CURRICULUM VITAE –Marcello Locatelli

PERSONAL INFORMATIONName and surname Marcello LocatelliE-mail m.locatelli@unich.itTelephone (work) +39-0871-3554590Mobile +39 348-5821600Fax (Department) +39 0871-3554911Nazionality ItalyBorn date Portomaggiore (Ferrara), 07 October 1979

FIELD OF INTEREST - SSD 03/A1 (Analytical Chemistry, ex CHIM/01)Analytical and bioanalytical chemistry, proteomics science, Chromatography-mass spectrometry

ACTUAL POSITIONDate from 01 November 2008Function Researcher, University “G. d’Annunzio” of Chieti-Pescara,

Department of PharmacyDate A.A. 2011-2014Function member of Department ComitteeDate from May, 2013Function referent for the Work Orientation

Member of Italian Chemical Society (SCI), American Chemical Society (ACS), and Italian PhytochemicalSociety (SIF).

A.A. 2009-2010: tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory ofAnalytical Chemistry”, Specialistic Degree, Faculty of PharmacyA.A. 2010-2011: tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory ofAnalytical Chemistry”, Specialistic Degree, Faculty of PharmacyA.A. 2011-2012: tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory ofAnalytical Chemistry”, Specialistic Degree, Faculty of PharmacyA.A. 2012-2013: tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory ofAnalytical Chemistry”, Specialistic Degree, Department of Pharmacy

A.A. 2013-2014: tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory ofAnalytical Chemistry”, Specialistic Degree, Department of Pharmacy.A.A. 2014-2015: tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory ofAnalytical Chemistry”, Specialistic Degree, Department of Pharmacy.

Optional Course:

A.A. 2009-2010: member of the examination commission for the optional course of InstrumentalAnalytical Chemistry, Specialistic Degree, Faculty of Pharmacy.A.A. 2010-2011: member of the examination commission for the optional course of InstrumentalAnalytical Chemistry, Specialistic Degree, Faculty of Pharmacy.A.A. 2011-2012: member of the examination commission for the optional course of InstrumentalAnalytical Chemistry, Specialistic Degree, Faculty of Pharmacy.A.A. 2012-2013: member of the examination commission for the optional course of InstrumentalAnalytical Chemistry, Specialistic Degree, Department of Pharmacy.A.A. 2013-2014: member of the examination commission for the optional course of InstrumentalAnalytical Chemistry, Specialistic Degree, Department of Pharmacy.

A.A. 2014-2015: tenured, with Prof. G. Carlucci, of the optional course “Forensic Analytical Chemistry”,Specialistic Degree, Department of Pharmacy.

WORKING EXPERIENCESDate from 8 January 2007 to 8 September 2007Function Scholarship: “mass spectrometric method for alimentary

contaminant analysis”, University of Bologna, Department ofpharmaceutical sciences” Site of work: bioanalyticallaboratory (Prof. Aldo Roda)

Date from 12 February 2008 to 12 August 2008Function Scholarship: “combined mass spectrometric analytical

method for pharmacokinetics profiles”, University of Bologna,Department of pharmaceutical sciences” Site of work:bioanalytical laboratory (Prof. Aldo Roda)

EDUCATIONDate 23 October 2003

Graduation Chemistry degree (supervisor Prof. A. Roda)Istitution University of Bologna, Department of chemistry “G.Ciamician”Title “Analytical method development for the analysis and

identification of proteins adduct with mass spectrometry”Votation 110/110

Date II session 2004 (November), University of FerraraGraduation Qualification to chemist professionVotation 88/100

Date 15 May 2007Degree PhD in Chemistry Sciences (supervisor Prof. Pierluigi

Reschiglian)Istitution University of Bologna, Department of chemistry “G.Ciamician”Title “Combined mass spectrometric method for the study of

pharmaceutical impurities and biomolecules metabolites”

GRADUATE TRAINING SCHEME- Course “Parametri di qualità di metodi analitici basati sulla spettrometria di massa”, Parma,

19-20 February 2004

- 3° National course of introduction to photochemistry, Bologna, 13-17 September 2004

- National school “Metodologie analitiche in Spettrometria di Massa”, Parma, 23-27 May 2005

- National school in analytical chemistry for PhD, Rocca di Papa, Roma, 03-07 October 2005

- National school in Phytochemistry “P. Ceccherelli” 2010, Tirrenia, Pisa, 30 September-02October 2010

- National school in Phytochemistry “P. Ceccherelli” 2012, Paestum, Salerno, 05-07 October2012

TUTOR- “Laboratorio di Chimica Bioanalitica”, Faculty of MM.FF.NN science, Bologna, A.A.

2004/2005

- “Laboratorio di Chimica Bioanalitica”, Faculty of MM.FF.NN science, Bologna, A.A.2007/2008

- Assistant in analytical chemistry, alimentary chemistry and mass spectrometry lesson

PERSONAL COMPETENCEResearch The research activity is aimed at the development and validation of chromatographic

methods (according to international guidelines, ICH) for the qualitative and quantitativedetermination of biologically active molecules in human and animal (eg. Serum, plasma,bile, liver tissue, hypothalamus, kidney, feces, urine), cosmetics, food, andenvironmental complex matrices.It provides, in addition, to the study of all processes related to pre-analytical stagessuch as sampling, extraction and purification, separation, enrichment, even theapplication of conventional and hyphenated analytical methods for the accurate,sensitive and selective determination of biologically active molecules.These procedures have been applied to different analytes: glucosamine [2], 5-amino-salicylic acid [4], natural or synthetic bile acids [21], anti-inflammatory [22, 23, 37] andfluoroquinolones [25, 42], secondary metabolites from plant [6, 7, 8, 10, 11, 12, 15, 16, 17, 18, 19, 20, 24,

26, 28, 32, 33, 35, 38, 43, 44], heavy metals [31, 36], also finding application in clinical and pre-clinical studies designed to assess the pharmacokinetic, bioequivalence andAbsorption, Distribution, Metabolism and Excretion (ADME) of the formulationsexamined [1, 3, 5], also in order to characterize new delivery systems of the activeprinciple [30, 41] to improve their pharmacological properties.In the development of the method are applied predictive models and chemometric bothfor the optimisation of extraction protocols and for final data processing [29].Particular attention is given to the new instrument configurations for the quantitativeanalysis in complex matrix [9, 13, 14, 27, 34, 39, 40].Scientific activity was attested by publication on international journal, by oral and postercommunication at international congress.Besides he is reviewer for international journals:

1. Trends in Analytical Chemistry;

2. Journal of Chromatography A;

3. Talanta;

4. Food Chemistry;

5. Food and Chemical Toxicology,

6. Journal of Food Composition and Analysis;

7. Instrumentation Science & Technology;

8. Analytical Letters;

9. Phytochemical Analysis;

10. Environmental Science and Pollution Research;

11. Acta Chromatographica;

12. Journal of Separation Science;

13. Environmental Science & Technology;

14. Journal of Enzyme Inhibition and Medicinal Chemistry;

15. Chemistry Central Journal;

16. Central European Journal of Chemistry;

17. Global Journal of Analytical Chemistry;

18. Industrial & Engineering Chemical Research;

19. Bioorganic & Medicinal Chemistry;

20. Natural Product Research;

21. Current Bioactive Compounds;

22. Current Organic Chemistry;

23. Catalysis Letters;

24. Molecules;

25. Medicinal Chemistry;

26. Mini-Review in Medicinal Chemistry;

27. Mini-Review in Organic Chemistry;

28. British Journal of Pharmaceutical Research;

29. Preparative Biochemistry and Biotechnology;

30. African Journal of Pharmacy and Pharmacology;

31. Bio Med Research International;

32. Journal of advances in medical and pharmaceutical Science;

33. European Journal of Medicinal Plants;

34. Evidence-Based Complementary and Alternative Medicine.

35. Czech Journal of Food Sciences;

36. Journal of Chemistry;

37. Journal of King Saud University

He’s a referee for MIUR Institution for National Projects (SIR).

He's member of the Editorial Board of the journal “Current Bioactive Compounds” (Bentham SciencePublisher), and "Pharmaceutica Analytica Acta" (Omics Publishing Group). He is a member of theScientific Committee of the journal "Science and Research", published by the Italian Association of theBook.

Organizational competencesScientific project elaboration and financial request for research, analytical report evaluation

Informatics competencesWindows. Applicatives for office automation (Word, Excel, PowerPoint, Publisher) and elaboration data.Software LC-UV, GC-MS e LC-MS (MassLynx V4. 0, QuanLynx, Data Explorer, Excalibur, MassFrontier 2.0, Empower 2.0, GraphPad Prism 4, Origin 7.5, ChemWindow, HyperChem Professional).

IntrumentationMass spectrometer:ESI-triple quadrupole (Quattro-LC, Micromass); ESI-Q-ReTOF (Q-Tof Micro,Micromass); MALDI-ReTOF (Voyager DE-PRO, Applied Biosystem); ESI-Ion Trap (LCQ Advantage,Thermo)HPLC: Waters Alliance 2695; Waters 1525 m with Waters 717 autosampler and Waters 2996PDA; Waters mod. 600; Agilent 1100 Series; MicroMass CapLC; Thermo Spectra System (P2000;SCM1000;UV6000LP)

ORGANIZED WORKSHOP AND CONGRESS1. Workshop “La tecnologia innovativa che rivoluzionerà la cromatografia liquida”; in collaboration

with Phenomenex; University “G. d’Annunzio” of Chieti-Pescara, Faculty Of Pharmacy; Dept. OfPharmaceutical Science; Chieti; Italy; 21 October 2009.

2. Workshop “Giornata di Studio di Scienza delle Separazioni”; in collaboration with Shimadzu;University “G. d’Annunzio” of Chieti-Pescara, Dept. Of Pharmacy; Chieti; Italy; 11 October 2013.

BIOANALYTICAL REPORTrep 1. Bioanalytical Report: Validation of a HPLC-ESI-MS/MS method for the determination of 5-

aminosalicylic acid and N-acetyl-5-aminosalicylic acid in human plasma (DIPMEDINT21/12/07; Bioanalytical Validation Report)

rep 2. Validation Report: Development and validation of a sensitive HPLC-ESI-MS/MS method forthe direct determination of glucosamine in human plasma (STUDY DIPSFAR09)

rep 3. Partial Validation Report: Partial validation of a HPLC-MS/MS assay for the determination ofglucosamine in human knee synovial fluid (STUDY DIPSFAR08; Bioanalytical ValidationReport)

rep 4. Bioanalytical Report: LC-MS determination of NCX 1000 and 15 bile acids in human faecalsamples collected during study NCX1000-x-102

rep 5. Bioanalytical Study Protocol, Pre-study Validation: Partial validation of a HPLC-MS/MS assayfor the determination of glucosamine in human plasma and long term stability in humanplasma (DIPSFAR06)

rep 6. Bioanalytical Study Protocol, In-study Validation: LC-MS/MS determination of glucosamine inhuman plasma samples collected during study 79/2003/O (DIPSFAR03)

rep 7. Bioanalytical Study Protocol, In-study Validation: LC-MS/MS determination of glucosamine inhuman urine samples collected during study 79/2003/O (DIPSFAR03)

rep 8. Bioanalytical Report: LC-MS/MS determination of glucosamine in human plasma samplescollected during study 79/2003/O (79/2003/O)

rep 9. Bioanalytical Report: LC-MS/MS determination of glucosamine sulphate in human urinesamples collected during study 79/2003/O (79/2003/O)

rep 10. Bioanalytical Study Protocol, In-study Validation: LC-MS/MS determination of glucosamine inhuman plasma samples collected during study SP191203

rep 11. Bioanalytical Report: LC-MS/MS determination of glucosamine in human plasma samplescollected during study SP191203 (DIPSPAR05/SP191203)

rep 12. Bioanalytical Study Protocol, In-study Validation: LC-MS/MS determination of glucosamine inhuman plasma samples collected during study GS PK3 (DIPSFAR07/GS PK3)

rep 13. Bioanalytical Report: LC-MS/MS determination of glucosamine in human plasma samplescollected during study GS PK3 (DIPSFAR07/GS PK3)

rep 14. Bioanalytical Study Protocol, In-study Validation: LC-MS/MS determination of glucosamine inhuman plasma and synovial fluid samples collected during study GS PK1 (DIPSFAR08/GSPK1)

rep 15. Bioanalytical Report: LC-MS/MS determination of glucosamine in human plasma and synovialfluid samples collected during study GS PK1 (DIPSFAR10/GS PK1)

PUBLICATIONSpub 1. “Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of

cristalline glucosamine sulfate in man"; S. Persiani, E. Roda, L. C. Rovati, M. Locatelli, G.Giacovelli, A. Roda; Osteoarthritis and cartilage, 13, 1041-1049, 2005;Impact Factor: 4.215 – full article

pub 2. “Development and Validation of a Sensitive HPLC-ES-MS/MS Method for the DirectDetermination of Glucosamine in Human Plasma”; Aldo Roda, Laura Sabatini, Anna Barbieri,Massimo Guardigli, Marcello Locatelli, Francesco Saverio Violante, Lucio C. Rovati, StefanoPersiani; Journal of Chromatography B, 844, 119–126, 2006;Impact Factor: 2.647 – full article

pub 3. “Synovial and plasma glucosamine concentrations in osteoarthritic patients following oralcrystalline glucosamine sulphate at therapeutic dose”; Persiani S, Rotini R, Trisolino G, RovatiLC, Locatelli M, Paganini D, Antonioli D, Roda A; Osteoarthritis and Cartilage, 7, 764-772,2007;Impact Factor: 3.793 – full article

pub 4. “Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and its major metabolite N-acetyl-5-aminosalicylic acid in human plasma”;Elisabetta Pastorini, Marcello Locatelli, Patrizia Simoni, Giulia Roda, Enrico Roda, Aldo Roda;Journal of Chromatography B, 872, 99–106, 2008;Impact Factor: 2.500 – full article

pub 5. “Pharmacokinetics and Safety of a New 1200 mg Single-Dose Delayed Release MesalazineMicrogranule Formulation”; Roda Aldo, Simoni Patrizia, Roda Giulia, Caponi Alessandra,Pastorini Elisabetta, Locatelli Marcello, Roda Enrico; Journal of Bioequivalence &Bioavailability, 1 (2), 044-051, 2009;Open access – full article

pub 6. “Anthraquinone profile and chemical fingerprint of Rhamnus saxatilis L. from Italy”; M.Locatelli, F. Tammaro, L. Menghini, G. Carlucci, F. Epifano and S. Genovese; PhytochemistryLetters, 4 (2), 223-226, 2009;Impact Factor: 0.957 – full article

pub 7. “Comparison of Three Different Extraction Methods and HPLC Determination of theAnthraquinones Aloe-emodine, Emodine, Rheine, Chrysophanol and Physcione in the Bark ofRhamnus alpinus L. (Rhamnaceae)”; S. Genovese, F. Tammaro, L. Menghini, G. Carlucci, F.

Epifano, M. Locatelli; Phytochemical Analysis, 21, 261-267, 2010;Impact Factor: 1.848 – full article

pub 8. “Quantification of 4’-geranyloxyferulic acid, a new natural colon cancer chemopreventiveagent, by HPLC-DAD in grapefruit skin extract”; S. Genovese, F. Epifano, G. Carlucci, M.C.Marcotullio, M. Curini, M. Locatelli; Journal of Pharmaceutical and Biomedical Analysis, 53,212-214, 2010.Impact Factor: 2.733 – full article

pub 9. “Advanced Capillary Electrophoresis Techniques in the Analytical Quantification of Drugs,Metabolites and Biomarkers in Biological Samples”; M. Locatelli, G. Carlucci; Global Journal ofAnalytical Chemistry, 1(3), 244-261, 2010.Open access – review

pub 10. “Anthraquinones: analytical techniques as a novel tool to investigate on the triggering ofbiological targets”; M. Locatelli; Current Drug Targets, 12 (3), 366-380, 2011.Impact Factor: 3.553 – review

pub 11. “Use of HPLC in the determination of the molar absorptivity of 4'-geranyloxyferulic acid andboropinic acid”; M. Locatelli, G. Carlucci, S. Genovese, M. Curini, F. Epifano;Chromatographia, 73, 889-896, 2011.Impact Factor: 1.195 – full article

pub 12. “Anthraquinone Profile, Antioxidant and Antimicrobial Properties of Bark Extracts of Rhamnuscatharticus and R. orbiculatus”; M. Locatelli, F. Epifano, S.Genovese, G. Carlucci, M. ZovkoKončić, I. Kosalec, D. Kremer; Natural Product Communications, 6 (9), 1275-1280, 2011.Impact Factor: 1.242 – full article

pub 13. “Recent application of analytical methods to phase I and phase II drugs development: areview.”; M. Locatelli, L. Governatori, G. Carlucci, S. Genovese, A. Mollica, F. Epifano;Biomedical Chromatography, 26, 283-300, 2012.Impact Factor: 1.945 – review

pub. 14 “Recent HPLC strategies to improve sensitivity and selectivity for the analysis of complexmatrices”; M. Locatelli, D. Melucci, G. Carlucci, C. Locatelli; Instrumentation Science &Technology, 40 (2-3), 112-137, 2012.Impact Factor: 0.429 – review

pub. 15 “Novel prodrugs for the treatment of colonic diseases based on 5-aminosalicylic acid, 4'-geranyloxyferulic acid, and auraptene: biological activities and analytical assays”; F. Epifano,S. Genovese, G. Carlucci, M. Locatelli; Current Drug Delivery, 9 (2), 112-121, 2012.Impact Factor: ... – review

pub. 16 “Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.)Schur and F. alnus Mill. bark”; D. Kremer, I. Kosalec, M. Locatelli, F. Epifano, S. Genovese, G,Carlucci, M. Zovko Končić; Food Chemistry, 131(4), 1174-1180, 2012.Impact Factor: 3.334 – full article

pub. 17 “Development and application of high-performance liquid chromatography for the study of twonew oxyprenylated-anthraquinones produced by Rhamnus species”; M. Locatelli, S.Genovese, G. Carlucci, D. Kremer, M. Randic, F. Epifano; Journal of Chromatography A,1225, 113-120, 2012.Impact Factor: 4.612– full article

pub. 18 Screening for oxyprenylated anthraquinones in Mediterranean Rhamnus species”; S.Genovese, F. Epifano, M. Curini, D. Kremer, G. Carlucci, M. Locatelli; BiochemicalSystematics and Ecology, 43, 125-127, 2012.Impact Factor: 1.153 – full article

pub. 19 “Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges ContainingDibrominated Indolic Systems”; Adriano Mollica, Marcello Locatelli, Azzurra Stefanucci,Francesco Pinnen; Molecules, 17, 6083-6099, 2012.

Impact Factor: 2.428 – review

pub. 20 “Re-investigation of the anthraquinone pool of Rhamnus spp.: madagascin from the fruits ofRhamnus cathartica and R. intermedia”; Epifano F, Genovese S, Kremer D, Carlucci G, andLocatelli M; Natural Product Communications, 7 (8), 1029-1032, 2012.Impact Factor: 0.956 – full article

pub. 21 “Reduced biliary sterol output with no change in total faecal excretion in mice expressing ahuman apolipoprotein A-I variant”; Cinzia Parolini, Silvia Caligari, Donatella Gilio, StefanoManzini, Marco Busnelli, Marco Montagnani, Marcello Locatelli, Erika Diani, Flavio Giavarini,Donatella Caruso, Enrico Roda, Aldo Roda, Cesare R. Sirtori and Giulia Chiesa; LiverInternational, 32 (9), 1363-1371, 2012.Impact Factor: 3.870 – full article

pub. 22 “Analysis of Anti-inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review”;Giuseppe Carlucci, Maura Carlucci, Marcello Locatelli; Anti-Inflammatory & Anti-AllergyAgents in Medicinal Chemistry, 11 (1), 96-112, 2012.Impact Factor: ... – review

pub. 23 “Recent Advances in Anti-Inflammatory and Immune-Modulator Drugs Development andAnalytical Tools for their Characterization”; Marcello Locatelli; Anti-Inflammatory & Anti-AllergyAgents in Medicinal Chemistry, 11 (1), 2-2, 2012.Impact Factor: ... – editorial/letters

pub. 24 “Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnusalaternus, R. fallax, R. intermedia and R. pumila”; I. Kosalec, D. Kremer, M. Locatelli, F.Epifano, S. Genovese, G. Carlucci, M. Randić, M. Zovko Končić; Food Chemistry, 136(2),335-341, 2013.Impact Factor: 3.259 – full article

pub. 25 “High Performance Liquid Chromatography determination of Prulifloxacin and five relatedimpurities in pharmaceutical formulations”; Marcello Locatelli, Federica De Lutiis, GiuseppeCarlucci; Journal of Pharmaceutical and Biomedical Analysis, 78-79, 27-33, 2013.Impact Factor: 2.829 – full article

pub. 26 “Biological active analogues of the opioid peptide Biphalin: mixed /3-peptides.”; AdrianoMollica, Francesco Pinnen, Roberto Costante, Marcello Locatelli, Azzurra Stefanucci, StefanoPieretti, Peg Davis, Josephine Lai, David Rankin, Frank Porreca and Victor J. Hruby; Journalof Medicinal Chemistry, 56, 3419-3423, 2013.Impact Factor: 5.480 – full article

pub. 27 “Novel techniques as a tool to investigate on the triggering of biological targets”; MarcelloLocatelli; Current Drug Targets, 14(9), 937, 2013.Impact Factor: 3.597 – editorial/letters

pub. 28 “Phytochemistry and Pharmacognosy of Naturally Occurring Prenyloxyanthraquinones”;Francesco Epifano, Serena Fiorito, Giuseppe Carlucci, Marcello Locatelli, SalvatoreGenovese; Current Drug Targets, 14(9), 959-963, 2013.Impact Factor: 3.597 – review article

pub. 29 “Application of Pyrolysis-Gas Chromatography-Mass Spectrometry and Multivariate Analysisto Study Bacteria and Fungi In Biofilms Used For Bioremediation”; Dora Melucci, StefanoFedi, Marcello Locatelli, Clinio Locatelli, Simona Montalbani, Martina Cappelletti; Current DrugTargets, 14(9), 1023-1033, 2013.Impact Factor: 3.597 – full article

pub. 30 “Anticancer Activity of Liposomal Bergamot Essential Oil (BEO) on Human NeuroblastomaCells”; Christian Celia, Elena Trapasso, Marcello Locatelli, Michele Navarra, Cinzia A Ventura,Joy Wolfram, Maria Carafa, Valeria M Morittu, Domenico Britti, Luisa Di Marzio, DonatellaPaolino; Colloids and Surfaces B: Biointerfaces, 112, 548-553, 2013.Impact Factor: 4.287 – full article

pub. 31 “Trace level voltammetric determination of heavy metals and total mercury in tea matrices(Camellia sinensis)”; Dora Melucci; Marcello Locatelli; Clinio Locatelli; Food and ChemicalToxicology, 62, 901-907, 2013.Impact Factor: 2.610 – full article

pub. 32 “HPLC analysis of 4'-geranyloxyferulic and boropinic acids in grapefruits of differentgeographical origin”; Salvatore Genovese; Francesco Epifano; Giuseppe Carlucci; SerenaFiorito; Marcello Locatelli; Phytochemistry Letters, 8(1), 190-192, 2014.

Impact Factor: ... – full article

pub. 33 “In vitro activity of Aloe vera inner gel against Helicobacter pylori strains”; Luigina Cellini,Soraya Di Bartolomeo, Emanuela Di Campli, Salvatore Genovese, Marcello Locatelli, Mara DiGiulio; Letters in Applied Microbiology, 59(1), 43-48, 2014.Impact Factor: ... – full article

pub. 34 “Extraction and Detection Techniques for PAHs Determination in Beverages: A Review”;Marcello Locatelli, Luca Forcucci, Francesco Sciascia, Roberta Cifelli, Vincenzo Ferrone,Giuseppe Carlucci; Current Chromatography, 1(2), 122-138, 2014.Impact Factor: ... – review article

pub. 35 “Analysis of Biologically Active Oxyprenylated Ferulic Acid Derivatives in Citrus Fruits”;Genovese S, Fiorito S, Locatelli M, Carlucci G, Epifano F; Plant Foods for Human Nutrition,69, 255-260, 2014.Impact Factor: ... – full article

pub. 36 “Toxic Metals in Herbal Medicines. A Review”; Clinio Locatelli, Dora Melucci, MarcelloLocatelli, Current Bioactive Compounds, 10, 181-188, 2014.Impact Factor: ... – review article

pub. 37 “MicroExtraction by Packed Sorbent and HPLC determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine”; Marcello Locatelli, Vincenzo Ferrone,

Roberta Cifelli, Renato C Barbacane, Giuseppe Carlucci, Journal of Chromatography A, 1367,1-8, 2014.Impact Factor: ... – full article

pub. 38 “Screening for novel plant sources of prenyloxyanthraquinones: Senna alexandrina Mill. andAloe vera (L.) Burm. F.”; Francesco Epifano, Serena Fiorito, Marcello Locatelli, VitoAlessandro Taddeo, Salvatore Genovese, Natural Product Research, 29(2), 180-184, 2015.Impact Factor: ... – full article

pub. 39 “Recent advances in the separation and determination of impurities in pharmaceuticalproducts”; Stefano Zaza, Stefano Maria Lucini, Francesco Sciascia, Vincenzo Ferrone,

Roberta Cifelli, Giuseppe Carlucci, Marcello Locatelli; Instrumentation Science & Technology,43(2), 182-196, 2015.Impact Factor: ... – review article

pub. 40 “Combined derivatization and high-performance liquid chromatography with fluorescence andultraviolet detection for simultaneous analysis of Octreotide and Gabexate Mesylatemetabolite in human pancreatic juice samples”; G. Carlucci, F. Selvaggi, S. Sulpizio, C. Bassi,M. Carlucci, R. Cotellese, V. Ferrone, P. Innocenti, M. Locatelli, Biomedical Chromatography,IN PRESS, 2015.Impact Factor: ... – full article

pub. 41 “Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device throughTurbiscan Lab Expert”; Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco,Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury,Christelle Tisserand, Renato C. Barbacane, Massimo Fresta, Luisa Di Marzio, DonatellaPaolino, Medicinal Chemistry, IN PRESS, 2015.Impact Factor: ... – full article

pub. 42 “Stability study of Prulifloxacin and Ulifloxacin in human plasma by HPLC-DAD”; MarcelloLocatelli, Roberta Cifelli, Giuseppe Carlucci, Annalisa Romagnoli, Journal Of EnzymeInhibition And Medicinal Chemistry, IN PRESS, 2015.Impact Factor: ... – full article

pub. 43 “Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of HumanNormal Colon Cells”; Paduch R, Wiater A, Locatelli M, Pleszczyńska M, Tomczyk M., CurrentDrug Targets, IN PRESS, 2015.Impact Factor: ... – full article

pub. 44 “(1→3)-α-D-Glucans from Aspergillus spp.: Structural Characterization and Biological Studyon Their Carboxymethylated Derivatives”; Wiater A, Paduch R, Choma A, Sylwia S,Pleszczyńska M, Tomczyk M, Locatelli M, Janusz S., Current Drug Targets, IN PRESS, 2015.Impact Factor: ... – full article

CHAPTERS IN BOOKS1. M. Locatelli, G. Carlucci, S. Genovese, F. Epifano “Analytical Methods And Phytochemistry Of The

Typical Italian Liquour “Limoncello”: A Review” in Phytochemicals - A Global Perspective of TheirRole in Nutrition and Health, Edited by Prof. Dr. A. Venketeshwer Rao, INTECH OPEN ACCESSPUBLISHER, University Campus, SteP Ri, Rijeka (Croatia), 2012, ISBN: 978-953-51-0296-0,Chapter 4, 93-106.

2. D. Melucci, C. Locatelli, M. Locatelli “Analytical tools and chemometrics in drug developmentprocess: a review” in Drug Development: Principles, Methodology and Emerging Challenges,Edited by Marco Rossi and Santina Bertone, NOVA SCIENCE PUBLISHERS, INC. 400 OserAvenue, Suite 1600 Hauppauge, NY 11788-3619 USA, 2013 - 2nd Quarter, ISBN: 978-1-62417-790-3, Chapter 2, 35-62.

3. D. Melucci, C. Locatelli, M. D’Annunzio, M. Rendina, and M. Locatelli “Analytical Methods ForOrganic And Inorganic Toxics Determination In Cosmetics Products” in New Developments inAnalytical Chemistry Research, NOVA SCIENCE PUBLISHERS, INC. 400 Oser Avenue, Suite1600 Hauppauge, NY 11788-3619 USA, 2015 – 1st Quarter, ISBN: 978-1-63463-427-4, Chapter 1,1-39.

BOOKS1. M. Locatelli, A. Mollica “Fondamenti di Chimica analitica e Analisi dei medicinali”, ARACNE

EDITRICE S.r.l (Roma), 2013, ISBN: 978-88-548-6106-0.

PROCEEDINGSpro 1. “The foetal-maternal circulation of bile acids and bilirubin: effects of cholestasis and UDCA

administration”; E. Baglivo, F. Azzaroli, M. Montagnani, V. Feletti, P. Simoni, M. Locatelli, D.De Aloysio, G. Pelusi, F. Lodato, D. Festi, A. Colecchia, A. Roda, E. Roda, G. Mazzella;Gastroenterology, 130, A802, 2006;Impact Factor: 12.460 – congress special issue - abstract

pro 2. “The foetal-maternal circulation of bile acids and bilirubin: Effects of cholestasis andursodeoxycholic acid administration”; Baglivo, E.; Azzaroli, F.; Montagnani, M.; Feletti, V.;Simoni, P.; Locatelli, M.; Aloysio, D. De; Pelusi, G.; Lodato, F.; Festi, D.; Colecchia, A.; Roda,A.; Roda, E.; Mazzella, G.; Digestive and Liver Disease, 38, Supplement 1, S95-S96, 2006;Impact Factor: 2.000 – congress special issue - abstract

pro 3. “Effects of UDCA on the foetus-maternal circulation of bilirubin in cholestasis of pregnancy”;Azzaroli, F.; Baglivo, E.; Feletti, V.; Locatelli, M.; Rizzo, N.; De Aloysio, D.; Pelusi, G.;Montagnani, M.; Lodato, F.; Festi, D.; Colecchia, A.; Roda, A.; Roda, E.; Mazzella, G.;Digestive and Liver Disease, 39, 3, A27, 2007;Impact Factor: 1.982 – congress special issue - abstract

pro 4. “Effects of UDCA on the foetus-maternal circulation of bilirubin in cholestasis of pregnancy”;Azzaroli, F.; Baglivo, E.; Feletti, V.; Locatelli, M.; Rizzo, N.; De Aloysio, D.; Pelusi, G.;Montagnani, M.; Lodato, F.; Festi, D.; Colecchia, A.; Roda, A.; Roda, E.; Mazzella, G..;Journal of Hepatology, 46, Supplement 1, S250, 2007;Impact Factor: 6.642 – congress special issue - abstract

pro 5. “Pharmacokinetics of glucosamine in man after oral administration of crystalline glucosaminesulfate or glucosamine hydrochloride alone or in combination with chondroitin sulfate”; S.Persiani, L.C. Rovati, E. Pastorini, M. Locatelli, G. Giacovelli, D. Paganini, A. Roda;Osteoarthritis Cartilage, 15 (Suppl C), C223, 2007;Impact Factor: 3.793 – congress special issue - abstract

pro 6. “High free and glycoconjugated and low tauroconjugated ba levels in serum are the mirror ofintestinal events and hepatic uptake”; Buonfiglioli, F.; Azzaroli, F.; Montagnani, M.; Simoni, P.;Locatelli, M.; Raspanti, M.E.; Lisotti, A.; Lodato, F.; Alessandrelli, F.; Colecchia, A.; Festi, D.;Roda, A.; Roda, E.; Mazzella, G.; Digestive and Liver Disease, 41, Supplement 1, S111, 2009;Impact Factor: 2.972 – congress special issue - abstract

pro 7. “High free and glycoconjugated and low tauroconjugated ba levels in serum are the mirror ofintestinal events and hepatic uptake”; Buonfiglioli, F.; Azzaroli, F.; Montagnani, M.; Simoni, P.;Locatelli, M.; Raspanti, M.E.; Lisotti, A.; Lodato, F.; Alessandrelli, F.; Colecchia, A.; Festi, D.;Roda, A.; Roda, E.; Mazzella, G.; Journal of Hepatology, 50, Supplement 1, S103, 2009;Impact Factor: 7.818 – congress special issue - abstract

pro 8. “Chromatogaphic determination of molar absorptivity of natural prenyloxycinnamic acids instandardless analysis”; Giuseppe Carlucci, Francesco Epifano, Salvatore Genovese, MarcelloLocatelli; Planta Medica, 78, 1251; 2012.Impact Factor: 2.348 – congress special issue – abstract

pro 9. “Validation of HPLC assay for the determination of oxyprenylated anthraquinones produced byrhamnus species”; Marcello Locatelli, Giuseppe Carlucci, Francesco Epifano, Dario Kremer,Salvatore Genovese; Planta Medica, 78, 1251; 2012.Impact Factor: 2.348 – congress special issue – abstract

pro 10. “Quantification of 4’-geranyloxyferulic acid and boropinic acid by HPLC-DAD in grapefruit skinfrom different country origins”; Marcello Locatelli, Giuseppe Carlucci, Salvatore Genovese,Francesco Epifano; Planta Medica, 78, 1251; 2012.Impact Factor: 2.348 – congress special issue – abstract

pro 11. “Anthraquinone chemical fingerprint: madagascin from the fruits of rhamnus spp.”; GiuseppeCarlucci, Francesco Epifano, Salvatore Genovese, Dario Kremer, Marcello Locatelli; PlantaMedica, 78, 1251; 2012.Impact Factor: 2.348 – congress special issue – abstract

pro 12. “Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry”;Adriano Mollica, Azzurra Stefanucci, Roberto Costante, Francesco Pinnen, Marcello Locatelli;Planta Medica, 78, 1284; 2012.Impact Factor: 2.348 – congress special issue – abstract

pro 13. “Ultratrace level voltammetric determination of total mercury and toxic metals in tea matrices”;Clinio Locatelli, Dora Melucci and Marcello Locatelli; Planta Medica, 78, 1256; 2012.Impact Factor: 2.348 – congress special issue – abstract

pro 14. “Mutual interference problems in the simultaneous voltammetric determination of ultra-tracetotal mercury (II) and toxic metals in medicinal herbs matrices”; Clinio Locatelli, Dora Melucciand Marcello Locatelli; Planta Medica, 78, 1256; 2012.Impact Factor: 2.348 – congress special issue – abstract

ORAL COMUNICATIONo 1. “Sviluppo di una metodologia analitica per l’analisi e l’identificazione di addotti proteici

mediante spettrometria di massa”; M. Locatelli, F. Dal Piaz, A. Roda; “Giornate di Scienzadelle Separazioni”, Montelibretti (Roma), 15-16 December 2003;

o 2. “Spettrometria di massa applicata all’analisi delle proteine: Proteomica Funzionale”; M.Locatelli, A. Roda; Seminario “Proteomica Funzionale”, Policlinico S. Orsola-Malpighi,Bologna, 07 March 2004;

o 3. “Correlazione materno-fetale degli acidi biliari in corso di colestasi gravidica”; E. Baglivo, F.Azzaroli, M. Locatelli, V. Feletti, P. Simoni, G. Santarsiero, M. Franchina, F. Lodato, M.Montagnani, A. Colecchia, D. Festi, E. Roda, A. Roda, G. Mazzella; 81° Congresso NazionaleSIGO (46° Congresso AOGOI - 13° Congresso AGUI), Bologna, Italia, 20-24 September2005;

o 4. “The foetal-maternal circulation of bile acids and bilirubin: effects of cholestasis andursodeoxycholic acid administration”; E. Baglivo, F. Azzaroli, M. Locatelli, V. Feletti, P. Simoni,G. Santarsiero, M. Franchina, F. Lodato, M. Montagnani, A. Colecchia, D. Festi, E. Roda, A.Roda, G. Mazzella; 39° Annual Meeting of the Italian Association of the Study of the Liver(A.I.S.F.), Roma, Italia, 15-17 February 2006;

o 5. “3rd year PhD students in chemistry discuss their research projects with Jean Marie Lehn”,Bologna, 05 April 2006;

o 6. “The foetal-maternal circulation of bile acids and bilirubin: effects of cholestasis andursodeoxycholic acid administration”; E. Baglivo, F. Azzaroli, M. Locatelli, V. Feletti, P. Simoni,G. Santarsiero, M. Franchina, F. Lodato, M. Montagnani, A. Colecchia, D. Festi, E. Roda, A.Roda, G. Mazzella; XII National Congress of the Italian Federation of Digestive Disease(SIGE), Napoli, Italia, 01-05 April 2006;

o 7. “Liquid chromatography-tandem mass spectrometry method for determination of 5-aminosalicylic acid (5-asa) and its major metabolite n-acetyl-5-asa in human plasma samples”;E. Pastorini, M. Locatelli, P. Simoni, G. Roda, E. Roda, A. Roda; 5th Pharmaday, Verona,Italia, 27-29 October 2008;

o 8. “Determinazione dell’assorbività molare di prodotti naturali ossiprenilati mediante tecnicaHPLC-DAD: il caso dell’acido 4’-geranilossiferulico, un nuovo chemopreventore del cancro alcolon, e l’acido boropinico, un agente anti-Helicobacter pylori”; F. Epifano, S. Genovese, G.Carlucci, M. Curini, M. Locatelli; Fitomed 2010, Cagliari, Italia, 23-26 June 2010;

o 9. “New HPLC-DAD method for the analyses of a novel group of secondary metabolites inRhamnus spp.: prenyloxyanthraquinones”; Marcello Locatelli, Francesco Epifano, GiuseppeCarlucci, Salvatore Genovese; “Incontri di Scienza delle Separazioni”, Roma, Italia, 22-23November 2011;

o 10. “Studi chimici e farmacologici su lawsone, lapacolo e loro derivati”; Serena Fiorito, FrancescoEpifano, Salvatore Genovese, Adriano Mollica, Marcello Locatelli, VeroniqueMathieu, RobertKiss; 13° SAYCS, Riccione, Italia, 28-30 October 2013;

o 11. “Study of scaffold and drugs delivery from electrospun nanostructured polymeric membranes”;Pantaleone Bruni, Marcello Locatelli, Vincenzo Ferrone, Stefano Narcisi, Oriana Trubiani,Francesca Diomede, Fausto Croce; 14° SAYCS, Riccione, Italia, 27-29 Ottobre 2014;

INTERNATIONAL EXCHANGE AND COLLABORATIONSHosted as teaching staff delegate at the Faculty of Pharmacy of University Complutense of Madrid(Spain) in the frame of the Socrates/Erasmus exchange program 2010 from September 19th, 2010 toSeptember 25th, 2010.

Hosted as teaching staff delegate at the Faculty of Pharmacy of University of Seville (Spain) in theframe of the Socrates/Erasmus exchange program 2011 from September 18th, 2011 to September25th, 2011.

INVITED LECTURESiL 1. “Development and Validation of analytical assay for drugs and metabolites in biological

matrices”; University Complutense of Madrid, Faculty of Pharmacy, Spain, 19-25 September2010;

iL 2. “Analytical method for chemical-physics characterization for novel synthetic molecules”;University Complutense of Madrid, Faculty of Pharmacy, Spain, 19-25 September 2010;

iL 3. “Development and Validation of analytical methods for drugs and metabolites in complexmatrices”; University of Seville, Faculty of Pharmacy, Spain, 18-25 September 2011;

iL 4. “Analytical method for synthetic new chemical entities characterization and drug impuritiesdetermination”; University of Seville, Faculty of Pharmacy, Spain, 18-25 September 2011;

POSTER COMUNICATIONp 1. “Oral bioavailability and dose-proportionality of cristalline glucosamine sul fate in man”; S.

Persiani, L.C. Rovati, V. Foschini, G. Giacovelli, M. Locatelli, A. Roda; 2004 ACR/ARHPANNUAL SCIENTIFIC MEETING, San Antonio, Texas, USA, 17-21 October 2004;

p 2. “The pharmacokinetics of oral cristalline glucosamine sulfate in man support its mechanism ofaction and clinical effects”; S. Persiani, L.C. Rovati, V. Foschini, G. Giacovelli, M. Locatelli, A.Roda; OARSI, 9th World Congress Chicago, IL, USA, 02-05 December 2004;

p 3. “The pharmacokinetics of oral cristalline glucosamine sulfate in man support its mechanism ofaction and clinical effects”; S. Persiani, L.C. Rovati, G. Giacovelli, M. Locatelli, A. Roda;ECCEO5, Fifth European Congress on Clinical and Economic Aspects of Osteoporosis andOsteoarthritis, Roma, Italia, 16-19 March 2005;

p 4. “Glucosamine plasma and synovial fluid concentration before and after oral administration ofcrystalline glucosamine sulfate in man”; S. Persiani, R. Rotini, L.C. Rovati, M. Locatelli, A.Roda; EULAR 2005, Annual European Congress of Rheumatology, Vienna, Austria, 08-11June 2005;

p 5. “Glucosamine plasma and synovial fluid concentration before and after oral administration ofcrystalline glucosamine sulfate in man”; S. Persiani, R. Rotini, G. Trisolino, L.C. Rovati, M.Locatelli, A. Roda; PharmSciFair 2005, Pharmaceutical Sciences Fair & Exibition, Nice,Francia, 12-17 June 2005;

p 6. “The Fetus-Maternal Circulation of Bile Acids in Cholestasis of Pregnancy: Preliminary Data”;Azzaroli F, Baglivo E, Locatelli M, Feletti V, Simoni P, Santarsiero G, Lodato F, Montagnani M,Colecchia A, Festi D, Roda E, Roda A, Mazzella G.; Reunion Week End, University of Yale,Yale, Connecticut, 01-03 April 2005;

p 7. “Glucosamine plasma and synovial fluid concentration before and after oral administration ofcrystalline glucosamine sulfate in knee osteoarthritis Patients”; S. Persiani, R. Rotini, G.Trisolino, L. Delliponti, L.C. Rovati, M. Locatelli, A. Roda; 2005 ACR/ARHP ANNUALSCIENTIFIC MEETING, San Diego, California, USA, 12-17 November 2005;

p 8. “Correlazione materno-fetale degli acidi biliari in corso di colestasi gravidica”; E. Baglivo, F.Azzaroli, M. Locatelli, V. Feletti, P. Simoni, G. Santarsiero, M. Franchina, F. Lodato, M.Montagnani, A. Colecchia, D. Festi, E. Roda, A. Roda, G. Mazzella; 81° Congresso NazionaleSIGO (46° Congresso AOGOI - 13° Congresso AGUI), Bologna, Italia, 20-24 September2005;

p 9. “Sviluppo di un metodo HPLC-ESI-MS/MS idoneo per la determinazione di impurezze emetaboliti in vivo di un nuovo farmaco: l’acido 3a, 7a-diidrossi, 6a-etil colanico”; M. Locatelli,M. Guardigli, P. Nanni, R. Pellicciari, B.M. Sadeghpour, S. Fiorucci, A. Roda; XIX Congressodi Chimica analitica, Università degli Studi di Cagliari, Centro Polaris, Pula (Sardegna), Italia,11-15 September 2005;

p 10. “The foetal-maternal circulation of bile acids and bilirubin: effects of cholestasis andursodeoxycholic acid administration”; E. Baglivo, F. Azzaroli, M. Montagnani, V. Feletti, P.Simoni, M. Locatelli, D. De Aloysio, G. Pelusi, F. Lodato, D. Festi, A. Colecchia, E. Roda, A.Roda, G. Mazzella; 41° Annual Meeting of the European Association for the study of the Liver,Vienna, Austria, 26-30 April 2006;

p 11. “Glucosamine plasma and synovial fluid concentration before and after oral administration ofcrystalline glucosamine sulfate in knee osteoarthritis Patients”; S. Persiani, R. Rotini, G.Trisolino, D. Paganini, L.C. Rovati, M. Locatelli, A. Roda;ECCEO6, Vienna, Austria, 15-18March 2006;

p 12. “Sviluppo e validazione di un metodo HPLC-ESI-MS/MS per la determinazione di glucosaminain plasma umano”; M. Locatelli, A. Roda, P. Nanni, M. Guardigli, Lucio C. Rovati, S. Persiani;XXII Congresso Nazionale della Società Chimica Italiana (SCI2006), Firenze, Italia, 10-15September 2006;

p 13. “The foetal-maternal circulation of bile acids and bilirubin: effects of cholestasis andursodeoxycholic acid administration”; F. Azzaroli, E. Baglivo, M. Montagnani, V. Feletti, P.Simoni, M. Locatelli, D. De Aloysio, G. Pelusi, F. Lodato, D. Festi, A. Colecchia, A. Roda, E.Roda, G. Mazzella; XIX International Bile Acid Meeting; Bile Acids: Biological Actions andClinical Relevance, Konzerthaus, Friburgo, Germania, 6-7 October 2006;

p 14. “Sviluppo e validazione di un metodo HPLC-ESI-MS/MS per la determinazione dell’acido 5-aminosalicilico (5-ASA) e dell’acido N-acetil-5-aminosalicilico, suo metabolita principale, incampioni di plasma umano”; M. Locatelli, E. Pastorini, P. Simoni, G. Roda, E. Roda, A. Roda;XX Congresso Nazionale di Chimica Analitica (SCI2007), S. Martino al Cimino (Viterbo), Italia,16-20 September 2007;

p 15. “Liquid Chromatography-tandem mass spectrometry method for determination of 5-aminosalicilic (5-ASA) acid and its major metabolite N-acetyl-5-aminosalicilic acid in humanplasma samples”; E. Pastorini, M. Locatelli, P. Simoni, G. Roda, E. Roda, A. Roda; 12thInternational meeting on recent developments in pharmaceutical analysis (RDPA2007), IsolaD’Elba, Italia, 23-26 September 2007;

p 16. “Pharmacokinetics of glucosamine in man after oral administration of crystalline glucosaminesulfate or glcosamine hydrochloride alone or in combination with chondroitin sulfate”; S.Persiani, L.C. Rovati, E. Pastorini, M. Locatelli, G. Giacovelli, D. Paganini, A. Roda; OARSI,Ft. Lauderdale, FL, USA, 06-09 December 2007;

p 17. “Liquid chromatography-tandem mass spectrometry method for determination of 5-aminosalicylic acid (5-asa) and its major metabolite N-acetyl-5-asa in human plasmasamples”; E. Pastorini, M. Locatelli, P. Simoni, G. Roda, E. Roda, A. Roda; 5th MS-Pharmaday 2008, Verona, 27-29 October 2008;

p 18. “Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicilic acid (5-ASA) and its major metabolite N-acetyl-5-aminosalicilic acid in humanplasma”; E. Pastorini, M. Locatelli, P. Simoni, G. Roda, S. Vecchiotti, A. Roda; Workshop“Spettrometria di massa quantitativa, tecniche di imaging e di screening per la determinazionedi proteine e farmaci”, Roma, Italia, 4-5 December 2008;

p 19. “Comparison of different sorbents for the simultaneous SPE of eight NSAIDs from humanplasma coupled with HPLC”; G. Carlucci, M. D’Ercole, L. Di Federico, P. Iuliani, M. Locatelli;XXIII Congresso Nazionale della Società Chimica Italiana, Sorrento, Italia, 5-10 July 2009;

p 20. “Preliminary HPLC-UV/Vis study for the quantification of 4’-geranyloxyferulic acid, a newnatural colon cancer chemopreventive agent, in complex matricies”; S. Genovese, M.

Locatelli, M. Curini, F. Epifano, G. Carlucci; 13th International meeting on recentdevelopments in pharmaceutical analysis (RDPA2009), Milano, Italia, 9-12 September 2009;

p 21. “Comparison of three different extraction methods and hplc determination of anthraquinones,aloe-emodine, emodine, rheine, chrysophanol and physcione, in bark of rhamnus alpinus”; M.Locatelli, F. Tammaro, L. Menghini, L. Leporini, G. Carlucci, L. Di Federico, F. Epifano, S.Genovese; Sezioni Toscana Umbria Marche Abruzzo, XXVIII Congresso Interregionale TUMA2009, Tirrenia (Pisa), 20-22 September 2009;

p 22. “Dati preliminari sulla contaminazione da idrocarburi di origine naturale in acquedell’appennino abruzzese”; Riccardo Petaccia, Sergio Rusi, Lucia Di Federico, MarcelloLocatelli, Giuseppe Carlucci; Sezioni Toscana Umbria Marche Abruzzo, XXVIII CongressoInterregionale TUMA 2009, Tirrenia (Pisa), 20-22 September 2009;

p 23. “HPLC determination of anthraquinones, aloe-emodine, emodine, rheine, chrysophanol andphyscione, in bark of rhamnus alpinus: comparison of three different extraction methods”;Salvatore Genovese, FernandoTammaro, Luigi Menghini, Giuseppe Carlucci, FrancescoEpifano, Marcello Locatelli; XVIII Italo-Latinoamerican Congress of Etnomedicine SILAE 2009,La Habana, Cuba, 14-18 September 2009;

p 24. “Selettività nelle separazioni in fase inversa: influenza del tipo di solvente, fase mobile e pHnella separazione di antinfiammatori non steroidei”; Lucia Di Federico, Piera Iuliani, MauraCarlucci, Marcello Locatelli, Giuseppe Carlucci; 9° SAYCS, Pesaro, 12-14 October 2009;

p 25. “Studio preliminare di quantificazione in matrici complesse mediante HPLC-UV/Vis dell’acido4’-geranilossiferulico, un nuovo agente chemopreventivo del cancro del colon”; F. Epifano, S.Genovese, G. Carlucci, M. Curini, M. Locatelli; Fitomed 2010, Cagliari, Italia, 23-26 June2010;

p 26. “Profilo quantitativo degli antrachinoni e chemical fingerprint della specie Rhamnus saxatilisL.”; M. Locatelli, D. Kremer, F. Tammaro, L. Menghini, G. Carlucci, L. Di Federico, F. Epifano,S. Genovese; Fitomed 2010, Cagliari, Italia, 23-26 June 2010;

p 27. “Sviluppo e validazione di un metodo per la determinazione simultanea di Flurochinolonici eMeropenem in plasma umano in HPLC-DAD”; G. Carlucci, L. Di Federico, M. Locatelli; XXIICongresso Nazionale di Chimica Analitica, Como, Italia, 12-16 September 2010;

p 28. “Meropenem, ofloxacin e ciprofloxacin determinati simultaneamente in plasma umano contecnica SPE -HPLC-DAD”; Margherita Settimio, Marcello Locatelli, Giuseppe Carlucci; 10°SAYCS, Pesaro, 18-20 October 2010;

p 29. “A novel group of secondary metabolites in Rhamnus spp.: Prenyloxyanthraquinones”;Salvatore Genovese, Francesco Epifano, Giuseppe Carlucci, Marcello Locatelli; InternationalConference on Natural Products, Castres, 24-27 May 2011;

p 30. “Simultaneous determination of meropenem, ciprofloxacin, and ofloxacin in human plasmausing RP-HPLC-DAD method development, validation and optimization of variousexperimental parameters”; Carlucci Giuseppe, Settimio Margherita, Locatelli Marcello; XXIVCongresso Nazionale di Chimica Analitica, Lecce, Italia, 11-16 September 2011;

p 31. “Development and validation of a new HPLC-UV/Vis method for the direct determination ofoxyprenylated-anthraquinones produced by Rhamnus spp.”; Locatelli M, Genovese S,Carlucci G, Kremer D, Epifano F; XX Italo-Latinoamerican Congress of Etnomedicine SILAE2011, Fortaleza, Brasile, 19-22 September 2011;

p 32. “Optimization of experimental parameters in the HPLC determination of carbapenems andfluoroquinolones in human plasma”; Margherita Settimio, Maura Carlucci, Marcello Locatelli,Giuseppe Carlucci; 11° SAYCS, Pesaro, 17-19 October 2011;

p 33. “Campionamento e dosaggio di analiti d’interesse farmaceutico da gocce di sangue seccomediante LC-MS/MS”; Giuseppe Carlucci, Marcello Locatelli; Sezioni Toscana Umbria MarcheAbruzzo, XXXI Congresso Interregionale TUMA 2012, Francavilla al Mare (CH), 18-20 June2012;

p 34. “Chromatogaphic determination of molar absorptivity of natural prenyloxycinnamic acids instandardless analysis”; Giuseppe Carlucci, Francesco Epifano, Salvatore Genovese, MarcelloLocatelli; International Congress on Natural Products Research ICNPR2012, New York City(NY), 28 July – 01 August 2012.

p 35. “Validation of HPLC assay for the determination of oxyprenylated anthraquinones produced byrhamnus species”; Marcello Locatelli, Giuseppe Carlucci, Francesco Epifano, Dario Kremer,Salvatore Genovese; International Congress on Natural Products Research ICNPR2012, NewYork City (NY), 28 July – 01 August 2012.

p 36. “Quantification of 4’-geranyloxyferulic acid and boropinic acid by HPLC-DAD in grapefruit skinfrom different country origins”; Marcello Locatelli, Giuseppe Carlucci, Salvatore Genovese,Francesco Epifano; International Congress on Natural Products Research ICNPR2012, NewYork City (NY), 28 July – 01 August 2012.

p 37. “Anthraquinone chemical fingerprint: madagascin from the fruits of rhamnus spp.”; GiuseppeCarlucci, Francesco Epifano, Salvatore Genovese, Dario Kremer, Marcello Locatelli;International Congress on Natural Products Research ICNPR2012, New York City (NY), 28July – 01 August 2012.

p 38. “Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry”;Adriano Mollica, Azzurra Stefanucci, Roberto Costante, Francesco Pinnen, Marcello Locatelli;International Congress on Natural Products Research ICNPR2012, New York City (NY), 28July – 01 August 2012.

p 39. “Ultratrace level voltammetric determination of total mercury and toxic metals in tea matrices”;Clinio Locatelli, Dora Melucci and Marcello Locatelli; International Congress on NaturalProducts Research ICNPR2012, New York City (NY), 28 July – 01 August 2012.

p 40. “Mutual interference problems in the simultaneous voltammetric determination of ultra-tracetotal mercury (II) and toxic metals in medicinal herbs matrices”; Clinio Locatelli, Dora Melucciand Marcello Locatelli; International Congress on Natural Products Research ICNPR2012,New York City (NY), 28 July – 01 August 2012.

p 41. “HPLC-DAD method for the simultaneous determination of Prulifloxacin and Ulifloxacin inhuman plasma samples for stability studies”; Giuseppe Carlucci, Annalisa Romagnoli,Federica De Lutiis, Marcello Locatelli; XXIII Congresso Nazionale della Divisione di ChimicaAnalitica, Isola d’Eba,Italia, 16-­20 September 2012;

p 42. “Secondary metabolites chemical fingerprint in rhamnus spp. using validated HPLC assay”;Giuseppe Carlucci, Francesco Epifano, Salvatore Genovese, Gerardo Bellino, MarcelloLocatelli; XXII Italo-Latinoamerican Congress of Etnomedicine SILAE 2013, Puntarenas,Costa Rica, 2-6 September 2013;

p 43. “Application of experimental designs in optimization of spe-hplc-uv method for thedetermination of nsaids in human plasma samples”; Valentina Masci, Marcello Locatelli,Giuseppe Carlucci; Sezioni Toscana Umbria Marche Abruzzo, XXXII CongressoInterregionale TUMA 2013, Sesto Fiorentino (FI), 1-2 July 2013;

p 44. “Solid phase microextraction (SPME) of drugs from biological samples”; Lorenza Piscione,Marcello Locatelli, Giuseppe Carlucci; Sezioni Toscana Umbria Marche Abruzzo, XXXIICongresso Interregionale TUMA 2013, Sesto Fiorentino (FI), 1-2 July 2013

p 45. “Asymmetric dimethylarginine, monomethylarginine, symmetric dimethylarginine and L-Arginine in biological fluids determined by Ultra Performance Liquid Chromatography withfluorescence detection”; Carlucci G, Scotti L, Bucciarelli T, Locatelli M; Sezioni ToscanaUmbria Marche Abruzzo, XXXII Congresso Interregionale TUMA 2013, Sesto Fiorentino (FI),1-2 July 2013

p 46. “Dried blood spot sampling for simultaneous determination of drugs”; Mariassunta Di Battuto,Marcello Locatelli, Giuseppe Carlucci; Sezioni Toscana Umbria Marche Abruzzo, XXXIICongresso Interregionale TUMA 2013, Sesto Fiorentino (FI), 1-2 July 2013

p 47. “Ultra performace liquid chromatography with fluorescence detection for simultaneousdetermination of asymmetric dimethylarginine, monomethylarginine, symmetricdimethylarginine and L-arginine in biological fluids”; Luca Scotti, Tonino Bucciarelli, MarcelloLocatelli, Giuseppe Carlucci; XXIV Congresso della Divisione di Chimica Analitica dellaSocietà Chimica Italiana, Sestri Levante (GE), 15-19 September 2013;

p 48. “HPLC analysis of 4'-geranyloxyferulic and boropinic acids in grapefruits of differentgeographical origin”; Salvatore Genovese, Francesco Epifano, Giuseppe Carlucci, DanilaPriscilli, Gerardo Bellino, Serena Fiorito, Marcello Locatelli; XIII Congresso della SocietàItaliana di Fitochimica, Gargnano, 19-21 September 2013;

p 49. “Complessi di Lawsone e Lapacolo ad attività citotossica”; Serena Fiorito, Francesco Epifano,Salvatore Genovese, Massimo Curini, Marcello Locatelli, Veronique Mathieu, Robert Kiss; XIIICongresso della Società Italiana di Fitochimica, Gargnano, 19-21 September 2013;

p 50. “Targeting MMP-2, MMP-9 and MMP-13 in pancreatic juice”; Sulpizio S., Franceschini N.,Ianni A., Locatelli M., Carlucci G., Bassi C., Cotellese R., Innocenti P., Selvaggi F.; 57°National Meeting of the Italian Society of Biochemistry and Molecular Biology, Ferrara, 18-20September 2013;

p 51. “Studio sull’interazione tra Glutatione e Morfolina”; Allocati Nerino, Masulli Michele, LocatelliMarcello, Carlucci Giuseppe, Di Ilio Carmine; 41° Congresso Nazionale Della Società ItalianaDi Microbiologia, Rimini, 13-16 October 2013;

p 52. “Recent developments in SPME techniques in drug analysis from biological matrices”;Lorenza Piscione, Maura Carlucci, Marcello Locatelli, Giuseppe Carlucci; 13° SAYCS,Riccione, Italia, 28-30 October 2013;

p 53. “Recent developments in SPME techniques in drug analysis from biological matrices”;Lorenza Piscione, Maura Carlucci, Marcello Locatelli, Giuseppe Carlucci; 13° SAYCS,Riccione, Italia, 28-30 October 2013;

p 54. “An easy HPLC-UV/Vis methodology for the quantification of polyphenols in propolis,grapefruit seeds, and elder fruits extracts”; Salvatore Genovese, Serena Fiorito, FrancescoEpifano, Vito Alessandro Taddeo, Marcello Locatelli; PSE Meeting – Phytochemicals inMedicine and Pharmacognosy, Piatra Neamt, Romania, 27-30 April 2014;

p 55. “Bergamot essential oil (BEO)-loaded liposomes: nanoformulation for anticancer activity onneuroblastoma cells”; Christian Celia, Elena Trapasso, Marcello Locatelli, Donato Cosco,Cinzia Anna Ventura, Joy Wolfram, Maria Carafa, Morittu Valeria, Domenico Britti, Luisa DiMarzio, Donatella Paolino; 9th World Meeting on Pharmaceutics, Biopharmaceutics andPharmaceutical Technology, Lisbona 31 Marzo-3 April 2014;

p 56. “Attività in vitro di aloe vera gel nei confronti di Helicobacter pylori”; Soraya Di Bartolomeo,

Valentina Cataldi, Riccardo Miracapillo, Salvatore Genovese, Marcello Locatelli, Mara Di

Giulio; X Congresso Nazionale della Società Italiana di Microbiologia Farmaceutica, Chieti, 6-7 June 2014;

p 57. “Valutazione di un sistema per la bonifica di aree contaminate da morfolina”; LocatelliMarcello, Masulli Michele, Ferrone Vincenzo, Carlucci Giuseppe, Di Ilio Carmine, AllocatiNerino; X Congresso Nazionale della Società Italiana di Microbiologia Farmaceutica, Chieti, 6-7 June 2014;

p 58. “Combined derivatization and HPLC-FL-DAD for simultaneous analysis of Octreotide andGabexate Mesylate metabolite in human pancreatic juice samples”; G. Carlucci, F. Selvaggi,S. Sulpizio, C. Bassi, R. Cotellese, V. Ferrone, P. Innocenti, M. Locatelli; XXV CongressoNazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 07-12 September 2014;

p 59. ““Study of the kinetic release of anti inflammatory drugs from electrospun nanostructuredpolymeric membranes”; Marcello Locatelli, Pantaleone Bruni, Vincenzo Ferrone, StefanoNarcisi, Giuseppe Carlucci, Fausto Croce; XXV Congresso Nazionale della Società ChimicaItaliana, Arcavacata di Rende (CS), 07-12 September 2014;

p 60. “PAHs detection in red wine using central composite design to optimise the extractionprocedure and GC-FID analyses“; Marcello Locatelli, Roberta Cifelli, Luca Forcucci, VincenzoFerrone, Martina Di Francesco, Rosita Primavera, Donato Cosco, Clinio Locatelli, DoraMelucci, Luisa Di Marzio, Christian Celia; Food Processing Innovation and Green ExtractionTechnologies: recent advances and applications in human health, Catanzaro (CZ), 25-26September 2014;

p 61. “Simultaneous determination of eperisone and paracetamol in pharmaceutical formulations byderivative spectrophotometry and high performance liquid chromatography”; GiuseppeCarlucci, Vincenzo Ferrone, Maura Carlucci, Marcello Locatelli; Sezioni Toscana UmbriaMarche Abruzzo, XXXII Congresso Interregionale TUMA 2014, Pesaro (PU), 16-18September 2014;

p 62. “Ulifloxacin, the active metabolite of Prulifloxacin measured in human plasma. devolopmentand validation of a HPLC-PDA method”; Giuseppe Carlucci, Vincenzo Ferrone, MauraCarlucci, Simona Bacchi, Giancarlo Palumbo, Marcello Locatelli; Sezioni Toscana Umbria

Marche Abruzzo, XXXII Congresso Interregionale TUMA 2014, Pesaro (PU), 16-18September 2014;

p 63. “Study of scaffold and drugs delivery from electrospun nanostructured polymericmembranes”; Pantaleone Bruni, Marcello Locatelli, Vincenzo Ferrone, Stefano Narcisi, OrianaTrubiani, Francesca Diomede, Fausto Croce; 14° SAYCS, Riccione, Italia, 27-29 October2014;

CONGRESS AND SEMINAR PARTECIPATIONpar 1. Seminar ”Spettrometria di Massa LC-MS Tandem: Tecniche operative e applicazioni”,

Bologna, 16 Gennaio 2004;

par 2. Seminar ”Recenti Sviluppi della Spettrometria di Massa con Ionizzazione Soft”, Bologna, 07Maggio 2004;

par 3. Seminar ”Mutation of metal regulatory protein”, Bologna, 14 Maggio 2004;

par 4. Giornata di studio “Sicurezza degli alimenti. Nuovi metodi di controllo per contaminanti naturaliin tracce”, Parma, 18 Maggio 2004;

par 5. Seminar ”The Biological Significance of the lambda N Protein Attenuation”, Bologna, 24Maggio 2004;

par 6. Seminar “Application of magnetic nanoparticles and magnetic flow sorting to cell analysis andseparation”, Bologna, 28 Maggio 2004;

par 7. Seminar “La nutraceutica del terzo millennio”, Bologna, 04 Giugno 2004;

par 8. Seminar Agilent Technologies “Proteomica e caratterizzazione delle proteine”, Milano, 08Giugno 2004;

par 9. XVIII Congresso Nazionale di Chimica Analitica, Parma, 19-23 Settembre 2004;

par 10. Seminar “Il proteoma, anno domini 2005”, Bologna, 10 Gennaio 2005;

par 11. Seminar ”Biological nanotechnology”, Bologna, 10 Febbraio 2005;

par 12. Seminar ”Use of Liquid Chromatography/Mass Spectrometry (LC/MS) and CapillaryElectrophoresis/Mass Spectrometry (CE/MS) in pharmaceutical analysis”, Bologna, 17Febbraio 2005;

par 13. Seminar “Frazionamento in campo-flusso per il cell-sorting: applicazioni alle cellule staminali”,Bologna, 04 Marzo 2005;

par 14. Seminar “Spectroscopic determination of protein structures by 2D NMR methods”, Bologna,15 Marzo 2005;

par 15. Seminar “Toward Proteomics with Flow Field-Flow Fractionation and Nanoflow LC-MSMS”,Bologna, 14 Aprile 2005;

par 16. Seminar “Il significato sociale, gli obiettivi e l’attività educativa della Convenzione sullaProibizione delle Armi Chimiche firmata da 169 Nazioni”, Bologna, 28 Aprile 2005;

par 17. Giornata di aggiornamento “Innovazione in Spettrometria di Massa”, Padova, 27 Settembre2005;

par 18. Seminar “La strumentazione virtuale nel campo della chimica”, Bologna, 19 Ottobre 2005;

par 19. Seminar “Informazione Formazione Progettazione sui principi della Convenzione di Parigi peril bando delle armi chimiche e del cattivo uso della chimica”, Bologna, 21 Dicembre 2005;

par 20. Lectio Magistralis, ISA Medal for Science “From Matter to Life: Chemistry?!”, Bologna, 04Aprile 2006;

par 21. Seminar “Elettronica Molecolare – un approccio ibrido?”, Bologna, 07 Aprile 2006;

par 22. Seminar “Nanobioscienza: lo studio dei fenomeni biologici una molecola alla volta”, Bologna,28 Aprile 2006;

par 23. Seminar “On-Line coupling of SPE-HPLC-MS/MS for fast trace analysis of pesticides indrinking and surface water”, Ferrara, 06 Giugno 2006;

par 24. Seminar “Evoluzione temporale della concentrazione atmosferica di CO2 presso la stazioneGAW di Monte Cimone: l’effetto serra visto da vicino”, Bologna, 08 Giugno 2006;

par 25. Seminar “Profili verticali di articolato atmosferico nella città di Milano. Le problematichenell’analisi dei dati sperimentali”, Bologna, 09 Giugno 2006;

par 26. Seminar “Recenti Sviluppi della Cromatografia Liquida accoppiata alla Spettrometria di Massanell’ambito farmaceutico”, Bologna, 12 Giugno 2006;

par 27. Convegno “Piano di tutela delle acque della Regione Emilia-Romagna”, AssessoratoAmbiente e Sviluppo Sostenibile, Regione Emilia-Romagna, Bologna, 7 Luglio 2006;

par 28. Workshop “Dalla Proteomica alla Metalloproteomica: nuove strategie analitiche”, Parma, 3Ottobre 2006;

par 29. Convegno “La Rete dell’alta Tecnologia dell’Emilia Romagna: I Laboratori a Rete e gli Spin-Off della provincia di Ferrara”, Ferrara, 5-6 Dicembre 2006;

par 30. Seminar “Dalle combinazioni gassose di Gay-Lussac all’ipotesi di Avogadro”, Bologna, 31Gennaio 2007;

par 31. Convegno “Mass Spectrometry integrated solution”, Bologna, 20 Febbraio 2007

par 32. Seminar “Towards a sustainable chemistry: strategic research and development at BASF”,Bologna, 13 Marzo 2007;

par 33. Seminar “Research and Application of Liquid Mixing technologies to the pharmaceuticalindustry: challenger and opportunities”, Bologna, 13 Marzo 2007;

par 34. Seminar “Il ruolo del chimico forense”, Bologna, 14 Marzo 2007;

par 35. Seminar “Luciferase from the Italian firefly lucciola Italica: first clonino and bioanalyticalapplications”, Bologna, 16 Marzo 2007;

par 36. Seminar “Utilizzo processuale delle tecniche analitiche nelle indagini legali”, Bologna, 21Marzo 2007;

par 37. Seminar “Proteomics & Small Molecules User’s Meeting”, Bologna, 28-29 Marzo 2007;

par 38. Seminar “Determinazione della cocaina e del suo metabolica benzoilecgonina nelle acquesuperficiali e reflue per la valutazione del consumo giornaliero”, Bologna, 21 Giugno 2007;

par 39. Seminar “Biomedicina e Biotecnologie per lo spazio: la sfida del prossimo futuro”, Bologna, 28Ottobre 2007;

par 40. “Giornata dei Dottori di Ricerca”, Bologna, 24 Novembre 2007;

par 41. Seminar “Chip-based analytical methods for clinical chemistry”, Bologna, 2 Ottobre 2008;

par 42. Seminar “Nuove soluzioni applicative nel campo dell’analisi ambientale e alimentare medianteLC/MS/MS”, Zola Predosa (Bo), 26 Novembre 2008;

par 43. Seminar “Gli oli volatili: aspetti fitochimici dei terpenoidi e loro estrazione dalla droga fresca”,Chieti (Ch), 21 Luglio 2009;

par 44. Seminar “Data, knowledge and disease context in drug discovery: traslational approaches tomanaging risk (from a reductionist to a holistic approach”, Chieti (Ch), 11 Settembre 2009;

par 45. Workshop “La tecnologia innovativa che rivoluzionerà la cromatografia liquida”, Chieti, 21Ottobre 2009;

par 46. Seminar “Approccio chemioterapico per l’ottimizzazione di metodi analitici nell’analisi dixenobiotici”, Chieti (Ch), 09 Febbraio 2010;

par 47. Seminar “Relazione QSAR e sua applicazione in ambito farmacéutico ambientale”, Chieti(Ch), 25 Febbraio 2010;

par 48. Seminar “Mass Spectrometry User Meeting”, Roma, 29-30 Novembre 2010;

par 49. Seminar “La Scienza per l’Arte: dal Rinascimento al Contemporaneo”, Chieti (Ch), 11 Gennaio2011;

par 50. Seminar "Agilent Technologies EXPO 2011", Pescara (Città Sant’Angelo), 24 Marzo 2011;

par 51. Seminar “CRANBERRY PROANTHOCYANIDINS: Natural weapons against periodontaldiseases. PROANTOCIANIDINE DEI MIRTILLI: RIMEDI NATURALI CONTRO LE MALATTIEPERIODONTALI”, Chieti (Ch), 19 Maggio 2011

MARCELLO LOCATELLI

The research activity is aimed at the development and validation of chromatographic methods (according to

international guidelines, ICH) for the qualitative and quantitative determination of biologically active

molecules in human and animal (eg. Serum, plasma, bile, liver tissue, hypothalamus, kidney, feces, urine),

cosmetics, food, and environmental complex matrices.

It provides, in addition, to the study of all processes related to pre-analytical stages such as sampling,

extraction and purification, separation, enrichment, even the application of conventional and hyphenated

analytical methods for the accurate, sensitive and selective determination of biologically active molecules.

These procedures have been applied to different analytes: glucosamine [2], 5-amino-salicylic acid [4], natural

or synthetic bile acids [21], anti-inflammatory [22, 23, 37] and fluoroquinolones [25, 42], secondary metabolites from

plant [6, 7, 8, 10, 11, 12, 15, 16, 17, 18, 19, 20, 24, 26, 28, 32, 33, 35, 38, 43, 44], heavy metals [31, 36], also finding application in

clinical and pre-clinical studies designed to assess the pharmacokinetic, bioequivalence and Absorption,

Distribution, Metabolism and Excretion (ADME) of the formulations examined [1, 3, 5], also in order to

characterize new delivery systems of the active principle [30, 41] to improve their pharmacological properties.

In the development of the method are applied predictive models and chemometric both for the optimisation of

extraction protocols and for final data processing [29].

Particular attention is given to the new instrument configurations for the quantitative analysis in complex

matrix [9, 13, 14, 27, 34, 39, 40].

Scientific activity was attested by publication on international journal, by oral and poster communication at

international congress.

Besides he is reviewer for international journals:

1. Trends in Analytical Chemistry;

2. Journal of Chromatography A;

3. Talanta;

4. Food Chemistry;

5. Food and Chemical Toxicology,

6. Journal of Food Composition and Analysis;

7. Instrumentation Science & Technology;

8. Analytical Letters;

9. Phytochemical Analysis;

10. Environmental Science and Pollution Research;

11. Acta Chromatographica;

12. Journal of Separation Science;

13. Environmental Science & Technology;

14. Journal of Enzyme Inhibition and Medicinal Chemistry;

15. Chemistry Central Journal;

16. Central European Journal of Chemistry;

17. Global Journal of Analytical Chemistry;

18. Industrial & Engineering Chemical Research;

19. Bioorganic & Medicinal Chemistry;

20. Natural Product Research;

21. Current Bioactive Compounds;

22. Current Organic Chemistry;

23. Catalysis Letters;

24. Molecules;

25. Medicinal Chemistry;

26. Mini-Review in Medicinal Chemistry;

27. Mini-Review in Organic Chemistry;

28. British Journal of Pharmaceutical Research;

29. Preparative Biochemistry and Biotechnology;

30. African Journal of Pharmacy and Pharmacology;

31. Bio Med Research International;

32. Journal of advances in medical and pharmaceutical Science;

33. European Journal of Medicinal Plants;

34. Evidence-Based Complementary and Alternative Medicine.

35. Czech Journal of Food Sciences;

36. Journal of Chemistry;

37. Journal of King Saud University

He’s a referee for MIUR Institution for National Projects (SIR).

He's member of the Editorial Board of the journal “Current Bioactive Compounds” (Bentham Science

Publisher), and "Pharmaceutica Analytica Acta" (Omics Publishing Group). He is a member of the Scientific

Committee of the journal "Science and Research", published by the Italian Association of the Book.

ELENCO DELLE PUBBLICAZIONI A STAMPApub 1. “Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of cristalline glucosamine

sulfate in man"; S. Persiani, E. Roda, L. C. Rovati, M. Locatelli, G. Giacovelli, A. Roda; Osteoarthritis andcartilage, 13, 1041-1049, 2005;Impact Factor: 4.215 – full article

pub 2. “Development and Validation of a Sensitive HPLC-ES-MS/MS Method for the Direct Determination ofGlucosamine in Human Plasma”; Aldo Roda, Laura Sabatini, Anna Barbieri, Massimo Guardigli, MarcelloLocatelli, Francesco Saverio Violante, Lucio C. Rovati, Stefano Persiani; Journal of Chromatography B, 844,119–126, 2006;Impact Factor: 2.647 – full article

pub 3. “Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosaminesulphate at therapeutic dose”; Persiani S, Rotini R, Trisolino G, Rovati LC, Locatelli M, Paganini D, Antonioli D,Roda A; Osteoarthritis and Cartilage, 7, 764-772,2007;Impact Factor: 3.793 – full article

pub 4. “Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and itsmajor metabolite N-acetyl-5-aminosalicylic acid in human plasma”; Elisabetta Pastorini, Marcello Locatelli,Patrizia Simoni, Giulia Roda, Enrico Roda, Aldo Roda; Journal of Chromatography B, 872, 99–106, 2008;Impact Factor: 2.500 – full article

pub 5. “Pharmacokinetics and Safety of a New 1200 mg Single-Dose Delayed Release Mesalazine MicrogranuleFormulation”; Roda Aldo, Simoni Patrizia, Roda Giulia, Caponi Alessandra, Pastorini Elisabetta, LocatelliMarcello, Roda Enrico; Journal of Bioequivalence & Bioavailability, 1 (2), 044-051, 2009;Open access – full article

pub 6. “Anthraquinone profile and chemical fingerprint of Rhamnus saxatilis L. from Italy”; M. Locatelli, F. Tammaro, L.Menghini, G. Carlucci, F. Epifano and S. Genovese; Phytochemistry Letters, 4 (2), 223-226, 2009;Impact Factor: 0.957 – full article

pub 7. “Comparison of Three Different Extraction Methods and HPLC Determination of the Anthraquinones Aloe-emodine, Emodine, Rheine, Chrysophanol and Physcione in the Bark of Rhamnus alpinus L. (Rhamnaceae)”; S.Genovese, F. Tammaro, L. Menghini, G. Carlucci, F. Epifano, M. Locatelli; Phytochemical Analysis, 21, 261-267,2010;Impact Factor: 1.848 – full article

pub 8. “Quantification of 4’-geranyloxyferulic acid, a new natural colon cancer chemopreventive agent, by HPLC-DAD ingrapefruit skin extract”; S. Genovese, F. Epifano, G. Carlucci, M.C. Marcotullio, M. Curini, M. Locatelli; Journal ofPharmaceutical and Biomedical Analysis, 53, 212-214, 2010.Impact Factor: 2.733 – full article

pub 9. “Advanced Capillary Electrophoresis Techniques in the Analytical Quantification of Drugs, Metabolites andBiomarkers in Biological Samples”; M. Locatelli, G. Carlucci; Global Journal of Analytical Chemistry, 1(3), 244-261, 2010.Open access – review

pub 10. “Anthraquinones: analytical techniques as a novel tool to investigate on the triggering of biological targets”; M.Locatelli; Current Drug Targets, 12 (3), 366-380, 2011.Impact Factor: 3.553 – review

pub 11. “Use of HPLC in the determination of the molar absorptivity of 4'-geranyloxyferulic acid and boropinic acid”; M.Locatelli, G. Carlucci, S. Genovese, M. Curini, F. Epifano; Chromatographia, 73, 889-896, 2011.Impact Factor: 1.195 – full article

pub 12. “Anthraquinone Profile, Antioxidant and Antimicrobial Properties of Bark Extracts of Rhamnus catharticus and R.orbiculatus”; M. Locatelli, F. Epifano, S.Genovese, G. Carlucci, M. Zovko Končić, I. Kosalec, D. Kremer; NaturalProduct Communications, 6 (9), 1275-1280, 2011.Impact Factor: 1.242 – full article

pub 13. “Recent application of analytical methods to phase I and phase II drugs development: a review.”; M. Locatelli, L.Governatori, G. Carlucci, S. Genovese, A. Mollica, F. Epifano; Biomedical Chromatography, 26, 283-300, 2012.Impact Factor: 1.945 – review

pub. 14 “Recent HPLC strategies to improve sensitivity and selectivity for the analysis of complex matrices”; M. Locatelli,D. Melucci, G. Carlucci, C. Locatelli; Instrumentation Science & Technology, 40 (2-3), 112-137, 2012.Impact Factor: 0.429 – review

pub. 15 “Novel prodrugs for the treatment of colonic diseases based on 5-aminosalicylic acid, 4'-geranyloxyferulic acid,and auraptene: biological activities and analytical assays”; F. Epifano, S. Genovese, G. Carlucci, M. Locatelli;Current Drug Delivery, 9 (2), 112-121, 2012.Impact Factor: ... – review

pub. 16 “Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.) Schur and F. alnusMill. bark”; D. Kremer, I. Kosalec, M. Locatelli, F. Epifano, S. Genovese, G, Carlucci, M. Zovko Končić; FoodChemistry, 131(4), 1174-1180, 2012.Impact Factor: 3.334 – full article

pub. 17 “Development and application of high-performance liquid chromatography for the study of two newoxyprenylated-anthraquinones produced by Rhamnus species”; M. Locatelli, S. Genovese, G. Carlucci, D.Kremer, M. Randic, F. Epifano; Journal of Chromatography A, 1225, 113-120, 2012.Impact Factor: 4.612– full article

pub. 18 Screening for oxyprenylated anthraquinones in Mediterranean Rhamnus species”; S. Genovese, F. Epifano, M.Curini, D. Kremer, G. Carlucci, M. Locatelli; Biochemical Systematics and Ecology, 43, 125-127, 2012.Impact Factor: 1.153 – full article

pub. 19 “Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated IndolicSystems”; Adriano Mollica, Marcello Locatelli, Azzurra Stefanucci, Francesco Pinnen; Molecules, 17, 6083-6099,2012.Impact Factor: 2.428 – review

pub. 20 “Re-investigation of the anthraquinone pool of Rhamnus spp.: madagascin from the fruits of Rhamnus catharticaand R. intermedia”; Epifano F, Genovese S, Kremer D, Carlucci G, and Locatelli M; Natural ProductCommunications, 7 (8), 1029-1032, 2012.Impact Factor: 0.956 – full article

pub. 21 “Reduced biliary sterol output with no change in total faecal excretion in mice expressing a human apolipoproteinA-I variant”; Cinzia Parolini, Silvia Caligari, Donatella Gilio, Stefano Manzini, Marco Busnelli, Marco Montagnani,Marcello Locatelli, Erika Diani, Flavio Giavarini, Donatella Caruso, Enrico Roda, Aldo Roda, Cesare R. Sirtoriand Giulia Chiesa; Liver International, 32 (9), 1363-1371, 2012.Impact Factor: 3.870 – full article

pub. 22 “Analysis of Anti-inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review”; GiuseppeCarlucci, Maura Carlucci, Marcello Locatelli; Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(1), 96-112, 2012.Impact Factor: ... – review

pub. 23 “Recent Advances in Anti-Inflammatory and Immune-Modulator Drugs Development and Analytical Tools for theirCharacterization”; Marcello Locatelli; Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11 (1), 2-2,2012.Impact Factor: ... editorial/letters

pub. 24 “Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R.intermedia and R. pumila”; I. Kosalec, D. Kremer, M. Locatelli, F. Epifano, S. Genovese, G. Carlucci, M. Randić,M. Zovko Končić; Food Chemistry, 136(2), 335-341, 2013.Impact Factor: 3.259 – full article

pub. 25 “High Performance Liquid Chromatography determination of Prulifloxacin and five related impurities inpharmaceutical formulations”; Marcello Locatelli, Federica De Lutiis, Giuseppe Carlucci; Journal ofPharmaceutical and Biomedical Analysis, 78-79, 27-33, 2013.Impact Factor: 2.829 – full article

pub. 26 “Biological active analogues of the opioid peptide Biphalin: mixed /3-peptides.”; Adriano Mollica, FrancescoPinnen, Roberto Costante, Marcello Locatelli, Azzurra Stefanucci, Stefano Pieretti, Peg Davis, Josephine Lai,David Rankin, Frank Porreca and Victor J. Hruby; Journal of Medicinal Chemistry, 56, 3419-3423, 2013.Impact Factor: 5.480 – full article

pub. 27 “Novel techniques as a tool to investigate on the triggering of biological targets”; Marcello Locatelli; Current DrugTargets, 14(9), 937, 2013.Impact Factor: 3.597 – editorial/letters

pub. 28 “Phytochemistry and Pharmacognosy of Naturally Occurring Prenyloxyanthraquinones”; Francesco Epifano,Serena Fiorito, Giuseppe Carlucci, Marcello Locatelli, Salvatore Genovese; Current Drug Targets, 14(9), 959-963, 2013.Impact Factor: 3.597 – review article

pub. 29 “Application of Pyrolysis-Gas Chromatography-Mass Spectrometry and Multivariate Analysis to Study Bacteriaand Fungi In Biofilms Used For Bioremediation”; Dora Melucci, Stefano Fedi, Marcello Locatelli, Clinio Locatelli,Simona Montalbani, Martina Cappelletti; Current Drug Targets, 14(9), 1023-1033, 2013.Impact Factor: 3.597 – full article

pub. 30 “Anticancer Activity of Liposomal Bergamot Essential Oil (BEO) on Human Neuroblastoma Cells”; ChristianCelia, Elena Trapasso, Marcello Locatelli, Michele Navarra, Cinzia A Ventura, Joy Wolfram, Maria Carafa,Valeria M Morittu, Domenico Britti, Luisa Di Marzio, Donatella Paolino; Colloids and Surfaces B: Biointerfaces,112, 548-553, 2013.Impact Factor: 4.287 – full article

pub. 31 “Trace level voltammetric determination of heavy metals and total mercury in tea matrices (Camellia sinensis)”;Dora Melucci; Marcello Locatelli; Clinio Locatelli; Food and Chemical Toxicology, 62, 901-907, 2013.Impact Factor: 2.610 – full article

pub. 32 “HPLC analysis of 4'-geranyloxyferulic and boropinic acids in grapefruits of different geographical origin”;Salvatore Genovese; Francesco Epifano; Giuseppe Carlucci; Serena Fiorito; Marcello Locatelli; PhytochemistryLetters, 8(1), 190-192, 2014.Impact Factor: ... – full article

pub. 33 “In vitro activity of Aloe vera inner gel against Helicobacter pylori strains”; Luigina Cellini, Soraya Di Bartolomeo,Emanuela Di Campli, Salvatore Genovese, Marcello Locatelli, Mara Di Giulio; Letters in Applied Microbiology,59(1), 43-48, 2014.Impact Factor: ... – full article

pub. 34 “Extraction and Detection Techniques for PAHs Determination in Beverages: A Review”; Marcello Locatelli, LucaForcucci, Francesco Sciascia, Roberta Cifelli, Vincenzo Ferrone, Giuseppe Carlucci; Current Chromatography,1(2), 122-138, 2014.Impact Factor: ... – review article

pub. 35 “Analysis of Biologically Active Oxyprenylated Ferulic Acid Derivatives in Citrus Fruits”; Genovese S, Fiorito S,Locatelli M, Carlucci G, Epifano F; Plant Foods for Human Nutrition, 69, 255-260, 2014.Impact Factor: ... – full article

pub. 36 “Toxic Metals in Herbal Medicines. A Review”; Clinio Locatelli, Dora Melucci, Marcello Locatelli, CurrentBioactive Compounds, 10, 181-188, 2014.Impact Factor: ... – review article

pub. 37 “MicroExtraction by Packed Sorbent and HPLC determination of seven non-steroidal anti-inflammatory drugs inhuman plasma and urine”; Marcello Locatelli, Vincenzo Ferrone, Roberta Cifelli, Renato C Barbacane, GiuseppeCarlucci, Journal of Chromatography A, 1367, 1-8, 2014.Impact Factor: ... – full article

pub. 38 “Screening for novel plant sources of prenyloxyanthraquinones: Senna alexandrina Mill. and Aloe vera (L.) Burm.F.”; Francesco Epifano, Serena Fiorito, Marcello Locatelli, Vito Alessandro Taddeo, Salvatore Genovese, NaturalProduct Research, 29(2), 180-184, 2015.Impact Factor: ... – full article

pub. 39 “Recent advances in the separation and determination of impurities in pharmaceutical products”; Stefano Zaza,Stefano Maria Lucini, Francesco Sciascia, Vincenzo Ferrone, Roberta Cifelli, Giuseppe Carlucci, MarcelloLocatelli; Instrumentation Science & Technology, 43(2), 182-196, 2015.Impact Factor: ... – review article

pub. 40 “Combined derivatization and high-performance liquid chromatography with fluorescence and ultravioletdetection for simultaneous analysis of Octreotide and Gabexate Mesylate metabolite in human pancreatic juicesamples”; G. Carlucci, F. Selvaggi, S. Sulpizio, C. Bassi, M. Carlucci, R. Cotellese, V. Ferrone, P. Innocenti, M.Locatelli, Biomedical Chromatography, IN PRESS, 2015.Impact Factor: ... – full article

pub. 41 “Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan LabExpert”; Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise,Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato C. Barbacane, MassimoFresta, Luisa Di Marzio, Donatella Paolino, Medicinal Chemistry, IN PRESS, 2015.Impact Factor: ... – full article

pub. 42 “Stability study of Prulifloxacin and Ulifloxacin in human plasma by HPLC-DAD”; Marcello Locatelli, RobertaCifelli, Giuseppe Carlucci, Annalisa Romagnoli, Journal Of Enzyme Inhibition And Medicinal Chemistry, INPRESS, 2015.Impact Factor: ... – full article

pub. 43 “Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells”;Paduch R, Wiater A, Locatelli M, Pleszczyńska M, Tomczyk M., Current Drug Targets, IN PRESS, 2015.Impact Factor: ... – full article

pub. 44 “(1→3)-α-D-Glucans from Aspergillus spp.: Structural Characterization and Biological Study on TheirCarboxymethylated Derivatives”; Wiater A, Paduch R, Choma A, Sylwia S, Pleszczyńska M, Tomczyk M,Locatelli M, Janusz S., Current Drug Targets, IN PRESS, 2015.Impact Factor: ... – full article

Pub. 5, 9, 34 not present on Scopus but is present 1 book chapter from NOVAPUBLISHER

At 29/01/2015: 44-9 (5, 9, 34, 39, 40, 41, 42, 43, 44)+1 chapter=36 works present on Scopus