

76. Cell Transport and Lysis in Plastic Microfluidic Chips, M. Witek, S. Wei, A. Adams, R. L. McCarley and S.A. Soper, Lab Chip 4 (2004) 464-472.

77. Online CE MALDI-TOF-MS using a Rotating Ball Interface, H.K. Musyimi, D. Narcisse, X. Xhang, S.A. Soper and K.K. Murray, Anal. Chem. 76 (2004) 5968-5973.

78. Rapid PCR in a Continuous Flow Device, M. Hashimoto, P. Chen, M.W. Mitchell, D.E. Nikitopoulos, S.A. Soper and M.C. Murphy, Lab Chip 4 (2004) 638-645.

79. Near-infrared Time-Resolved Fluorescence Lifetime Determinations in Poly(Methyl Methacrylate) Microchip Electrophoresis Devices, S. Llopis and S.A. Soper, Electrophoresis 25 (2004) 3810-3819.

80. Electrokinetically-synchronized Polymerase Chain Reaction Microchip Fabricated in Polycarbonante, J. Chen, H. Chen, M. Wabuyele, D. Patterson, M. Hupert, H. Shadpour, S.A. Soper, Anal. Chem. 77 (2005) 658-666.

81. Resist-Free Patterning of Surface Architectures in Polymer-Based Microanalytical Devices, R.L. McCarley, B. Vaidya, S. Wei, A.F. Smith, A.B. Patel, J. Feng, M.C. Murphy, and S. A. Soper, J. Am. Chem. Soc. 127 (2005) 842-843.

82. Rapid Patterning of DNA Microarrays on Photo-Activated PMMA for the Detection of Low Abundant Point Mutations in K-ras Genes, C. Situma, Y. Wang, M. Hupert, F. Barany, R.L. McCarley and S.A. Soper, Anal. Biochem. 340 (2005) 123-135.

83. Ligase Detection Reaction/Hybridization Assays using Three-Dimensional Microfluidic Networks for

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the Detection of Low Abundant DNA Mutations, M. Hashimoto, M. Hupert, Y. Cheng, F. Barany and S.A. Soper, Anal. Chem. 77 (2005) 3243-3255.

84. Out of Plane Microlens Array Fabricated using UV-Lithography, R. Yang, S.A. Soper, W. Wang, Appl. Phys. Lett. 86 (2005) 161110-1 – 161110-3.

85. Photochemically Patterned Poly(methyl methacrylate) Surfaces Used in the Fabrication of Microanalytical Devices, S. Wei, B. Vaidya, A.B. Patel, S.A. Soper and R.L. McCarley, J. Phys. Chem. B 109 (2005) 16988-16996.

86. Direct Coupling of Polymer-Based Microchip Electrophoresis to On-line Matrix Assisted Laser Desorption / Ionization Mass Spectrometry (MALDI MS) Using a Rotating Ball Inlet. H. K. Musyimi, J. Guy, D. A. Narcisse, S. A. Soper and Kermit K. Murray, Electrophoresis 26 (2005) 4703-4710.

87. Fabrication of DNA microarrays onto polymer substrates using UV modification protocols with integration into microfluidic platforms for the sensing of low-abundant DNA point mutations, S.A. Soper, M. Hashimoto, C. Situma, M.C. Murphy, R.L. McCarley, Y.W. Chen, F. Barany, Methods 37 (2005) 103-113.

88. Investigation of the Physico-Chemical Properties of Various Polymers for Microchip Electrophoresis Applications, H. Shadpour, H. Musyimi, J. Chen and S.A. Soper, J. Chromatogr. A 1111 (2006) 238-251.

89. Fabrication of gold microelectrodes for amperometric detection on a polycarbonate chip by photo-directed electroless plating. Y. Kong, H. Chen, Y. Wang, S.A. Soper, Electrophoresis 27 (2006) 2940-2950.

90. Polymerase Chain Reaction/Ligase Detection Reaction/Hybridization Assays Using Flow-Through Microfluidic Devices for the Detection of Low Abundant DNA Point Mutations, M. Hashimoto, F. Barany and S.A. Soper, Biosen. & Bioelectr. 21 (2006) 1915-1923.

91. SPRI for Isolating Genomic DNA from Whole Cell Lysates, L. Perry, M. Witek, R. Sinville and S.A. Soper, Nucleic Acids Res. 34 (2006) e74.

92. Microfabrication of pre-aligned fiber bundle couplers using ultraviolet lithography of SU-8, R. Yang, S.A. Soper and W. Wang, Sensors and Actuators A 127 (2006) 123-130.

93. Point-of-Care Biosensors for Cancer Diagnostics/Prognostics, S.A. Soper, et al., Biosen. & Bioelectr. 21 (2006) 1932-1942.

94. Two-Dimensional Separation of Proteins using Poly(methyl methacrylate) Microchips, H. Shadpour and S.A. Soper, Anal. Chem. 78 (2006) 3519-3527. This article was featured in AC Research Highlights and J. Proteome Res. (2006).

95. Merging Microfluidics Technology into Microarray-Based Bioassays, C. Situma, M. Hashimoto, S.A. Soper, Biomol. Eng. 23 (2006) 213-231.

96. Designing Highly Specific Biosensing Surfaces using Aptamer Monolayers on Gold, S. Balamurugan, A. Obubuafo, S. A. Soper,* R. L. McCarley, D. A. Spivak, Langmuir 22 (2006) 6446-6453.

97. Continuous Flow Thermal Cycler Microchip for Cycle Sequencing, J. Chen, H. Wang and S.A. Soper, Anal. Chem. 78 (2006) 6223-6231.

98. A New UV Lithography Photoresist Based on Composite of EPON Resins 165 and 154 for Fabrication of High-Aspect-Ratio Microstructures, R. Yang, S.A. Soper and W. Wang, Sens. & Act. A 127 (2006) 123-130.

99. Cost-benefit analysis of the RFA, N. Dovichi and S.A. Soper, Science 314 (2006) 1682.

100. Micro-milling of polymers for microfluidic applications, M. Hupert, H. Shadpour, D. Nikitopoulos

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and S.A. Soper, Microfluidics and Nanofluidics 3 (2007) 1-11.

101. Synthesis and Properties of Water-Soluble Zn(II)-phthalocyanine-peptide Conjugates, M. Vazquez, I. Nesterova, A. Santos, S.A. Soper and G. Vicente, Bioconj. Chem. 18 (2007) 410-420.

102. Multi-channel microchip electrophoresis device fabricated in polycarbonate with an integrated contact conductivity sensor array, H. Shadpour, M. Hupert, D. Patterson, C. Liu, W. Stryjewski and S.A. Soper, Anal. Chem. 79 (2007) 870-878. This article was one of the top 15 most highly downloaded articles in January-June, 2007.

103. Immobilization of Molecular Beacon Probes onto UV-Activated PMMA Surfaces: Analysis of Drosophilia melongastor Genes, C. Situma, A. Moehring, M. Noor and S.A. Soper, Anal. Biochem. 363 (2007) 35-45.

104. Surface Modification of PMMA Microfluidic Devices for High-Resolution Separations of Single-Stranded DNA, S. Llopis, J. Osiri and S.A. Soper, Electrophoresis 28 (2007) 984-993.

105. Metallo-Phthalocyanines: The Role of the Solubilizing Groups on the Spectral and Photophysical Properties, V. Verdree, S. Pakhomov, G. Su, M.W. Allen, R.P. Hammer and S.A. Soper, J. Fluoresc. 17 (2007) 547-563.

106. Functional Template-derived PMMA Nanopillars for Solid-Phase Biological Reactions, G. Chen, R.L. McCarley, S.A. Soper, C. Situma and J.G. Bolivar, Chem. of Mat. 19 (2007) 3855-3857.

107. High Resolution DNA Separations using Microchip Electrophoresis, R. Sinville and S.A. Soper, J. Sep. Sci. 30 (2007) 1714-1728.

108. Serial Processing of Polymerase Chain Reaction/Ligase Detection Reaction Using Flow-Through Microfluidic Devices for the Detection of Low-Abundant DNA Point Mutations, M. Hashimoto, F. Barany and S.A. Soper, Analyst 132 (2007) 913-920.

109. A New UV Lithography Photoresist Based on Composite of EPON Resins 165 and 154 for Fabrication of High-Aspect-Ratio Microstructures, R. Yang, S.A. Soper and W.J. Wang, Sens. Act. A 135 (2007) 625-636.

110. Fabrication of Large Area Mold Inserts for Replication of Polymer Microparts, D. Park, M. Witek, M. Hupert, R.L. McCarley, S.A. Soper and M.C. Murphy, Biomed. Microdev. 9 (2007).

111. Free-standing, Erect Ultra-high-aspect-ratio Polymer Nanopillar and Nanotube Ensembles, G. Chen, S.A. Soper and R.L. McCarley, Langmuir 23 (2007) 11777-11781.

112. Metallo-Phthalocyanine Near-IR Fluorophores: Oligonucleotide Conjugates and Their Applications, I. Nesterova, V.T. Verdree, S. Pakhomov, K. Strickler, M.W. Allen, R.P. Hammer and S.A. Soper, Bioconj. Chem. 18 (2007) 2159-2168.

113. Polymer Microfluidic Chips with Integrated Waveguides for Reading Microarrays, F. Xu, P. Datta, H. Wang, S. Gurung, M. Hashimoto, S. Wei, J. Goettert, R. L. McCarley, S. A. Soper, Anal. Chem. 79 (2007) 9007-9013.

114. Integration of Large Area Polymer Nanopillar Arrays into Microfluidic Chips using in situ Polymerization Cast Molding, G. Chen, R.L. McCarley and S.A. Soper, Lab Chip 7 (2007) 1424-1427.

115. A High Performance Polycarbonate Electrophoresis Microchip with Integrated Three Electrode System for End-channel Amperometric Detection, Y. Wang, H. Chen, Q. He and

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S.A. Soper, Electrophoresis 29 (2008) 1881-1888.

116. Solid-Phase Synthesis of Asymmetrically Substituted "AB3-type" Phthalocyanines, S.S. Erdem, I. Nesterova, S.A. Soper and R.L. Hammer, J. Org. Chem. 73 (2008) 5003-5007.

117. Charge-Coupled Device Operated in a Time-Delayed Integration Mode as an Approach to High-Throughput Flow-Based Single Molecule Analysis, J. Emory and S.A. Soper, Anal. Chem. 80 (2008) 3897-3903.

118. Temperature Distribution Effects on Micro-CFPCR Performance, P. C. Chen, D.E. Nikitopoulos, S.A. Soper, M.C. Murphy, Biomed. Microdev. 10 (2008) 141-152.

119. Capture and Enumeration of Circulating Tumor Cells from Peripheral Blood using Microfluidics, A.A. Adams, P. Okagbare, J. Feng, R.L. McCarley, M.C. Murphy and S.A. Soper, J. Am. Chem. Soc. 130 (2008) 8633-8641.

120. A Titer Plate-based Polymer Microfluidic Platform for High Throughput Nucleic Acid Purification. D.S.W. Park, M.L. Hupert, M.A. Witek, B.H. You, P. Datta, J. Guy, J.B. Lee, S.A. Soper, D.E. Nikitopoulos, M.C. Murphy Biomed. Microdev. 10 (2008) 21-33.

121. Surface immobilization methods for aptamer diagnostic applications. S. Balamurugan, A. Obubuafo, S.A. Soper, D.A. Spivak Anal. Bioanal. Chem. 390 (2008) 1009-1-21.

122. A High-Performance Polycarbonate Electrophoresis Microchip with Integrated Three-Electrode System for End-Channel Amperometric Detection. Y.R. Wang, H.W. Chen and S.A. Soper Electrophoresis 29 (2008) 1881-1888.

123. Fabrication of Microfluidic Reactors and Mixing Studies for Luciferase Detection. Q. Mei, Z. Xia, F. Xu, S.A. Soper and Z. H. Fan. Anal. Chem. 80 (2008) 6045-6050.

124. 96 Well Microfluidic Titer Plate for High Throughput Purification of DNA and RNA, M. Witek, D. Park, M. Hupert, R.L. McCarley, M.C. Murphy and S.A. Soper, Anal. Chem. 80 (2008) 3483-3491.

125. Design and Fabrication of an Electrochemically Actuated (ECM) Microvalve, D.E. Lee, S.A. Soper and W. Wang, Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing System 14 (2008) 1751-1756.

126. Ligase Detection Reaction Mutation Screening via Free Solution Electrophoresis in a Polymeric Microfluidic Device, R. Sinville, S.A. Soper, J. Coyne, R.J. Meagher, A. Barron, Y.-W. Cheng, F. Barany, Electrophoresis 29 (2008) 4751-4760.

127. Poly(methylmethacrylate) Microchip Affinity Capillary Gel Electrophoresis of Aptamer-Protein Complexes for the Analysis of Thrombin in Plasma, A. Obubuafo, S. Balamurugan, H. Shadpour, D. Spivak, R.L. McCarley, and S.A. Soper, Electrophoresis 29 (2008) 3436-3445.

128. Development of an Automated Digestion and Droplet Deposition Microfluidic Chip for MALDI-TOF MS, J. Lee, H. K. Musyimi, S. A. Soper, and K. K. Murray, J. Am. Soc. Mass Spectrosc. 19 (2008) 964-972.

129. Effect of Linker Structure on Surface Density of Aptamer Monolayers and their Corresponding Protein Binding Efficiency, S. Balamurugan, A. Obubuafo, R. L. McCarley, S. A. Soper and D. A. Spivak, Anal. Chem. 80 (2008) 9630-9634.

130. Generating High Peak Capacity 2-Dimensional Maps of Complex Proteomes Using Poly(methyl methacrylate) Microchip Electrophoresis. J. Osiri, H. Shadpour S. Park, B.C. Snowden, Z. Chen and S.A. Soper, Electrophoresis 29 (2008) 4984 - 4992.

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131. Nitroavidin as a Ligand for the Surface Capture and Release of Biotinylated Proteins. J.G. Bolivar, S.A. Soper and R.L. McCarley, Anal. Chem. 80 (2008) 9336 - 9342.

132. Phthalocyanine Dimerization-based Molecular Beacons Using Near-IR Fluorescence. I. Nesterova, R.P. Hammer and S.A. Soper, J. Am. Chem. Soc. 131 (2009) 2432-2433.

133. Passive Micro-assembly Modular, Hot Embossed Polymer Microfluidic Devices Using Exact Constraint Design. You, B.-H., Chen, P.-C., Park, D.S., Park, S., Nikitopoulos, D.E., Soper, S.A., Murphy, M.C., J. Micromech. Microeng. 19 (2009) 1-11.

134. Microfluidics with MALDI-MS Analysis for Proteomics. J. Lee, S.A. Soper, K.K. Murray, Anal. Chim. Acta 649 (2009) 180-190.

135. Highly Efficient Capture and Enumeration of Low Abundance Prostate Cancer Cells Using Prostate-Specific Membrane Antigen Aptamers Immobilized to a Polymeric Microfluidic Device. U. Dharmasiri, S. Balamurugan, R.L. McCarley, D. Spivak and S.A. Soper, Electrophoresis 30 (2009) 3289-3300.

136. Effect of Linker Structure on Surface Density of Aptamer Monolayers and Their Corresponding Protein Binding Efficiency. A. Obubuafo, S. Balamurugan, U. Dharmasiri, D. A. Spivak and S. A. Soper, Analyst 80 (2009) 9630-9634.

137. Development of an Efficient On-Chip Digestion System for Protein Analysis Using MALDI-TOF MS. J. Lee, S.A. Soper, K.K. Murray. Analyst 134 (2009) 2426-2433.

138. High Throughput Single Molecule Detection and Monitoring of Biochemical Interactions using Single Molecule Energy Transfer, P. Okagbare and S.A. Soper, Analyst 134 (2009) 97-106.

139. Mono-Amine Functionalized Phthalocyanines: Microwave-Assisted Solid-Phase Synthesis and Bioconjugation Strategies, S.S. Erdem, I.V. Nesterova, S.A. Soper and R.P. Hammer, J. Org. Chem. 74 (2009), 9280-9286.

140. Single-Pair Fluorescence Resonance Energy Transfer (spFRET) for the High Sensitivity Analysis of Low Abundant Proteins using Apatamers as Molecular Recognition Elements. W. Lee, A. Obubuafo, Y. Lee, and S.A. Soper, J. Fluoresc. 20 (2010) 203-213.

141. Fabrication of a Cyclic Olefin Copolymer Waveguide for Evanescence Excitation. P.I. Okagbare, J.M. Emory, P. Datta, J. Goettert and S.A. Soper. Lap Chip 10 (2010) 66-73.

142. Fabrication and Mathematical Analysis of an Electrochemical Microactuator (ECM) Using Electrodes Coated with Platinum Nano-particles. D.E. Lee, S.A. Soper, W.J. Wang, Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing Systems 16 (2010) 381-390.

143. Cross-Talk Free Dual-Color Fluorescence Cross-Correlation Spectroscopy (FCCS) for the Study of Enzyme Activity, W. Lee Y.-Ill Lee, J. Lee, L. M. Davis, P. Deininger, and S. A. Soper, Anal. Chem. 82 (2010) 1401-1410.

144. Thermoswitchable Electrokinetic Ion-Enrichment/Elution Based on a Poly(N-isopropylacrylamide Hydrogel Plug in a Microchannel, Z. Li, Q. He, D. Ma, H.W. Chen, S.A. Soper, Anal. Chem. 82 (2010) 10030-10036.

145. Enrichment and Detection of Escherichia coli O157:H7 from Water Samples Using an Antibody Modified Microfluidic Chip, U. Dharmasiri, M. A. Witek, A. A. Adams, J. K. Osiri, M. L. Hupert, T. S. Bianchi, D. L. Roelke, and S. A. Soper, Anal. Chem. 82 (2010) 2844-2849.

146. Microsystems for the Capture of Low Abundant Cells, U. Dharmasiri, A.A. Adams, M. Witek and S.A. Soper, Annual Reviews in Analytical Chemistry 3 (2010) 409-431.

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147. Ligase Detection Reaction Generation of Molecular Beacons for the Real-Time Analysis of Bacterial Pathogens using Single-Pair FRET, Z. Pang and S.A. Soper, Anal. Chem. 82 (2010) 9727-9735.

148. Polymer-based Dense Fluidic Network for High Throughput Screening with Ultrasensitive Fluorescence Detection, P.I. Okagbare and S.A. Soper, Electrophoresis 31 (2010) 3074-3082.

149. Titer-plate formatted continuous flow thermal reactors: Design and performance of a nanoliter reactor, P.C. Chen, D.S. Park, B.H. You, N. Kim, T. Park, S.A. Soper, D.E. Nikitopoulos, and M.C. Murphy, Sens. Act. B 149 (2010) 291-300.

150. Ultra-fast Two-Dimensional Microchip Electrophoresis using SDS-PAGE and Microemulsion Electrokinetic Chromatography for Protein Profiling, J. Osiri, H. Shadpour and S.A. Soper, Anal. Bioanal. Chem. 398 (2010) 489-498.

151. Microchip Electrophoresis of Alu Elements for Gender Determination and Inference of Human Ethnic Origin, S.K. Njoroge, M.K. Witek, M.L. Hupert, S.A. Soper, Electrophoresis 31 (2010) 981-990.

152. Titer-plate Formatted Continuous Flow Thermal Reactors for High Throughput Applications, D. Park, P.-C. Chen, B.H. You, N. Kim, T. Park, T.Y. Lee, P. Datta, Y. Desta, S.A. Soper, D.E. Nikitopoulos, M.C. Murphy, J. Micromechn. Microeng. 20 (2010) 055003.

153. Simple Fabrication Methods for Producing 1D Nanoslits in Thermoplastics and the Transport Dynamics of Double-Stranded DNA through these Slits, R. Chantiwas, M. Hupert, S. Park, P. Datta, J. Goettert, Y.-K. Cho, and S. A. Soper, Lab on a Chip 10 (2010) 3255-3264.

154. Assessment of Glycoprotein Interactions with 4-[(2-aminoethyl)carbamoyl]phenylboronic Acid Surfaces using Surface Plasmon Resonance Spectroscopy, D. Guzman, J. Macalindong, S.A. Soper, and R.L. McCarley, Anal. Chem. 82 (2010) 8970-8977.

155. Near-IR Single Fluorophore Quenching System Based on Phthalocyanine Aggregation and its Application for High Throughput Screening (HTS) Assays, I. V. Nesterova, C. A. Bennett, S. S. Erdem, R. P. Hammer, P. L. Deininger, and S. A. Soper, Analyst 136 (2011) 1103-1105.

156. Fabrication and Applications of Polymer Nanochannels and Nanoslits, R. Chantiwas, S. Park, S.A. Soper, B.L. Kim, S. Takayama, V. Sunkara, H. Hwang, Y.K. Cho, Chem. Soc. Rev. 40 (2011) 3677-3702.

157. High-throughput Selection, Enumeration, Electrokinetic Manipulation, and Molecular Profiling of Low-Abundance Circulating Tumor Cells. U. Dharmisiri, S.A. Soper, Anal. Chem. 83 (2011) 2301-2309.

158. Simple and Instantaneous Room Temperature Bonding of Thermoplastics and Poly(dimethyl siloxane), V. Sunkara, D.K. Park, H. Hwang, R. Chantiwas, S.A. Soper and Y.K. Cho, Lab Chip 11 (2011) 962-965.

159. Solid-Phase Bioreactor with Continuous Sample Deposition for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, J. Lee, S.A. Soper, and K.K. Murray, Rap. Comm. Mass Spectrometry 25 (2011) 693-699.

160. Gas-liquid Two-phase Flows in Rectangular polymer microchannels, N. Kim, E. Evans, D. Park, S.A. Soper, M.C. Murphy and D. Nikitopoulos, Exp. Fluids 51 (2011) 373-393.

161. Surface Modification of Droplet Polymeric Microfluidic Devices for the Stable and

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Continuous Generation of Aqueous Droplets, S. Balamurugan, N. Kim, W. Lee, D.A. Spivak, D. Nikitopoulos, R.L. McCarley, and S.A. Soper, Langmuir 27 (2011) 7949-7957.

162. A vertically-stacked, polymer, microfluidic PCR/ExoSAP-IT®/LDR analyzer: High accuracy detection of low-abundance K-ras point mutations, K. Han, T.Y. Lee, M.C. Murphy, D.E. Nikitopoulos, S.A. Soper, and M.A. Batzer, Anal. Biochem. (2011, accepted for publication).

163. Integrated Modular Microfluidic System with CFPCR and Affinity Purification of the Resulting Products, S. Njoroge, M. Witek and S.A. Soper, Electrophoresis (2011, accepted for publication).

SUBMITTED FOR PUBLICATION:

164. Fully Integrated and Field Deployable Genosensor System for the Diagnosis of Infectious Diseases: Determination of Multi-Drug Resistant Mycobacterium Tuberculosis, H. Wang, H.-W. Chen, M. Hupert, P.-C. Chen, M. Witek, P. Datta, T.L. Pittman, D. Patterson, W. Stryjewski, J. Goettert, M.C. Murphy, D. Nikitopoulos, D. Williams, F. Barany and S.A. Soper, PNAS (2011, submitted for publication).

165. Development of an Efficient On-chip Digestion System for Protein Analysis Using MALDI-TOF MS, J. Lee, S.A. Soper and K.K. Murray, Analyst (2011, submitted for publication).

166. A Compact, Field Deployable Single-Molecule Instrument Based on an Integrated Fiber Optic Waveguides, Field Programmable Gate Array, and a Compact Single Photon Avalanche Detector, J. Emory, M.L. Hupert, D. Patterson, B. Ellison and S.A. Soper, Analyst (2011, submitted for publication).

167. Microfluidic Culturing of Bacteria with MALDI Mass Spectrometry Detection, J. Lee, S.A. Soper, and K.K. Murray, Analyst (2011, submitted for publication).

168. Modular Microfluidic System Fabricated in Polymers for the Rapid Detection of Bacterial Pathogens, H.W. Chen, H. Wong, M. Hupert, S.A. Soper, Anal. Chem. (2011, submitted for publication).

169. Identification of Methicillin-resistant Staphylococcus aureus using an integrated and modular microfluidic system, H.W. Chen, H. Wong, M. Hupert, S.A. Soper, Analyst (2011, submitted for publication).

170. Hydrodynamic Shearing of DNA in a Polymeric Microfluidic Device, I. Nesterova, M. Hupert, M. Witek and S.A. Soper, Lab on a Chip (2011, submitted for publication).

OTHER PUBLICATIONS: Books:

171. Pharmaceutical and Biomedical Applications of Capillary Electrophoresis, Pergamon, Great Britain, Ed. Susan M. Lunte and Donna M. Radzik, Optical Detection Strategies in Capillary Electrophoresis, S.A. Soper (1997, pp. 181-228).

172. Micro Total Analysis Systems 2001, Kluwer Academic Publishers, Ed. J. Michael Ramsey, Albert van den Berg: Fabrication of Modular Microsystems for Analyzing K-ras Mutations using LDR, S.A. Soper and G. Thomas (2001, pp. 459-461).

173. Micro Total Analysis Systems 2001, Kluwer Academic Publishers, Ed. J. Michael Ramsey, Albert van den Berg: Chemical Foundations for Plastic-based Microdevices: Chemically Modified Poly(methyl methacrylate) and Poly(carbonate) Substrates used in the

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Fabrication of Microanalytical Devices, A. Henry, R.L. McCarley and S.A. Soper (2001, pp. 607-608).

174. Micro Total Analysis Systems 2002, Kluwer Academic Publishers, Ed. J. Michael Ramsery, Albert van den Berg: Photoresist-free micropatterning of polymer surfaces used in microanalytical devices, B. Vaidya, S.A. Soper, R.L. McCarley, (2002, pp. 446-448).

175. Micro Total Analysis Systems 2002, Kluwer Academic Publishers, Proceedings of the mTAS 2002 Symposium, 6th, Nara, Japan, Nov. 3-7: Smart, temperature-responsive surfaces, A.F. Smith, S.A. Soper, R.L. McCarley, (2002, pp. 473-475).

176. Single Molecule Detection in the Near-IR, Wiley-VCH, Ed. Ch. Zander, J. Enderlein, R.A. Keller: Single Molecule Detection in the Near-IR, S.A. Soper, C.V. Owens, B. Legendre (2002, pp. 323-362).

177. Topics in Fluorescence Spectroscopy: DNA Technology, Plenum Publishing Corporation, Ed. Joseph Lakowicz: DNA Sequencing, S. Lassiter, C.V. Owens, S.A. Soper (2002, pp. 410-445).

178. Biomedical Photonics Handbook, CRC Press, Ed. Tuan Vo Dinh: Fluorescence Detection in DNA Sequencing, S. Lassiter, C.V. Owens, S.A. Soper (2003, pp. 53-1 – 53-48).

179. Micro Total Analysis Systems 2003, Kluwer Academic Publishers, Ed. M. Allen Northrup, Kavs F. Jensen and D. Jed Harrison: Polymer-based Modular Microsystems for DNA Sequencing, S.A. Soper, M. Hupert, M. Hashimoto, R.L. McCarley, M.C. Murphy (2003, pp. 717-720).

180. Micro Total Analysis Systems 2004, Kluwer Academic Publishers, Ed. M. Allen Northrup, Klavs F. Jensen and D. Jed Harrison: Patterning of surface-capture architectures in polymer-based microanalytical devices, R.L. McCarley, S.A. Soper, M.C. Murphy, S. Wei, A.F. Smith, B. Vaidya, J. Feng, Special Publication - Royal Society of Chemistry (2004, pp. 130-132).

181. Micro Total Analysis Systems, 2004. Kluwer Academic Publishers, Ed. Klavs F. Jensen, D. Jed Harrison, J. Voldman: Low abundant biomarker screening in poly(methylmethacrylate) high aspect ratio microstructures using immunoaffinity-based molecular recognition, A. Adams and S.A. Soper, Special Publication: Royal Society of Chemistry, 1, 132-134 (2004).

182. Micro Total Analysis Systems 2005, Kluwer Academic Publishers, Ed. Klavs F. Jensen, D. Jed Harrison, J. Voldman: Highly efficient protein capture and enzyme reactor beds based on ultra-high-aspect-ratio nanostructures (UHARNS), G. Chen, J.G. Bolivar, S.A. Soper, R. L. McCarley, Special Publication - Royal Society of Chemistry (2005, pp. 1261-1263).

183. Reviews in Fluorescence 2006 (Volume 3), Kluwer Academic/Plenum Publishers, Ed. C. Geddes and J. L. Lakowitz: Multiplexed Fluorescence Detection for DNA Sequencinig, L. Zhu and S.A. Soper (2006, pp. 525-569).

184. Ultrasensitive Fluorescence Detection, Wiley Publishers, Ed. Nancy Xu: Multiplexed Time-Resolved Fluorescence Detection, L. Zhu and S.A. Soper (2006).

185. Micro Total Analysis Systems 2006, Kluwer Academic Publishers, Ed. Klavs F. Jensen, D. Jed Harrison, J. Voldman: Integrated Microfluidic System for Proteomics using Mixed-Scale Structures and MALDI-TOF-MS, H. Musyimie, H. Shadpour, G. Chen, R.L. McCarley, K. Murray and S.A. Soper, Special Publication - Royal Society of Chemistry (2006).

186. Micro Total Analysis Systems 2006, Kluwer Academic Publishers, Ed. Klavs F. Jensen, D. Jed Harrison, J. Voldman: Three-Dimensional Biologically-Active Nanostructured Architectures in Polymer-Based Microfluidic Devices for Biomarker Detection. G. Chen, C.

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Situma, S. A. Soper and Robin L. McCarley. Special Publication - Royal Society of Chemistry (2006).

187. Bio-MEMS: Technologies and Applications 2006, CRC Press, Ed. Wanjun Wang, Steven A. Soper.

188. Bio-MEMS: Technologies and Applications 2006, CRC Press, Ed. Wanjun Wang, Steven A. Soper: Single Cell and Single Molecule Analyses using Microfluidics, M.A. Witek, M.L. Hupert and S.A. Soper (2006) pp. 391-442.

189. Miniturized Systems for Chemistry and Life Sciences, 2008, Chemical and Biological Microsystems Society, Ed. Laurie E. Locascio, Michael Gaitan, Brian M. Paegel, David J. Ross, and Wyatt N. Vreeland: A Compact Microfluidic System With An Integrated Optical System for Single-Molecule Detection Via Fluorescence Resonance Energy Transfer for Real-Time Molecular Analyses, J. M. Emory, Z. Peng, F. Crawford-Drake, P. C. Chen, M. Murphy, and S.A. Soper (2008) pp. 402-407.

190. Miniaturized Systems for Chemistry and Life Sciences, 2008, Chemical and Biological Microsystems Society, Ed. Laurie E. Locascio, Michael Gaitan, Brian M. Paegel, David J. Ross, and Wyatt N. Vreeland: Polymer-Based Dense Fluidic Networks For High Throughput Screening (HTS) With Ultrasensitive Fluorescence, P.I. Okagbare, J. Gottert, P. Datta, V. Singh and S.A. Soper (2008) pp. 594-596.

191. Miniaturized Systems for Chemistry and Life Sciences, 2008, Chemical and Biological Microsystems Society, Ed. Laurie E. Locascio, Michael Gaitan, Brian M. Paegel, David J. Ross, and Wyatt N. Vreeland: Design And Performance Of A Rapid Nanoliter Continuous Flow Polymerase Chain Reactor For A High Throughput Microsystem, P. C. Chen, D.S. Park, B.H. You, N. Kim, T. Park, P. Datta, Y. Desta, S.A. Soper, D.E. Nikitopoulos, and M.C. Murphy (2008) pp. 619-621.

192. Miniaturized Systems for Chemistry and Life Sciences, 2008, Chemical and Biological Microsystems Society, Ed. Laurie E. Locascio, Michael Gaitan, Brian M. Paegel, David J. Ross, and Wyatt N. Vreeland: Analysis Of Single DNA Molecules Translocating Through Nanochannels Fabricated in SiO2, L. D. Menard, S. A. Soper, K. L. Braun, C. Huang, and J. Michael Ramsey (2008) pp. 847-849.

193. Miniaturized Systems for Chemistry and Life Sciences, 2008, Chemical and Biological Microsystems Society, Ed. Laurie E. Locascio, Michael Gaitan, Brian M. Paegel, David J. Ross, and Wyatt N. Vreeland: Human Identification Using ALUs Analyzed Via An Integrated Microfluidic System With Multicolor Fluorescence and Microship Free Solution Conjugate Electrophoresis, S.K. Njoroge, M.A. Witek, M.L. Hupert, J. Coyne, A. Barron, M.A. Batzer, and S.A. Soper. L. D. Menard, S. A. Soper, (2008) pp. 946-948.

194. Miniaturized Systems for Chemistry and Life Sciences, 2008, Chemical and Biological Microsystems Society, Ed. Laurie E. Locascio, Michael Gaitan, Brian M. Paegel, David J. Ross, and Wyatt N. Vreeland: A Field-Deployable System For Automated Molecular Testing Using Modular Microfluidics, M.L. Hupert, H. Wang, H.-W. Chen, W. Stryjewski, D. Patterson, M.A. Witek, P. Datta, J. Goettert, M.C. Murphy and S.A. Soper (2008) pp.1946-1948.

195. Integrated Multifunctional Microsystems for Automated Proteome Analysis, John K. Osiri, Hamed Shadpour, Makgorzata Witek and Steven A. Soper. Springer Series on Topics in Current Chemistry (2011, accepted for publication).

196. Integrated Microfluidic Systems for DNA Analysis, Samuel K. Njoroge, Hui-Wen Chen, Makgorzata Witek and Steven A. Soper, Springer Series on Topics in Current Chemistry

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(2011, accepted for publication).

Conference Proceedings:

197. Rapid DNA Sequencing Based Upon the Detection of Single Molecules, S.A. Soper, L.M. Davis, F.R. Fairfield, M.L. Hammond, C.A. Harger, J.H. Jett, R.A. Keller, B.L. Marrone, J.C. Martin, H.L. Nutter, E.B. Shera and D.J. Simpson, Proceedings of the Society of Photo-optical Instrumentation Engineers, 1435 (1991) 168-178.

198. Fluorescence Detection of Single Near Infrared Molecules and Applications in Bioanalytical Chemistry, S.A. Soper, Q.L. Mattingly, D. Williams, J. Flanagan, B. Legendre, Jr. and R.P. Hammer, Proceedings of the Society of Photo-optical Instrumentation Engineering, 1895 (1993) 113-122.

199. Picosecond Laser Studies of the Solvent-Dependent Nonradiative Pathways in Near-IR Fluorescent Dyes: Implications on their Use in Ultrasensitive Applications, S.A. Soper, Q.L. Mattingly and B.L. Legendre, Jr., Proceedings of the Society of Photo-optical Instrumentation Engineers, 2138 (1994) 216-227.

200. Ultrasensitive Fluorescence Detection in Capillary Electrophoretic Separations, S.A. Soper, D.C. Williams, J.H. Flanagan, B.L. Legendre, Jr. and R.P. Hammer, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2136 (1994) 244-254.

201. Single Lane, Single Fluor Sequencing Using Dideoxy-Labeled, Heavy-Atom Modified Near-IR Fluorescent Dyes, D.C. Williams, J.H. Flanagan, B.L. Legendre, R.P. Hammer and S.A. Soper, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2386 (1995) 55-65.

202. Thermodynamic and Binding Properties of NIR Fluorescent Dyes to Double-Stranded DNA, Y.Y. Davidson and S.A. Soper, Proceedings of the Society of Photo-optical Instrumentation Engineers 2388 (1995) 226-236.

203. New Directions in Near-IR Fluorescence Detection for Capillary Electrophoresis, S.A. Soper, J.H. Flanagan, B.L. Legendre, D.C. Williams, R.P. Hammer, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2680 (1996) 134-145.

204. Micro-DNA Sequence Analysis Using Capillary Electrophoresis and Near-IR Fluorescence Detection, S.A. Soper, Y.Y. Davidson, J.H. Flanagan, B.L. Legendre, C. Owens, D.C. Williams and R.P. Hammer, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2680 (1996) 235-246.

205. Heavy-atom Modified Near-IR Fluorescent Dyes for DNA Sequencing Applications: Synthesis and Photophysical Characterization. J.H. Flanagan, Jr., S.E. Romero, B.L. Legendre, Jr., R.P. Hammer, S.A. Soper, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2980 (1997) 328-337.

206. Microelectrophoresis devices with integrated fluorescence detectors and reactors for high-throughput DNA sequencing. S.A. Soper, S.M. Ford, J. Davies, D.C. Williams, B. Cheng, J.M. Klopf, G.M. Calderon, V. Saile, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2985 (1997) 36-46.

207. All-Solid-State TCPC Instrument for Dynamic Lifetime Measurements in Sensitive DNA Analysis. R. Erdmann, M. Wahl, K. Lauritsen, J. Enderlein, B.L. Legendre, Jr., D.C. Williams, S.A. Soper, Proceedings of the Society of Photo-optical Instrumentation Engineers, 2985 (1997) 138-144.

208. Nano-Scale Sample Preparation Methods Directly Coupled to PMMA-Based Micro-chips and Gel-Filled Capillaries for the Analysis of Oligonucleotides, S.A. Soper, S.M. Ford, Y.

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Xu, S. McWhorter, S. Lassiter, D. Patterson, Proceedings of the Society of Photo-optical Instrumentation Engineers, 3602 (1999) 392-402.

209. A Simple Scanning Near-Infrared Time-Correlated Single Photon Counting Instrument with a Pulsed Diode Laser and Avalanche Photodiode (APD) For Time-Resolved Measurements in Scanning Applications with DNA Sequencer, Y. Zhang, S.A. Soper, L.R. Middendorf, J. Wurm, R. Erdmann and M. Wahl, Proceedings of the Society of Photo-optical Instrumentation Engineers, 3602 (1999) 403-414.

210. Multiplexed Analysis Using Time-Resolved Near-IR Fluorescence for the Detection of Genomic Material. W.J. Stryjewski, S.A. Soper, S. Lassiter, L.M. Davis, Proceedings of the Society of Photo-optical Instrumentation Engineers, 4626 (2002) 201-209.

211. A Continuous Flow Polymerization Chain Reaction (CFPCR) Micro-Chip, Y. Bejat, X. Liu, D. E. Nikitopoulos, M. C. Murphy, M. W. Mitchell and S. A. Soper, Bulletin of the American Physical Society, 47 (2002) 15. In, 55th Annual Meeting of the APS Division of Fluid Dynamics, Dallas TX.

212. Detection of Low Abundant Mutations in DNA Using Single Molecule FRET and Ligase Detection Reactions. M. Wabuyele, H. Farquar, R.P. Hammer, Y.-Wei Cheng, F. Barany and S.A. Soper, Proceedings of the Society of Photo-optical Instrumentation Engineers, 4962 (2003) 58-69.

213. Polymer-based Modular Microsystems for DNA Sequencing, S.A. Soper, R.L. McCarley, M.C. Murphy, J. Chen, J. Zhu, S. Wei, Micro Total Analysis Systems 2003, 1 (2003) 717-720.

214. Augmenting the capabilities of polymeric microanalytical devices, R.L. McCarley, S.A. Soper, B. Vaidya, A.C. Henry, A.F. Smith, S. Wei, M. Galloway, Y. Wang, Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 44 (2003) 549.

215. Polymer-based Microfluidic Systems for Biomedical Applications. M.L. Hupert, M.A. Witek, Y. Wang, M.W. Mitchell, Y. Liu, Y. Bejat, D.E. Nikitopoulos, J. Goettert, M.C. Murphy and S.A. Soper, Proceedings of the Society of Photo-optical Instrumentation Engineers, 4982 (2003) 52-64.

216. Modeling and Validation of a Molded Polycarbonate Continuous-flow Polymerase Chain Reaction Device. M.W. Mitchell, X. Liu, Y. Bejat, D.E. Nikitopoulos, S.A. Soper, M.C. Murphy, Proceedings of the Society of Photo-optical Instrumentation Engineers, 4982 (2003) 83-98.

217. Electrochemical Micropump and Its Application in a DNA Mixing and Analysis System. D.E. Lee, H-P Chen, S.A. Soper, W. Wang, Proceedings of the Society of Photo-optical Instrumentation Engineers, 4982 (2003) 264-271.

218. Augmenting the capabilities of polymeric microanalytical devices, R.L. McCarley, S.A. Soper, B. Vaidya, A.C. Henry, A.F. Smith, S. Wei, M. Galloway, Y. Wang, Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 44 (2003) 549.

219. Electrochemical Micropump and its Application in a DNA Mixing and Analysis System, D. Lee, H. Chen, S.A. Soper and W. Wang, Proceedings of the Society of Photo-optical Instrumentation Engineers 4982 (2003) 264-271.

220. Separation of Breast Cancer Cells in Peripherally Circulating Blood Using Antibodies Fixed in Microchannels, J. Feng, S.A. Soper, R.L. McCarley, and M.C. Murphy, Proceedings of the Society of Photo-optical Instrumentation Engineers 5312 (2004) 278-293.

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221. Solid-phase immunoassay on polymer-based microanalytical devices, S. Wei, S.A. Soper, R.L. McCarley, Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 45 (2004) 434-435.

222. Design of a Microfabricated Device for Ligase Detection Reactions, D. Barrett, A. Maha, Y. Wang, S.A. Soper, D. Nikitopoulos and M.C. Murphy, Proceedings of the Society of Photo-optical Instrumentation Engineers 5345 (2004) 78-88.

223. Simulation and Design of Micro-Mixers for Microfluidic Devices, A. Maha, D. Barrett, S.A. Soper, M.C. Murphy and D. Nikitopolous, Proceedings of the Society of Photo-optical Instrumentation Engineers 5345 (2004) 183-193.

224. Simulation and Design of Micro-Mixers for Microfluidic Devices, Amit Maha, Dwhyte O. Barrett, D. E. Nikitopoulos, S. A. Soper, M. C. Murphy, Proceedings of the Society of Photo-optical Instrumentation Engineers, 5345 (2004) 183-193.

225. Solid-phase immunoassay on polymer-based microanalytical devices, S. Wei, S.A. Soper, R.L. McCarley, Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 45 (2004) 434-435.

226. Limiting Performance of High Throughput Continouous Flow micro-PCR”, Pin-Chuan Chen, Masahiko Hashimoto, M. W. Mitchell, D. E. Nikitopoulos, S. A. Soper, and M. C. Murphy, Paper IMECE2004-62091, ASME International Mechanical Engineering Congress and RD&D Expo, November 13-19, 2004, Anaheim, California USA.

227. Design of a Microfabricated Device for the Ligase Detection Reaction (LDR), D.O. Barrett, A. Maha, Y. Wang, S.A. Soper, D.E. Nikitopoulos, and M.C. Murphy, Paper IMECE2004-62111, ASME International Mechanical Engineering Congress and RD&D Expo, November 13-19, 2004, Anaheim, California USA.

228. Fabrication of out-of-plane concave and convex refractive microlens array, R. Yang, S. Soper, W. Wang, Proceedings of MEMS/MOEMS Components and Their Applications II, the SPIE International Symposium on MOEMS-MEMS Micro & Nanofabrication, Photonics West, 2005, 5717, San Jose, California, 134-141.

229. Microfabrication of an Integrated SU-8 Waveguide with an Imbedded Focusing Lens for Application in Single Molecule Detection (SMD), R. Yang, S. A. Soper, W. Wang, Proceedings of Microfluidics, BioMEMS and Medical Microsystems III, The SPIE International Symposium on MOEMS-MEMS Micro & Nanofabrication Photonics West, 5718, 2005, San Jose, California, 54-59.

230. Microfabrication and test of pre-aligned fiber bundle couplers using UV lithography of SU-8, R. Yang, S.A. Soper, W. Wang, The SPIE International Symposium on MOEMS-MEMS Micro- & Nanofabrication Photonics West, 2005 (submitted for publication).

231. Fabrication and test of an electrochemical microactuator, D.E. Lee, W. Wang, S.A. Soper, The SPIE International Symposium on MOEMS-MEMS Micro- & Nanofabrication Photonics West, 2005.

232. Design Aspects and Simulations of a Modified Micro-Scale Electrophoretron, N. Elmajdoub, D. E. Nikitopoulos, S. A. Soper, M. C.Murphy, Proceedings of the ASME IMECE 2006, Paper IMECE2006-15365.

233. Simulation of Electroosmotic and Pressure Driven Flows in Microfluidic Interconnects, S. D. Rani, S. A. Soper, D. E. Nikitopoulos, M. C.Murphy, Proceedings of the ASME IMECE 2006, Paper IMECE2006-15388.

234. Performance of an Electrokinetic Shuttle Polymerase Chain Reactor, P.-C. Chen, J.

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Chen, D. E. Nikitopoulos, S. A. Soper, and M. C. Murphy, Proceedings of the ASME IMECE 2006, Paper IMECE2006-15239.

235. Tolerance Variation and Passive Alignment in Modular, Polymer Microfluidic Devices, B. H. You, D. S. Park, C. Mock, W. M. Caceres, D. E. Nikitopoulos, S. A. Soper, and M. C. Murphy, Proceedings of the ASME IMECE 2006,Paper IMECE2006-15258.

236. Microtiter Plate-based Microfluidic Platforms: Sealing, Leakage Testing, and Performance of a 96-well SPRI Device, D. S. Park, M. L. Hupert, J. Guy, P. Datta, M. Witek, B. H. You, J.-B. Lee, S. A. Soper, D. E. Nikitopoulos, and M. C. Murphy, Proceedings of the ASME IMECE 2006, Paper IMECE2006-15275.

237. Passive Alignment Structures in Modular, Polymer Microfluidic Devices", B. H. You, P.-C. Chen, J. Guy, D. E. Nikitopoulos, S. A. Soper, and M. C. Murphy, Proceedings of the ASME IMECE 2006, Paper IMECE2006-16100.

238. Polymer-based Micro-and Nanofluidic Chips. Simple Strategies for Their Surfaces Modifications to Accommodate Applications in Biology, S. A. Soper, R. L. McCarley, S. Park, and D. E. Nikitipoulos Proceedings of the Materials Research Symposium 2009

239. Transport of Single Molecules Through Nanochannels: A Noval Approach to DNA Sequencing. R. Chantiwas, M.L. Hupert, J.T. Lopez, P.Datta, J. Gottert, B. Novak, D. Moldovan, S. Jha, S. Park, M.C. Murphy, D.E. Nikitopoulos, and S. A. Soper. Proceedings of the MicroTas Conference 2009.

240. Polymer-based Micro- and Nanofluidic Chips: Simple Strategies for Their Surfaces Modifications to Accommodate Applications in Biology. Proceedings from the Materials Research Symposium, 2009.

Patents:

241. Microsystems for Rapid DNA Sequencing, S.A. Soper, J. Davies, Louisiana State University, June, 1996 (granted, 1998).

242. Resistless Patterning of Microstructures on Polymers, S.A. Soper and R.L. McCarley, Louisiana State University (submitted, 2003).

243. Electrokinetic Cyclic Thermal Cyclers, S.A. Soper, D. Nikitopoulos, Louisiana State University (submitted, 2005).

244. Lithographically Prepared Optical Fiber Couplers, W. Wang, R. Yang, S.A. Soper, Louisiana State University (submitted, 2005).

245. Tetraazaporphyrin-based Compounds and their Uses, R.P. Hammer, S.A. Soper, S. Pakhomov, T.J. Jensen, M.W. Allen, I.V. Nesterova, M.G. Vicente, Louisiana State University (submitted, 2006).

246. Polymer-based Alignment Structures for Preparing Modular Microfluidic Systems, P.C. Chen, D.A. Park, D.K. Nikitopoulos, S.A. Soper and M.C. Murphy, Louisiana State University (submitted 2008).

247. Isolation and Enumeration of Circulating Tumor Cells using Polymer Microfluidics, A. Adams, J. Feng, M.C. Murphy, R.L. McCarley and S.A. Soper, Louisiana State University (submitted 2009).

248. New Systems for Next Generation Sequencing, G. Grills, S.A. Soper and F. Barany, Weill Cornell Medical College and Louisiana State University (submitted, 2011).

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SYMPOSIUM ORGANIZED (since 1995):

1. DNA Sequencing Technologies, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA, February (1995, conference chair).

2. High Throughput Genomic Analyses using Fluorescence Detection, Proceeding of the Society of Photo-Optical Instrumentation Engineers (San Jose, CA, Winter 1996).

3. Genomic Sequencing and Diagnostics: Optical Instruments, Proceeding of the Society of Photo-Optical Instrumentation Engineers (San Jose, CA, Winter, 1997).

4. Bioanalytical Applications of Near-IR Fluorescence Detection, PITTCON (Atlanta, GA, Spring, 1997).

5. Microfluidic Systems for Applications in Genomics, PITTCON (New Orleans, LA, Spring, 1998).

6. Automated Systems for High Throughput DNA Sequence Analysis, Proceeding of the Society of Photo-Optical Instrumentation Engineers (San Jose, CA, Winter, 1999).

7. Single Molecule Detection: Applications in Genomics and Proteomics, PITTCON (Chicago, IL, Spring, 2004).

8. Polymer-based Microfluidic Devices, American Electrophoresis Society, American Institute of Chemical Engineering Meeting (Austin, TX, November, 2004).

9. Single Molecule Detection: A Fifteen Year Perspective, PITTCON (Orlando, FL, Spring, 2005).

10. Biosensors for Cancer Detection, National Institutes of Health, National Cancer Institute (Washington, D.C., 2005).

11. Analytical Methods for the Diagnosis of Cancers, PITTCON (Orlando, FL, Spring, 2006).

12. Near-IR Fluorescence for Sensitive Applications in the Life Sciences, Eastern Analytical Symposium (Sommerset, NJ, Fall, 2006).

13. Microchemical Techniques using Microfluidics, Eastern Analytical Symposium (Sommerset, NJ, Fall, 2006).

14. Bioanalytical Applications of Single Molecule Detection, PITTCON (Chicago, IL, Spring, 2007).

15. Near-IR Fluorescence Detection in Biology, PITTCON (New Orleans, LA, Spring, 2008).

16. Microfluidic Systems for Protein Analyses, PITTCON (Orlando, FL, Spring, 2010).

17. Bioanalytical Sensors, Gordon Research Conference (New Hampshire, Summer, 2010).

18. Integrated Micro- and Nanofluidic Systems, PITTCON (Atlanta, GA, Spring, 2011).

19. 2012 Gordon Research Conference on Bioanalytical Sensors (Newport Beach, RI, 2012).

INVITED PRESENTATIONS (since 1995): National and International Meetings:

1. Spectroscopic and Thermodynamic Properties of Near-IR Dyes Bound to Double-Stranded DNA, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA, February (1995).

2. Pushing the Limit of Detection to the Single Molecule Level Using Near-IR Fluorescence

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Detection, American Chemical Society Meeting, Chicago, IL, August(1995).

3. Single Molecule Detection in the Near-IR: Applications in Bioanalytical Chemistry, Analytical Gordon Conference, New Hampton, NH, August (1995).

4. On-Line Fluorescence Lifetime Measurements in CGE As An Approach for Highly Accurate Base-Calling in DNA Sequencing Applications, Optical Society of America Symposium, Portland, OR, September (1995).

5. Single Molecule Detection in the Near-Infrared: Monitoring Real-World Type Chemical Phenomena at the Ultimate Level of Sensitivity, International Workshop on "Single Molecule Detection: Basics and Applications in Life Science," Berlin, Germany, October (1995, key-note address).

6. High-Speed DNA Sequencing Using Near-IR Fluorescence Detection and Miniaturized CGE Systems, Proceeding of the Society of Photo-Optical Instrumentation Engineers , San Jose, CA, February (1996).

7. Near-IR, Laser-Induced Fluorescence Detection System for Ultrasensitive Analyses in Capillary Electrophoretic Applications, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA, February (1996, conference co-chair).

8. Micro-Systems for DNA Sequence Analysis with Near-IR Fluorescence Detection, Workshop on Bioanalytical Chemistry, University of Kansas, Lawrence, KS (1996).

9. Applications of Single Molecule Detection for the Analysis of DNA, International Workshop on "Single Molecule Detection: Basics and Applications in the Life Sciences," Berlin, Germany, September (1996).

10. Micro-Instrumentation for the Analysis of DNA, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA, February (1997, conference chair).

11. Heavy-Atom Modified Near-IR Fluorescent Dyes for DNA Sequencing Applications, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA, February (1997).

12. Single Molecule Detection in the Near-IR: A Logical Choice, Pittsburgh Conference, Atlanta, GA (1997, conference chair).

13. High-Aspect Ratio Micromachining in Polymethymethacrylate (PMMA) using X-ray Lithography for the Fabrication of Micro-Electrophoresis Devices, Wintergreen Conference on Capillary Chromatography, Wintergreen, VA (1997).

14. Micro-Devices for Efficient Single Molecule Detection, Third International Workshop on Single Molecule Detection, Berlin, Germany (1997).

15. Near-IR Fluorescence Detection for the Ultrasensitive Analysis of Oligonucleotides, FACSS meeting, Providence, RI (1997).

16. High-Aspect Ratio Micro-machining in Plastics for the Rapid Size Separation of Oligonucleotides, Eastern Analytical Symposium (1997).

17. Integrated Micro-systems for High Throughput DNA Sequencing Applications, BECON Meeting, Washington, D.C. (1998).

18. High Aspect Ratio Micromachining in PMMA, Capillary Electrochromatography and Capillary Electrophoresis, Wintergreen, VA (1998).

19. Integrated Microsystems for Analyzing DNA: Smaller is Better, PITTCON, New Orleans (1998, conference chair).

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20. Microfabricated Devices for the High Throughput Analysis of Double-Stranded DNAs, The Whitaker Foundation (1998).

21. Nano-Scale Sample Preparation Platforms Directly Interfaced to Micro-chip Electrophoresis Devices, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA (1999, conference chair).

22. Nano-Reactors Coupled to Capillary Gel Electrophoresis and Micro-chip Electrophoresis for the Analysis of DNA, High Performance Capillary Electrophoresis, Palm Springs, CA (1999).

23. Single Molecule Detection in Genomics using Near-IR Fluorescence and Micro-devices, Knowledge Foundation, Boston, MA (1999).

24. Single Molecule Detection using Near Infrared Fluorescence and Micro-Electrophoresis Devices for Applications in Genomics, Single Molecule International Workshop, Berlin, Germany (1999).

25. The Heteroduplex Analysis of Rifampin Resistant TB Strains using Capillary Electrophoresis, Frederick Conference on Capillary Electrophoresis, Frederick, MD (1999).

26. Highly Efficient Base Calling using Time-Resolved Near-IR Fluorescence Detection, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA (2000).

27. High-Aspect Ratio Microstructures Fabricated in Polymer Materials for Microfluidic Device Applications, American Chemical Society , San Francisco, CA (2000).

28. Microfluidic Devices for Bioanalytical Applications, Conference on Micromanufacturing and Applications, Ruston, LA (2000).

29. Near-IR Fluorescence Detection in the Life Sciences, Cambridge Health Institute Symposium on Dye Labels for the Biosciences, Washington, D.C. (2000).

30. Near-Infrared Time-Resolved Fluorescence for Multiplexed Applications in Genomics, Eastern Analytical Symposium, Atlantic City, NJ (2000).

31. High-Aspect-Ratio Micromachining in Plastics using LIGA for Fabricating Microfluidic Devices, FACSS, Nashville, TN (2000).

32. Ultrasensitive, Time-Resolved Near-IR Fluorescence Detection in DNA Microarrays, FACSS, Nashville, TN (2000).

33. Multiplexed Time-resolved Near-IR Fluorescence for DNA Analyses, International Conference on Analytical Sciences, Tokyo, Japan (2001).

34. Modular Microsystems Fabricated in Polymers Using High Aspect Ratio Micromachining, Gordon Research Conference on Microfluidics, Oxford, England (2001).

35. Surface Modification of Polymers used in Microfluidic Applications, FACSS, Detroit, MI (2001).

36. Fabrication of Modular Microsystems for Analyzing K-ras Mutations using Ligase Detection Reactions, Micro-TAS, Monterey, CA (2001).

37. The Analysis of Point Mutations in K-ras Oncogenes using Modular Microsystems and LDR, Cambridge Health Institute Symposium on Clinical Diagnostics, San Diego, CA (2002).

38. Single Molecule Detection in Polymer-based Microfluidic Systems, Jet Propulsion Laboratory Workshop on Remote Sensing, Pasadena, CA (2002).

39. Time-Resolved Near-IR Fluorescence for Multiplexed Detection in Genomics, Tour Speaker,

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Society for Applied Spectroscopy, New England Section, Arizona Section and Ohio Section (2002).

40. Polymer-based Modular Microfluidic Systems for the Analysis of Low Abundant Mutations, Cambridge Health Institute Symposium on BioMEMS and Nanotechnology World, Columbus, OH (2002).

41. Two-Color, Time-resolved Fluorescence for Highly Multiplexed DNA Sequencing, PITTCON 2003, Orlando, FL (2003).

42. Fluorescence Lifetime Measurements on Plastic Microchips, PITTCON 2003, Orlando, FL (2003).

43. spFRET Analysis of Low Abundant Mutations using Near-IR Fluorescence Detection, PITTCON 2003, Orlando, FL (2003).

44. spFRET and Single Molecule Analysis of Low Abundant Mutations in K-ras Genes, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA (2003).

45. Polymer-Based Microfluidic Systems for Genomic Analysis, Proceeding of the Society of Photo-Optical Instrumentation Engineers, San Jose, CA (2003, plenary speaker).

46. Sample Preparation Chips for the Automated High Throughput Analysis of Genomic Samples, Lab Automation, Palm Springs, CA (2003).

47. Two-color Time-Resolved Fluorescence for Highly Multiplexed DNA Sequencing, PITTCON, Orlando, FL (2003).

48. Two-color, Time-Resolved Fluorescence Microscope for Reading Fluorescence from Multichannel Microchips, PITTCON, Orlando, FL (2003).

49. Single Pair FRET and LDR Assays using Near-IR Fluorescence for Real-Time Molecular Diagnostics, PITTCON, Orlando, FL (2003).

50. Rapid PCR Analysis of Genomic DNA using a Continuous Flow Device Fabricated in PC, National ACS Meeting, New Orleans, LA (2003).

51. Polymer-based Modular Microfluidic Systems for High Throughput DNA Sequencing, S.A. Soper, L. Zhu, M. Wabuyele, M. Galloway, Y. Wang, and R.L. McCarley, SmallTalk, San Jose, CA (2003).

52. Polymer-based Microfluidic Systems for High Throughput Genome Sequencing, S.A. Soper, R.L. McCarley, M. Wabuyele, M. Galloway, and L. Zhu, Micro-Total Analysis Systems Conference, Squaw Valley, CA (2003).

53. Micro-Capillary Electrophoresis of DNA Sequencing and Diagnostics, S.A. Soper, G. Thomas, R. Sinville, L. Zhu and S. Sutton, Lab Automation, San Jose, CA (2004).

54. Fabrication of Modular Microfluidic Systems Containing High-Aspect-Ratio Microstructures in Polymers for the Detection of Low Abundant Point Mutations, S.A. Soper, R.L. McCarley, M. Murphy, J. Goettert, F. Barany, A. Adams, S. Wei, J. Feng, PTTCON, Chicago, IL (2004).

55. Single Molecule Detection and Microfluidics: Applications in DNA Sequencing and DNA Diagnostics, S.A. Soper, M. Wabuyele, PITTCON, Chicago, IL (2004).

56. Center for BioModular Microsystems, S.A. Soper, Pfizer Pharmaceutical, Groton, CN (2004).

57. Approaching Real-Time Molecular Analysis: Amplification and Interrogation of DNA Structure using Modular Microfluidic Systems, Electrochemical Society Meeting, Honolulu, HI (October, 2004).

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58. Single Molecule Detection and Microfluidics: Rethinking the DNA Diagnostic Paradigm, International Single Molecule Detection Workshop, Berlin, Germany (September, 2004).

59. Amplification and Interrogation of DNA Structure using Modular Microfluidic Systems, Association of Bioscience Resource Facilities, Atlanta, GA (February, 2005).

60. High Throughput Array Electrophoresis Chips Fabricated in Polymers, MicroScale Bioseparations, New Orleans, LA (February, 2005).

61. DNA Diagnostics using Single Molecule Detection, PITTCON 2005 (March, 2005).

62. Flow-Through Biochips for the Multiplexed Analysis of Genetic Mutations for Cancer Detection, NIH Symposium on Biosensors and Cancer Detection, Washington, D.C. (June, 2005).

63. Highly Multiplexed Detection of Rare Mutations using Modular Microfludics, IMAT Meeting, NIH/NCI Symposium, Washington, D.C. (September, 2005).

64. Building Effective Nationally Competitive Research Centers in EPSCoR States, National NSF EPSCoR Meeting, Puerto Rico (September, 2005).

65. Building Three-Dimensional Architectures of Fluidic Systems for Analyzing Complex Biological Samples, Gordon Research Conference on Biosensors, Ventura, CA (February, 2006).

66. Single Molecule Detection and Clinical Applications: Detection of Rare Point Mutations in Genomic DNA, PITTCON, Orlando, FL (March, 2006).

67. Flow-through Lab-on-a-Chip Biosensors for Analyzing Clinical BioMarkers, The American Association of Clinical Chemists (Oak Ridge Conference), San Jose, CA (April, 2006).

68. High Throughput Biomolecular Analyses: Single Molecule Detection and Microfluidic Systems, NSF Workshop on Bioinstrumentation, Tucson, AZ (April, 2006).

69. Automated Systems for Proteomics using Polymer-based Microfluidics, µ-TAS, Tokyo, Japan (November, 2006).

70. Fluorescence Resonance Energy Transfer Dyes that Possess Near-IR Fluorescence Properties, Eastern Analytical Symposium, Sommerset, NJ (November, 2006).

71. From Single Cells to Single Molecules: An Example of Microchemical Analysis, Eastern Analytical Symposium, Sommerset, NJ (November, 2006).

72. Single Molecule Detection in the Near-IR, PITTCON (Chicago, IL, March, 2007).

73. Microfluidics for Analyzing Molecular Signatures of Diseases, Asianalysis (Plenary Speaker, Jeju Island, South Korea, October, 2007).

74. The Role of Integrated Optics for BioMEMS, SPIE Proceedings, San Jose, CA, January, 2008).

75. Near-IR Fluorescent Dyes for Ultrasensitive Fluorescence Measurements, PITTCON (New Orleans, LA, March, 2008).

76. Integrated Microfluidic Systems for DNA Diagnostics, Micro-scale Bioseparations (Berlin, Germany, March, 2008).

77. Near-Infrared Dyes for Ultra-sensitive Fluorescence Measurements, ACS Meeting (Philadelphia, PA, August, 2008).

78. Single Molecule Detection for Bioanalytical Applications, NSF Workshop on Bio-Instrumentation (Washington, D.C., September, 2008).

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79. Real-time Molecule Diagnostics using Single Molecule Detection as the Readout Modality, AOAC Meeting (Dallas, TX, October, 2008).

80. Integrated Microfluidic Systems for in vitro Molecular Diagnostics, Keynote Speaker, International µ-TAS meeting (Nanjing, China, November, 2008).

81. Real-time Reporting of Molecular Markers using Single Molecule Detection, Extreme Biosensing (Maui, HI, December, 2008).

82. High Throughput Screening Using Microfluidics and Ultrasensitive Near-IR Fluorescence Detection (Rayleigh, NC, February, 2009).

83. Integrated Microfluidic Systems for Point-of-Care Monitoring of Infectious Diseases (Roche Diagnostics, San Francisco, CA, 2009).

84. Polymer-based Micro- and Nanofluidic Chips: Simple Strategies for Their Surface Modifications to Accommodate Applications in Biology (Materials Research Society Meeting, San Francisco, CA, 2009).

85. Selection and Enumeration of Rare Circulating Tumor Cells (National Cancer Institute, National Institutes of Health, Bethesda, MD, 2009).

86. The Use of Phthalocyanine Dyes as Ultra-sensitive Probes for Fluorescence (PITTCON, Chicago, IL, 2009).

87. The Use of Microfluidics for the Selection and Enumeration of Rare Circulating Tumor Cells (Mary Bird Perkins Cancer Center, Baton Rouge, LA, 2009).

88. High Performance Functional Material for Device-Oriented Applications, Nano-Scale and Functional Materials, National Science Foundation, UNICAMP, Brazil (2009).

89. Single Molecule Detection for Bioanalytical Applications (Eastern Analytical Symposium, New Jersey, November, 2009).

90. Thermoplastics for Lab-on-a-Chip Applications: From the Micro-Scale to the Nano-Scale (Lab Chip International Conference, Shanghai, China, November, 2009).

91. Nano-scale Sensors for the Analysis of DNAs, National Science Federation of Thailand, Bangkok, Thailand (November, 2009).

92. Modular Microfluidics for the Analysis of Integral Membrane Proteins, PITTCON 2010 (Orlando, FL, March, 2010).

93. Single-Molecule DNA Sequencing using Modular Micro- & Nanofluidics, Samsung Corporation (Seoul, South Korea, April, 2010).

94. Modular Microfluidics for the Analysis of Integral Membrane Proteins, MASSCP Seminar Series (Boston, MA, April, 2010).

95. Molecular Profiling of Circulating Tumor Cells using Modular Microfluidics, Southern Biomedical Engineering Conference (Baltimore, MD, May, 2010).

96. Single Molecule Detection and Microfluidics: Real-Time Reporting of Molecular Signatures, Naval Research Laboratory (Washington, DC, May, 2010).

97. Polymer-based Microchips for the High Resolution Electrophoretic Separation of Nucleic Acids and Proteins: Successes and Failures, International Conference on Capillary Electrophoresis (Baltimore, MD, September, 2010).

98. Moving Single-Molecule Detection into the Clinic for in vitro Diagnostics, International Workshop on Single-Molecule Detection (Berlin, Germany, September, 2010).

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99. Polymer-based Nanofluidic Systems: Determining Biopolymer Structure using Single Molecule Processing, Biotronics (Seoul, South Korea, October, 2010).

100. Polymer-based Microchips for the Selection and Enumeration of Circulating Tumor Cells, TRI-CON Conference (San Francisco, CA, February, 2011).

101. Point-of-Care Systems for Automated Genotyping: Monitoring Infectious Diseases, PITTCON 2011 (Atlanta, GA, March, 2011).

102. Selection and Enumeration of Circulating Tumor Cells using Polymer Microfluidics, PITTCON 2011 (Atlanta, GA, March, 2011).

103. Single-Molecule Detection and Microfluidics: Molecular Profiling of Circulating Tumor Cells, ICAS 2011 (Kyoto, Japan, May, 2011).

104. Detection of Single Cells and Single Molecules using Capacitance Measurements, Shikata Discussions 2011 (Awaji Island, Japan, May, 2011).

105. Circulating Tumor Cells (CTCs): Their Clinical Utility and New Strategies for Their Selection from Whole Blood (Busan National Hospital, Busan, South Korea, May, 2011).

106. Polymer-Based Nanofluidic Systems: Determining Biopolymer Structure using Single Molecule Processing, Korean Society of Microchips (Seoul, South Korea, June, 2011).

107. Polymer-based Modular Microfluidic Point-of-Care System for Automated Genotyping, NIH/NCI: Global Cancer Care (Bethesda, MD, August, 2011).

108. Single-Molecule Chromatography: A New Approach for Elucidating the Primary Structure of Biopolymers, IUPAC Meeting (Puerto Rico, August, 2011).

109. Selection, Enumeration and Molecular Profiling of Circulating Tumor Cells (CTCs) using Polymer-based Microfluidics, ACS National Meeting (Denver, CO, August, 2011).

110. Single Particle Conductance Measurements: Applications in Biology and Medicine, ACS National Meeting (Denver, CO, August, 2011).

Universities:

111. Sequencing the Human Genome using Near-IR Fluorescence: A Logical Choice, S.A. Soper, University of New Orleans (October, 1995).

112. Near-IR Fluorescence Detection for Large-Scale DNA Sequencing Applications, S.A. Soper, University of Utah (February, 1996).

113. Micromachining in Plastics and Near Infrared Fluorescence Detection for the Rapid Analysis of DNA, Kansas State University (October, 1998).

114. Sequencing the Human Genome Using Near-IR Fluorescence Detection, The University of Kansas (June, 1996).

115. Near-Infrared Fluorescence for the Analysis of DNA, Utah State University (October, 1996).

116. Near-Infrared Fluorescence for the Analysis of DNA, University of Utah (October, 1996).

117. Applications of Near-IR Fluorescence in the Human Genome Project, Clemson University (March, 1997).

118. Multiplexed Time-Resolved Near-IR Fluorescence Detection in Genomics, University of Alberta (March, 2000).

119. Multiplexed Detection of Genetic Mutations using NIR Fluorescence and Microfluidic

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Devices, Mississippi State University (November, 2000).

120. Building Modular Microsystems with a Diverse Research Team: Tackling a Small Problem Using Many Disciplines in Chemistry and Engineering, University of Kansas (October, 2001).

121. Modular Microsystems for Detecting Point Mutations in Genes with Diagnostic Value, Michigan State University (October, 2001).

122. Integrated Microsystems Fabricated from Polymers, Iowa State University (November, 2001).

123. Modular Microsystems Fabricated from Polymers used to Detection Point Mutations in Gene Fragments: A Group Approach to a Small Problem, University of Iowa (November, 2001).

124. Fabrication of Modular Microsystems from Polymers for DNA Diagnostic Applications, University of Virginia (January, 2002).

125. Finding Mutations in Genomes for Diagnostic Applications using Polymer-based Modular Microfluidic Systems, Florida State University (January, 2003).

126. Sequencing Genomes using Microfluidic Systems and NIR Detection, University of West Virginia (October, 2003).

127. High Throughput Genomic Diagnostics using Plastic Microchips and Single Molecule Detection, University of Maryland (November, 2003).

128. Automated Sequence Analysis of Genomes using Modular Microfluidic Systems, Virginia Polytechnical University (December, 2003).

129. Single Molecule Detection for Real-time Molecular Analysis, Colorado State University (February, 2004).

130. Detection of Single Molecules using spFRET for Real-time Molecular Analysis, Mississippi State University (February, 2004).

131. Microfluidic Systems for High Throughput Genome Sequencing, Baylor College of Medicine (April, 2004).

132. DNA Electrophoretic Separations using Polymer-based Microchips, Louisiana State University, Baton Rouge, LA (June, 2004).

133. Analyzing Genomes using Microfluidics: Meeting the Demands of High Throughput for Clinical Applications, University of Florida (September, 2004).

134. Single Molecule Detection and Microfluidics, University of Southern Illinois (November, 2004).

135. Modular Microfluidic Devices Fabricated in Polymers for Molecular Diagnostic Applications, University of Pittsburgh (November, 2004).

136. New Ideas for Analyzing Genomes in Diagnostic Applications, The University of Buffalo, New York, Buffalo, NY (March, 2005).

137. High Throughput Devices for Clinical Diagnostic Applications, Cancer Center, Tulane Health Science Center, New Orleans, LA (May, 2005).

138. Modular Systems for High Throughput Applications, Louisiana State University, Baton Rouge, LA (June, 2005).

139. Flow-Through Lab-on-a-Chip Biosensors for the Detection of Low Abundant Point

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Mutations in Genomic DNA, University of Wisconsin, Madison, WI (September, 2005).

140. Capturing Rare Cells from Mixed Populations and the Analysis of their Intracellular Contents using Modular Microfluidics, Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA (September, 2005).

141. Flow-Through Lab-on-a-Chip Biosensors for the Detection of Low Abundant Point Mutations in Genomic DNA, University of Tennessee, Knoxville, TN (October, 2005).

142. Flow-Through Lab-on-a-Chip Biosensors for the Detection of Low Abundant Point Mutations in Genomic DNA, University of Texas, San Antonio, San Antonio, TX (November, 2005).

143. Single Molecule Detection for the Analysis of Low Abundant Point Mutations using Microfluidics, State University of New York, Buffalo, NY (February, 2006).

144. Flow-Through Biosensors for the Detection of Point Mutations in Genomic DNA with High Diagnostic Value for Colorectal Cancers, The Ohio State University, Columbus, OH (February, 2006).

145. Highly Multiplexed Assays for Diagnostic Applications using Polymer-based Microfluidics, The University of California, Riverside, Riverside, CA (January, 2007).

146. The Role of Microfluidics in Chemistry, Redlands University, Redlands, CA (January, 2007).

147. BioMEMS as Functional Platforms for the Analysis of BioMarkers using Single Molecule Readout, University of Tennessee Space Institute, Tullahoma, TN (April, 2007).

148. Fluorescence Detection at the Single Molecule Level, University of Idaho, Idaho Fall, ID (May, 2007).

149. Single Cell and Single Molecule Detection: Applications in Biology, Medicine and Drug Discovery, University of Pittsburgh, Pittsburgh, PA (September, 2007).

150. Single Cell and Single Molecule Detection: Applications in Biology, Medicine and Drug Discovery, University of Utah, Salt Lake City, UT (August, 2007).

151. Integrated Microfluidic Systems for Real-time Molecular Reporting, University of Southern Mississippi, Hattiesburg, MS (September, 2008).

152. Microfluidic Systems Made From Polymers for Molecular Profiling, Zhejiang University, Hangzhou, China (November, 2008).

153. Microfluidic Systems Made From Polymers for Infectious Diseases, Southeast University, Nanjing, China (November, 2008).

154. Integrated Polymer-based Microfluidic Systems for Molecular Profiling, University of North Carolina, Chapel Hill (February, 2009).

155. Personalized Cancer Care: The Importance of Polymer-based Microfluidic Systems for Transitioning DNA Sequencing into the Clinic, Weill Cornell Medical College, New York, NY (May, 2009).

156. Microfluidics for the Remote Diagnosis of Infectious Diseases, Mahidol University, Bangkok, Thailand (November, 2009).

157. Polymer-based Modular Microfluidics for DNA Diagnostics, Notre Dame University, South Bend, IN (January, 2010).

158. Point-of-Care System for Automated Genotyping: Monitoring Infectious Diseases,

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Louisiana Technical University, Ruston, LA (January, 2010).

159. Single-Molecule Detection and Microfluidics: Real-Time Reporting of Molecular Signatures, University of North Carolina, Chapel Hill and North Carolina State University, Rayleigh, North Carolina (March, 2010).

160. Integrated Polymer-based Microfluidic Systems for the Analysis of Integral Membrane Proteins, Yonsei University, Seoul, South Korea (July, 2010).

161. Polymer-based Nanofluidic Systems for Processing Single-Molecules, Dankook University, Seoul, South Korea (July, 2010).

162. Polymer-based Nanofluidic Systems for Single-Molecule DNA Sequencing, Changwon University, Changwon, South Korea (August, 2010).

163. Single-Molecule Detection and Micro-/Nanofluidics: Approaching Real-time in vitro Diagnostics Reporting, Seoul National University (October, 2010).

164. Single-Molecule Detection and Micro-/Nanofluidics: Approaching Real-time in vitro Diagnostics Reporting, Karcher-Barton Seminar, University of Oklahoma (January, 2011).

165. Circulating Tumor Cells (CTCs): Their Clinical Utility and New Strategies for Their Selection from Whole Blood, Cell-to-Cell Communications Special Seminar Series, Ulsan National Institute of Science and Technology (February, 2011).

166. Circulating Tumor Cells (CTCs): Their Clinical Utility and New Strategies for Their Selection from Whole Blood, Chungnam University (Deaju, South Korea).

167. Circulating Tumor Cells (CTCs): Their Clinical Utility and New Strategies for Their Selection from Whole Blood, POSTECH Institute (Pohang, South Korea).

Ph.D. STUDENTS

1. James H. Flanagan, Jr. (Ph.D, 1998); Current Position - TransGenomic, Omaha, NE; Dissertation Title - "Synthesis and Photophysical Characterization of Near-IR Probes for Bioanalytical Applications."

2. Benjamin L. Legendre, Jr. (Ph.D., 1998); Current Position - TransGenomic, Omaha, NE; Dissertation Title - "Fluorescence Lifetime Discrimination of Near-Infrared Dye-Labeled Oligonucleotide Fragments Separated by Capillary Gel Electrophoresis for Base-Calling Applications in DNA Sequencing."

3. Daryl C. Williams (Ph.D., 1998); Current Position - General Electric, Louisville, KY; Dissertation Title - "A Novel Approach to DNA Sequencing Employing Near-IR Fluorescence Detection Coupled to Nano-Scale Reaction Vessels with Capillary Electrophoresis."

4. Yolanda Y. Davidson (Ph.D., 1999); Current Position – Jackson State University, Jackson, MS; Dissertation Title - "Immobilization of Enzymes to Solid Phase Reactors for the Micro-digestion of DNA."

5. Clyde V. Owens (Ph.D., 2000); Current Position – United States Environmental Protection Agency, Rayleigh, NC; Dissertation Title - "Synthesis and Photophysical Characterization of Novel Water Soluble Phthalocyanine and Naphthalocyanine Near-IR Dyes."

6. Emanuel Waddell (Ph.D., 2000); Current Position – Assistant Professor, University of Alabama, Huntsville; Dissertation Title - "The Design, Construction, and Application of Novel Near Infrared Time-Correlated Single Photon Counting Devices."

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7. Scott McWhorter (Ph.D., 2000); Current Position - DOE Savannah River Site, Aiken, SC; Dissertation Title - "Micro-Separation of Anions and Polyanions using PMMA-Based Micro-chips with Conductivity Detection."

8. Sean Ford (Ph.D., 2001); Current Position – BioDiagnostics, Los Angeles, CA; Dissertation Title – “Fabricating Microfluidic Devices in Polymers for Bioanalytical Applications.”

9. Suzanne J. Lassiter (Ph.D., 2001); Current Position – Albemarle Corporation, Baton Rouge, LA; Dissertation Title – “Multiplexed Detection in DNA Sequencing using Time-Resolved Fluorescence Detection in the Near-IR.”

10. Gloria Thomas (Ph.D., 2002); Current Position – Assistant Professor, Mississippi Sate University, Starkville, MS; Dissertation Title - “Capillary and Microdevice Electrophoresis Tools for Genetic Analyses: Heteroduplex Anaylsis for Tuberculosis Drug Susceptibility and Ligase Detection Reaction for Colorectal Cancer Detection.”

11. Musundi Wabuyele (Ph.D., 2003); Current Position – Glaxo Smith Kline Research; Dissertation Title – “Single Molecule Detection in Microfluidic Chips Fabricated from Polymers.”

12. Yichuan Xu (Ph.D., 2003); Current Position – Post-Doctoral Associate, University of Cornell, Dissertation Title – “Low Volume Reactors coupled to Capillary Electrophoresis for Performing Highly Efficient Sanger Sequencing:”

13. Yun Wang (Ph.D., 2003); Current Position – Post-Doctoral Associate, University of Wisconsin; Dissertation Title – “DNA Microarrays Assembled in Microfluidic Chips for the Detection of Low Abundant Point Mutations.”

14. Michelle Galloway (Ph.D., 2004); Current Position – Post-Doctoral Associate, National Institutes of Health, Dissertation Title – “Contact Conductivity Detection in Polymer-based Microfluidic Devices.”

15. Li Zhu (Ph.D., 2005); Current Position – Researcher, GE Global Research Center, Dissertation Title – “Capillary and Microchip Gel Electrophoresis using Multiplexed Fluorescence Detection with both Time-Resolved and Spectral-Discrimination Capabilities: Applications in DNA Sequencing using Near-Infrared Fluorescence.”

16. Shawn Llopis (Ph.D., 2006); Current Position – Instructor, Southeast Louisiana University, Dissertation Title – “Time-Resolved Fluorescence Detection for DNA sequencing applications using Microchip Electrophoresis.”

17. Harrison Musyimi (Ph.D., 2006); Current Position – National Institutes of Health, Dissertation Title – “Integrated Microfluidic Systems for Proteome Analysis and their Interface to MALDI Mass Spectrometry.”

18. Hamed Shadpour (Ph.D., 2006); Current Position – Post-Doctoral Associate, University of North Carolina, Chapel Hill, Dissertation Title – “Multi-Dimensional Separations of Proteins using Microfluidic Systems for Proteome Applications.”

19. Catherine Situma (Ph.D., 2007); Current Position – Instructor, Louisiana State University, Dissertation Title – “DNA Microarrays Fabricated on PMMA Substrates and Addressed using Microfluidics.”

20. Vera Verdree (Ph.D., 2007) – Current Position – Staff Researcher, Burroughs, Houston, TX, “The Spectral and Photophysical Characterization of Water Soluble Metal Phthalocyanines for Highly Sensitive Near-IR Fluorescence Detection of Targets in Biological Studies.”

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21. Andre Adams (Ph.D., 2008) – Current Position – Post Doctoral Researcher, Naval Research Laboratory, “High Throughput Microsampling Unit for the Capture and Enumeration of Circulating Tumor Cells.

22. Anne Obubuafu (Ph.D., 2008) – Current Position – St. Thomas University, MN “The Use of Aptamers as Highly Selective Molecular Recognition Elements in Bioanalytical Assays”.

23. Rondedrick Sinville (Ph.D., 2008) – Current Position – Post Doctoral Researcher, University of Minnesota, “High Resolution Microchip Electrophoresis for the Analysis of Low Abundant Point Mutations in Genomic DNA.”

24. Paul Okagbare (Ph.D., 2009) – Current Position – Post-Doctoral Researcher, University of Michigan, “Polymer-based Microfluidic Devices for High Throughput Single Molecule Detection: Applications in Biology and Drug Discovery.”

25. Jason Emory (Ph.D., 2009) – Current Position – Post-Doctoral Researcher, Colorado State University, “Single Molecule Detection for Molecular Diagnostics.”

26. John Kalu Osiri (Ph.D., 2009) – Current Position – Post-Doctoral Researcher, Washington State University, “High Resolution Multi-dimensional Microchip Electrophoresis for Proteomic-based Analyses.”

27. Wonbae Lee (Ph.D., 2010) – Current Position – Post-Doctoral Researcher, University of Oregon, “Cross-Talk-Free Dual-Color Fluorescence Cross-Correlation Spectroscopy for High-Throughput Screening.”

28. Jeonghoon Lee (Ph.D., 2010) – Current Position – Post-Doctoral Researcher, Washington State University, “MALDI Mass Spectrometry and Polymer Microfluidics.”

29. Udara Dharmasiri (Ph.D., 2010) – Current Position – Post-Doctoral Researcher, University of Texas A&M, “Selection, Enumeration and the Molecular Profiling of Rare Circulating Tumor Cells using Polymer Microfluidics.”

30. Samuel Njoroge (Ph.D., 2011) – Current Position – Post-Doctoral Researcher, Cal Tech, “Integrated Modular Microfluidic System for Forensic Alu Typing.”

31. Hui-Wen Chen (Ph.D., 2011) – Current Position – Post-Doctoral Researcher, “Integrated Polymer-based Microfluidic Systems for the Analysis of Bacterial Pathogens.”

32. Franklin I. Uba (M.S., 2011) – Current Position – Graduate Student, University of North Carolina, Chapel Hill, “Nanogap Sensors for the Analysis of Single Molecules.”

33. Brandon Young (M.S., 2011) – Current Position – Graduate Student, University of North Carolina, Chapel Hill, “Single Molecule Detection for In Vitro Molecular Diagnostics.”

POST-DOCTORAL ASSOCIATES (PAST) 1. Jack Davies – Current Position – Shakespeare Polymers, Columbia, SC. 2. Shize Xi – Current Position - Microsystems BioTechnology Inc., Santa Clara, CA. 3. Larry Li – Current Position – Post-Doctoral Associate, University of Toronto, Canada 4. Bill Kar – Current Position – TransGenomics, Omaha, NE. 5. Masahiko Hashimoto – Current Position – Assistant Professor, Keio University,

Yamagata, Japan. 6. Michael Allen – Current Position – Thermo Electron Corporation, Fitchburg, WI 7. Jifeng Chen – Current Position – Protea Biosciences, Inc., Morgantown, WV. 8. Guofang Chen – Current Position – Assistant Professor, St. John’s University, New

York, NY.

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9. Rattikan Chantiwas – Current Position – Mahadol University, Bangkok, Thailand.

VISITING SCHOLARS 1. Hengwu Chen – Department of Chemistry, Zhejiang University, Hangzhou China, 2002-

2003. 2. Yong-Ill Lee – Department of Chemistry, Changwon National University, Changwon,

South Korea, 2006-2007. 3. Akira Kotani – Department of Pharmaceutical Science, University of Tokyo, Tokyo,

Japan, 2009. 4. Yong-Ill Lee – Department of Chemistry, Changwon National University, Changwon,

South Korea, 2011-2012.

CURRENT PERSONNEL (Excluding graduate students)

1. Dr. Makgorzata Witek (research associate). Maggie is working on single cell transport and lysis in microfluidic systems. She is also investigating the extraction and isolation of certain classes of proteins from whole cell lysates using micro-solid-phase extraction methods. Class specific extraction is being carried out using surface-modified polymeric materials. She is supported through an NSF grant.

2. Dr. Matt Hupert (research associate). Matt is working on micromachining and fabrication of fluidic interconnects for assembling modules. His efforts to this juncture have been directed toward learning microfabrication principles and also, designing low dead volume interconnects. Matt is support by the Governor’s Biotechnology Initiative.

3. Dr. Hong Wang (post-doctoral associate). Dr. Wang is working on our DNA sequencing project (supported by the NIH). He is assembling the various microfluidic modules into an integrated system and testing the system on templates received from Prof. Mark Batzer.

4. Dr. Subramanian Balamurugan (post-doctoral associate). Dr. Balamuragan is part of a new National Cancer Institute project awarded to my group for developing high throughput capture microdevices for low abundant cells shed from primary tumor sites.

5. Dr. Irina Nesterova (post-doctoral associate). Dr. Nesterova is working on a joint project sponsored by the NIH to develop labeling strategies of phthalocyanine dyes to various biopolymer targets and their photophysical characterization.

6. Mr. Jason Guy (technician). Jason is a master machinist and is currently working on high precision micromilling of materials from which to microreplicate polymer-based microfluidic elements. Jason is supported through the Governor’s Biotechnology Initiative.

7. Mr. Donald Patterson (technician). Don is an electronics design engineer and is developing control circuitry for our microfluidic systems. Don is supported through the Governor’s Biotechnology Initiative.

FUNDING (TOTAL - $39,787,069) Current:

1. Augmenting BioMEMS/BioNEMS at Louisiana State University: Pushing into the Nanometer Regime. Louisiana Governor’s Biotechnology Initiative, 1/03-?, $942,375.

2. Polymer Science and Engineering Research and Educational Cluster, Louisiana State University, 7/07 - ?, $5,000,000.

3. High Throughput Biochemical Screening of Combinatorial Libraries using Microfluidics,

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National Institutes of Health, 2007-2011, $2,645,500. National Institutes of Health (PI).

4. High Throughput Biochemical Screening of Combinatorial Libraries using Microfluidics ARRA Supplement, National Institutes of Health, 2009-2011, $118,400 (PI).

5. Louisiana’s Infrastructure Improvement: CBM2 – Interdisciplinary Research, National Science Foundation – EPSCoR Program, 2007-2011, $2,600,000 (PI).

6. Integrated System for the Molecular Diagnosis of Stroke, National Institutes of Health (BRG), 2011-2015, $3,379,099 (PI).

7. Development of Novel Polymer-based Platforms for DNA Sequencing, Roche Diagnostics, $75,000 (Co-PI, with Cornell Medical College, New York, NY, PI – Francis Barany).

8. National Institutes of Health, National Human Genome Research Institutes, Nanosensor Arrays for Time-of-Flight Reading of DNA Sequence Information (R21), 2011 – 2013, $534,650 (PI).

9. Multi-scale Simulation and Experimental Investigation of Single DNA Nucleotide Translocation through Nanochannels: A New Paradigm for Fast DNA Sequencing, National Science Foundation (CBET), 2009-2012, $679,700 (Co-PI with Sunggook Park, LSU).

Past:

1. Microsampling Unit for Capturing Low Abundant Cells and their Intracellular Analysis, National Cancer Institute, National Institutes of Health, 2003 – 2010, $1,750,491 (PI).

2. Genotyping molecular signatures of CRC using polymer microchip-CE and FSCE, National Institutes of Health, IMAT Program, 2007 – 2010, $384,577 (PI).

3. Three-Dimensional Flow Sorters Prepared using SU-8 Lithography, National Science Foundation, 2007 – 2010, $245,850, Co-PI (PI: Prof. Wanjun Wang, Louisiana State University).

4. Building Polymer-based Microfluidic Valves, Microsystems Biotechnology Incorporated, 2007-2009, $26,000, PI.

5. Modular Microfluidic Systems for Automated DNA Sequence Analysis, National Human Genome Research Institute, National Institutes of Health, 2003 – 2007, $2,169,237.

6. Center for BioModular Microsystems, National Science Foundation (EPSCoR), 2004 – 2007, $9,000,000 with $1,000,000 match from LSU (PI).

7. Synthesis and Characterization of Fluorescent Porphyrinoid Bioconjugates for Imaging and Bioanalyses, National Science Foundation (CRC), 2003 – 2006, $750,000 (Co-PI).

8. The Design and Fabrication of Novel Micro-Instrument Platforms for Performing Genetic-Based Analysis, National Institutes of Health, 2000 - 2006, $2,883,730 (PI).

9. Multiplexed Fluorescence Analysis, National Institutes of Health (SBRI Phase I), 2004-2005, $115,500, Co-PI (PI: Prof. Michael Metzker, Baylor College of Medicine).

10. Designing Single Cell Proteome Micro-Modular Systems, National Science Foundation, 2002-2005, $820,721 (PI).

11. Planning Grant for an Engineering Research Center (ERC) for Modular Microsystems. Louisiana Board of Regents; NSF EPSCOR, 3/00 - 12/03, $60,000 (Co-PI).

12. High Throughput DNA Sequencing Using Nano-Reactors and Micro-Electrophoresis, National Institutes of Health, 2000 - 2003, $1,446,008 (PI).

13. Acquisition of Instruments for Microsystems Research, NSF-MRI Program, 9/1/99 –

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12/31/02, $237,551 (Co-PI).

14. Multiplexed DNA Sequencing Using CGE and NIR Fluorescence, National Institutes of Health (FIRST Award), 1995-2000, $492,255 (PI).

15. DNA Sequencing with Infrared Fluorescence Biomolecules, National Institutes of Health, 1997-1999, $100,000 (Co-PI).

16. High Throughput DNA Sequencing Using Micro-Reactors and Micro-CE, National Institutes of Health, 1996-1999, $940,056 (PI).

17. Ultrasensitive Analyses of Trace Heavy Metals in Ground Water, Department of Energy, 1996, $15,000 (Co-PI).

18. Thermodynamics and Binding Properties of Near-IR Fluorescent Dyes to Double-Stranded DNA, American Chemical Society, Petroleum Research Fund, 1993-1995, $20,000 (PI).

19. DNA Sequencing Using Heavy-Atom Modified Near-IR Dyes, National Institutes of Health (Shannon Award), 1994-1995, $80,000 (PI).

20. Ultra-sensitive Multidimensional Near-Infrared Fluorescence for Biomedical and Environmental Monitoring Applications, Center for Energy Studies, Louisiana State University, 1994-1995, $17,500 (PI).

21. Development of a Highly Multiplexed and Miniaturized Chemical Analysis System for Obtaining Restriction Maps of Double-Stranded DNA, Whitaker Foundation, 1995-1997, $136,748 (PI).

22. Development of Near-Field Scanning Optical Microscopy, Louisiana Educational Quality Support Fund, 1996, $145,000 (PI).

23. Single Lane, Single Dye Sequencing Using NIR Detection, Louisiana Educational Quality Support Fund, 1994-1996, $125,567 (PI).

Pending:

24. A Microneedle Array-Based Pre-Concentrator for Sampling Whole Blood for Breast Cancer Detection and Treatment Monitoring, National Institutes of Health (BCRP), 2010-2012, $555,000 (Co-PI with Michael C. Murphy, Louisiana State University, LSU).

25. Development of an Integrated Micro Cytometer with Imbedded Optical Measurement System for Space and Other Remote Point-of-Care Applications, Louisiana Board of Regents (NASA EPSCoR), 2010-2013, $1,118,448 (Co-PI with Wanjun Wang, LSU).

26. Microfabricated, High Throughput, Thermal Reactor Arrays for Biology and Medicine, Louisiana Board of Regents, 2009-2012, $325,000 (Co-PI with Michael Murphy, LSU).

27. Hand Held-Point-of-Care Device for Bacterial Counting in Body Fluids using a Cell Wall Specific Protein Maker, Department of Defense (CDMRP – Congressionally Directed Medical Research Programs), 2011-2012, $149,953 (Co-PI with Roger Laine, LSU).

28. Integrated Microfluidic Systems for the Molecular Profiling of Circulating Tumor Cells, National Institutes of Health (National Cancer Institute), 2012 – 2016, $4,254,500 (PI).

COLLABORATORS

1. Prof. J. Michael Ramsey, University of North Carolina, Chapel Hill, Department of Chemistry (DNA Translocations through Nanoconfined Environments).

2. Prof. Annelise Barron, Northwestern University, Department of Chemical Engineering (Free Solution Separation of DNA with Drag Tags).

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3. Prof. Richard Gibbs, Baylor College of Medicine, Department of Human Genetics (DNA Sequencing of M13 clones from Human chromosome 16).

4. Prof. Francis Barany, Cornell Medical College, Department of Molecular Biology (LDR for detecting low abundant point mutations in K-ras genes).

5. Dr. Pat Paty, Sloan Kettering Memorial Cancer Center (LDR for detecting low abundant point mutations in K-ras genes).

6. Prof. Patrick Limbach University of Cincinnati, Department of Chemistry (ESI mass spectrometry interface to microfluidic chips for proteomic research).

7. Prof. Robin McCarley, Louisiana State University, Department of Chemistry (surface modification of polymer-based microdevices).

8. Prof. Robert Hammer, Louisiana State University, Department of Chemistry (synthesis of novel near-IR fluorescent labeling dyes).

9. Prof. David Spivak, Louisiana State University, Department of Chemistry (development of surface imprinted polymers for capture of specific target cells)

10. Prof. Graca Vicente, Louisiana State University, Department of Chemistry (synthesis and spectroscopic characterization of novel near-IR fluorescent reporters).

11. Prof. Kermit Murray, Louisiana State University, Department of Chemistry (MALDI mass spectrometry interface to polymer-based microfluidic devices for proteomic research).

12. Prof. Michael Murphy, Louisiana State University, Department of Mechanical Engineering (fabrication of PCR microdevices and development of nano-fluidic interconnects for modular systems).

13. Prof. Kevin Kelly, Louisiana State University, Department of Mechanical Engineering (development of injection molding for the rapid and low cost fabrication polymer-based microfluidic systems).

14. Prof. Dimitris Nikitopoulos, Louisiana State University, Department of Mechanical Engineering (simulations and modeling of fluid transport in microsystems).

15. Prof. Wanjun Wang, Louisiana State University, Department of Mechanical Engineering (integration of micropumps to BioMEMS devices fabricated in polymers).

16. Dr. Jost Goettert, Louisiana State University, Center for Advanced Microstructures and Devices (development of multi-level mold inserts, nano-mold inserts and tapered wall inserts).

17. Dr. William Kim, University of North Carolina Medical School (determining the mutational status of circulating tumor cells isolated from patients with bladder cancer).

18. Prof. Bingqing Wei, Louisiana State University, Electrical and Computer Science (development of novel applications for carbon nanotubes).

19. Prof. Mark Batzer, Louisiana State University, Department of Biological Sciences (sequencing of Alu repeats for comparative genomics).

20. Prof. Terry Bricker, Louisiana State University, Department of Biological Sciences (two-dimensional electrophoretic separation and isolation of lumenal proteins).

21. Prof. Diana Williams, Louisiana State University, Veterinary Medicine School (molecular biological analysis of mycobacterium tuberculosis and its drug resistant forms).

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22. Prof. Alison Baird, SUNY Downstate Stroke Center, Professor of Neurology and Physiology/Pharmacology (using mRNAs for the in vitro diagnosis of stroke).

23. Prof. Roger Laine, Louisiana State University, Professor of Biological Sciences (developing flow cytometric systems for the enumeration and sorting of bacterial pathogens).

24. Prof. Michael Metzker, Baylor College of Medicine, Professor of Molecular Medicine (assisting on developing microfluidic chips for the high resolution separation of DNA sequencing fragments).

25. Prof. Sunggook Park, Louisiana State University, Professor of Mechanical Engineering (fabrication of nano-scale sensors using NanoImprint Lithography).

26. Prof. Dorel Moldovan, Louisiana State University, Professor of Mechanical Engineering (Non-equilibrium Molecular Dynamic Simulations of the transport of single molecules through nano-scale flight tubes).

27. Dr. Jen Jen Yeh, University of North Carolina Medical School (determining the mutational status of circulating tumor cells isolated from patients with colorectal cancer).

PROFESSIONAL CONSULTING 1. Science Advisor, Southeast Regional Laboratory, Food and Drug Administration, New

Orleans, LA, 1993-1998. 2. FMC BioProducts, Rockport Maine, 1997-1999. 3. Li-COR Biotechnology, Lincoln, NE, 1996-1999. 4. Center for Fluorescence Spectroscopy, University of Maryland Medical Center, 2005-2006. 5. Celula BioTechnologies, San Diego, CA, 2008 – present. 6. ApoCell, Houston, TX, 2010 – present. COMMITTEE ASSIGNMENTS 1. Graduate Recruiting Committee, Department of Chemistry (1991 – 2002). 2. GBI Search Committee, Departments of Chemistry and Mechanical Engineering, Chair

(2002). 3. Chemistry Department Morale Committee, Department of Chemistry (1992 – 1995). 4. Choppin Hall Space Committee, Department of Chemistry (2000 – 2005). 5. Department of Chemistry Facilities Committee (1998 – 2004). 6. Graduate Student Recruiting Committee, Department of Chemistry (1991 – 2001). 7. College of Basic Sciences Promotion and Tenure Committee (2003). 8. College of Basic Sciences, Dean Search Committee (2004). 9. CAMD User Committee (2002 – 2006, Chair in 2005). 10. Louisiana State University, Vice Chancellor for Research Search Committee (2005 – 2006). 11. Director, Center for BioModular Multi-Scale Systems (2003 – present).

This Center consists of 17 research activity faculty that possess 67 active research grants totaling over $56M per year (direct costs). The Center consists of approximately 211 participants, including faculty, staff, post-doctoral associates, and graduate/undergraduate students. As part of the mission of this Center, education and outreach to not only the research community, but to the general public is seen as vital components.

12. Louisiana State University, Vice Chancellor for Research and Economic Development Search Committee (2006).

13. South Campus Task Force (Chair, 2006 – present). 14. Multidisciplinary Hiring Executive Search Committee (Chair, 2007 – present). 15. CAMD Director Search Committee (2006 – 2008). 16. Chair, Promotion and Tenure Committee, Chemistry (2009).

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17. Promotion and Tenure Committee for the College of Basic Sciences and Chemistry (2008-2010).

18. Program Review Panel, Veterinary Medical Sciences (2009). 19. Chair, Microfabrication Resource Center, Louisiana State University (2009 – present). 20. Advisory Board to Provost on Tenure Decisions, Louisiana State University, 2009. 21. Chair, Promotion and Tenure Committee, Department of Chemistry (2009 – present).

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STATEMENT OF TEACHING PHILOSOPHY The teaching mission of a professor at a major research institution takes on many forms, such as

instruction in a formal class setting and mentorship of future professionals (graduate/ undergraduate students and post-doctoral associates). While both of these activities are equally important, I have devoted a large amount of my time toward graduate student mentorship as evidenced by the large research group I have sustained over a number of years (currently 12 graduate students). While I realize the importance of undergraduate training, both in the classroom and the research lab, I view graduate mentorship as one of the most important tasks for a research professor. I have adopted a strategy to assist in the training of these students for competitively pursuing professional opportunities, whether in the private sector or academia, using a collaborative and multi-disciplinary approach. My research group is organized into several teams, with each team focused on a particular project (DNA diagnostics, DNA sequencing, Proteomics). For each project, students are developing a particular component for the target application, with each student required to heavily interact and be familiar with activities of other members of the team. What is intriguing is the fact that they are not just interacting with their own research group members, but with students in Mechanical Engineering or Biological Sciences also working as part of these teams.

To assist in forming effective collaborative efforts amongst students in a particular project team, we hold bi-weekly team meetings. This has been an effective method for students to understand how their work fits into a large project and also, to learn how to interact with others in different disciplines and how to be a team player in multi-disciplinary efforts. My feeling is that these experiences prepare them well for their post-graduate work. In addition, I have found that the students become more independent and seek out assistance not only from myself, but their peers and other professors. The post-doctoral associates I support are intimately involved in this activity as well. They typically organize these meetings and select the agenda with input from other team members. This creates an atmosphere of the team members “owning” the project and therefore, become more responsible towards its completion.

I have also been involved in undergraduate research and not just through summer research programs, such as REU programs. Over my years at LSU I have had five undergraduates who have joined my research group as freshmen and have stayed within the group during their entire tenure at LSU. Three of these students have/are participated in graduate programs in Chemistry (Christie Sayes, Rice University; Sarah Romero, Delaware University and Jason Brabham, Texas A&M University). These undergraduate students are integrated into the research teams outlined above and actively participate in team meetings.

In formal class settings, I have been involved with 11 different courses while at LSU both at the graduate and undergraduate levels. Due to the number of different courses that I have been associated with, a large amount of effort was devoted to developing class notes and general restructuring of the course content. For example, CHEM 2001, our sophomore-level quantitative analysis course, was a new course that was initiated in the Fall of 1992. I assisted in developing the curriculum for this course and selecting the textbook. In the Spring of 1994, a comprehensive separations class was formulated for graduate-level students. This course offers a complete overview of analytical chromatographic techniques and covers fundamental concepts, gas chromatography, liquid chromatography and specialty areas such as capillary electrophoresis, affinity chromatography and chiral separations. Again, I was intimately involved in developing the content for this course and I am still teaching this course on a regular basis.

During my first few years at LSU, my teaching duties were specifically oriented toward revamping much of the analytical laboratory courses, which had not experienced a change in over 15 years. My efforts were primarily directed toward both the quantitative analysis course (sophomore-level) and the senior instrumental analysis laboratory. In fact, most of my contributions to the LSU teaching program have come from the restructuring of these laboratories. Not only did I design and troubleshoot new laboratories, but diligently sought out new instruments for these teaching laboratories in order to expose students to state-of-the-art analysis in analytical chemistry. Many times this meant going to local industry to secure appropriate equipment that could easily be assimilated into the laboratory.

Shown below is a listing of the instructor ratings that I have received over the course of my tenure at LSU. As can be seen, the ratings have been consistently higher than the College and Department instructor average, except in two instances. The ratings dropped below the College and Department average for a graduate level course, which dealt with separation science as described above. This course, while securing high enrollment numbers due to the content, has been a very difficult course for graduate students due to the complexity and high level of information contained within this course. As such, it is very challenging for the student and as a result, many students get grades that are less than satisfactory.

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My philosophy for upper level graduate courses is to present the student with a large amount of information due to the expected maturity level of the student and the extensive experience the student should have at this level of his/her career in education. Unfortunately, this philosophy has not been too agreeable to the students and as a result, the instructor ratings suffered for this particular course.

The other low ranking appeared in 1994 due to the instigation of the new sophomore-level quantitative analysis course, which is a very challenging course due to the shear nature of the material covered (quantitative analysis as well as instrumental analysis). This course over the years has scored poorly for all instructors.

There have been few student evaluations over the last several years, since I have been involved in teaching our senior-level instrumental analysis laboratory (no student evaluations in laboratory classes). This course consists of a series of core instrumental laboratories followed by an independent laboratory in which the students decide on the topic. The independent laboratory requires extensive library work, followed by developing a hypothesis and designing experiments to test their hypothesis. Also, during 2003-2006, my teaching contract was bought out by the major NSF funding of the Center for BioModular Multi-Scale Systems.

Courses Taught While at LSU CHEM 1432, Freshman Honors (F91, enrollment 45) CHEM 7750, Graduate Optics (S93, enrollment 7) CHEM 2001, Sophomore Quantitative Analysis (F93, enrollment 65) CHEM 7750, Graduate Separation Science (S94, enrollment 42) CHEM 2001, Sophomore Quantitative Analysis (S94, enrollment 54) CHEM 7153, Graduate Molecular Analysis (F95, enrollment 21) CHEM 4553, Instrumental Analysis (S96, enrollment 16) CHEM 7750, Graduate Separation Science (S97, enrollment 44) CHEM 7250, Graduate Molecular Spectroscopy (F97, enrollment 17) CHEM 7750, Fluorescence Spectroscopy (S98, enrollment 10) CHEM 2001, Sophomore Quantitative Analysis (S99, enrollment 83) CHEM 1202, Freshman Chemistry (F99, enrollment 195) CHEM 1202, Freshman Chemistry (S00, enrollment 155) CHEM 2001, Sophomore Quantitative Analysis (F00, enrollment 73) CHEM 4553, Instrumental Analysis (S01-F03, enrollment 20 per semester) CHEM 2001, Sophomore Quantitative Analysis (S07, enrollment 65) CHEM 2001, Sophomore Quantitative Analysis (F07, enrollment 69) CHEM 4553, Instrumental Analysis (S08, enrollment 14) CHEM 7750, Bioanalysis, Graduate-level class (F08, enrollment 26) CHEMI 2001, Sophomore Quantitative Analysis (S09, enrollment 62) CHEM 4553, Instrumental Analysis (F09, enrollment 10)

F91 S93 F93 S94 S94 F95 S96 S97 F97 S98 S99 F99 S00

7.0

7.5

8.0

8.5

9.0

9.5

Inst

ruct

or R

atin

g

Semester

College Chemistry Soper

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PROFESSIONAL/UNIVERSITY SERVICE I have been involved with a number of professional and/or university services throughout my career at Louisiana

State University. Many of these have been associated with service through traditional routes, such as committee assignments for the department, college and university, but others are more non-traditional. For example, my current major activity is serving as Director for the aforementioned Center of Excellence (CoE) on the campus of Louisiana State University with collaborators across the state and nationwide with a technology focus on the development and applications of BioMEMS/BioNEMS. The core of this CoE already includes researchers at Louisiana State University in the College of Basic Sciences (Chemistry, Biological Sciences, and Physics), the College of Engineering (Mechanical and Chemical Engineering) and CAMD, but also includes researchers and educators from within the state and those outside. In addition, we have built international collaborations as well, including those in Europe and Asia. We are leveraging our extensive facilities and expertise in micro- and nanofabrication to solicit funding from several different agencies to sustain the activities of this Center both from a research and educational perspective.

Another mission of the Center is to provide major research infrastructure for new and existing faculty within the state of Louisiana. I have written a number of infrastructure awards at both the State and National levels to secure major equipment for our researchers. For example, a State grant written by myself was awarded to Louisiana State University that allowed the purchase of rapid prototyping equipment for BioMEMS/BioNEMS that has been placed into core fabrication facilities to allow access to this equipment by researchers in Louisiana. In addition, new capabilities were added by the acquisition of NanoImprint Lithography equipment as well as the hiring of a new assistant professor that was supported through these funds. In addition, this state-directed grant has allowed the hiring of one new faculty within the Department of Chemistry at Louisiana State University. Finally, I just secured funds to acquire a dual column focused ion beam/scanning electron microscope for patterning nanometer-scale structures in silicon stamps to be used for nanoimprint lithography.

I have also been intimately involved at the national level of servicing the fields of analytical chemistry and genomics for many years and continue to do so. For example, I have been an ad hoc reviewer for the National Institutes of Health (National Cancer Institute, National Human Genome Institute and General Medical Institute) since 1995. I also served as a permanent member to the ISD study panel. In addition to my role as a reviewer for NIH, I have also served on panels for the National Science Foundation and as a Chair for several special emphasis panels for the Department of Energy as well as NIH. I am also on the editorial board for three international journals (Analyst, Journal of Fluorescence and Analytical Chemistry). The premier journal of my field is Analytical Chemistry and I served an appointment as an Associate Editor for A-page contributions.

I have also focused on developing entrepreneurial skill sets in students and post-doctoral associates as well. For example, I founded the Company, BioFluidica Microtechnologies, which has recently been awarded several grants from state and national agencies. The company is focused on developing new platforms for searching for rare cells from mixed populations for both clinical and environmental applications. The grants that were recently funded were written primarily by a research associate in my laboratory who has been working under my direction for 6 years.

My primary service contributions to our University has been directed toward serving on a variety of campus and College committees, for example, the College Promotion and Tenure Committee (Chair, 2003-2004), Center for Advanced Microstructures and Devices Users Committee (Chair), Materials Science Ad Hoc Committee, and several departmental and College search committees. I view my future role at this University in developing working models for performing interdisciplinary research. I will be working hard, as part of our Center’s mission, to develop new collaborative initiatives between various units on campus and support existing ones. I am convinced that our University’s national research prominence can be substantially improved by developing strong programs built on expertise already in place across this University. The Center for BioModular Multi-Scale Systems is an inter-institutional, multidisciplinary research initiative that is focused on developing enabling tools for

basic discovery in the life sciences and diagnostics in medicine. The core research thrusts include materials, fabrication and genome sciences.

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